{"id":"https://openalex.org/W654165184","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","title":"Characterization of the N\u2010terminal Arms of the Polymerase Manager Protein UmuD","display_name":"Characterization of the N\u2010terminal Arms of the Polymerase Manager Protein UmuD","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W654165184","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","mag":"654165184"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.561.10","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077763400","display_name":"David A. Murison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Murison","raw_affiliation_strings":["<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081333991","display_name":"Jaylene N. Ollivierre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaylene Ollivierre","raw_affiliation_strings":["<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004964034","display_name":"Qiuying Huang","orcid":"https://orcid.org/0000-0002-4224-0710","observed_orcids":["https://orcid.org/0000-0002-4224-0710"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiuying Huang","raw_affiliation_strings":["<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080153031","display_name":"David E. Budil","orcid":"https://orcid.org/0000-0003-2384-7928","observed_orcids":["https://orcid.org/0000-0003-2384-7928"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Budil","raw_affiliation_strings":["<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015910317","display_name":"Penny J. Beuning","orcid":"https://orcid.org/0000-0002-7770-022X","observed_orcids":["https://orcid.org/0000-0002-7770-022X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penny Beuning","raw_affiliation_strings":["<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"1-->Chemistry and Chemical BiologyNortheastern UniversityBostonMAUnited States","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00619109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umud","display_name":"UmuD","score":0.9850000143051147},{"id":"https://openalex.org/keywords/n-terminal-cleavage","display_name":"N-terminal cleavage","score":0.7379999756813049},{"id":"https://openalex.org/keywords/sos-response","display_name":"SOS response","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dna-polymerase-iii-alpha-subunit","display_name":"DNA polymerase III alpha subunit","score":0.8529999852180481},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/umuc","display_name":"UmuC","score":0.7879999876022339},{"id":"https://openalex.org/keywords/uv-hypersensitivity","display_name":"UV hypersensitivity","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7350000143051147},{"id":"https://openalex.org/keywords/site-directed-spin-labeling","display_name":"site-directed spin labeling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/covalent-cross-linking","display_name":"covalent cross-linking","score":0.8489999771118164},{"id":"https://openalex.org/keywords/homodimer","display_name":"homodimer","score":0.5220000147819519},{"id":"https://openalex.org/keywords/heterodimer","display_name":"heterodimer","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2780852648","wikidata":"https://www.wikidata.org/wiki/Q143584","display_name":"SOS response","level":4,"score":0.6747578382492065},{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.542728841304779},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.45425111055374146},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4475819766521454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4028632640838623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39098984003067017},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3663884997367859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3579803705215454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3485727906227112},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3357393145561218},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.28962475061416626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26110273599624634},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.561.10","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.561.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2594227148","https://openalex.org/W7045442962","https://openalex.org/W3174818310","https://openalex.org/W1974566232","https://openalex.org/W2286882747","https://openalex.org/W7221375302","https://openalex.org/W7221409364","https://openalex.org/W2025002741","https://openalex.org/W4389019481","https://openalex.org/W2001729821"],"abstract_inverted_index":{"Escherichia":[0],"coli":[1],"cells":[2,196],"that":[3,17,137],"are":[4,115],"exposed":[5],"to":[6,41,56,81,198,206,212,230,248],"exogenous":[7],"or":[8],"endogenous":[9],"DNA":[10,170],"damaging":[11],"agents":[12],"invoke":[13],"the":[14,21,85,88,117,120,138,142,156,167,232,236,240,250,264],"SOS":[15],"response":[16],"involves":[18],"expression":[19,190],"of":[20,62,72,79,87,103,119,140,147,155,191,235,239],"umuD":[22],"gene":[23],"products.":[24],"Full-length":[25],"UmuD":[26,45,63,80,105,110,148,175,183,193,201,242,254],"is":[27,177,261],"expressed":[28],"as":[29,50,65,127,129,179,181],"a":[30,70],"139-amino-acid":[31],"protein,":[32,89],"which":[33,253],"eventually":[34],"cleaves":[35],"its":[36],"N-terminal":[37,101,121,143,157,237],"24":[38],"amino":[39,145],"acids":[40,146],"form":[42,57,207],"UmuD\u2032.":[43],"Both":[44],"and":[46,68,90,109,114,159,186,227,268],"UmuD\u2032":[47,82],"exist":[48,64],"alone":[49],"homodimers,":[51],"but":[52,189,209],"can":[53],"also":[54],"exchange":[55],"UmuDD\u2032":[58],"heterodimers.":[59],"The":[60],"N-termini":[61],"conformationally-dynamic":[66],"arms,":[67,122],"contain":[69],"number":[71],"recognition":[73],"sites":[74,165],"for":[75,93,163,220],"partner":[76,168],"proteins.":[77],"Cleavage":[78],"dramatically":[83],"affects":[84],"function":[86],"activates":[91],"UmuC":[92],"translesion":[94],"synthesis":[95],"(TLS).":[96],"We":[97,135,215],"have":[98],"constructed":[99],"additional":[100],"truncations":[102],"UmuD,":[104],"8":[106,176,194,255],"(UmuD":[107,112],"\u03941-7)":[108],"18":[111,202],"\u03941-17),":[113],"probing":[116],"conformation":[118,154],"their":[123,130],"effect":[124,131],"on":[125,132,166],"cleavage":[126],"well":[128],"protein-protein":[133],"interactions.":[134],"found":[136],"loss":[139],"just":[141],"seven":[144],"results":[149],"in":[150,153,160,184,187],"significant":[151],"changes":[152],"arms":[158,238],"relative":[161],"preference":[162],"binding":[164],"protein":[169],"polymerase":[171],"III":[172],"\u03b1":[173],"subunit.":[174],"cleaved":[178],"efficiently":[180],"full-length":[182],"vitro":[185],"vivo,":[188],"plasmid-borne":[192],"makes":[195],"hypersensitive":[197],"UV":[199,213,257],"irradiation.":[200,214],"does":[203],"not":[204],"cleave":[205],"UmuD\u02b9,":[208],"confers":[210],"resistance":[211],"used":[216],"site-directed":[217],"spin":[218],"labeling":[219],"analysis":[221],"by":[222,252,263],"electron":[223],"paramagnetic":[224],"resonance":[225],"(EPR)":[226],"covalent":[228],"cross-linking":[229],"characterize":[231],"local":[233],"motion":[234],"different":[241],"variants.":[243],"This":[244,259],"investigation":[245],"will":[246],"lead":[247],"understanding":[249],"mechanism":[251],"causes":[256],"hypersensitivity.":[258],"work":[260],"supported":[262],"National":[265],"Science":[266],"Foundation":[267],"American":[269],"Cancer":[270],"Society.":[271]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
