{"id":"https://openalex.org/W650761501","doi":null,"title":"The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development","display_name":"The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W650761501","mag":"650761501"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1357","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086298459","display_name":"Lisa M. Nilsson","orcid":"https://orcid.org/0000-0002-5222-7210","observed_orcids":["https://orcid.org/0000-0002-5222-7210"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa M. Nilsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5222-7210","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086298459"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p18ink4c","display_name":"p18INK4c","score":0.9769999980926514},{"id":"https://openalex.org/keywords/p19ink4d","display_name":"p19INK4d","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ink4-family","display_name":"INK4 family","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tumor-spectrum","display_name":"tumor spectrum","score":0.5339999794960022},{"id":"https://openalex.org/keywords/hemangioma","display_name":"hemangioma","score":0.5649999976158142},{"id":"https://openalex.org/keywords/hemangiosarcoma","display_name":"hemangiosarcoma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/emu-myc-transgenic-mice","display_name":"E\u03bc-myc transgenic mice","score":0.7429999709129333},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.8159999847412109},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.5400000214576721},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.7210000157356262},{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.9162584543228149},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6224126815795898},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.6168026328086853},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.595561683177948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47562769055366516},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46049952507019043},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.44841307401657104},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.43986812233924866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3500049114227295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3478343188762665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29176419973373413},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19680887460708618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1357","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:650761501","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/7759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1357","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W190015672","https://openalex.org/W614669698","https://openalex.org/W1481295510","https://openalex.org/W1520222296","https://openalex.org/W1538028541","https://openalex.org/W1560485148","https://openalex.org/W1560780012","https://openalex.org/W1603531409","https://openalex.org/W1911118961","https://openalex.org/W1922152600","https://openalex.org/W1932315029","https://openalex.org/W1936178817","https://openalex.org/W1965049479","https://openalex.org/W1966383348","https://openalex.org/W1968075576","https://openalex.org/W1969255091","https://openalex.org/W1971402068","https://openalex.org/W1971657539","https://openalex.org/W1979950447","https://openalex.org/W1981844030","https://openalex.org/W1984159955","https://openalex.org/W1984164498","https://openalex.org/W1984948591","https://openalex.org/W1985679278","https://openalex.org/W1985844240","https://openalex.org/W1987485050","https://openalex.org/W1990213657","https://openalex.org/W1990427876","https://openalex.org/W1991494214","https://openalex.org/W1992708996","https://openalex.org/W1994600118","https://openalex.org/W1994794031","https://openalex.org/W1998492363","https://openalex.org/W2001480633","https://openalex.org/W2001627329","https://openalex.org/W2003223749","https://openalex.org/W2003381961","https://openalex.org/W2003907692","https://openalex.org/W2004205790","https://openalex.org/W2004391147","https://openalex.org/W2005542290","https://openalex.org/W2006528936","https://openalex.org/W2007618242","https://openalex.org/W2008797552","https://openalex.org/W2011912935","https://openalex.org/W2017235640","https://openalex.org/W2020330574","https://openalex.org/W2021015704","https://openalex.org/W2021484300","https://openalex.org/W2024019673","https://openalex.org/W2024218128","https://openalex.org/W2025438239","https://openalex.org/W2028210102","https://openalex.org/W2028319593","https://openalex.org/W2028612559","https://openalex.org/W2028933307","https://openalex.org/W2029080338","https://openalex.org/W2029142481","https://openalex.org/W2030364029","https://openalex.org/W2033156691","https://openalex.org/W2034269086","https://openalex.org/W2034882416","https://openalex.org/W2042316019","https://openalex.org/W2042661096","https://openalex.org/W2044240831","https://openalex.org/W2046919270","https://openalex.org/W2046958356","https://openalex.org/W2047936759","https://openalex.org/W2048938594","https://openalex.org/W2051506850","https://openalex.org/W2052465225","https://openalex.org/W2052912081","https://openalex.org/W2054616973","https://openalex.org/W2058065336","https://openalex.org/W2058481892","https://openalex.org/W2058705034","https://openalex.org/W2064670731","https://openalex.org/W2064879069","https://openalex.org/W2066520916","https://openalex.org/W2066669204","https://openalex.org/W2066848701","https://openalex.org/W2069023233","https://openalex.org/W2070811212","https://openalex.org/W2071275297","https://openalex.org/W2072581924","https://openalex.org/W2074017756","https://openalex.org/W2074113171","https://openalex.org/W2074312019","https://openalex.org/W2075152619","https://openalex.org/W2077858999","https://openalex.org/W2079852484","https://openalex.org/W2080401826","https://openalex.org/W2084891010","https://openalex.org/W2086773265","https://openalex.org/W2088120691","https://openalex.org/W2088740611","https://openalex.org/W2088948404","https://openalex.org/W2095919371","https://openalex.org/W2096462919","https://openalex.org/W2096632866","https://openalex.org/W2098048551","https://openalex.org/W2098203835","https://openalex.org/W2101626171","https://openalex.org/W2103100861","https://openalex.org/W2113604152","https://openalex.org/W2115692032","https://openalex.org/W2118862408","https://openalex.org/W2121619780","https://openalex.org/W2123433818","https://openalex.org/W2125267517","https://openalex.org/W2126393916","https://openalex.org/W2126679757","https://openalex.org/W2126772757","https://openalex.org/W2129730239","https://openalex.org/W2132066963","https://openalex.org/W2132207544","https://openalex.org/W2133697422","https://openalex.org/W2145862670","https://openalex.org/W2145941500","https://openalex.org/W2150608281","https://openalex.org/W2152110552","https://openalex.org/W2154799239","https://openalex.org/W2155009866","https://openalex.org/W2155609574","https://openalex.org/W2155625886","https://openalex.org/W2156299289","https://openalex.org/W2156822710","https://openalex.org/W2156952955","https://openalex.org/W2157986354","https://openalex.org/W2158190831","https://openalex.org/W2161228462","https://openalex.org/W2161378573","https://openalex.org/W2164559478","https://openalex.org/W2164714646","https://openalex.org/W2170331239","https://openalex.org/W2171216706","https://openalex.org/W2174418452","https://openalex.org/W2235427389","https://openalex.org/W2316647275","https://openalex.org/W2317691069","https://openalex.org/W2322822178","https://openalex.org/W2395959362","https://openalex.org/W2530014580","https://openalex.org/W4298304887"],"related_works":["https://openalex.org/W1661151633","https://openalex.org/W1981844030","https://openalex.org/W7097648675","https://openalex.org/W2127998424","https://openalex.org/W2424145886","https://openalex.org/W2054616973","https://openalex.org/W2523303858","https://openalex.org/W2021805025","https://openalex.org/W59920814","https://openalex.org/W2024381232"],"abstract_inverted_index":{"Progression":[0],"through":[1],"the":[2,10,35,39,44,49,85,140,159,179,197,218,232,251,257,283,333,339,364,373,382,390,411,416,433,473],"G1,":[3],"S,":[4],"G2":[5],"and":[6,19,103,105,111,119,163,171,187,194,223,240,305,316,392,447],"M":[7],"phases":[8],"of":[9,34,41,65,80,89,94,97,124,153,161,169,196,221,238,246,250,259,274,313,321,325,335,341,357,366,384,394,419,436,450],"cell":[11,120,126,299,336,458],"cycle":[12,121,127],"is":[13,73,131,190,287,351,403,465],"controlled":[14],"by":[15,47,77],"cyclin-dependent":[16],"kinases":[17],"(Cdks)":[18],"cyclins.":[20],"These":[21,253],"proteins":[22],"form":[23],"active":[24],"Cdk:cyclin":[25,32],"complexes":[26,33],"that":[27,62,349,463],"phosphorylate":[28],"specific":[29,264],"substrates.":[30],"The":[31,91,150],"G1/S":[36],"transition":[37],"regulate":[38],"progression":[40],"cells":[42,295,304],"into":[43,363],"S":[45],"phase":[46],"phosphorylating":[48],"retinoblastoma":[50],"protein":[51,317,434],"(Rb).":[52],"This":[53,71,286,401,440],"prevents":[54],"Rb":[55],"from":[56,307,346],"sequestering":[57],"E2F,":[58],"a":[59,78,191,229,248,262,288,395,452],"transcription":[60],"factor":[61],"induces":[63],"expression":[64,449],"genes":[66,143,201,368],"required":[67],"for":[68,268,381,455,467],"DNA":[69],"synthesis.":[70],"process":[72],"in":[74,136,148,166,182,202,231,256,278,293,327,369,442,444,472],"part":[75],"regulated":[76],"family":[79,87,93],"Cdk":[81],"inhibitors":[82],"(CKIs)":[83],"called":[84],"Ink4":[86,92,142,367,385],"(Inhibitors":[88],"Cdk4).":[90],"CKIs":[95],"consists":[96],"four":[98],"members;":[99],"p16Ink4a,":[100],"p15Ink4b,":[101],"p18Ink4c":[102,162,314],"p19Ink4d,":[104],"they":[106],"bind":[107],"specifically":[108],"to":[109,157,235,398,430],"Cdk4":[110],"Cdk6,":[112],"thereby":[113],"negatively":[114],"regulating":[115],"their":[116],"kinase":[117],"activities":[118],"progression.":[122],"Because":[123],"its":[125],"inhibitory":[128],"role,":[129],"p16Ink4a":[130],"frequently":[132,199],"mutated":[133,200,207],"or":[134,338],"deleted":[135],"human":[137,203],"cancer,":[138],"whereas":[139],"other":[141],"are":[144,210],"only":[145,412],"occasionally":[146],"altered":[147],"cancer.":[149,204],"overall":[151],"aim":[152],"this":[154,328],"thesis":[155],"was":[156,276,379],"study":[158],"roles":[160],"p19Ink4d":[164],"using":[165],"vivo":[167],"models":[168],"cancer":[170],"embryonic":[172],"development.":[173,343,439],"In":[174,270],"paper":[175,271],"I,":[176],"we":[177],"analyzed":[178,380],"tumor":[180,192,233,249,265,342,355],"spectrum":[181,234],"mice":[183,309],"lacking":[184],"p53,":[185,260],"Ink4c":[186,224,275,326,350],"Ink4d.":[188],"p53":[189,208,222],"suppressor":[193,356],"one":[195],"most":[198],"Mice":[205],"carrying":[206],"alleles":[209],"highly":[211],"tumor-prone":[212,280],"but":[213],"develop":[214],"predominantly":[215],"lymphomas.":[216,300,359],"However,":[217],"combined":[219],"loss":[220,273,324],"(but":[225],"not":[226,331,352],"Ink4d)":[227],"caused":[228],"shift":[230],"increased":[236],"incidences":[237],"hemangiomas":[239],"hemangiosarcomas,":[241],"as":[242,244],"well":[243],"appearance":[245],"medulloblastomas,":[247],"cerebellum.":[252],"data,":[254],"revealed":[255],"absence":[258],"suggest":[261],"cell-type":[263],"suppressing":[266],"role":[267,365],"p18Ink4c.":[269],"II,":[272],"evaluated":[277],"another":[279],"mouse":[281,290],"model;":[282],"E\u00b5-Myc":[284,308],"mouse.":[285],"transgenic":[289],"overexpressing":[291],"c-Myc":[292],"B":[294,298,303],"causing":[296],"clonal":[297],"Surprisingly,":[301],"precancerous":[302],"lymphomas":[306],"exhibited":[310],"elevated":[311],"levels":[312],"mRNA":[315],"despite":[318],"high":[319],"rates":[320],"proliferation.":[322],"Moreover,":[323],"model":[329],"did":[330],"affect":[332],"rate":[334],"proliferation":[337],"onset":[340],"We":[344,460],"conclude":[345],"these":[347],"studies":[348],"an":[353],"important":[354,454,466],"Myc-induced":[358],"To":[360],"gain":[361],"insight":[362],"early":[370],"vertebrate":[371],"development,":[372,408],"African":[374],"clawed":[375],"frog,":[376],"Xenopus":[377],"laevis,":[378],"presence":[383],"homologs.":[386],"Paper":[387],"III":[388],"describes":[389],"cloning":[391],"characterization":[393],"gene":[396,453],"homologous":[397],"Ink4d,":[399],"Xl-Ink4d.":[400],"CKI":[402,413],"expressed":[404],"throughout":[405],"frog":[406],"embryo":[407],"making":[409],"Xl-Ink4d":[410,427,437,464],"present":[414],"during":[415,438],"cleavage":[417],"stages":[418],"X.":[420],"laevis.":[421],"Antisense":[422],"morpholino":[423],"oligonucleotides":[424],"directed":[425],"against":[426],"were":[428],"used":[429],"knock":[431],"down":[432],"level":[435],"resulted":[441],"defects":[443],"head":[445],"tissues":[446],"reduced":[448],"Twist,":[451],"neural":[456,469],"crest":[457,470],"migration.":[459],"therefore":[461],"propose":[462],"proper":[468],"differentiation":[471],"frog.":[474]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}