{"id":"https://openalex.org/W656409696","doi":"https://doi.org/10.1007/s13277-015-3597-6","title":"The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks","display_name":"The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks","publication_year":2015,"publication_date":"2015-06-16","ids":{"openalex":"https://openalex.org/W656409696","doi":"https://doi.org/10.1007/s13277-015-3597-6","mag":"656409696","pmid":"https://pubmed.ncbi.nlm.nih.gov/26081618"},"language":"en","primary_location":{"id":"doi:10.1007/s13277-015-3597-6","doi":"https://doi.org/10.1007/s13277-015-3597-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13277-015-3597-6","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://gcris.iyte.edu.tr/bitstreams/35858a2b-201f-46c0-8efb-216122ddb3ec/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017604184","display_name":"Aysun Adan","orcid":"https://orcid.org/0000-0002-3747-8580","observed_orcids":["https://orcid.org/0000-0002-3747-8580"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aysun Adan","raw_affiliation_strings":["Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, 35430, Urla, \u0130zmir, Turkey","Department of Molecular Biology and Genetics, Izmir Institute of Technology Urla, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, 35430, Urla, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Izmir Institute of Technology Urla, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038397744","display_name":"Yusuf Baran","orcid":"https://orcid.org/0000-0002-1056-4673","observed_orcids":["https://orcid.org/0000-0002-1056-4673"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]},{"id":"https://openalex.org/I95293974","display_name":"Abdullah G\u00fcl University","ror":"https://ror.org/00zdyy359","country_code":"TR","type":"education","lineage":["https://openalex.org/I95293974"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Yusuf Baran","raw_affiliation_strings":["Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, 35430, Urla, \u0130zmir, Turkey. yusufbaran@iyte.edu.tr","Faculty of Life and Natural Sciences, Abdullah Gul University, 38080, Kayseri, Turkey. yusufbaran@iyte.edu.tr","Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, Urla, Turkey","Faculty of Life and Natural Sciences, Abdullah Gul University, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, 35430, Urla, \u0130zmir, Turkey. yusufbaran@iyte.edu.tr","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"Faculty of Life and Natural Sciences, Abdullah Gul University, 38080, Kayseri, Turkey. yusufbaran@iyte.edu.tr","institution_ids":["https://openalex.org/I95293974"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, \u0130zmir Institute of Technology, Urla, Turkey","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"Faculty of Life and Natural Sciences, Abdullah Gul University, Kayseri, Turkey","institution_ids":["https://openalex.org/I95293974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038397744"],"corresponding_institution_ids":["https://openalex.org/I120217413","https://openalex.org/I95293974"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":2.3649,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.86068716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"36","issue":"11","first_page":"8973","last_page":"8984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fisetin","display_name":"fisetin","score":1.0},{"id":"https://openalex.org/keywords/hesperetin","display_name":"hesperetin","score":1.0},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9120000004768372},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9520000219345093},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9789999723434448},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.949999988079071},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2777252647","wikidata":"https://www.wikidata.org/wiki/Q411310","display_name":"Hesperetin","level":4,"score":0.946434736251831},{"id":"https://openalex.org/C2777376040","wikidata":"https://www.wikidata.org/wiki/Q418384","display_name":"Fisetin","level":4,"score":0.9206287860870361},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7348690032958984},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5375624895095825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5263078212738037},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.5163084864616394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.449537992477417},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4425649642944336},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3446439802646637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32582926750183105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3048749566078186},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.23154258728027344},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.09354263544082642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s13277-015-3597-6","doi":"https://doi.org/10.1007/s13277-015-3597-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13277-015-3597-6","pdf_url":null,"source":{"id":"https://openalex.org/S12644804","display_name":"Tumor Biology","issn_l":"1010-4283","issn":["1010-4283","1423-0380"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Biology","raw_type":"journal-article"},{"id":"pmid:26081618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26081618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:gcris.iyte.edu.tr:11147/5826","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11147/5826","pdf_url":"http://gcris.iyte.edu.tr/bitstreams/35858a2b-201f-46c0-8efb-216122ddb3ec/download","source":{"id":"https://openalex.org/S4377196445","display_name":"IYTE GCRIS Database (Izmir Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.iyte.edu.tr:11147/5826","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11147/5826","pdf_url":null,"source":{"id":"https://openalex.org/S4377196445","display_name":"IYTE GCRIS Database (Izmir Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:openaccess.iyte.edu.tr:8080:11147/5826","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13277-015-3597-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400894","display_name":"\u0130YTE (\u0130ZM\u0130R Y\u00dcKSEK TEKNOLOJ\u0130 ENST\u0130T\u00dcS\u00dc)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:gcris.iyte.edu.tr:11147/5826","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11147/5826","pdf_url":"http://gcris.iyte.edu.tr/bitstreams/35858a2b-201f-46c0-8efb-216122ddb3ec/download","source":{"id":"https://openalex.org/S4377196445","display_name":"IYTE GCRIS Database (Izmir Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W656409696.pdf","grobid_xml":"https://content.openalex.org/works/W656409696.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W208962477","https://openalex.org/W243680527","https://openalex.org/W1563199792","https://openalex.org/W1590086377","https://openalex.org/W1602745681","https://openalex.org/W1802924733","https://openalex.org/W1934949992","https://openalex.org/W1953358365","https://openalex.org/W1965430288","https://openalex.org/W1968526777","https://openalex.org/W1978014361","https://openalex.org/W1980572685","https://openalex.org/W1986384663","https://openalex.org/W1991774590","https://openalex.org/W1993334239","https://openalex.org/W2006118708","https://openalex.org/W2006842094","https://openalex.org/W2020420780","https://openalex.org/W2030373321","https://openalex.org/W2034895966","https://openalex.org/W2036380534","https://openalex.org/W2037330932","https://openalex.org/W2039717570","https://openalex.org/W2047818504","https://openalex.org/W2051295838","https://openalex.org/W2059903966","https://openalex.org/W2063299574","https://openalex.org/W2065403806","https://openalex.org/W2081871956","https://openalex.org/W2083869312","https://openalex.org/W2089099860","https://openalex.org/W2097774235","https://openalex.org/W2098920338","https://openalex.org/W2113999599","https://openalex.org/W2120343885","https://openalex.org/W2121460037","https://openalex.org/W2122725894","https://openalex.org/W2135726973","https://openalex.org/W2143238584","https://openalex.org/W2147327518","https://openalex.org/W2151207344","https://openalex.org/W2159190794","https://openalex.org/W2160769584","https://openalex.org/W2172326429","https://openalex.org/W3003583917","https://openalex.org/W4240331705"],"related_works":["https://openalex.org/W2134243435","https://openalex.org/W2945596314","https://openalex.org/W2077327626","https://openalex.org/W4320497723","https://openalex.org/W4210282981","https://openalex.org/W4301430985","https://openalex.org/W2922384667","https://openalex.org/W4387748684","https://openalex.org/W2981884645","https://openalex.org/W2019141005"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}