{"id":"https://openalex.org/W657213033","doi":null,"title":"Modelling late toxicity in hypofractionated radiation therapy","display_name":"Modelling late toxicity in hypofractionated radiation therapy","publication_year":2013,"publication_date":"2013-02-22","ids":{"openalex":"https://openalex.org/W657213033","mag":"657213033"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/32036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32036","pdf_url":"http://hdl.handle.net/2077/32036","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/32036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078902716","display_name":"Niclas Pettersson","orcid":"https://orcid.org/0000-0003-4962-0799","observed_orcids":["https://orcid.org/0000-0003-4962-0799"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Niclas Pettersson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4962-0799","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078902716"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/normal-tissue-complication-probability","display_name":"normal tissue complication probability","score":0.8180000185966492},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.5619999766349792},{"id":"https://openalex.org/keywords/fractionation-effects","display_name":"fractionation effects","score":0.7440000176429749},{"id":"https://openalex.org/keywords/linear-quadratic-model","display_name":"linear-quadratic model","score":0.9599999785423279},{"id":"https://openalex.org/keywords/organs-at-risk","display_name":"organs at risk","score":0.6940000057220459},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/rib-fractures","display_name":"rib fractures","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/brachytherapy","display_name":"brachytherapy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/genitourinary-toxicity","display_name":"genitourinary toxicity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/urethral-pain","display_name":"urethral pain","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dose-response-curves","display_name":"dose-response curves","score":0.578000009059906},{"id":"https://openalex.org/keywords/patient-reported-symptoms","display_name":"patient-reported symptoms","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5818695425987244},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5080206394195557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4499616324901581},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17734289169311523}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/32036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32036","pdf_url":"http://hdl.handle.net/2077/32036","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:657213033","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/32036/1/gupea_2077_32036_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/32036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/32036","pdf_url":"http://hdl.handle.net/2077/32036","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W657213033.pdf","grobid_xml":"https://content.openalex.org/works/W657213033.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W146989469","https://openalex.org/W158925505","https://openalex.org/W173611375","https://openalex.org/W1523389686","https://openalex.org/W1576463423","https://openalex.org/W1771200015","https://openalex.org/W1781834802","https://openalex.org/W1965753447","https://openalex.org/W1967034912","https://openalex.org/W1968114652","https://openalex.org/W1968626722","https://openalex.org/W1971747664","https://openalex.org/W1974040882","https://openalex.org/W1974492960","https://openalex.org/W1975292370","https://openalex.org/W1977410687","https://openalex.org/W1977820476","https://openalex.org/W1983228790","https://openalex.org/W1991655915","https://openalex.org/W1993777632","https://openalex.org/W1995276441","https://openalex.org/W1997716779","https://openalex.org/W1997925433","https://openalex.org/W2004006404","https://openalex.org/W2004439942","https://openalex.org/W2008182080","https://openalex.org/W2016871222","https://openalex.org/W2018895767","https://openalex.org/W2019246236","https://openalex.org/W2024347398","https://openalex.org/W2026678422","https://openalex.org/W2029328961","https://openalex.org/W2029517266","https://openalex.org/W2030454158","https://openalex.org/W2030543370","https://openalex.org/W2031005529","https://openalex.org/W2033456044","https://openalex.org/W2035950812","https://openalex.org/W2036018628","https://openalex.org/W2038719581","https://openalex.org/W2040706746","https://openalex.org/W2041547867","https://openalex.org/W2043474993","https://openalex.org/W2043945205","https://openalex.org/W2044205664","https://openalex.org/W2045295764","https://openalex.org/W2045678013","https://openalex.org/W2046701188","https://openalex.org/W2051563205","https://openalex.org/W2052297197","https://openalex.org/W2060653243","https://openalex.org/W2061684576","https://openalex.org/W2065184437","https://openalex.org/W2065840363","https://openalex.org/W2071072154","https://openalex.org/W2071925100","https://openalex.org/W2074386077","https://openalex.org/W2077642996","https://openalex.org/W2081447169","https://openalex.org/W2087286129","https://openalex.org/W2094344741","https://openalex.org/W2095527462","https://openalex.org/W2097512974","https://openalex.org/W2098507748","https://openalex.org/W2100699934","https://openalex.org/W2101459435","https://openalex.org/W2104101548","https://openalex.org/W2104631398","https://openalex.org/W2105150213","https://openalex.org/W2106391737","https://openalex.org/W2106787323","https://openalex.org/W2111050311","https://openalex.org/W2117032294","https://openalex.org/W2119805230","https://openalex.org/W2120431409","https://openalex.org/W2122835483","https://openalex.org/W2123478181","https://openalex.org/W2131860931","https://openalex.org/W2140024826","https://openalex.org/W2141983610","https://openalex.org/W2146130778","https://openalex.org/W2149884878","https://openalex.org/W2150852129","https://openalex.org/W2151819325","https://openalex.org/W2154488733","https://openalex.org/W2154738842","https://openalex.org/W2155979219","https://openalex.org/W2157700029","https://openalex.org/W2158698596","https://openalex.org/W2159598747","https://openalex.org/W2159677793","https://openalex.org/W2160612556","https://openalex.org/W2163217542","https://openalex.org/W2167270572","https://openalex.org/W2171509297","https://openalex.org/W2232271406","https://openalex.org/W3146401935"],"related_works":["https://openalex.org/W2023067849","https://openalex.org/W2155647244","https://openalex.org/W2049357786","https://openalex.org/W3198905338","https://openalex.org/W2152541019","https://openalex.org/W7221628048","https://openalex.org/W2967647023","https://openalex.org/W2891478556","https://openalex.org/W2040755747","https://openalex.org/W3196434360"],"abstract_inverted_index":{"In":[0],"hypofractionated":[1,88,223,281],"radiation":[2,136,277],"therapy":[3,137,278],"(RT),":[4],"the":[5,26,91,107,165,170,174,201,231,270,287,371,378,392,401,445,463,472],"treatment":[6,140,365],"is":[7,18,29,40,71,78,234,284,321],"delivered":[8,30],"by":[9,87,164,370,462],"few":[10],"fractions":[11,33],"with":[12,34,138,183,238,269,293,327,339,363,428,436],"high":[13],"doses":[14,36,133,355,461],"per":[15,37],"fraction.":[16,38],"This":[17],"in":[19,31,43,54,67,83,134,205,245,356,377,466],"contrast":[20],"to":[21,79,99,130,144,151,286,315,330,344,352,400],"conventionally":[22,273],"fractionated":[23,274,295],"RT":[24,44,89],"where":[25,147],"total":[27],"dose":[28,244,313,375,416],"many":[32],"low":[35,243],"Hypofractionation":[39],"increasingly":[41],"used":[42,470],"for":[45,64,218,225,266,290,323,387,396,425,433,444,471],"small":[46],"tumour":[47],"volumes,":[48],"but":[49,394],"knowledge":[50],"about":[51],"radiation-induced":[52,81,219],"tox\u00acicity":[53],"healthy":[55],"tissue":[56,85,118],"(organs":[57],"at":[58,200],"risk,":[59],"OARs)":[60],"and":[61,96,113,142,173,209,280,307,422,438],"suitable":[62],"methods":[63,95],"modelling":[65,94,122,171,175,216],"toxicity":[66,82,264,288],"this":[68,76],"specific":[69],"situation":[70],"limited.":[72],"The":[73,155,177,227,263,382],"aim":[74],"of":[75,93,116,254,272,373],"thesis":[77,110,156],"investigate":[80],"normal":[84,117],"caused":[86],"through":[90],"development":[92],"their":[97],"applications":[98,179],"clinical":[100,178],"data.":[101],"Particular":[102],"emphasis":[103],"will":[104],"be":[105,404],"on":[106],"fractionation":[108,160],"effect.\\nThe":[109],"treats":[111],"theoretical":[112],"practical":[114],"aspects":[115],"complication":[119],"probability":[120],"(NTCP)":[121],"such":[123,319],"as":[124,162,441,443],"radiobiologically":[125],"consistent":[126],"dose-response":[127],"curves,":[128],"how":[129,143,159],"estimate":[131,353],"composite":[132,354,458],"combined":[135],"limited":[139,364],"information":[141,376],"manage":[145],"situations":[146],"non-treatment-related":[148],"factors":[149],"contribute":[150],"a":[152,242,246,252,350,410],"studied":[153],"toxicity.":[154],"also":[157],"discusses":[158],"effects":[161],"described":[163],"linear-quadratic":[166],"model":[167],"may":[168,403],"affect":[169],"procedure":[172],"results.":[176],"involve":[180],"two":[181],"datasets":[182],"non-small-cell":[184],"lung":[185],"cancer":[186,193,261,305,361,380],"(NSCLC)":[187],"patients":[188,194],"(n=26)":[189],"or":[190,418],"localized":[191],"prostate":[192,260,304,360,379,402],"(n=874).":[195],"Patients":[196],"were":[197,455],"consecutively":[198],"treated":[199,268,292,427,435],"Sahlgrenska":[202],"University":[203],"Hospital":[204],"G\u00f6teborg,":[206],"Sweden,":[207],"1998-2005":[208],"1993-2006,":[210],"respectively.\\nThe":[211],"first":[212],"paper":[213,250,299,348,408],"presents":[214,251,409],"NTCP":[215],"results":[217,228],"rib":[220,239],"fractures":[221],"after":[222,359],"SBRT":[224],"NSCLC.":[226],"indicate":[229],"that":[230,309],"high-dose":[232],"region":[233],"more":[235,335,340],"strongly":[236],"asso\u00acciated":[237],"fracture":[240],"than":[241,337,341],"large":[247],"volume.\\nThe":[248],"second":[249],"survey":[253],"21":[255],"patient-reported":[256],"genitourinary":[257],"symptoms":[258],"among":[259,303],"survivors.":[262],"profile":[265,289],"survivors":[267,291,306,338,434],"combination":[271],"external":[275],"beam":[276],"(EBRT)":[279],"brachytherapy":[282],"(EBRT+BT)":[283],"similar":[285],"convention\u00acally":[294],"EBRT.":[296,429],"\\nThe":[297,346],"third":[298],"investigates":[300],"urethral":[301,312,333],"pain":[302,334],"finds":[308],"higher":[310,316],"fractionation-corrected":[311],"corresponds":[314],"prevalence;":[317],"no":[318],"relationship":[320,411],"seen":[322],"absorbed":[324],"dose.":[325],"Survivors":[326],"three":[328,342],"years":[329,343],"follow-up":[331],"report":[332],"fre\u00acquently":[336],"follow-up.":[345],"fourth":[347],"suggests":[349],"method":[351,383,464],"pelvic":[357],"OARs":[358,388,397],"EBRT+BT":[362,439,473],"information.":[366],"It":[367],"was":[368],"motivated":[369],"lack":[372],"BT":[374],"dataset.":[381],"produces":[384],"robust":[385],"estimations":[386,395],"located":[389,398],"far":[390],"from":[391,452],"prostate,":[393],"close":[399],"less":[405],"robust.\\nThe":[406],"fifth":[407],"between":[412],"mean":[413],"urinary":[414,423,459],"bladder":[415,460],"(with":[417],"without":[419],"frac\u00actionation":[420],"correction)":[421],"leakage":[424],"men":[426],"Analyses":[430],"are":[431,469],"performed":[432],"EBRT":[437],"separately":[440],"well":[442],"whole":[446],"study":[447],"population.":[448],"Symptom":[449],"background":[450],"rates":[451],"non-irradiated":[453],"controls":[454],"considered.":[456],"Estimated":[457],"suggested":[465],"Paper":[467],"IV":[468],"group.":[474]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
