{"id":"https://openalex.org/W65399072","doi":"https://doi.org/10.1007/978-1-4615-5049-5_11","title":"Platelet Cyclic Nucleotide Phosphodiesterases","display_name":"Platelet Cyclic Nucleotide Phosphodiesterases","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W65399072","doi":"https://doi.org/10.1007/978-1-4615-5049-5_11","mag":"65399072"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-5049-5_11","doi":"https://doi.org/10.1007/978-1-4615-5049-5_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-5049-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Platelet Physiology and Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2500017370","display_name":"Handbook of Platelet Physiology and Pharmacology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104652394"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03368894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"251","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.44850000739097595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.8849999904632568},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ticlopidine","display_name":"ticlopidine","score":0.996999979019165},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.7979999780654907},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.6349999904632568},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.6600000262260437},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.7829999923706055},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.43799999356269836},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8393315076828003},{"id":"https://openalex.org/C2778905298","wikidata":"https://www.wikidata.org/wiki/Q420571","display_name":"Ticlopidine","level":4,"score":0.7665309906005859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7130056023597717},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.6238605976104736},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5854471921920776},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5141122937202454},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5125746130943298},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4822717308998108},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48031964898109436},{"id":"https://openalex.org/C2777858674","wikidata":"https://www.wikidata.org/wiki/Q1248007","display_name":"Vascular occlusion","level":2,"score":0.4625406265258789},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.41017359495162964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39345261454582214},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3691980242729187},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.3080548644065857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1923103630542755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13715210556983948},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0970926582813263},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-5049-5_11","doi":"https://doi.org/10.1007/978-1-4615-5049-5_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-5049-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Platelet Physiology and Pharmacology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W32226917","https://openalex.org/W182423970","https://openalex.org/W349964573","https://openalex.org/W357710163","https://openalex.org/W955237871","https://openalex.org/W1430426163","https://openalex.org/W1483147897","https://openalex.org/W1504222076","https://openalex.org/W1505892934","https://openalex.org/W1519694171","https://openalex.org/W1550626564","https://openalex.org/W1559386011","https://openalex.org/W1564714436","https://openalex.org/W1566938829","https://openalex.org/W1575601729","https://openalex.org/W1589511629","https://openalex.org/W1598689840","https://openalex.org/W1760775102","https://openalex.org/W1837479159","https://openalex.org/W1875395090","https://openalex.org/W1933359372","https://openalex.org/W1963861627","https://openalex.org/W1965477172","https://openalex.org/W1966179419","https://openalex.org/W1970325050","https://openalex.org/W1970435627","https://openalex.org/W1979282739","https://openalex.org/W1989926896","https://openalex.org/W1998836600","https://openalex.org/W2013039234","https://openalex.org/W2023558599","https://openalex.org/W2026021985","https://openalex.org/W2045220433","https://openalex.org/W2051444789","https://openalex.org/W2056645340","https://openalex.org/W2056853181","https://openalex.org/W2057426775","https://openalex.org/W2058470254","https://openalex.org/W2064227075","https://openalex.org/W2076934335","https://openalex.org/W2077690636","https://openalex.org/W2080048815","https://openalex.org/W2080955714","https://openalex.org/W2081123642","https://openalex.org/W2092004001","https://openalex.org/W2099375764","https://openalex.org/W2104380573","https://openalex.org/W2114497687","https://openalex.org/W2127988771","https://openalex.org/W2132023176","https://openalex.org/W2237660709","https://openalex.org/W2279740172","https://openalex.org/W2396985334","https://openalex.org/W2397721351","https://openalex.org/W2399245753","https://openalex.org/W2400092280","https://openalex.org/W2402287558","https://openalex.org/W2410371734","https://openalex.org/W2410476517","https://openalex.org/W2412215872","https://openalex.org/W2414021185","https://openalex.org/W2414075848","https://openalex.org/W2415703274","https://openalex.org/W2418005070","https://openalex.org/W2424635345","https://openalex.org/W2429652665","https://openalex.org/W2951851254","https://openalex.org/W4406985750"],"related_works":["https://openalex.org/W2163196582","https://openalex.org/W2005898347","https://openalex.org/W1842348654","https://openalex.org/W2079841305","https://openalex.org/W4242989629","https://openalex.org/W2054113896","https://openalex.org/W2033835214","https://openalex.org/W127902162","https://openalex.org/W2027922695","https://openalex.org/W2095364558"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}