{"id":"https://openalex.org/W652638929","doi":null,"title":"[Interactive pathway of ARF-mdm2-p53].","display_name":"[Interactive pathway of ARF-mdm2-p53].","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W652638929","mag":"652638929","pmid":"https://pubmed.ncbi.nlm.nih.gov/12654198"},"language":"zh","primary_location":{"id":"pmid:12654198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12654198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ai zheng = Aizheng = Chinese journal of cancer","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015909450","display_name":"\u6797\u9759","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Lin","raw_affiliation_strings":["Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, P.R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ming-Hua Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming-Hua Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015909450"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"],"apc_list":null,"apc_paid":null,"fwci":0.1667,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52341199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"3","first_page":"328","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arf-genes","display_name":"ARF genes","score":0.878000020980835},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.7990000247955322},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.8489999771118164},{"id":"https://openalex.org/keywords/alternative-open-reading-frames","display_name":"alternative reading frame","score":0.7549999952316284},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gene-inactivation","display_name":"gene inactivation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-suppressor-pathways","display_name":"tumor suppressor pathways","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4027068018913269}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12654198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12654198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ai zheng = Aizheng = Chinese journal of cancer","raw_type":"Journal Article"},{"id":"mag:2413592382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12654198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:652638929","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/90720X/200303/7462753.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413592382","https://openalex.org/W1983751803","https://openalex.org/W2349006162","https://openalex.org/W2333579323","https://openalex.org/W2141529421","https://openalex.org/W43976814","https://openalex.org/W1557175916","https://openalex.org/W2082441472","https://openalex.org/W2136422121","https://openalex.org/W2115290061"],"abstract_inverted_index":{"The":[0,33],"inhibitor":[1],"of":[2,18,37,56,86,93],"cyclin-dependent":[3],"kinase":[4],"4-p16INK4":[5],"alpha":[6],"and":[7,30],"its":[8],"alterative":[9],"reading":[10,49],"frame":[11],"(ARF)-INK4/ARF":[12],"gene":[13,29,66,75],"locates":[14],"at":[15],"CDKN2A":[16],"locus":[17,23],"human":[19],"chromosome":[20],"9p21.":[21],"This":[22],"encodes":[24],"two":[25,38],"overlapped":[26],"genes:":[27],"ARF":[28,51,65,74],"p16INK4":[31],"alpha.":[32],"amino":[34],"acid":[35],"sequences":[36],"genes":[39],"are":[40,45],"completely":[41],"different":[42],"because":[43],"they":[44],"encoded":[46],"by":[47,59],"alternative":[48],"frames.":[50],"participates":[52],"in":[53,71,83],"the":[54,73,80,84],"regulation":[55],"mdm2-p53":[57],"pathway":[58],"mdm2.":[60],"Recent":[61],"studies":[62],"showed":[63],"that":[64],"may":[67,78],"play":[68],"a":[69,91],"role":[70],"tumorigenesis;":[72],"promoter":[76],"hypermethylation":[77],"be":[79],"principal":[81],"mechanism":[82],"inactivation":[85],"this":[87],"gene.":[88],"Here":[89],"is":[90],"review":[92],"ARF-mdm2-p53":[94],"interacting":[95],"pathway.":[96]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
