{"id":"https://openalex.org/W649260125","doi":null,"title":"[Production, identification and redirected cytotoxicity of CD3/CD19 bispecific monoclonal antibody].","display_name":"[Production, identification and redirected cytotoxicity of CD3/CD19 bispecific monoclonal antibody].","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W649260125","mag":"649260125","pmid":"https://pubmed.ncbi.nlm.nih.gov/11717991"},"language":"zh","primary_location":{"id":"pmid:11717991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11717991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040850463","display_name":"\u9648\u6653\u948e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X Chen","raw_affiliation_strings":["Institute of Hematology, CAMS and PUMC, Tianjin 300020"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, CAMS and PUMC, Tianjin 300020","institution_ids":["https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012209358","display_name":"\u6c88\u5fb7\u8bda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033170315","display_name":"\u5b59\u540c\u54f2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041983415","display_name":"\u767d\u91d1\u82ac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082886292","display_name":"\u9ec4\u5229\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.04923138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":"351","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.625},{"id":"https://openalex.org/keywords/t-cell-redirection","display_name":"T cell redirection","score":0.6359999775886536},{"id":"https://openalex.org/keywords/hybridoma-cells","display_name":"hybridoma","score":0.7139999866485596},{"id":"https://openalex.org/keywords/nalm-6-cells","display_name":"Nalm-6 cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/activated-t-cells","display_name":"activated T cells","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.5609999895095825},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3545075058937073}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11717991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11717991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae","raw_type":"Journal Article"},{"id":"mag:2409295084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11717991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:649260125","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/94855X/199805/3178967.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541547","display_name":"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u5b66\u62a5","issn_l":"1000-503X","issn":["1000-503X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u5b66\u62a5","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W570575800","https://openalex.org/W2409295084","https://openalex.org/W1029928806","https://openalex.org/W1214227848","https://openalex.org/W1840766718","https://openalex.org/W997957793","https://openalex.org/W950924441","https://openalex.org/W2336975734","https://openalex.org/W3169517691","https://openalex.org/W3212948643"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"prepare":[2],"CD3/CD19":[3,15,42,53,55,59,79,98],"bispecific":[4],"monoclonal":[5],"antibody":[6,57],"(BsAb)":[7],"and":[8,32,58],"study":[9],"its":[10],"biological":[11],"effects.":[12],"METHODS:":[13],"The":[14,23,78],"BsAb":[16,26,80,99],"was":[17,27,83],"prepared":[18,82],"by":[19,29],"using":[20],"hybri-hybridoma":[21],"technique.":[22],"presence":[24],"of":[25,41,67,103],"demonstrated":[28],"double-isotype":[30],"ELISA":[31],"cell":[33],"conjugate":[34],"assay.":[35],"RESULTS:":[36],"We":[37],"obtained":[38],"three":[39],"strains":[40],"quadromas,":[43],"including":[44],"a":[45],"stable":[46],"one.":[47],"51Cr":[48],"release":[49],"assay":[50],"showed":[51],"that":[52,96],"supernatants,":[54],"purified":[56],"chemical":[60],"heterocongjugate":[61],"greatly":[62],"enhanced":[63],"the":[64,97],"cytotoxic":[65],"activity":[66],"CD3":[68],"AK":[69],"cells":[70,73,89],"against":[71,90],"Nalm-6":[72],"(P":[74],"<":[75],"0.05-0.001).":[76],"CONCLUSIONS:":[77],"we":[81],"efficient":[84],"in":[85],"redirecting":[86],"activated":[87],"T":[88],"target":[91],"tumor":[92],"cells.":[93],"This":[94],"indicates":[95],"has":[100],"potential":[101],"value":[102],"clinical":[104],"use.":[105]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
