{"id":"https://openalex.org/W6506697","doi":null,"title":"Transactivation by human Adenovirus Early Region 1A-Conserved Region Three","display_name":"Transactivation by human Adenovirus Early Region 1A-Conserved Region Three","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W6506697","mag":"6506697"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-1250","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/157","pdf_url":"https://uwo.scholaris.ca/bitstreams/4377d2a6-0cff-4074-93d3-f7c6e1d3ae1e/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uwo.scholaris.ca/bitstreams/4377d2a6-0cff-4074-93d3-f7c6e1d3ae1e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042635564","display_name":"Jailal Ablack","orcid":"https://orcid.org/0000-0001-6156-4967","observed_orcids":["https://orcid.org/0000-0001-6156-4967"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jailal Ng Ablack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042635564"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00042282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-adenovirus","display_name":"human adenovirus","score":0.8600000143051147},{"id":"https://openalex.org/keywords/e1a-protein","display_name":"E1A protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/viral-transactivation","display_name":"viral transactivation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/gcn5","display_name":"GCN5","score":0.7929999828338623},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/negative-regulation","display_name":"negative regulation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.7049999833106995},{"id":"https://openalex.org/keywords/protein-solution-structure","display_name":"protein solution structure","score":0.6859999895095825},{"id":"https://openalex.org/keywords/zinc-coordination","display_name":"zinc coordination","score":0.8050000071525574},{"id":"https://openalex.org/keywords/adenovirus-type-5","display_name":"adenovirus type 5","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9803946614265442},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.6540915966033936},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5989276766777039},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5800668001174927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5635247826576233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4823957681655884},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4458483159542084},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3925710618495941},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3616456389427185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27918821573257446},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-1250","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/157","pdf_url":"https://uwo.scholaris.ca/bitstreams/4377d2a6-0cff-4074-93d3-f7c6e1d3ae1e/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/36518","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/36518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:6506697","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=1250&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-1250","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/157","pdf_url":"https://uwo.scholaris.ca/bitstreams/4377d2a6-0cff-4074-93d3-f7c6e1d3ae1e/download","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6506697.pdf","grobid_xml":"https://content.openalex.org/works/W6506697.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W71701210","https://openalex.org/W80842343","https://openalex.org/W266936544","https://openalex.org/W288417973","https://openalex.org/W1499242516","https://openalex.org/W1512433654","https://openalex.org/W1512653355","https://openalex.org/W1532812722","https://openalex.org/W1533787993","https://openalex.org/W1560526335","https://openalex.org/W1589295940","https://openalex.org/W1637499098","https://openalex.org/W1655574943","https://openalex.org/W1747895236","https://openalex.org/W1765590204","https://openalex.org/W1765650288","https://openalex.org/W1799118371","https://openalex.org/W1820274388","https://openalex.org/W1848001398","https://openalex.org/W1848412382","https://openalex.org/W1868260061","https://openalex.org/W1884105702","https://openalex.org/W1890770000","https://openalex.org/W1893246485","https://openalex.org/W1901541715","https://openalex.org/W1910600152","https://openalex.org/W1911649157","https://openalex.org/W1919861045","https://openalex.org/W1924891182","https://openalex.org/W1942570407","https://openalex.org/W1942979564","https://openalex.org/W1963851622","https://openalex.org/W1965646268","https://openalex.org/W1966063731","https://openalex.org/W1968383985","https://openalex.org/W1970542209","https://openalex.org/W1972593665","https://openalex.org/W1972892595","https://openalex.org/W1973218522","https://openalex.org/W1977088755","https://openalex.org/W1977389857","https://openalex.org/W1979498694","https://openalex.org/W1980807416","https://openalex.org/W1982680690","https://openalex.org/W1986091786","https://openalex.org/W1987975025","https://openalex.org/W1989969910","https://openalex.org/W1991056002","https://openalex.org/W1992480402","https://openalex.org/W1999952815","https://openalex.org/W2003171435","https://openalex.org/W2003301112","https://openalex.org/W2003479600","https://openalex.org/W2004103813","https://openalex.org/W2004283007","https://openalex.org/W2004545851","https://openalex.org/W2006069610","https://openalex.org/W2006708542","https://openalex.org/W2007281794","https://openalex.org/W2007694332","https://openalex.org/W2007905768","https://openalex.org/W2009115410","https://openalex.org/W2009181699","https://openalex.org/W2009637278","https://openalex.org/W2009826707","https://openalex.org/W2010605653","https://openalex.org/W2011542817","https://openalex.org/W2011660968","https://openalex.org/W2013345205","https://openalex.org/W2013844573","https://openalex.org/W2014892069","https://openalex.org/W2019603938","https://openalex.org/W2019725379","https://openalex.org/W2021207245","https://openalex.org/W2024044146","https://openalex.org/W2024540147","https://openalex.org/W2029627613","https://openalex.org/W2030071623","https://openalex.org/W2031486205","https://openalex.org/W2031583162","https://openalex.org/W2032258076","https://openalex.org/W2034902271","https://openalex.org/W2037626623","https://openalex.org/W2037640053","https://openalex.org/W2040015936","https://openalex.org/W2042037931","https://openalex.org/W2044157441","https://openalex.org/W2044159910","https://openalex.org/W2044296969","https://openalex.org/W2045650289","https://openalex.org/W2048122656","https://openalex.org/W2049056816","https://openalex.org/W2055490337","https://openalex.org/W2057058623","https://openalex.org/W2060490849","https://openalex.org/W2067991344","https://openalex.org/W2070398971","https://openalex.org/W2070850468","https://openalex.org/W2071812173","https://openalex.org/W2072581924","https://openalex.org/W2073269836","https://openalex.org/W2073394065","https://openalex.org/W2073694728","https://openalex.org/W2075085499","https://openalex.org/W2075891777","https://openalex.org/W2075915863","https://openalex.org/W2076368732","https://openalex.org/W2080402857","https://openalex.org/W2081879614","https://openalex.org/W2082512342","https://openalex.org/W2084179103","https://openalex.org/W2087550833","https://openalex.org/W2088088951","https://openalex.org/W2089241243","https://openalex.org/W2090332697","https://openalex.org/W2092216600","https://openalex.org/W2093362562","https://openalex.org/W2093897768","https://openalex.org/W2094653142","https://openalex.org/W2094807913","https://openalex.org/W2098623017","https://openalex.org/W2098912985","https://openalex.org/W2099878756","https://openalex.org/W2101909278","https://openalex.org/W2102743010","https://openalex.org/W2103813902","https://openalex.org/W2104706207","https://openalex.org/W2106526289","https://openalex.org/W2106969933","https://openalex.org/W2106977971","https://openalex.org/W2109393508","https://openalex.org/W2110669425","https://openalex.org/W2111364560","https://openalex.org/W2114202686","https://openalex.org/W2116071714","https://openalex.org/W2117101063","https://openalex.org/W2117928617","https://openalex.org/W2118882129","https://openalex.org/W2121868771","https://openalex.org/W2122205071","https://openalex.org/W2123449896","https://openalex.org/W2124528320","https://openalex.org/W2125956665","https://openalex.org/W2126189696","https://openalex.org/W2126361876","https://openalex.org/W2127835664","https://openalex.org/W2130559009","https://openalex.org/W2130784814","https://openalex.org/W2132557917","https://openalex.org/W2133436471","https://openalex.org/W2134907726","https://openalex.org/W2134908844","https://openalex.org/W2134910213","https://openalex.org/W2135974521","https://openalex.org/W2140147801","https://openalex.org/W2140222781","https://openalex.org/W2141237233","https://openalex.org/W2142707328","https://openalex.org/W2144706906","https://openalex.org/W2144891310","https://openalex.org/W2144924084","https://openalex.org/W2145312783","https://openalex.org/W2149225310","https://openalex.org/W2151869527","https://openalex.org/W2152291583","https://openalex.org/W2152823907","https://openalex.org/W2153710947","https://openalex.org/W2156574495","https://openalex.org/W2159313431","https://openalex.org/W2159505828","https://openalex.org/W2165409475","https://openalex.org/W2168565771","https://openalex.org/W2168824779","https://openalex.org/W2168847459","https://openalex.org/W2169821755","https://openalex.org/W2171790111","https://openalex.org/W2310108266","https://openalex.org/W2314898622","https://openalex.org/W2320568382","https://openalex.org/W2324168078","https://openalex.org/W2326407907","https://openalex.org/W2326889571","https://openalex.org/W2328476123","https://openalex.org/W2334093679","https://openalex.org/W2395671575","https://openalex.org/W2400310281","https://openalex.org/W2411615016","https://openalex.org/W2461272340","https://openalex.org/W3191062208"],"related_works":["https://openalex.org/W2010250205","https://openalex.org/W2133522607","https://openalex.org/W2127835664","https://openalex.org/W2110669425","https://openalex.org/W7096478152","https://openalex.org/W109375810","https://openalex.org/W2098623017","https://openalex.org/W2071812173","https://openalex.org/W2053794026","https://openalex.org/W3044695036"],"abstract_inverted_index":{"One":[0],"of":[1,5,18,26,63,102,119,126,174,193,200,217,226,244,253,272,282,291,301],"the":[2,19,60,86,100,116,127,179,206,212,224,269],"critical":[3,235,259],"functions":[4],"human":[6],"adenovirus":[7],"(hAd)":[8],"early":[9,20,64],"region":[10,31,34,46],"1A":[11],"(E1A)":[12],"protein":[13],"is":[14,82,219,234],"to":[15,59,147,163,168,204,221,260,276],"activate":[16,93,164],"transcription":[17,57,165],"viral":[21,48,65,303],"genes.":[22,66],"The":[23,155,197],"largest":[24],"isoform":[25],"E1A":[27,87,105,120,132,150,161,194,209,227,245,273],"contains":[28],"a":[29,39,189,230,254,289],"unique":[30],"termed":[32],"conserved":[33,135,170],"3":[35],"(CR3),":[36],"which":[37],"includes":[38],"Cysteine-4":[40],"(C4)":[41],"zinc":[42,214,256],"finger":[43,215],"domain.":[44],"This":[45],"activates":[47],"gene":[49],"expression":[50],"by":[51,104,115,130,159,228,249],"interacting":[52],"with":[53,75],"and":[54,263,294],"recruiting":[55],"cellular":[56,144,156,180],"machinery":[58],"regulatory":[61],"regions":[62],"Although":[67],"this":[68,299],"process":[69],"has":[70],"been":[71],"studied":[72],"at":[73],"length":[74],"hAd":[76,91,109,131,149,176,284],"type":[77],"5":[78],"E1A,":[79],"far":[80],"less":[81],"known":[83],"about":[84],"how":[85],"proteins":[88],"from":[89,107,223],"other":[90],"types":[92],"transcription.":[94],"There":[95],"are":[96,134,152],"dramatic":[97],"differences":[98],"in":[99],"potency":[101],"transactivation":[103,275],"CR3s":[106,151],"representative":[108,172,280],"species":[110],"that":[111,124,142,233],"cannot":[112],"be":[113,169],"explained":[114],"current":[117],"model":[118,271],"transactivation.":[121,196,237],"I":[122,139],"hypothesized":[123,141],"many":[125],"co-activators":[128,157],"targeted":[129],"CR3":[133,162,195,218,246,261,274],"between":[136],"types.":[137],"However,":[138],"also":[140,153,287],"additional":[143],"factors":[145],"specific":[146],"certain":[148],"required.":[154],"required":[158,203],"hAd5":[160],"were":[166],"demonstrated":[167],"among":[171],"members":[173,281],"each":[175,283],"species.":[177],"Furthermore,":[178],"lysine":[181],"acetyl":[182],"transferase":[183],"(KAT)":[184],"GCN5":[185,201],"was":[186,202,247,258],"identified":[187],"as":[188],"novel":[190],"negative":[191,292],"regulator":[192],"KAT":[198],"activity":[199],"exert":[205],"effect":[207],"on":[208],"CR3.":[210],"Finally,":[211],"C4":[213],"domain":[216],"predicted":[220],"differ":[222],"rest":[225],"exhibiting":[229],"stable":[231,241],"structure":[232,243,262],"for":[236],"A":[238],"well":[239],"defined":[240],"solution":[242],"confirmed":[248],"NMR":[250],"spectroscopy.":[251],"Coordination":[252],"single":[255],"ion":[257],"folding.":[264],"Together":[265],"these":[266],"observations":[267],"expand":[268],"existing":[270],"not":[277],"only":[278],"include":[279],"species,":[285],"but":[286],"implicate":[288],"layer":[290],"regulation":[293],"provide":[295],"structural":[296],"insight":[297],"into":[298],"paradigm":[300],"non-acidic":[302],"transactivators.":[304]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
