{"id":"https://openalex.org/W654580105","doi":"https://doi.org/10.1016/j.exger.2015.11.021","title":"Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model","display_name":"Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W654580105","doi":"https://doi.org/10.1016/j.exger.2015.11.021","mag":"654580105","pmid":"https://pubmed.ncbi.nlm.nih.gov/26656745"},"language":"en","primary_location":{"id":"doi:10.1016/j.exger.2015.11.021","doi":"https://doi.org/10.1016/j.exger.2015.11.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exger.2015.11.021","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062835538","display_name":"A. Gay\u00e0 Puig","orcid":"https://orcid.org/0000-0002-9555-9864","observed_orcids":["https://orcid.org/0000-0002-9555-9864"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1ngela Puig","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: angela-puig91@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: angela-puig91@gmail.com","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056369985","display_name":"Lisa Ranc\u00e1n","orcid":"https://orcid.org/0000-0003-1556-192X","observed_orcids":["https://orcid.org/0000-0003-1556-192X"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lisa Rancan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: lisa_rancan@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: lisa_rancan@hotmail.com","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014651094","display_name":"Sergio Damian Paredes","orcid":"https://orcid.org/0000-0002-4646-4199","observed_orcids":["https://orcid.org/0000-0002-4646-4199"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio D. Paredes","raw_affiliation_strings":["Department of Physiology, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: sergiodamianparedes@med.ucm.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: sergiodamianparedes@med.ucm.es","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024894104","display_name":"Adri\u00e1n Carrasco Munera","orcid":"https://orcid.org/0000-0002-2282-8445","observed_orcids":["https://orcid.org/0000-0002-2282-8445"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n Carrasco","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: adriancamu8@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: adriancamu8@gmail.com","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007383535","display_name":"Germaine Escames","orcid":"https://orcid.org/0000-0003-1256-7656","observed_orcids":["https://orcid.org/0000-0003-1256-7656"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Germaine Escames","raw_affiliation_strings":["University of Granada, Institute of Biotechnology, Center of Biomedical Investigation, Edificio Fray Luis de Granada C/ Ram\u00f3n y Cajal, 4, 18003 Granada, Spain. Electronic address: gescames@ugr.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Granada, Institute of Biotechnology, Center of Biomedical Investigation, Edificio Fray Luis de Granada C/ Ram\u00f3n y Cajal, 4, 18003 Granada, Spain. Electronic address: gescames@ugr.es","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056806139","display_name":"Elena Vara","orcid":"https://orcid.org/0000-0002-5361-5215","observed_orcids":["https://orcid.org/0000-0002-5361-5215"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Vara","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: evaraami@ucm.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: evaraami@ucm.es","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029175890","display_name":"J Tresguerres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jes\u00fas A.F. Tresguerres","raw_affiliation_strings":["Department of Physiology, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: guerres@med.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Complutense University of Madrid, Avda. Complutense s/n, 28040 Madrid, Spain. Electronic address: guerres@med.es","institution_ids":["https://openalex.org/I121748325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029175890"],"corresponding_institution_ids":["https://openalex.org/I121748325"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":2.12,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.84698113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/lung-aging","display_name":"lung aging","score":0.9269999861717224},{"id":"https://openalex.org/keywords/senescence-accelerated-mouse","display_name":"senescence-accelerated mice","score":0.8489999771118164},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.8730000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9039999842643738},{"id":"https://openalex.org/keywords/8-hydroxyguanosine","display_name":"8-hydroxyguanosine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nf-kappab2","display_name":"NF-\u03baB2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bad","display_name":"Bad","score":0.7770000100135803},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.996999979019165},{"id":"https://openalex.org/keywords/aif","display_name":"AIF","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8526698350906372},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8313126564025879},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7174457311630249},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7037139534950256},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5739755034446716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38634803891181946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38341042399406433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37244927883148193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3706720173358917},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35170868039131165},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15614008903503418}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exger.2015.11.021","doi":"https://doi.org/10.1016/j.exger.2015.11.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exger.2015.11.021","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:26656745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26656745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W58720712","https://openalex.org/W1485887944","https://openalex.org/W1558813989","https://openalex.org/W1894030112","https://openalex.org/W1899080772","https://openalex.org/W1965334734","https://openalex.org/W1967083479","https://openalex.org/W1973081785","https://openalex.org/W1983754228","https://openalex.org/W1992935314","https://openalex.org/W2010748171","https://openalex.org/W2011437912","https://openalex.org/W2015114583","https://openalex.org/W2017824629","https://openalex.org/W2024704513","https://openalex.org/W2044561693","https://openalex.org/W2049077113","https://openalex.org/W2055988844","https://openalex.org/W2056620406","https://openalex.org/W2059395780","https://openalex.org/W2059881173","https://openalex.org/W2065738132","https://openalex.org/W2068337326","https://openalex.org/W2069981583","https://openalex.org/W2073995412","https://openalex.org/W2082378013","https://openalex.org/W2088038548","https://openalex.org/W2090495565","https://openalex.org/W2094156327","https://openalex.org/W2104822687","https://openalex.org/W2107277218","https://openalex.org/W2107876767","https://openalex.org/W2114648685","https://openalex.org/W2127652299","https://openalex.org/W2129434699","https://openalex.org/W2131278010","https://openalex.org/W2133574882","https://openalex.org/W2134615716","https://openalex.org/W2163849426","https://openalex.org/W2169250251","https://openalex.org/W2192280717","https://openalex.org/W2274602227","https://openalex.org/W2315512556","https://openalex.org/W2321320422"],"related_works":["https://openalex.org/W2073995412","https://openalex.org/W1894030112","https://openalex.org/W2059395780","https://openalex.org/W2040232546","https://openalex.org/W2147474668","https://openalex.org/W1974894829","https://openalex.org/W2024704513","https://openalex.org/W2097304043","https://openalex.org/W2027915363","https://openalex.org/W7134961539"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
