{"id":"https://openalex.org/W650697093","doi":null,"title":"Sodium butyrate protects the intestinal barrier function in peritonitic mice.","display_name":"Sodium butyrate protects the intestinal barrier function in peritonitic mice.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W650697093","mag":"650697093","pmid":"https://pubmed.ncbi.nlm.nih.gov/26064302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3425542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100655105","display_name":"Xiaofeng Han","orcid":"https://orcid.org/0009-0001-1719-4812","observed_orcids":["https://orcid.org/0009-0001-1719-4812"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Han","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huimin Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Song","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103264613","display_name":"Yunlei Wang","orcid":"https://orcid.org/0000-0003-2302-8965","observed_orcids":["https://orcid.org/0000-0003-2302-8965"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunlei Wang","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055486175","display_name":"Yingmo Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingmo Sheng","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100332998","display_name":"Jie Chen","orcid":"https://orcid.org/0000-0003-1945-0047","observed_orcids":["https://orcid.org/0000-0003-1945-0047"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6922,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.64667209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"3","first_page":"4000","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.21739999949932098,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.20829999446868896,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":1.0},{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.8349999785423279},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9309999942779541},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9829999804496765},{"id":"https://openalex.org/keywords/intestinal-injury","display_name":"intestinal injury","score":0.5690000057220459},{"id":"https://openalex.org/keywords/systemic-infection","display_name":"systemic infection","score":0.6740000247955322},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8594082593917847},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.7878134250640869},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.7250704765319824},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.6712551116943359},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.6197544932365417},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5560626983642578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5112428665161133},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.43655261397361755},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33846309781074524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08613455295562744},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3425542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4443136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:26064302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26064302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:650697093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26064302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3425542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W199295108","https://openalex.org/W1877854700","https://openalex.org/W1934624334","https://openalex.org/W1963295122","https://openalex.org/W1981344570","https://openalex.org/W1992152055","https://openalex.org/W2000843748","https://openalex.org/W2004699378","https://openalex.org/W2009344706","https://openalex.org/W2017279390","https://openalex.org/W2029180586","https://openalex.org/W2029619625","https://openalex.org/W2037355663","https://openalex.org/W2057445637","https://openalex.org/W2059202294","https://openalex.org/W2059699981","https://openalex.org/W2103125336","https://openalex.org/W2105335085","https://openalex.org/W2114725115","https://openalex.org/W2118151477","https://openalex.org/W2142543682","https://openalex.org/W2145090182","https://openalex.org/W2156076412","https://openalex.org/W2441169818","https://openalex.org/W2569329648"],"related_works":["https://openalex.org/W3031539763","https://openalex.org/W4205672613","https://openalex.org/W3010535095","https://openalex.org/W3207573978","https://openalex.org/W3157899816","https://openalex.org/W3107841832","https://openalex.org/W3097891435","https://openalex.org/W7139933919","https://openalex.org/W2551726694","https://openalex.org/W3013630853"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Peritonitis":[1],"is":[2,13,23],"a":[3,199],"commonly":[4],"seen":[5],"disease":[6],"with":[7],"high":[8],"morbidity":[9],"and":[10,34,82,110],"mortality.":[11],"It":[12],"prevalently":[14],"considered":[15],"that":[16,50,144,175],"the":[17,24,31,37,40,67,90,95,139,146],"impaired":[18],"intestinal":[19,57,96,111,134,204],"barrier":[20,58,205],"during":[21],"peritonitis":[22,181],"access":[25],"point":[26],"of":[27,39,69,76,92,102,126,136,145],"gut":[28,108],"microbes":[29],"into":[30],"blood":[32],"system,":[33],"acts":[35],"as":[36],"engine":[38],"following":[41,180],"systemic":[42],"infection.":[43],"In":[44,60],"our":[45],"previous":[46],"study,":[47,62],"we":[48,63],"found":[49],"Sodium":[51],"Butyrate":[52],"(NaB)":[53],"was":[54,86,151,160,166,182,191],"protective":[55,201],"on":[56,71,94,203],"function.":[59],"this":[61],"aim":[64],"to":[65,88],"evaluate":[66],"effects":[68,91],"NaB":[70,93,103,118,127,137,140,156,170,186,197],"overwhelming":[72],"infection":[73],"animal":[74],"models":[75],"peritonitis.":[77,208],"METHODS:":[78],"Mouse":[79],"cecal":[80],"ligation":[81],"puncture":[83],"(CLP)":[84],"model":[85],"used":[87],"study":[89,173],"barrier.":[97],"Experimental":[98],"animals":[99],"were":[100,114,123],"fed":[101],"by":[104,154,169,185,194],"gavage.":[105],"Post-CLP":[106],"mortality,":[107],"permeability":[109,159],"histological":[112],"alterations":[113],"studied.":[115,124],"RESULTS:":[116],"Gastrointestinal":[117],"pharmacodynamics":[119],"profiles":[120],"after":[121,163],"medication":[122],"Measurements":[125],"concentration":[128,135],"in":[129,138,207],"chyme":[130],"showed":[131,174],"significantly":[132,152],"higher":[133],"treated":[141],"group":[142],"than":[143],"control":[147],"group.":[148],"CLP-induced":[149],"mortality":[150],"decreased":[153],"oral":[155],"treatments.":[157,187],"Gut":[158],"largely":[161],"increased":[162],"CLP,":[164],"which":[165],"partially":[167],"prevented":[168],"feeding.":[171],"Histological":[172],"intestinal,":[176],"especially":[177],"ileal":[178],"injury":[179],"substantially":[183],"alleviated":[184],"Moreover,":[188],"tissue":[189],"regeneration":[190],"also":[192],"prompted":[193],"NaB.":[195],"CONCLUSION:":[196],"has":[198],"potential":[200],"effect":[202],"function":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}