{"id":"https://openalex.org/W65241012","doi":null,"title":"Stromal Modulation of Radiation Carcinogenesis in Breast Cancer","display_name":"Stromal Modulation of Radiation Carcinogenesis in Breast Cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W65241012","mag":"65241012"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt46k352g8","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46k352g8","pdf_url":"https://escholarship.org/uc/item/46k352g8","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/46k352g8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103507750","display_name":"David H.H. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David H.H. Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103507750"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.15389999747276306,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-breast-cancer","display_name":"radiation-induced breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ionizing-radiation-carcinogenesis","display_name":"ionizing radiation carcinogenesis","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6661880612373352},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6506055593490601},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6409807205200195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6378660798072815},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5830084085464478},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5796367526054382},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5789350271224976},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5160622000694275},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.45410025119781494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1862141489982605}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt46k352g8","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46k352g8","pdf_url":"https://escholarship.org/uc/item/46k352g8","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt46k352g8","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/46k352g8","pdf_url":"http://www.escholarship.org/uc/item/46k352g8","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nguyen, David Hiendat Hua. (2011). Stromal Modulation of Radiation Carcinogenesis in Breast Cancer. UC Berkeley: Endocrinology. Retrieved from: http://www.escholarship.org/uc/item/46k352g8","raw_type":"dissertation"},{"id":"mag:65241012","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt46k352g8/qt46k352g8.pdf?t=mtfrna","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt46k352g8","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/46k352g8","pdf_url":"https://escholarship.org/uc/item/46k352g8","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W65241012.pdf","grobid_xml":"https://content.openalex.org/works/W65241012.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W193273571","https://openalex.org/W1482923899","https://openalex.org/W1503270785","https://openalex.org/W1560089133","https://openalex.org/W1892496998","https://openalex.org/W1965161737","https://openalex.org/W1967061237","https://openalex.org/W1976537773","https://openalex.org/W1979440527","https://openalex.org/W1983793363","https://openalex.org/W1985099245","https://openalex.org/W1988070337","https://openalex.org/W1988865098","https://openalex.org/W1989663680","https://openalex.org/W1997006958","https://openalex.org/W1997280228","https://openalex.org/W1997626619","https://openalex.org/W2000536166","https://openalex.org/W2001144553","https://openalex.org/W2003664270","https://openalex.org/W2008524570","https://openalex.org/W2010040980","https://openalex.org/W2010571055","https://openalex.org/W2010867675","https://openalex.org/W2014194530","https://openalex.org/W2015971523","https://openalex.org/W2018852959","https://openalex.org/W2019171053","https://openalex.org/W2019522090","https://openalex.org/W2021231315","https://openalex.org/W2023427658","https://openalex.org/W2028612365","https://openalex.org/W2035467827","https://openalex.org/W2039135884","https://openalex.org/W2039817787","https://openalex.org/W2041353769","https://openalex.org/W2043944733","https://openalex.org/W2045406127","https://openalex.org/W2045414448","https://openalex.org/W2049860203","https://openalex.org/W2062932571","https://openalex.org/W2069837734","https://openalex.org/W2073302269","https://openalex.org/W2076356585","https://openalex.org/W2082630425","https://openalex.org/W2084047311","https://openalex.org/W2091961739","https://openalex.org/W2095671568","https://openalex.org/W2096079397","https://openalex.org/W2097255042","https://openalex.org/W2097881747","https://openalex.org/W2098016561","https://openalex.org/W2099840919","https://openalex.org/W2101017424","https://openalex.org/W2106292881","https://openalex.org/W2113545264","https://openalex.org/W2117963341","https://openalex.org/W2118096781","https://openalex.org/W2118758371","https://openalex.org/W2120865735","https://openalex.org/W2121583524","https://openalex.org/W2123004009","https://openalex.org/W2127057139","https://openalex.org/W2127449951","https://openalex.org/W2128985829","https://openalex.org/W2129314972","https://openalex.org/W2131994307","https://openalex.org/W2134153962","https://openalex.org/W2135548733","https://openalex.org/W2137162822","https://openalex.org/W2141647078","https://openalex.org/W2141865234","https://openalex.org/W2142739240","https://openalex.org/W2143036745","https://openalex.org/W2144247813","https://openalex.org/W2146119340","https://openalex.org/W2150671673","https://openalex.org/W2153051750","https://openalex.org/W2156237866","https://openalex.org/W2156624320","https://openalex.org/W2157018908","https://openalex.org/W2157795344","https://openalex.org/W2159187598","https://openalex.org/W2160779973","https://openalex.org/W2161102475","https://openalex.org/W2161856911","https://openalex.org/W2163292580","https://openalex.org/W2163563958","https://openalex.org/W2166247816","https://openalex.org/W2167515838","https://openalex.org/W2170349147","https://openalex.org/W2184305136","https://openalex.org/W2318605753","https://openalex.org/W2339107861","https://openalex.org/W4300601572"],"related_works":["https://openalex.org/W2049860203","https://openalex.org/W7095456206","https://openalex.org/W2127449951","https://openalex.org/W2027785401","https://openalex.org/W2024116708","https://openalex.org/W2270046154","https://openalex.org/W1998616828","https://openalex.org/W2116184323","https://openalex.org/W3118308293","https://openalex.org/W1881910195"],"abstract_inverted_index":{"Tissue":[0],"microenvironment":[1,106,179],"is":[2,36,140],"an":[3,33,231],"important":[4,232],"determinant":[5],"of":[6,47,113,187],"carcinogenesis.":[7],"We":[8,197],"demonstrate":[9],"that":[10,63,139,158,190,218],"ionizing":[11],"radiation,":[12],"a":[13,27,150],"known":[14],"carcinogen,":[15],"affects":[16,107],"cancer":[17,114,138,223,236],"frequency":[18],"and":[19,59,72,96,109,117,148,169,200,210,226],"characteristics":[20],"by":[21],"acting":[22],"on":[23,79],"the":[24,77,104,177,188],"microenvironment.":[25],"Using":[26],"mammary":[28,99,154],"chimera":[29,155],"model":[30,156],"in":[31,193,238],"which":[32],"irradiated":[34,84,105],"host":[35,159,219],"transplanted":[37],"with":[38,127,134],"oncogenic":[39],"Trp53":[40],"null":[41],"epithelium,":[42],"we":[43],"show":[44,62],"accelerated":[45],"development":[46],"aggressive":[48,166],"tumors":[49,82],"whose":[50],"molecular":[51,68,199,224],"signatures":[52,69,225],"were":[53,86],"distinct":[54,116,205],"from":[55,83],"non-irradiated":[56],"hosts.":[57],"Molecular":[58],"genetic":[60,201],"approaches":[61,202],"TGF-beta":[64,71,75,94,208],"mediated":[65],"tumor":[66,167],"acceleration;":[67],"implicated":[70],"genetically":[73],"reducing":[74],"abrogated":[76],"effect":[78,92],"latency.":[80],"Surprisingly,":[81],"hosts":[85],"predominantly":[87],"estrogen":[88,145,171],"receptor":[89,146],"negative.":[90],"This":[91],"was":[93],"independent":[95],"linked":[97],"to":[98,121,143,176,203],"stem":[100,211],"cell":[101,212],"activity.":[102],"Thus":[103,174],"latency":[108],"clinically":[110],"relevant":[111],"features":[112,189],"through":[115],"unexpected":[118],"mechanisms.":[119],"Compared":[120],"sporadic":[122],"breast":[123,137,195],"cancer,":[124],"women":[125],"treated":[126],"radiation":[128],"for":[129,185,235],"childhood":[130],"cancers":[131],"are":[132,191,230],"diagnosed":[133],"early":[135],"onset":[136],"more":[141],"likely":[142],"be":[144],"negative":[147],"have":[149],"worse":[151],"prognosis.":[152],"Our":[153,214],"shows":[157,217],"irradiation":[160],"alone":[161],"can":[162],"reduce":[163],"latency,":[164],"increase":[165],"growth":[168],"promote":[170],"receptor-negative":[172],"cancers.":[173],"changes":[175,229],"stromal":[178],"rather":[180],"than":[181],"DNA":[182],"damage":[183],"accounts":[184],"many":[186],"observed":[192],"radiation-preceded":[194],"cancer.":[196],"combined":[198],"identify":[204],"mechanisms":[206],"via":[207],"activity":[209],"deregulation.":[213],"study":[215],"further":[216],"biology":[220],"significantly":[221],"alters":[222],"such":[227],"microenvironmental":[228],"biological":[233],"conduit":[234],"risk":[237],"humans.":[239]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
