{"id":"https://openalex.org/W65010420","doi":null,"title":"INVESTIGATIONS INTO MODULATION OF BRAIN OXIDATIVE STRESS BY VARIOUS INTERVENTIONS","display_name":"INVESTIGATIONS INTO MODULATION OF BRAIN OXIDATIVE STRESS BY VARIOUS INTERVENTIONS","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W65010420","mag":"65010420"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:chemistry_etds-1012","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/chemistry_etds/12","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1012&context=chemistry_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemistry","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1012&context=chemistry_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014127636","display_name":"Jessica L. Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jessica L. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014127636"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00418558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.871999979019165},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.746999979019165},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8370000123977661},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9409999847412109},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.9449999928474426},{"id":"https://openalex.org/keywords/gsk-3beta-inhibition","display_name":"GSK-3\u03b2 inhibition","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6036979556083679},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.45380571484565735},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4261905252933502},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42577916383743286},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33357805013656616},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2912026643753052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14922469854354858},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10585987567901611},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10361430048942566},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:chemistry_etds-1012","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/chemistry_etds/12","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1012&context=chemistry_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemistry","raw_type":"text"},{"id":"mag:65010420","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1012&context=chemistry_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:chemistry_etds-1012","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/chemistry_etds/12","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1012&context=chemistry_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemistry","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W65010420.pdf","grobid_xml":"https://content.openalex.org/works/W65010420.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W41825302","https://openalex.org/W80953942","https://openalex.org/W121254590","https://openalex.org/W864036077","https://openalex.org/W1480273589","https://openalex.org/W1482472937","https://openalex.org/W1483825698","https://openalex.org/W1502736133","https://openalex.org/W1512705089","https://openalex.org/W1541944730","https://openalex.org/W1546972840","https://openalex.org/W1567624342","https://openalex.org/W1590784339","https://openalex.org/W1843243568","https://openalex.org/W1911339081","https://openalex.org/W1925799544","https://openalex.org/W1942154378","https://openalex.org/W1963762598","https://openalex.org/W1965021646","https://openalex.org/W1967013632","https://openalex.org/W1967612716","https://openalex.org/W1967758708","https://openalex.org/W1968069432","https://openalex.org/W1970836777","https://openalex.org/W1974036368","https://openalex.org/W1975515966","https://openalex.org/W1975579571","https://openalex.org/W1976320711","https://openalex.org/W1977334935","https://openalex.org/W1978042177","https://openalex.org/W1979165975","https://openalex.org/W1979356762","https://openalex.org/W1982947429","https://openalex.org/W1983055247","https://openalex.org/W1986384924","https://openalex.org/W1986537744","https://openalex.org/W1987743911","https://openalex.org/W1988470611","https://openalex.org/W1989036097","https://openalex.org/W1994151063","https://openalex.org/W1994274140","https://openalex.org/W1996147899","https://openalex.org/W1998645487","https://openalex.org/W1999148207","https://openalex.org/W1999708416","https://openalex.org/W2000237824","https://openalex.org/W2000744762","https://openalex.org/W2001210466","https://openalex.org/W2003975298","https://openalex.org/W2006116784","https://openalex.org/W2007361012","https://openalex.org/W2009429846","https://openalex.org/W2012144638","https://openalex.org/W2013205631","https://openalex.org/W2014343991","https://openalex.org/W2015594543","https://openalex.org/W2016777985","https://openalex.org/W2016892258","https://openalex.org/W2022887646","https://openalex.org/W2026193582","https://openalex.org/W2028349507","https://openalex.org/W2029742967","https://openalex.org/W2031102482","https://openalex.org/W2031179697","https://openalex.org/W2032115754","https://openalex.org/W2032920422","https://openalex.org/W2035218123","https://openalex.org/W2036246693","https://openalex.org/W2036338889","https://openalex.org/W2037870372","https://openalex.org/W2038612772","https://openalex.org/W2041136117","https://openalex.org/W2042400232","https://openalex.org/W2043095629","https://openalex.org/W2044263529","https://openalex.org/W2045295833","https://openalex.org/W2045777403","https://openalex.org/W2046078109","https://openalex.org/W2047427096","https://openalex.org/W2049132241","https://openalex.org/W2049262684","https://openalex.org/W2050779639","https://openalex.org/W2052152340","https://openalex.org/W2057346271","https://openalex.org/W2057522312","https://openalex.org/W2058138221","https://openalex.org/W2063968553","https://openalex.org/W2064483915","https://openalex.org/W2065397424","https://openalex.org/W2065961022","https://openalex.org/W2066009040","https://openalex.org/W2071128441","https://openalex.org/W2073292164","https://openalex.org/W2079718442","https://openalex.org/W2086681204","https://openalex.org/W2086751197","https://openalex.org/W2089032508","https://openalex.org/W2091501538","https://openalex.org/W2091945251","https://openalex.org/W2092816488","https://openalex.org/W2094377417","https://openalex.org/W2101444238","https://openalex.org/W2101861123","https://openalex.org/W2102235083","https://openalex.org/W2104679832","https://openalex.org/W2104962877","https://openalex.org/W2104969714","https://openalex.org/W2105731956","https://openalex.org/W2105939406","https://openalex.org/W2107501146","https://openalex.org/W2108986477","https://openalex.org/W2113675798","https://openalex.org/W2114358785","https://openalex.org/W2118898883","https://openalex.org/W2119080788","https://openalex.org/W2120114673","https://openalex.org/W2121785931","https://openalex.org/W2124263476","https://openalex.org/W2124634545","https://openalex.org/W2125904354","https://openalex.org/W2126043496","https://openalex.org/W2131949164","https://openalex.org/W2132004503","https://openalex.org/W2132870100","https://openalex.org/W2133347001","https://openalex.org/W2133574882","https://openalex.org/W2137598362","https://openalex.org/W2141982524","https://openalex.org/W2143628100","https://openalex.org/W2149117501","https://openalex.org/W2155040316","https://openalex.org/W2155324869","https://openalex.org/W2165500341","https://openalex.org/W2167529018","https://openalex.org/W2167573033","https://openalex.org/W2167590630","https://openalex.org/W2171218310","https://openalex.org/W2171830717"],"related_works":["https://openalex.org/W7099141676","https://openalex.org/W2058227131","https://openalex.org/W1993473208","https://openalex.org/W2882137215","https://openalex.org/W7046599826","https://openalex.org/W2601136449","https://openalex.org/W4399864419","https://openalex.org/W4400486149","https://openalex.org/W4372207309","https://openalex.org/W2029742967"],"abstract_inverted_index":{"In":[0],"this":[1],"thesis":[2],"study":[3],"we":[4,171],"examined":[5],"glycogen":[6],"synthase":[7],"kinase-3\u03b2":[8],"(GSK-3\u03b2)":[9],"and":[10,15,84,95,117,128,133,158,187,192],"its":[11,50,160],"effects":[12],"over":[13,53],"Nrf2":[14,39,130],"Pin":[16,78,134],"1":[17,79,135],"as":[18,137,162],"it":[19],"relates":[20],"to":[21,66,71,178,183],"Alzheimer\u2019s":[22],"disease":[23,29],"(AD).":[24],"AD":[25,157],"is":[26,40],"a":[27,32,138,163,173],"neurodegenerative":[28],"characterized":[30],"by":[31],"prolonged":[33],"high":[34],"oxidative":[35,47,68,126,154,185],"environment.":[36],"Transcription":[37],"factor":[38],"vital":[41],"in":[42,64,88,151,196],"the":[43,58,72,99,120,141,152,168,179],"brain\u2019s":[44,59],"defense":[45,61],"against":[46],"insults":[48],"through":[49],"up-regulation":[51],"of":[52,57,74,91,103,140,143,156,181,190],"100":[54],"antioxidants.":[55],"Depletion":[56],"antioxidant":[60],"system":[62],"results":[63,87,147],"intolerance":[65],"an":[67,184],"environment,":[69],"contributing":[70],"progression":[73],"AD.":[75,104,197],"The":[76],"regulatory":[77],"protein":[80],"promotes":[81],"cellular":[82],"homeostasis,":[83],"when":[85],"down-regulated":[86],"increased":[89,129,153,188],"deposits":[90,189],"neurofibrillary":[92],"tangles":[93],"(NFTs)":[94],"amyloid-\u03b2":[96],"(A\u03b2)":[97],"plaques,":[98],"two":[100],"pathological":[101],"hallmarks":[102],"Using":[105],"aged":[106],"SAMP8":[107],"mice":[108],"treated":[109],"with":[110],"antisense":[111],"oligonucleotide":[112],"(AO)":[113],"directed":[114],"at":[115],"GSK-3\u03b2":[116,149,177],"random":[118],"AO,":[119],"data":[121],"presented":[122],"here":[123],"demonstrate":[124],"decreased":[125],"stress":[127,155],"transcriptional":[131],"activity":[132,150],"levels":[136],"result":[139],"down-regulation":[142],"GSK-3\u03b2.":[144],"Collectively,":[145],"these":[146],"implicate":[148],"support":[159],"inhibition":[161],"possible":[164,174],"therapeutic":[165],"treatment":[166],"for":[167],"disease.":[169],"Further,":[170],"elucidate":[172],"mechanism":[175],"connecting":[176],"loss":[180],"tolerance":[182],"environment":[186],"NFTs":[191],"A\u03b2":[193],"plaques":[194],"observed":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
