{"id":"https://openalex.org/W65415065","doi":null,"title":"Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of a protozoan parasite.","display_name":"Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of a protozoan parasite.","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W65415065","mag":"65415065","pmid":"https://pubmed.ncbi.nlm.nih.gov/2680908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385514"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022617720","display_name":"Julia J. Wirth","orcid":"https://orcid.org/0000-0002-1006-9349","observed_orcids":["https://orcid.org/0000-0002-1006-9349"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J J Wirth","raw_affiliation_strings":["Department of Microbiology and Public Health, Michigan State University, East Lansing 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Public Health, Michigan State University, East Lansing 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108543546","display_name":"P J Fraker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Fraker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013151184","display_name":"FELIPE KIERSZENBAUM","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Kierszenbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9163,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.68471085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"68","issue":"1","first_page":"114","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-deficiency","display_name":"zinc deficiency","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.9020000100135803},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9200000166893005},{"id":"https://openalex.org/keywords/parasite-killing","display_name":"parasite killing","score":0.7960000038146973},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.925000011920929},{"id":"https://openalex.org/keywords/trace-elements","display_name":"trace elements","score":0.7649999856948853},{"id":"https://openalex.org/keywords/zinc-supplementation","display_name":"zinc supplementation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.33899998664855957},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nickel","display_name":"nickel","score":0.7689999938011169},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.9400361180305481},{"id":"https://openalex.org/C2776928490","wikidata":"https://www.wikidata.org/wiki/Q20057872","display_name":"Zinc deficiency (plant disorder)","level":3,"score":0.7115679383277893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6115235686302185},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.5923773646354675},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.5636674165725708},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5518216490745544},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4131256639957428},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3841300904750824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28942447900772095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2264057695865631},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15077471733093262},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1385514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:2680908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2680908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:65415065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2680908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385514","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385514","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5476492809","display_name":"DIETARY ZINC:  ITS EFFECT ON THE IMMUNE RESPONSE","funder_award_id":"R22HD010586","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1508909031","https://openalex.org/W1602708296","https://openalex.org/W1642046246","https://openalex.org/W1858270401","https://openalex.org/W1896946344","https://openalex.org/W1950719471","https://openalex.org/W1960937410","https://openalex.org/W1974401900","https://openalex.org/W1979966330","https://openalex.org/W1989437103","https://openalex.org/W2035203209","https://openalex.org/W2059719837","https://openalex.org/W2083375040","https://openalex.org/W2113905385","https://openalex.org/W2160040629","https://openalex.org/W2204627580","https://openalex.org/W2332380136","https://openalex.org/W2341278415","https://openalex.org/W2418387071","https://openalex.org/W4256108466"],"related_works":["https://openalex.org/W1950719471","https://openalex.org/W2407220202","https://openalex.org/W156462186","https://openalex.org/W4254542866","https://openalex.org/W2035131248","https://openalex.org/W263613585","https://openalex.org/W2058897192","https://openalex.org/W2979203853","https://openalex.org/W130504464","https://openalex.org/W3134882456"],"abstract_inverted_index":{"The":[0],"effects":[1,167],"of":[2,5,14,40,50,72,83,115,130,168,190],"suboptimal":[3],"levels":[4],"zinc,":[6],"an":[7,175],"essential":[8],"trace":[9,155],"element,":[10],"on":[11,66],"the":[12,48,55,70,81,152,166,181,191],"ability":[13],"murine":[15],"macrophages":[16,75,87,92],"to":[17,100,147,164,174],"associate":[18],"with":[19,77,135,185],"and":[20,53,63,80,95,150,161,188],"destroy":[21],"a":[22,41],"pathogenic":[23],"parasite,":[24],"Trypanosoma":[25],"cruzi,":[26],"were":[27,33,58,88],"evaluated.":[28],"Young":[29],"adult":[30],"A/J":[31],"mice":[32,57,98,103,116,134],"fed":[34,104],"zinc-deficient,":[35],"zinc-adequate":[36,42,107,127],"or":[37,106,126],"restricted":[38,105,125],"amounts":[39],"diet":[43],"for":[44,91,139,178],"28":[45],"days.":[46],"On":[47],"basis":[49],"weight":[51],"loss":[52],"parakeratosis,":[54],"zinc-deficient":[56,65,113,133],"further":[59],"divided":[60],"into":[61],"moderately":[62,94],"severely":[64,96],"Day":[67],"28.":[68],"Both":[69],"percentage":[71],"mouse":[73],"peritoneal":[74],"(MPM)":[76],"associated":[78,184],"parasites":[79,84,120],"number":[82],"per":[85],"100":[86],"significantly":[89],"lower":[90],"from":[93,102,111,124,132],"deficient":[97],"compared":[99],"MPM":[101,110,123,131],"diet.":[108],"Furthermore,":[109],"both":[112,144],"groups":[114],"killed":[117],"fewer":[118],"internalized":[119],"than":[121],"did":[122],"mice.":[128],"Pretreatment":[129],"5":[136],"micrograms":[137],"zinc/ml":[138],"30":[140],"min":[141],"completely":[142],"restored":[143],"their":[145],"capacity":[146],"take":[148],"up":[149],"kill":[151],"parasites.":[153],"Other":[154],"metals":[156],"tested,":[157],"including":[158],"copper,":[159],"manganese":[160],"nickel,":[162],"failed":[163],"reverse":[165],"zinc":[169,179],"deficiency.":[170],"These":[171],"results":[172],"point":[173],"important":[176],"role":[177],"in":[180],"biochemical":[182],"events":[183],"macrophage":[186],"uptake":[187],"killing":[189],"parasite.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}