{"id":"https://openalex.org/W64910033","doi":null,"title":"The efficacy and safety of amoxicillin-clavulanic acid 1000/125mg twice daily extended release (XR) tablet for the treatment of bacterial community-acquired pneumonia in adults.","display_name":"The efficacy and safety of amoxicillin-clavulanic acid 1000/125mg twice daily extended release (XR) tablet for the treatment of bacterial community-acquired pneumonia in adults.","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W64910033","mag":"64910033","pmid":"https://pubmed.ncbi.nlm.nih.gov/21888181"},"language":"en","primary_location":{"id":"pmid:21888181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Indian Medical Association","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008307486","display_name":"Prahlad Prabhudesai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150536","display_name":"Alkem (India)","ror":"https://ror.org/04kwy9224","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210150536"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P P Prabhudesai","raw_affiliation_strings":["Alkem Lab Ltd, Mumbai 400013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkem Lab Ltd, Mumbai 400013","institution_ids":["https://openalex.org/I4210150536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033626728","display_name":"Sanjay Kumar Jain","orcid":"https://orcid.org/0000-0001-9620-7070","observed_orcids":["https://orcid.org/0000-0001-9620-7070","https://orcid.org/0000-0002-9241-3114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay Jain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074562415","display_name":"Aziz A. Keshvani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aziz Keshvani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"K P Kulkarni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K P Kulkarni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.00740195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"109","issue":"2","first_page":"124","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.9129999876022339},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/community-acquired-pneumonia","display_name":"community-acquired pneumonia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9750000238418579},{"id":"https://openalex.org/keywords/amoxicillin-resistance","display_name":"amoxicillin resistance","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pharmacokinetic-enhancement","display_name":"pharmacokinetic enhancement","score":0.7279999852180481},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.4309999942779541},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5640000104904175},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.5149999856948853},{"id":"https://openalex.org/keywords/respiratory-tract-infections","display_name":"respiratory infections","score":0.5870000123977661},{"id":"https://openalex.org/keywords/antibiotic-efficacy-and-safety","display_name":"antibiotic efficacy and safety","score":0.5720000267028809},{"id":"https://openalex.org/keywords/neutrophil-percentage","display_name":"neutrophil percentage","score":0.6959999799728394},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fever-and-cough","display_name":"fever and cough","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.948608934879303},{"id":"https://openalex.org/C2776102371","wikidata":"https://www.wikidata.org/wiki/Q460030","display_name":"Community-acquired pneumonia","level":3,"score":0.8743414878845215},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.7135134935379028},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.7062889337539673},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.6873275637626648},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6553795337677002},{"id":"https://openalex.org/C2776205632","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Amoxicillin/clavulanic acid","level":5,"score":0.6512624025344849},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6368735432624817},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.5059322714805603},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4430701732635498},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34048992395401},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.22662296891212463},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.187888503074646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08830326795578003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21888181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Indian Medical Association","raw_type":"Journal Article"},{"id":"mag:64910033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053264126","https://openalex.org/W2165005886","https://openalex.org/W2105953236","https://openalex.org/W1990704154","https://openalex.org/W2050767024","https://openalex.org/W2166836716","https://openalex.org/W1867214292","https://openalex.org/W164682896","https://openalex.org/W2049346418","https://openalex.org/W189384885"],"abstract_inverted_index":{"This":[0,38],"study":[1,46,58,130,135,139],"was":[2,142,159,267,282,297,315],"designed":[3],"to":[4,36,54,67,127,186,233,279,299],"demonstrate":[5],"the":[6,104,134,138,154,249,263,306],"efficacy":[7,77,96],"and":[8,87,92,100,112,131,169,182,205,220,229,240,255,272,303],"safety":[9],"of":[10,106,156,251,265,270,275,308],"pharmacokinetically":[11],"enhanced":[12],"amoxicillin/clavulanic":[13],"acid":[14],"2000":[15],"mg/125":[16],"mg":[17,261,290],"extended":[18],"release":[19],"formulation":[20],"(ER),":[21],"than":[22],"conventional":[23],"formulations":[24],"against":[25],"community-acquired":[26,73,115,309],"respiratory":[27],"tract":[28],"pathogens,":[29],"particularly":[30],"Streptococcus":[31],"pneumoniae,":[32],"with":[33,70],"reduced":[34],"susceptibility":[35],"amoxicillin.":[37],"is":[39],"an":[40],"open":[41],"labelled,":[42],"multicentric,":[43],"prospective,":[44],"interventional":[45],"carried":[47],"out":[48],"across":[49],"India":[50],"from":[51,172,225],"June":[52],"2008":[53],"March":[55],"2009.":[56],"The":[57],"included":[59],"adult":[60,312],"patients":[61,117,124,286],"(>18":[62],"years),":[63],"weighing":[64],"between":[65],"40":[66],"60":[68],"kg":[69],"radiologically":[71,113],"confirmed":[72,114],"pneumonia":[74,116,310],"(CAP).":[75],"Primary":[76],"parameters":[78,97,152,214],"were":[79,98,118,125],"clinical":[80,147],"response":[81],"(fever,":[82],"cough":[83,165],"severity,":[84,166],"sputum":[85,167],"characteristics":[86],"improvement":[88,145,162],"in":[89,120,146,163,284,305,311],"dyspnoea":[90,170],"grades)":[91],"laboratory":[93,151],"parameters.":[94],"Secondary":[95],"radiological":[99,256],"bacteriological":[101],"findings":[102],"at":[103,153,248,262],"end":[105,155,250,264],"therapy.":[107,157],"A":[108],"total,":[109],"727":[110],"clinically":[111,301],"enrolled":[119],"this":[121],"study.":[122],"Eighteen":[123],"lost":[126],"follow-up":[128],"during":[129],"709":[132],"completed":[133],"as":[136,148,150,216],"per":[137],"protocol.":[140],"There":[141,158],"a":[143,160],"significant":[144,161],"well":[149,316],"fever,":[164],"characteristic":[168],"grades":[171],"101.88":[173],"+/-":[174,177,180,184,188,194,200,207,227,231,235,242],"1.55,":[175],"2.18":[176],"0.76,":[178],"1.75":[179],"0.77":[181],"1.91":[183],"1.23":[185],"98.14":[187],"0.87":[189],"(p":[190,196,202,209,237,244],"<":[191,197,203,210,238,245],"0.0001),":[192,198],"0.24":[193],"0.45":[195],"0.14":[199],"0.39":[201],"0.0001)":[204,211,239,246],"0.20":[206],"0.47":[208],"respectively.":[212,277],"Laboratory":[213],"such":[215],"total":[217],"WBC":[218],"count":[219],"neutrophil":[221],"percentage":[222],"decreased":[223],"significantly":[224],"15317":[226],"662":[228],"80":[230],"9":[232,243],"9067":[234],"558":[236],"67":[241],"respectively":[247],"treatment.":[252],"Bacteriological":[253],"success":[254,257],"for":[258,294],"amoxicillin-clavulanate":[259],"1,000/62.5":[260,289],"treatment":[266,307],"94.33%":[268],"(150":[269],"159)":[271],"98.7%":[273],"(700":[274],"709)":[276],"Mild":[278],"moderate":[280],"diarrhoea":[281],"reported":[283],"61/709":[285],"(8.6%).":[287],"Amoxicillin-clavulanate":[288],"given":[291],"twice":[292],"daily":[293],"ten":[295],"days":[296],"shown":[298],"be":[300],"effective":[302],"safe":[304],"patients.":[313],"Therapy":[314],"tolerated.":[317],"[J":[318],"Indian":[319],"Med":[320],"Assoc":[321],"2011;":[322],"109:":[323],"124-7]":[324]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
