{"id":"https://openalex.org/W65392852","doi":null,"title":"Eicosapentaenoic acid inhibits antigen-presenting cell function of murine splenocytes.","display_name":"Eicosapentaenoic acid inhibits antigen-presenting cell function of murine splenocytes.","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W65392852","mag":"65392852","pmid":"https://pubmed.ncbi.nlm.nih.gov/1551695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384715"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011713081","display_name":"Mariko Fujikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Fujikawa","raw_affiliation_strings":["First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040716404","display_name":"Naohiro Yamashita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Yamashita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028937405","display_name":"Eiji Sugiyama","orcid":"https://orcid.org/0000-0001-8534-6729","observed_orcids":["https://orcid.org/0000-0001-8534-6729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Sugiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058359940","display_name":"Haruo Suzuki","orcid":"https://orcid.org/0000-0001-9020-9753","observed_orcids":["https://orcid.org/0000-0001-9020-9753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014965523","display_name":"Tomohito Hamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.202,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.96229359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"75","issue":"2","first_page":"330","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/helper-t-cell-clones","display_name":"helper T cell clones","score":0.7099999785423279},{"id":"https://openalex.org/keywords/keyhole-limpet-hemocyanin","display_name":"keyhole limpet hemocyanin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9089999794960022},{"id":"https://openalex.org/keywords/docosapentaenoic-acid","display_name":"docosapentaenoic acid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":1.0},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.878000020980835},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6159999966621399},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.8389787673950195},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7302981615066528},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6460583806037903},{"id":"https://openalex.org/C2776727803","wikidata":"https://www.wikidata.org/wiki/Q1496686","display_name":"Keyhole limpet hemocyanin","level":3,"score":0.6336601972579956},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5966160893440247},{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.5834101438522339},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5551975965499878},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5460429787635803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.53667813539505},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4981253147125244},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.4791809320449829},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.44709721207618713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.387011855840683},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38441216945648193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35858115553855896},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.2631792426109314},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.25857457518577576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25200530886650085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16118013858795166},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013025","descriptor_name":"Glycine max","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:1551695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:65392852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384715","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384715","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1503459193","https://openalex.org/W1504474349","https://openalex.org/W1572975633","https://openalex.org/W1595593983","https://openalex.org/W1989435086","https://openalex.org/W1990895936","https://openalex.org/W2000581651","https://openalex.org/W2005246059","https://openalex.org/W2014042634","https://openalex.org/W2023265227","https://openalex.org/W2051008150","https://openalex.org/W2063564258","https://openalex.org/W2068282814","https://openalex.org/W2081483462","https://openalex.org/W2094636783","https://openalex.org/W2125841464","https://openalex.org/W2127977816","https://openalex.org/W2131538203","https://openalex.org/W2150500113","https://openalex.org/W2166833626","https://openalex.org/W2231225642","https://openalex.org/W2321334948","https://openalex.org/W2327515496","https://openalex.org/W2416585191"],"related_works":["https://openalex.org/W2468186913","https://openalex.org/W2086220715","https://openalex.org/W2151613538","https://openalex.org/W1177561968","https://openalex.org/W2029690976","https://openalex.org/W2090021550","https://openalex.org/W1606227540","https://openalex.org/W2131721650","https://openalex.org/W2149639364","https://openalex.org/W2569792555"],"abstract_inverted_index":{"Recently,":[0],"many":[1],"investigators":[2],"have":[3,50],"studied":[4],"the":[5,30,37,40,59,97,100,124,132,161,189],"effects":[6,20,41,162],"of":[7,21,24,42,61,105,112,123,134,163,172,191,195,203,207],"eicosapentaenoic":[8],"acid":[9,102,116],"(EPA)-rich":[10],"fish":[11,25],"oil":[12,26],"on":[13,29,44,166],"immune":[14,17,31,217],"function":[15],"and":[16,67,80,110,114,156],"disease.":[18],"However,":[19],"dietary":[22,211],"supplementation":[23,212],"or":[27,85],"EPA":[28,43,113,130,214],"system":[32,180],"are":[33],"still":[34],"unclear.":[35],"In":[36,94],"present":[38,138],"study,":[39],"antigen":[45,62,139,208],"presentation":[46,209],"were":[47,75],"investigated.":[48],"We":[49,158],"used":[51],"antigen-specific":[52],"helper":[53,142,152],"T-cell":[54,143,153,177],"clones":[55],"that":[56,111],"proliferate":[57],"in":[58,201],"presence":[60],"[keyhole":[63],"limpet":[64],"haemocyanin":[65],"(KLH)]":[66],"spleen":[68,106],"cells":[69,72,107,136],"as":[70],"antigen-presenting":[71],"(APC).":[73],"Mice":[74],"divided":[76],"into":[77],"two":[78,150],"groups":[79],"fed":[81,96],"an":[82],"experimental":[83,98],"diet":[84,88],"a":[86,176],"control":[87,125],"for":[89,149],"4":[90],"weeks":[91],"ad":[92],"libitum.":[93],"mice":[95],"diet,":[99],"arachidonic":[101],"(AA)":[103],"content":[104],"was":[108,117,147,186],"decreased":[109],"docosapentaenoic":[115],"increased":[118],"markedly":[119],"compared":[120],"to":[121,137,140,175,188],"those":[122],"diet.":[126],"Dietary":[127],"enrichment":[128],"with":[129,197,213],"inhibited":[131],"ability":[133],"accessory":[135],"murine":[141],"clones.":[144],"This":[145],"effect":[146],"observed":[148],"distinct":[151],"clones,":[154],"Th1":[155],"Th2.":[157],"also":[159],"examined":[160],"EPA-TG":[164,173,192,198],"emulsion":[165,174,199],"APC":[167,182,204],"function.":[168,183,205],"The":[169,184],"direct":[170],"addition":[171],"proliferation":[178],"assay":[179],"suppressed":[181],"inhibition":[185,202],"proportional":[187],"concentration":[190],"emulsion.":[193],"Pretreatment":[194],"splenocytes":[196],"resulted":[200],"Inhibition":[206],"by":[210],"might":[215],"depress":[216],"reactivity.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
