{"id":"https://openalex.org/W654865015","doi":null,"title":"NF-kB : a network hub controlling immunity, inflammation, and cancer : a subject collection from Cold Spring Harbor perspectives in biology","display_name":"NF-kB : a network hub controlling immunity, inflammation, and cancer : a subject collection from Cold Spring Harbor perspectives in biology","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W654865015","mag":"654865015"},"language":"en","primary_location":{"id":"mag:654865015","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/ncid/BB04136967","pdf_url":null,"source":{"id":"https://openalex.org/S4306467950","display_name":"Cold Spring Harbor Laboratory eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cold Spring Harbor Laboratory Press eBooks","raw_type":null},"volume":null,"type":"book","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056315342","display_name":"Michael Karin","orcid":"https://orcid.org/0000-0002-2758-6473","observed_orcids":["https://orcid.org/0000-0002-2758-6473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Karin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2758-6473","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025942951","display_name":"Louis M. Staudt","orcid":"https://orcid.org/0000-0002-1735-2892","observed_orcids":["https://orcid.org/0000-0002-1735-2892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis M. Staudt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1735-2892","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.375,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.9430000185966492},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6359999775886536},{"id":"https://openalex.org/keywords/immune-signaling","display_name":"immune signaling","score":0.5220000147819519},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dna-binding-specificity","display_name":"DNA binding specificity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lymphocyte-response","display_name":"lymphocyte response","score":0.796999990940094},{"id":"https://openalex.org/keywords/neuroimmune-signaling","display_name":"neuroimmune signaling","score":0.49399998784065247},{"id":"https://openalex.org/keywords/inflammation-cancer-link","display_name":"inflammation-cancer link","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-death-and-survival","display_name":"cell survival and death","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6804696321487427},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6746973991394043},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6049501299858093},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5905377864837646},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.543271005153656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47009870409965515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42763036489486694},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42186999320983887},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4186607003211975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4000437259674072},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34783560037612915},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3331497311592102},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29821348190307617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2266244888305664}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:654865015","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/ncid/BB04136967","pdf_url":null,"source":{"id":"https://openalex.org/S4306467950","display_name":"Cold Spring Harbor Laboratory eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cold Spring Harbor Laboratory Press eBooks","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137639610","https://openalex.org/W7096425717","https://openalex.org/W994574370","https://openalex.org/W3030532554","https://openalex.org/W2247218376","https://openalex.org/W204422267","https://openalex.org/W4200459954","https://openalex.org/W2028382049","https://openalex.org/W2381008319","https://openalex.org/W2428928844"],"abstract_inverted_index":{"NF-kB":[0,79,88,111,127,142],"is":[1,147],"a":[2,23,40,113,133,148],"critical":[3,114],"signaling":[4],"molecule":[5],"in":[6,37,50,89,97,129,139,160],"the":[7,51,58,67,70,84,102,124],"immune":[8,90],"system":[9],"that":[10,26,110],"regulates":[11],"cell":[12,15,152,163],"survival":[13],"and":[14,19,46,65,73,75,118,132,153,157],"death,":[16],"lymphocyte":[17],"responses,":[18],"inflammation.":[20],"Acting":[21],"as":[22,92,94,101],"transcription":[24],"factor":[25],"can":[27],"receive":[28],"several":[29],"inputs,":[30],"it":[31],"coordinates":[32],"distinct":[33],"gene":[34],"expression":[35],"programs":[36],"response":[38],"to":[39],"wide":[41],"variety":[42],"of":[43,60,69,78,87,126,162],"stimuli.":[44],"Written":[45],"edited":[47],"by":[48,136],"experts":[49],"field,":[52],"this":[53,145],"volume":[54,146],"includes":[55],"contributions":[56],"covering":[57],"structure":[59],"NF-kB,":[61],"its":[62,95],"DNA-binding":[63],"activity":[64],"specificity,":[66],"role":[68,86],"inhibitor":[71],"I-?B,":[72],"canonical":[74],"alternative":[76],"mechanisms":[77],"activation.":[80],"The":[81],"contributors":[82],"examine":[83],"physiological":[85],"cells,":[91],"well":[93],"functions":[96],"other":[98],"tissues,":[99],"such":[100],"nervous":[103],"system.":[104],"They":[105],"also":[106],"discuss":[107],"work":[108],"indicating":[109],"represents":[112],"link":[115],"between":[116],"inflammation":[117],"cancer.":[119],"Including":[120],"clinical":[121],"perspectives":[122],"on":[123],"use":[125],"inhibitors":[128],"cancer":[130],"therapy":[131],"historical":[134],"introduction":[135],"David":[137],"Baltimore,":[138],"whose":[140],"lab":[141],"was":[143],"discovered,":[144],"vital":[149],"reference":[150],"for":[151],"molecular":[154],"biologists,":[155],"immunologists,":[156],"pathologists":[158],"interested":[159],"regulation":[161],"function.":[164]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}