{"id":"https://openalex.org/W65192012","doi":"https://doi.org/10.1096/fasebj.21.6.a1202","title":"A key role of 12/15\u2010Lipoxygenase in acute lung injury (ALI).","display_name":"A key role of 12/15\u2010Lipoxygenase in acute lung injury (ALI).","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W65192012","doi":"https://doi.org/10.1096/fasebj.21.6.a1202","mag":"65192012"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1202","doi":"https://doi.org/10.1096/fasebj.21.6.a1202","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1202","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019726220","display_name":"Alexander Zarbock","orcid":"https://orcid.org/0000-0002-2124-1714","observed_orcids":["https://orcid.org/0000-0002-2124-1714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Zarbock","raw_affiliation_strings":["Cardiovascular Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108521053","display_name":"Emily Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Smith","raw_affiliation_strings":["Cardiovascular Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064839208","display_name":"Gerhard Kr\u00f6nke","orcid":"https://orcid.org/0000-0002-7566-4325","observed_orcids":["https://orcid.org/0000-0002-7566-4325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerhard kronke","raw_affiliation_strings":["Cardiovascular Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032461686","display_name":"Brian L. Harry","orcid":"https://orcid.org/0000-0001-7947-3908","observed_orcids":["https://orcid.org/0000-0001-7947-3908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Harry","raw_affiliation_strings":["Cardiovascular Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045616017","display_name":"Catherine C. Hedrick","orcid":"https://orcid.org/0000-0003-2045-4117","observed_orcids":["https://orcid.org/0000-0003-2045-4117"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Hedrick","raw_affiliation_strings":["Department of Medicine Cardiovascular Medicine University of Virginia Health System 415 Lane Road Charlottesville 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Cardiovascular Medicine University of Virginia Health System 415 Lane Road Charlottesville 22903","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105351645","display_name":"Jerry L. Nadler","orcid":"https://orcid.org/0000-0002-4200-6991","observed_orcids":["https://orcid.org/0000-0002-4200-6991"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Nadler","raw_affiliation_strings":["Department of Medicine University of Virginia Health System 415 Lane Road Charlottesville VA 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of Virginia Health System 415 Lane Road Charlottesville VA 22903","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020082525","display_name":"Klaus F. Ley","orcid":"https://orcid.org/0000-0001-9339-3672","observed_orcids":["https://orcid.org/0000-0001-9339-3672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus Ley","raw_affiliation_strings":["Cardiovascular Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00950887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/12-15-lipoxygenase","display_name":"12/15-lipoxygenase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lps-induced-lung-injury","display_name":"lipopolysaccharide-induced lung injury","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.9739999771118164},{"id":"https://openalex.org/keywords/kc-chemokine","display_name":"KC chemokine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acid-induced-lung-injury","display_name":"acid-induced lung injury","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-marrow-chimeras","display_name":"bone marrow chimeras","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6938403248786926},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5727526545524597},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.5427515506744385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5368407964706421},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.533966600894928},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5205984115600586},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.5109145045280457},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.46747326850891113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46528521180152893},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.43403956294059753},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4155488610267639},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4141383171081543},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39285808801651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38071221113204956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3340747356414795},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.26039189100265503},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24743422865867615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23402264714241028},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.15654784440994263},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.12000596523284912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1202","doi":"https://doi.org/10.1096/fasebj.21.6.a1202","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1202","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5397043517","display_name":null,"funder_award_id":"(AZ 428/2\u20131) and NIH HL073361","funder_id":"https://openalex.org/F4320308022","funder_display_name":"California Department of Fish and Game"}],"funders":[{"id":"https://openalex.org/F4320308022","display_name":"California Department of Fish and Game","ror":"https://ror.org/02v6w2r95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100441361","https://openalex.org/W1774666547","https://openalex.org/W2102252008","https://openalex.org/W2036030118","https://openalex.org/W2124579854","https://openalex.org/W18448610","https://openalex.org/W1913937884","https://openalex.org/W2791374939","https://openalex.org/W1998104092","https://openalex.org/W2962741338"],"abstract_inverted_index":{"ALI":[0],"is":[1,11,19,146],"a":[2,168,208],"highly":[3],"prevalent":[4],"disease":[5,122],"and":[6,27,32,59,77,80,102,135,164,189,203,223],"despite":[7],"improved":[8,183],"treatment,":[9],"it":[10],"associated":[12],"with":[13],"high":[14],"mortality.":[15],"12/15":[16],"lipooxygenase":[17],"(12/15\u2010LO)":[18],"an":[20],"enzyme":[21],"involved":[22,42],"in":[23,43,51,73,84,90,118,152,161,211],"arachidonic":[24,36],"acid":[25,30,37,60,171],"metabolism":[26],"produces":[28],"12\u2010hydroperoxy\u2010eicosatetraenoic":[29],"(12\u2010HPETE)":[31],"15\u2010HPETE.":[33],"As":[34],"other":[35],"metabolites":[38],"like":[39],"TXA2":[40],"are":[41],"ALI,":[44,173],"we":[45],"investigated":[46],"the":[47,74,106,139,195,204,212],"role":[48,210],"of":[49,54,64,70,138,170,214],"12/15\u2010LO":[50,91,97,116,124,162,174,202],"murine":[52],"models":[53],"LPS":[55,65,109,157],"induced":[56,61,172],"pulmonary":[57],"inflammation":[58],"ALI.":[62,153,215],"Inhalation":[63],"led":[66],"to":[67,148,194,219],"significant":[68],"accumulation":[69],"neutrophils":[71],"(PMN)":[72],"intravascular,":[75],"interstitial,":[76],"alveolar":[78],"compartment":[79],"increased":[81,128],"vascular":[82,100,191],"permeability":[83,101,192],"WT":[85,165],"mice,":[86],"which":[87,145],"was":[88],"attenuated":[89],"\u2212/\u2212":[92,125,163,175],"mice.":[93,166],"Transgenic":[94],"mice":[95,126,176],"overexpressing":[96],"showed":[98,127],"exacerbated":[99],"PMN":[103,187],"recruitment":[104,188],"into":[105],"lung":[107],"upon":[108,156],"inhalation.":[110],"Bone":[111],"marrow":[112],"chimeras":[113],"revealed":[114],"that":[115,201],"expression":[117],"hematopoitic":[119],"cells":[120],"controlled":[121],"outcome.":[123],"KC":[129,154],"plasma":[130],"concentrations":[131,155],"under":[132],"baseline":[133],"conditions":[134],"down":[136],"regulation":[137],"chemokine":[140],"receptor":[141],"CXCR2":[142],"on":[143],"PMNs,":[144],"known":[147],"be":[149],"critically":[150],"important":[151],"challenge":[158],"were":[159,177],"similar":[160],"In":[167],"model":[169],"also":[178],"protected":[179],"as":[180],"shown":[181],"by":[182,217],"gas":[184],"exchange,":[185],"reduced":[186],"decreased":[190],"compared":[193],"control":[196],"group.":[197],"Our":[198],"data":[199],"suggest":[200],"downstream":[205],"products":[206],"play":[207],"crucial":[209],"development":[213],"Supported":[216],"DFG":[218],"A.Z.":[220],"(AZ":[221],"428/2\u20131)":[222],"NIH":[224],"HL073361.":[225]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}