{"id":"https://openalex.org/W655276629","doi":null,"title":"Effects of \u03b2-carotene and selenium supplementation in aged humans.","display_name":"Effects of \u03b2-carotene and selenium supplementation in aged humans.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W655276629","mag":"655276629"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/186598","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/186598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026373677","display_name":"Steven Matley. Wood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven Matley. Wood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026373677"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.29910001158714294,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.8309999704360962},{"id":"https://openalex.org/keywords/selenium-supplementation","display_name":"selenium supplementation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9639999866485596},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.781000018119812},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7300000190734863},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.828000009059906},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.7124062776565552},{"id":"https://openalex.org/C2776998673","wikidata":"https://www.wikidata.org/wiki/Q190156","display_name":"Carotene","level":2,"score":0.5691680312156677},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3394573926925659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3136502802371979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23411959409713745},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/186598","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/186598","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},{"id":"mag:655276629","doi":null,"is_oa":false,"landing_page_url":"https://arizona.openrepository.com/handle/10150/186598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986378808","https://openalex.org/W2064397740","https://openalex.org/W2106985608","https://openalex.org/W1867192595","https://openalex.org/W1910857921","https://openalex.org/W2150348160","https://openalex.org/W2004146431","https://openalex.org/W7100604041","https://openalex.org/W7100467769","https://openalex.org/W2349662522"],"abstract_inverted_index":{"Aging":[0],"is":[1,17],"progressive":[2],"deterioration":[3],"of":[4,15,30,73,107,116,178,205,212,265,304,315],"biological":[5],"functions":[6],"causing":[7],"increased":[8,13,301],"susceptibility":[9],"to":[10,65,87,220,250,281],"disease.":[11,37],"This":[12],"risk":[14],"disease":[16,45,80,338],"associated":[18],"with":[19,113,157,209],"a":[20,28,70,222,261],"concomitant":[21],"decrease":[22],"in":[23,44,79,99,137,289,326],"immune":[24,97,141,324],"\"responsiveness.\"":[25],"Antioxidants":[26],"are":[27],"group":[29],"compounds":[31],"that":[32,109],"prevent":[33,50,66],"oxidative":[34,51],"damage":[35,52],"and":[36,81,92,143,146,194,214,245,254,267,293,321,330],"Researchers":[38],"have":[39,55],"focused":[40],"on":[41,312],"anti-oxidizing":[42],"factors":[43],"prevention;":[46],"however,":[47],"nutrients":[48],"which":[49],"may":[53,334],"also":[54],"immunomodulating":[56],"properties.":[57,340],"\u03b2eta-carotene":[58],"(BC),":[59],"an":[60,129,287],"antioxidant,":[61],"has":[62,76],"been":[63,111],"shown":[64,77],"cancer;":[67],"while":[68,126,174],"selenium,":[69,230],"key":[71],"component":[72],"glutathione":[74],"peroxidase,":[75],"promise":[78],"cancer":[82],"prevention.":[83],"The":[84],"objective":[85],"was":[86,152],"determine":[88],"if":[89],"supplemental":[90,319],"BC":[91,213],"selenium":[93,127,179,238,320],"could":[94],"enhance":[95,185],"the":[96,104,138,175,302],"response":[98,142],"elderly":[100,199],"individuals.":[101],"We":[102],"investigated":[103],"functional":[105],"responsiveness":[106],"lymphocytes":[108],"had":[110,309],"incubated":[112],"various":[114],"concentrations":[115,177],"\u03b2-carotene":[117,120,158,181,234,255,299,308,322],"and/or":[118],"selenium.":[119,160,215],"enhanced":[121,165,323],"natural":[122],"killer":[123],"(NK)":[124],"cytotoxicity":[125],"caused":[128,260,286],"immuno-suppressive":[130],"effect.":[131],"Interleukin-6":[132],"(IL-6)":[133],"(a":[134,148],"major":[135],"factor":[136],"acute":[139],"phase":[140],"B-cell":[144],"differentiation)":[145],"IL-8":[147,188],"chemotactic":[149],"factor)":[150],"production":[151,167],"evaluated":[153],"after":[154],"short-term":[155],"incubation":[156],"or":[159,180,187,231],"Selenium":[161,253,284,297],"(0.":[162],"16":[163],"\u03bcg/ml)":[164],"IL-6":[166,186],"by":[168],"46":[169],"percent":[170],"(P":[171],"<":[172],"0.05)":[173],"other":[176],"did":[182],"not":[183],"significantly":[184],"production.":[189],"To":[190],"further":[191],"investigate":[192],"selenium's":[193],"\u03b2-carotene's":[195],"immunological":[196],"effects,":[197],"healthy":[198,327],"people":[200],"(at":[201],"least":[202],"60":[203],"years":[204],"age),":[206],"were":[207,217,248],"supplemented":[208],"high":[210],"levels":[211],"Participants":[216],"randomly":[218],"assigned":[219],"receive":[221],"daily":[223],"placebo,":[224],"45":[225,232],"mg":[226,233],"\u03b2-carotene,":[227],"400":[228,236],"\u03bcg":[229,237],"plus":[235,298],"for":[239,257,269],"six":[240,275],"months.":[241],"NK":[242,270,277,305],"cell":[243,271,278],"activity":[244,272,279],"lymphocyte":[246],"subpopulations":[247],"compared":[249],"pretreatment":[251,282],"levels.":[252,283],"supplementation":[256,285,300],"three":[258],"months":[259],"statistically":[262],"significant":[263],"increase":[264,288],"59%":[266],"32%":[268],"respectively.":[273],"At":[274],"months,":[276],"returned":[280],"total":[290],"T":[291,295],"cells":[292,306],"CD4\u207a":[294],"cells.":[296],"population":[303],"whereas":[307],"little":[310],"effect":[311],"phenotypic":[313],"expression":[314],"lymphocytes.":[316],"In":[317],"conclusion,":[318],"function":[325],"aged":[328],"participants":[329],"their":[331,337],"immunolomodulatory":[332],"effects":[333],"partially":[335],"explain":[336],"preventive":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
