{"id":"https://openalex.org/W6544556","doi":null,"title":"Crevicular fluid biomarkers of oral bone loss.","display_name":"Crevicular fluid biomarkers of oral bone loss.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W6544556","mag":"6544556","pmid":"https://pubmed.ncbi.nlm.nih.gov/9655016"},"language":"en","primary_location":{"id":"pmid:9655016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9655016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in periodontology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044774272","display_name":"William V. Giannobile","orcid":"https://orcid.org/0000-0002-7102-9746","observed_orcids":["https://orcid.org/0000-0002-7102-9746"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W V Giannobile","raw_affiliation_strings":["Department of Periodontology, Harvard School of Dental Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Harvard School of Dental Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044774272"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.2061,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83955659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":null,"first_page":"11","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/periodontal-bone-loss","display_name":"periodontal bone loss","score":0.878000020980835},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8790000081062317},{"id":"https://openalex.org/keywords/periodontal-risk-assessment","display_name":"periodontal risk assessment","score":0.7540000081062317},{"id":"https://openalex.org/keywords/periodontal-disease-diagnosis","display_name":"periodontal diagnosis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7541759610176086},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6461676359176636},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6186339855194092},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.5820618867874146},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5538688898086548},{"id":"https://openalex.org/C2778401919","wikidata":"https://www.wikidata.org/wiki/Q7824270","display_name":"Tooth loss","level":3,"score":0.4698335826396942},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.4411185383796692},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4136846363544464},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3344433903694153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1967310905456543},{"id":"https://openalex.org/C2992672162","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Oral health","level":2,"score":0.12942001223564148},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9655016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9655016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in periodontology","raw_type":"Journal Article"},{"id":"mag:6544556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9655016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3803561504","display_name":"INSTITUTIONAL DENTIST SCIENTIST AWARD PROGRAM","funder_award_id":"K16DE000275","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993382850","https://openalex.org/W2117582159","https://openalex.org/W2070204900","https://openalex.org/W2016563003","https://openalex.org/W2025335147","https://openalex.org/W2182187960","https://openalex.org/W2778590077","https://openalex.org/W1826204675","https://openalex.org/W7136989660","https://openalex.org/W4385509450"],"abstract_inverted_index":{"The":[0,39,98],"lack":[1],"of":[2,17,41,52,91,100,109],"predictive":[3],"value":[4],"in":[5,14,58,82],"periodontal":[6,23,36,60,77],"disease":[7,29],"detection":[8],"has":[9],"stimulated":[10],"intense":[11],"research":[12],"efforts":[13],"the":[15,64,107],"development":[16,99],"diagnostic":[18,102],"tests.":[19],"Present":[20],"methodology":[21],"using":[22],"probes":[24],"or":[25],"radiographs":[26],"to":[27,32,70,115],"determine":[28],"susceptibility":[30],"fails":[31],"allow":[33],"an":[34],"accurate":[35],"risk":[37],"assessment.":[38],"analysis":[40,108],"gingival":[42],"crevicular":[43],"fluid":[44],"components":[45],"offers":[46,112],"great":[47,113],"potential":[48],"as":[49],"a":[50],"source":[51],"factors":[53],"that":[54,105],"may":[55],"be":[56],"involved":[57],"active":[59,76,118],"bone":[61,92,96],"loss.":[62,97],"Over":[63],"past":[65],"decade":[66],"investigators":[67],"have":[68,86],"begun":[69],"identify":[71],"several":[72],"molecules":[73],"associated":[74],"with":[75],"tissue":[78],"destruction.":[79],"Recent":[80],"advances":[81],"orthopedics":[83],"and":[84],"osteoporosis":[85],"provided":[87],"new":[88,101],"biochemical":[89],"markers":[90,111],"resorption,":[93],"including":[94],"oral":[95],"test":[103],"strategies":[104],"target":[106],"bone-specific":[110],"promise":[114],"accurately":[116],"assess":[117],"disease.":[119]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}