{"id":"https://openalex.org/W64886019","doi":null,"title":"Role of Interleukin 21 in CD4 T cell regulation","display_name":"Role of Interleukin 21 in CD4 T cell regulation","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W64886019","mag":"64886019"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:3355","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3355/1/Attridge_12_PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3355/1/Attridge_12_PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49369","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089980191","display_name":"Kesley Attridge","orcid":"https://orcid.org/0000-0003-4521-9009","observed_orcids":["https://orcid.org/0000-0003-4521-9009"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kesley Attridge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4521-9009","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089980191"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.7549999952316284},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.765999972820282},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.75},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6579999923706055},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5889999866485596},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.5860000252723694},{"id":"https://openalex.org/keywords/germinal-center-reaction","display_name":"germinal center reaction","score":0.6480000019073486},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.6147332787513733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6123024225234985},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6118502020835876},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5921972990036011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4721772074699402},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.44098642468452454},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4400210976600647},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.43048354983329773},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.41598182916641235},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.40166395902633667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38248807191848755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34468919038772583}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:3355","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3355/1/Attridge_12_PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3355/1/Attridge_12_PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:49369","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49369","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49369","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/991742","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/991742","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:64886019","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/3355/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:49369","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49369","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/49369","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W64886019.pdf","grobid_xml":"https://content.openalex.org/works/W64886019.grobid-xml"},"referenced_works_count":313,"referenced_works":["https://openalex.org/W175676769","https://openalex.org/W1489480103","https://openalex.org/W1490870966","https://openalex.org/W1495069682","https://openalex.org/W1498093713","https://openalex.org/W1513178664","https://openalex.org/W1526621387","https://openalex.org/W1530782041","https://openalex.org/W1537063289","https://openalex.org/W1538902372","https://openalex.org/W1542536286","https://openalex.org/W1543659825","https://openalex.org/W1550965773","https://openalex.org/W1558051000","https://openalex.org/W1558446780","https://openalex.org/W1560702178","https://openalex.org/W1564622887","https://openalex.org/W1573001167","https://openalex.org/W1573470869","https://openalex.org/W1577380979","https://openalex.org/W1579678099","https://openalex.org/W1581904411","https://openalex.org/W1585992677","https://openalex.org/W1586126658","https://openalex.org/W1587765371","https://openalex.org/W1588694091","https://openalex.org/W1591484058","https://openalex.org/W1592985354","https://openalex.org/W1597292086","https://openalex.org/W1599245394","https://openalex.org/W1610777332","https://openalex.org/W1634158134","https://openalex.org/W1656371604","https://openalex.org/W1656896650","https://openalex.org/W1666812184","https://openalex.org/W1672186364","https://openalex.org/W1673999527","https://openalex.org/W1691370130","https://openalex.org/W1745273943","https://openalex.org/W1872870079","https://openalex.org/W1889753107","https://openalex.org/W1898102248","https://openalex.org/W1901606394","https://openalex.org/W1914851639","https://openalex.org/W1929236283","https://openalex.org/W1930746622","https://openalex.org/W1932652655","https://openalex.org/W1939229836","https://openalex.org/W1942668068","https://openalex.org/W1946955186","https://openalex.org/W1948195609","https://openalex.org/W1962132325","https://openalex.org/W1963750108","https://openalex.org/W1964253805","https://openalex.org/W1964787243","https://openalex.org/W1965600238","https://openalex.org/W1965734808","https://openalex.org/W1966184156","https://openalex.org/W1966476962","https://openalex.org/W1967261754","https://openalex.org/W1967351618","https://openalex.org/W1968343481","https://openalex.org/W1971487921","https://openalex.org/W1974259787","https://openalex.org/W1975275391","https://openalex.org/W1976750616","https://openalex.org/W1977715526","https://openalex.org/W1977957847","https://openalex.org/W1978373343","https://openalex.org/W1981365528","https://openalex.org/W1981699748","https://openalex.org/W1982051091","https://openalex.org/W1985577573","https://openalex.org/W1987032872","https://openalex.org/W1987076250","https://openalex.org/W1987628377","https://openalex.org/W1988317772","https://openalex.org/W1991271747","https://openalex.org/W1991365762","https://openalex.org/W1991392411","https://openalex.org/W1993051112","https://openalex.org/W1997531619","https://openalex.org/W2000648336","https://openalex.org/W2000869878","https://openalex.org/W2001809800","https://openalex.org/W2002424665","https://openalex.org/W2002726823","https://openalex.org/W2002987322","https://openalex.org/W2006249161","https://openalex.org/W2006885289","https://openalex.org/W2007721356","https://openalex.org/W2007761469","https://openalex.org/W2007807255","https://openalex.org/W2008713912","https://openalex.org/W2009343059","https://openalex.org/W2009900854","https://openalex.org/W2011608246","https://openalex.org/W2011658568","https://openalex.org/W2012077729","https://openalex.org/W2012228539","https://openalex.org/W2012989963","https://openalex.org/W2013146483","https://openalex.org/W2014655610","https://openalex.org/W2014750930","https://openalex.org/W2014785961","https://openalex.org/W2015054607","https://openalex.org/W2015085911","https://openalex.org/W2015347941","https://openalex.org/W2017142317","https://openalex.org/W2018316453","https://openalex.org/W2021009347","https://openalex.org/W2021070713","https://openalex.org/W2021951643","https://openalex.org/W2025705733","https://openalex.org/W2025748968","https://openalex.org/W2027265343","https://openalex.org/W2027699993","https://openalex.org/W2028752713","https://openalex.org/W2029836713","https://openalex.org/W2030758053","https://openalex.org/W2031247425","https://openalex.org/W2031622194","https://openalex.org/W2032406291","https://openalex.org/W2032596171","https://openalex.org/W2035866203","https://openalex.org/W2035939390","https://openalex.org/W2037920661","https://openalex.org/W2038976543","https://openalex.org/W2039047676","https://openalex.org/W2040838085","https://openalex.org/W2042142548","https://openalex.org/W2042657642","https://openalex.org/W2043209647","https://openalex.org/W2045932062","https://openalex.org/W2047206208","https://openalex.org/W2049406042","https://openalex.org/W2050155919","https://openalex.org/W2050297562","https://openalex.org/W2050356515","https://openalex.org/W2051058933","https://openalex.org/W2051298343","https://openalex.org/W2052172628","https://openalex.org/W2052873213","https://openalex.org/W2055712900","https://openalex.org/W2056280614","https://openalex.org/W2057968168","https://openalex.org/W2058344053","https://openalex.org/W2058794781","https://openalex.org/W2060637301","https://openalex.org/W2061071534","https://openalex.org/W2062443745","https://openalex.org/W2062573090","https://openalex.org/W2063223775","https://openalex.org/W2063516590","https://openalex.org/W2065338955","https://openalex.org/W2067049479","https://openalex.org/W2067197398","https://openalex.org/W2068521142","https://openalex.org/W2068622538","https://openalex.org/W2068639447","https://openalex.org/W2070064097","https://openalex.org/W2071177608","https://openalex.org/W2072170105","https://openalex.org/W2072449713","https://openalex.org/W2074572906","https://openalex.org/W2075097313","https://openalex.org/W2075481963","https://openalex.org/W2076067786","https://openalex.org/W2077926649","https://openalex.org/W2078948501","https://openalex.org/W2079721061","https://openalex.org/W2080890675","https://openalex.org/W2081041392","https://openalex.org/W2081613377","https://openalex.org/W2082871926","https://openalex.org/W2082964303","https://openalex.org/W2083826829","https://openalex.org/W2084416533","https://openalex.org/W2085062445","https://openalex.org/W2085921835","https://openalex.org/W2087482409","https://openalex.org/W2087998194","https://openalex.org/W2089031335","https://openalex.org/W2089037219","https://openalex.org/W2090481553","https://openalex.org/W2092233067","https://openalex.org/W2092235636","https://openalex.org/W2096067806","https://openalex.org/W2096094429","https://openalex.org/W2097811455","https://openalex.org/W2097843798","https://openalex.org/W2099739487","https://openalex.org/W2099853023","https://openalex.org/W2100474263","https://openalex.org/W2100564391","https://openalex.org/W2100683309","https://openalex.org/W2101230909","https://openalex.org/W2101693605","https://openalex.org/W2102642734","https://openalex.org/W2104777875","https://openalex.org/W2105132195","https://openalex.org/W2106187671","https://openalex.org/W2106190040","https://openalex.org/W2106756221","https://openalex.org/W2107235439","https://openalex.org/W2107377230","https://openalex.org/W2107770435","https://openalex.org/W2108617074","https://openalex.org/W2108685327","https://openalex.org/W2110528006","https://openalex.org/W2111185687","https://openalex.org/W2111329034","https://openalex.org/W2112133235","https://openalex.org/W2112812475","https://openalex.org/W2112866067","https://openalex.org/W2113687173","https://openalex.org/W2113847305","https://openalex.org/W2117455815","https://openalex.org/W2121267322","https://openalex.org/W2121604038","https://openalex.org/W2121789150","https://openalex.org/W2122874647","https://openalex.org/W2123833754","https://openalex.org/W2124254978","https://openalex.org/W2124621398","https://openalex.org/W2124870236","https://openalex.org/W2125311191","https://openalex.org/W2125521670","https://openalex.org/W2125792818","https://openalex.org/W2125938085","https://openalex.org/W2125985469","https://openalex.org/W2126897233","https://openalex.org/W2127440907","https://openalex.org/W2127997822","https://openalex.org/W2128057499","https://openalex.org/W2129526943","https://openalex.org/W2130026861","https://openalex.org/W2130486201","https://openalex.org/W2131371764","https://openalex.org/W2131814542","https://openalex.org/W2131874142","https://openalex.org/W2132545691","https://openalex.org/W2133395692","https://openalex.org/W2133449490","https://openalex.org/W2134342374","https://openalex.org/W2134648443","https://openalex.org/W2135280067","https://openalex.org/W2135340773","https://openalex.org/W2135604027","https://openalex.org/W2136616777","https://openalex.org/W2137086195","https://openalex.org/W2138278594","https://openalex.org/W2138319166","https://openalex.org/W2138651252","https://openalex.org/W2139008734","https://openalex.org/W2139127018","https://openalex.org/W2139191751","https://openalex.org/W2139237097","https://openalex.org/W2139476329","https://openalex.org/W2139869391","https://openalex.org/W2140066663","https://openalex.org/W2140582776","https://openalex.org/W2142017607","https://openalex.org/W2144320908","https://openalex.org/W2144690750","https://openalex.org/W2146604395","https://openalex.org/W2146870173","https://openalex.org/W2146934919","https://openalex.org/W2146965628","https://openalex.org/W2147450297","https://openalex.org/W2148759300","https://openalex.org/W2149915530","https://openalex.org/W2151185914","https://openalex.org/W2151962109","https://openalex.org/W2153389047","https://openalex.org/W2154740756","https://openalex.org/W2155013311","https://openalex.org/W2155779547","https://openalex.org/W2156253561","https://openalex.org/W2156657486","https://openalex.org/W2157474210","https://openalex.org/W2159117871","https://openalex.org/W2159955113","https://openalex.org/W2159987448","https://openalex.org/W2160072626","https://openalex.org/W2160683795","https://openalex.org/W2161354474","https://openalex.org/W2161485037","https://openalex.org/W2161545566","https://openalex.org/W2162675860","https://openalex.org/W2162791009","https://openalex.org/W2162888477","https://openalex.org/W2163577434","https://openalex.org/W2163828646","https://openalex.org/W2164254316","https://openalex.org/W2164701887","https://openalex.org/W2164924638","https://openalex.org/W2165214298","https://openalex.org/W2165521534","https://openalex.org/W2165588484","https://openalex.org/W2165608602","https://openalex.org/W2166282414","https://openalex.org/W2166307427","https://openalex.org/W2166438464","https://openalex.org/W2167327834","https://openalex.org/W2167863101","https://openalex.org/W2168985658","https://openalex.org/W2169233545","https://openalex.org/W2172094131","https://openalex.org/W2175077154","https://openalex.org/W2776663677","https://openalex.org/W2784110492","https://openalex.org/W4313333698"],"related_works":["https://openalex.org/W7000998523","https://openalex.org/W2150037434","https://openalex.org/W2110471797","https://openalex.org/W2128161623","https://openalex.org/W2084705440","https://openalex.org/W2154001070","https://openalex.org/W2993423367","https://openalex.org/W2982112650","https://openalex.org/W142486038","https://openalex.org/W2046374777"],"abstract_inverted_index":{"IL-21":[0,32,53,74,147,183,245],"is":[1],"crucial":[2],"for":[3,84],"anti-viral":[4],"defense,":[5],"the":[6,107,123,157,168,210,234,251],"germinal":[7],"center":[8],"reaction":[9],"and":[10,81,162,177,241,255],"anti-tumour":[11],"immunity.":[12,116,256],"Conversely,":[13],"it":[14],"has":[15],"been":[16],"implicated":[17],"in":[18,86,132,209,217,247],"various":[19],"autoimmune":[20],"conditions,":[21],"including":[22],"type-1":[23],"diabetes.":[24],"This":[25,65],"study":[26],"set":[27],"out":[28],"to":[29,45,60,77],"explore":[30],"how":[31,95,167,242],"influences":[33,174],"CD4":[34,57,96,186,237],"T":[35,58,91,97,114,136,171,187,206,238],"cell":[36,98,115,137,172,239],"immune":[37],"responses,":[38],"with":[39,68,199,225],"particular":[40],"emphasis":[41],"on":[42,55,128],"its":[43],"ability":[44],"counteract":[46],"Treg-mediated":[47],"suppression.":[48,64],"These":[49,179,228],"experiments":[50,180],"revealed":[51,181],"that":[52,119,146,182],"acted":[54],"conventional":[56,87],"cells":[59,188,201,207],"release":[61],"them":[62],"from":[63],"was":[66,75,102,189],"associated":[67],"loss":[69],"of":[70,94,106,113,125,160,170,212,236,244],"Treg":[71],"homeostasis,":[72],"as":[73],"able":[76],"inhibit":[78],"IL-2":[79,85],"production":[80,176,184],"could":[82,121,148,249],"substitute":[83],"but":[88],"not":[89],"regulatory":[90],"cells.":[92,227],"Analysis":[93],"responses":[99,193,240],"are":[100],"controlled":[101],"broadened":[103],"by":[104,130,153,185,195],"investigation":[105],"CTLA-4":[108,120,161],"pathway,":[109],"a":[110,141],"major":[111],"regulator":[112],"We":[117],"showed":[118,145],"decrease":[122],"level":[124],"CD86":[126,151],"expression":[127,152],"APCs":[129],"trans-endocytosis":[131],"vivo,":[133],"thereby":[134],"limiting":[135],"CD28":[138],"signalling.":[139],"In":[140],"further":[142],"development,":[143],"we":[144,165],"directly":[149],"upregulate":[150],"B":[154,200,226],"cells,":[155],"illustrating":[156],"opposing":[158],"functions":[159],"IL-21.":[163],"Finally,":[164],"explored":[166],"nature":[169],"activation":[173],"cytokine":[175],"pathogenicity.":[178],"strongly":[190],"induced":[191],"during":[192],"driven":[194],"DCs,":[196],"whilst":[197],"stimulation":[198],"promoted":[202],"IFN\u03b3":[203],"expression.":[204],"Moreover,":[205],"activated":[208],"presence":[211],"DCs":[213],"were":[214],"profoundly":[215],"diabetogenic":[216],"an":[218],"adoptive":[219],"transfer":[220],"system,":[221],"unlike":[222],"those":[223],"co-stimulated":[224],"data":[229],"provide":[230],"new":[231],"insight":[232],"into":[233],"regulation":[235],"levels":[243],"produced":[246],"vivo":[248],"modulate":[250],"balance":[252],"between":[253],"tolerance":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}