{"id":"https://openalex.org/W655063786","doi":null,"title":"STRUCTURAL AND FUNCTIONAL ANALYSES OF THE INTERACTION BETWEEN THE USP7-NTD AND THE E2-CONJUGATING ENZYMES, UBE2E2 AND UBE2E3","display_name":"STRUCTURAL AND FUNCTIONAL ANALYSES OF THE INTERACTION BETWEEN THE USP7-NTD AND THE E2-CONJUGATING ENZYMES, UBE2E2 AND UBE2E3","publication_year":2014,"publication_date":"2014-08-27","ids":{"openalex":"https://openalex.org/W655063786","mag":"655063786"},"language":"en","primary_location":{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/28292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/28292","pdf_url":"https://yorkspace.library.yorku.ca/bitstreams/a0ab086a-0207-4369-96a2-b8bd291c1070/download","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://yorkspace.library.yorku.ca/bitstreams/a0ab086a-0207-4369-96a2-b8bd291c1070/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067549630","display_name":"Leila Ashurov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leila Ashurov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067549630"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp7","display_name":"USP7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.953000009059906},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9039999842643738},{"id":"https://openalex.org/keywords/co-crystal-structure","display_name":"co-crystal structure","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7559999823570251},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.49026086926460266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4280739426612854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4236505925655365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36636635661125183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35221463441848755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2988297939300537}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/28292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/28292","pdf_url":"https://yorkspace.library.yorku.ca/bitstreams/a0ab086a-0207-4369-96a2-b8bd291c1070/download","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:655063786","doi":null,"is_oa":false,"landing_page_url":"https://yorkspace.library.yorku.ca/xmlui/bitstream/handle/10315/28292/Ashurov_Leila_2014_Masters.pdf;sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/28292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/28292","pdf_url":"https://yorkspace.library.yorku.ca/bitstreams/a0ab086a-0207-4369-96a2-b8bd291c1070/download","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W655063786.pdf","grobid_xml":"https://content.openalex.org/works/W655063786.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1491406159","https://openalex.org/W1507188651","https://openalex.org/W1762734860","https://openalex.org/W1832030339","https://openalex.org/W1969825515","https://openalex.org/W1978139429","https://openalex.org/W1979408355","https://openalex.org/W1980300257","https://openalex.org/W1980936182","https://openalex.org/W2003493907","https://openalex.org/W2014768688","https://openalex.org/W2032610349","https://openalex.org/W2036105918","https://openalex.org/W2037239543","https://openalex.org/W2039778682","https://openalex.org/W2047444409","https://openalex.org/W2048664325","https://openalex.org/W2051419563","https://openalex.org/W2061086112","https://openalex.org/W2065687763","https://openalex.org/W2065886319","https://openalex.org/W2069018419","https://openalex.org/W2080553628","https://openalex.org/W2083690210","https://openalex.org/W2094153604","https://openalex.org/W2094362595","https://openalex.org/W2095424116","https://openalex.org/W2114668514","https://openalex.org/W2115416706","https://openalex.org/W2125795148","https://openalex.org/W2126133378","https://openalex.org/W2127217324","https://openalex.org/W2135682361","https://openalex.org/W2139364069","https://openalex.org/W2151439322","https://openalex.org/W2162579949","https://openalex.org/W2168837438","https://openalex.org/W2171832958"],"related_works":["https://openalex.org/W1980936182","https://openalex.org/W2557726139","https://openalex.org/W3160839480","https://openalex.org/W2898644652","https://openalex.org/W2621100484","https://openalex.org/W3093877749","https://openalex.org/W3106732360","https://openalex.org/W2069018419","https://openalex.org/W7010259245","https://openalex.org/W7161794757"],"abstract_inverted_index":{"Ubiquitin-specific":[0],"protease":[1],"7":[2],"(USP7)":[3],"is":[4,131],"a":[5,15,42,61,128,132],"deubiquitinating":[6],"enzyme":[7],"that":[8,22,67,92,111],"regulates":[9],"the":[10,36,57,81,88,93,102,118,141],"turnover":[11],"of":[12,35,39,80,84,121,134],"proteins":[13,70],"in":[14,25,116,140],"cell.":[16],"To":[17],"date":[18],"several":[19],"interacting":[20,37],"partners":[21,38],"are":[23,95,138],"involved":[24,115,139],"various":[26],"cellular":[27,119],"processes":[28],"have":[29,46,65],"been":[30,109],"identified":[31,47],"for":[32],"USP7.":[33],"Many":[34],"USP7":[40,73,85,112],"contain":[41,56],"P/AxxS":[43,58,76,104],"motif.":[44,59,77],"We":[45],"two":[48],"E2":[49,69,89,103],"ubiquitin-conjugating":[50,135],"enzymes,":[51,136],"UbE2E2":[52],"and":[53,87,101],"UbE2E3,":[54],"which":[55,137],"Using":[60],"co-immunoprecipitation":[62],"assay":[63],"we":[64],"shown":[66],"these":[68],"interact":[71],"with":[72],"through":[74],"their":[75],"Co-crystal":[78],"structures":[79],"N-terminal":[82],"domain":[83],"(USP7-NTD)":[86],"peptides":[90],"reveal":[91],"interactions":[94],"formed":[96],"between":[97],"USP7-NTD":[98],"residues":[99],"164DWGF167":[100],"motifs.":[105],"It":[106],"has":[107],"also":[108],"established":[110],"may":[113],"be":[114],"regulating":[117],"levels":[120],"UbE2E2.":[122],"Overall,":[123],"our":[124],"findings":[125],"suggest":[126],"USP7,":[127],"de-ubiquitinating":[129],"enzyme,":[130],"regulator":[133],"ubiquitination":[142],"cascade.":[143]},"counts_by_year":[],"updated_date":"2026-09-16T18:09:00.828671","created_date":"2016-06-24T00:00:00"}