{"id":"https://openalex.org/W653132437","doi":null,"title":"EGCG\u7ecfPI3K-AKT\u4fe1\u53f7\u901a\u8def\u8bf1\u5bfc\u4eba\u80c3\u764cBGC-823\u7ec6\u80deG1\u671f\u963b\u6ede","display_name":"EGCG\u7ecfPI3K-AKT\u4fe1\u53f7\u901a\u8def\u8bf1\u5bfc\u4eba\u80c3\u764cBGC-823\u7ec6\u80deG1\u671f\u963b\u6ede","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W653132437","mag":"653132437"},"language":"en","primary_location":{"id":"mag:2387977763","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-HYYY200803011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765042655","display_name":"Journal of Nanhua University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361093890","host_organization_name":"Nanhua University","host_organization_lineage":["https://openalex.org/P4361093890"],"host_organization_lineage_names":["Nanhua University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nanhua University","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007828109","display_name":"\u9648\u6653\u71d5","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9648\u6653\u71d5","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Qiang Wang","orcid":"https://orcid.org/0000-0001-5095-4062","observed_orcids":["https://orcid.org/0000-0001-5095-4062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5095-4062","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025909300","display_name":"\u6587\u5c0f\u73b2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6587\u5c0f\u73b2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031859386","display_name":"\u7bab\u8d6a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u7bab\u8d6a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030193892","display_name":"\u7f57\u62db\u9633","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u7f57\u62db\u9633","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3964,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6809156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"3","first_page":"310","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bgc-823-cells","display_name":"BGC-823 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9470000267028809},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.43142372369766235},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.41804343461990356},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39256376028060913},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36550116539001465},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32246559858322144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.252020001411438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19306251406669617},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.17971479892730713},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13598835468292236}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2387977763","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-HYYY200803011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765042655","display_name":"Journal of Nanhua University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361093890","host_organization_name":"Nanhua University","host_organization_lineage":["https://openalex.org/P4361093890"],"host_organization_lineage_names":["Nanhua University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nanhua University","raw_type":null},{"id":"mag:653132437","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/96889A/200803/28165876.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545069","display_name":"\u5357\u534e\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5357\u534e\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2387977763","https://openalex.org/W996265856","https://openalex.org/W2373352409","https://openalex.org/W2389310838","https://openalex.org/W2341235693","https://openalex.org/W1002055178","https://openalex.org/W906080293","https://openalex.org/W853883609","https://openalex.org/W3031860247","https://openalex.org/W1985245844"],"abstract_inverted_index":{"\u76ee\u7684\u63a2\u8ba8\u8868\u6ca1\u98df\u5b50\u513f\u8336\u7d20\u6ca1\u98df\u5b50\u9178\u916f\uff08Epigallocatechin-3-gallate\uff0cEGCG\uff09\u901a\u8fc7PI3K-AKT\u901a\u8def\u5bf9\u4eba\u80c3\u764cBGC-823\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u7684\u5206\u5b50\u673a\u5236\u3002\u65b9\u6cd5\u91c7\u7528\u567b\u5511\u84dd\u6bd4\u8272\u6cd5\uff08MTT\uff09\u68c0\u6d4bBGC-823\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff1b\u7898\u5316\u4e19\u5576\uff08PI\uff09\u67d3\u8272\u6d41\u5f0f\u7ec6\u80de\u672f\uff08flow":[0],"cytometry\uff0cVCM\uff09\u68c0\u6d4bEGCG\u5904\u7406\u524d\u540eBGC823\u7ec6\u80de\u5468\u671f\u7684\u53d8\u5316\uff1bWestern":[1],"blot\u68c0\u6d4bPI3K-AKT\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\u3002\u7ed3\u679cEGCG\u80fd\u591f\u6291\u5236BGC823\u7ec6\u80de\u7684\u751f\u957f\uff0c\u4e14\u8fd9\u79cd\u6291\u5236\u4f5c\u7528\u4e0e\u8bf1\u5bfcBGC823\u7ec6\u80deG1\u671f\u963b\u6ede\u6709\u5173\u3002EGCG\u53ef\u4ee5\u4e0b\u8c03\u5de9K-AKT\u4fe1\u53f7\u901a\u8def\u86cb\u767dAkt\u7684\u78f7\u9178\u5316\u8868\u8fbe\uff0c\u5bf9\u901a\u8def\u4e0b\u6e38\u5468\u671f\u76f8\u5173\u86cb\u767dcyclinD1\u7684\u8868\u8fbe\u4e5f\u6709\u6291\u5236\u4f5c\u7528\u3002\u7ed3\u8bbaEGCG\u80fd\u591f\u901a\u8fc7\u6d3b\u5316PLK-AKT\u4fe1\u53f7\u901a\u8def\u53d1\u6325\u8bf1\u5bfc\u4eba\u80c3\u764cBGC823\u7ec6\u80deG1\u671f\u963b\u6ede\u7684\u4f5c\u7528\u3002":[2]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
