{"id":"https://openalex.org/W64880087","doi":null,"title":"An Analysis of Estrogen Metabolism and Breast Cancer Risk","display_name":"An Analysis of Estrogen Metabolism and Breast Cancer Risk","publication_year":2010,"publication_date":"2010-06-28","ids":{"openalex":"https://openalex.org/W64880087","mag":"64880087"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7073","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7073/1/StacyMLloyd6142010Dissertation.pdf","pdf_url":"https://d-scholarship.pitt.edu/7073/1/StacyMLloyd6142010Dissertation.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022620022","display_name":"Stacy M. Lloyd","orcid":"https://orcid.org/0000-0002-8505-5670","observed_orcids":["https://orcid.org/0000-0002-8505-5670"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stacy M. Lloyd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8505-5670","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022620022"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00548082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9139999747276306},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.9800000190734863},{"id":"https://openalex.org/keywords/2-hydroxyestrone","display_name":"2-hydroxyestrone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.9359999895095825},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.8519999980926514},{"id":"https://openalex.org/keywords/african-american-women","display_name":"African American women","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-passage-number","display_name":"cell passage number","score":0.5099999904632568},{"id":"https://openalex.org/keywords/endogenous-estrogen","display_name":"endogenous estrogen","score":0.6639999747276306},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.5879999995231628},{"id":"https://openalex.org/keywords/breast-cancer-biomarkers","display_name":"breast cancer biomarkers","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.9011958241462708},{"id":"https://openalex.org/C155701950","wikidata":"https://www.wikidata.org/wiki/Q14905165","display_name":"CYP1B1","level":4,"score":0.6642836332321167},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5725724697113037},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5424886345863342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5146409273147583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5082592368125916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45729079842567444},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4148636758327484},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.16396808624267578},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.06701108813285828}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:7073","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7073/1/StacyMLloyd6142010Dissertation.pdf","pdf_url":"https://d-scholarship.pitt.edu/7073/1/StacyMLloyd6142010Dissertation.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:64880087","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/7073/1/StacyMLloyd6142010Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W38808096","https://openalex.org/W107899610","https://openalex.org/W197541195","https://openalex.org/W214196595","https://openalex.org/W282555118","https://openalex.org/W1485748895","https://openalex.org/W1526348192","https://openalex.org/W1658682427","https://openalex.org/W1679925763","https://openalex.org/W1715326565","https://openalex.org/W1786886910","https://openalex.org/W1884538664","https://openalex.org/W1964526941","https://openalex.org/W1965614209","https://openalex.org/W1967422953","https://openalex.org/W1970668319","https://openalex.org/W1971545670","https://openalex.org/W1973053346","https://openalex.org/W1973177197","https://openalex.org/W1975689131","https://openalex.org/W1975884285","https://openalex.org/W1980944838","https://openalex.org/W1981427333","https://openalex.org/W1981841418","https://openalex.org/W1985164435","https://openalex.org/W1989292079","https://openalex.org/W1989543876","https://openalex.org/W1992928602","https://openalex.org/W1994480513","https://openalex.org/W1995954745","https://openalex.org/W1997366241","https://openalex.org/W1997388940","https://openalex.org/W1998866958","https://openalex.org/W2001732788","https://openalex.org/W2003205311","https://openalex.org/W2005177013","https://openalex.org/W2007657603","https://openalex.org/W2009370455","https://openalex.org/W2011258934","https://openalex.org/W2011971524","https://openalex.org/W2013142209","https://openalex.org/W2013519213","https://openalex.org/W2013849139","https://openalex.org/W2016669181","https://openalex.org/W2017350244","https://openalex.org/W2018190464","https://openalex.org/W2023982571","https://openalex.org/W2024268846","https://openalex.org/W2024347479","https://openalex.org/W2026420736","https://openalex.org/W2027704821","https://openalex.org/W2028691872","https://openalex.org/W2029066152","https://openalex.org/W2030310859","https://openalex.org/W2030975106","https://openalex.org/W2035091931","https://openalex.org/W2036669175","https://openalex.org/W2043652943","https://openalex.org/W2046194218","https://openalex.org/W2047687060","https://openalex.org/W2049749452","https://openalex.org/W2049786577","https://openalex.org/W2050132247","https://openalex.org/W2050847082","https://openalex.org/W2057768258","https://openalex.org/W2058484936","https://openalex.org/W2060439544","https://openalex.org/W2062058806","https://openalex.org/W2063932485","https://openalex.org/W2065159375","https://openalex.org/W2067420397","https://openalex.org/W2067707819","https://openalex.org/W2071302304","https://openalex.org/W2072380234","https://openalex.org/W2073325756","https://openalex.org/W2074625888","https://openalex.org/W2076450243","https://openalex.org/W2078978161","https://openalex.org/W2080509529","https://openalex.org/W2084746075","https://openalex.org/W2085078390","https://openalex.org/W2085205176","https://openalex.org/W2087683876","https://openalex.org/W2087962059","https://openalex.org/W2089352475","https://openalex.org/W2090560500","https://openalex.org/W2093879092","https://openalex.org/W2094879937","https://openalex.org/W2097679086","https://openalex.org/W2099423538","https://openalex.org/W2101649975","https://openalex.org/W2101709227","https://openalex.org/W2101879098","https://openalex.org/W2102230994","https://openalex.org/W2102820726","https://openalex.org/W2102930722","https://openalex.org/W2103001347","https://openalex.org/W2107410297","https://openalex.org/W2109063533","https://openalex.org/W2111829340","https://openalex.org/W2112025328","https://openalex.org/W2117899344","https://openalex.org/W2121688629","https://openalex.org/W2122908256","https://openalex.org/W2124408989","https://openalex.org/W2125376081","https://openalex.org/W2126694781","https://openalex.org/W2127529986","https://openalex.org/W2129688964","https://openalex.org/W2130343048","https://openalex.org/W2132602296","https://openalex.org/W2132763951","https://openalex.org/W2134520787","https://openalex.org/W2135995733","https://openalex.org/W2136032233","https://openalex.org/W2137664436","https://openalex.org/W2138597496","https://openalex.org/W2139269097","https://openalex.org/W2139372524","https://openalex.org/W2141239229","https://openalex.org/W2146534328","https://openalex.org/W2148360798","https://openalex.org/W2155433804","https://openalex.org/W2157096805","https://openalex.org/W2161222044","https://openalex.org/W2161836295","https://openalex.org/W2161966331","https://openalex.org/W2162756556","https://openalex.org/W2163151567","https://openalex.org/W2164124129","https://openalex.org/W2164961968","https://openalex.org/W2165777378","https://openalex.org/W2166365114","https://openalex.org/W2166888153","https://openalex.org/W2168289223","https://openalex.org/W2169804985","https://openalex.org/W2170199100","https://openalex.org/W2188748308","https://openalex.org/W2206749611","https://openalex.org/W2313869316","https://openalex.org/W2330332146","https://openalex.org/W2416594583","https://openalex.org/W2498520064"],"related_works":["https://openalex.org/W2131338651","https://openalex.org/W2059769560","https://openalex.org/W7098677769","https://openalex.org/W2076956960","https://openalex.org/W2075620858","https://openalex.org/W2118156630","https://openalex.org/W1646169967","https://openalex.org/W1983038564","https://openalex.org/W7100147940","https://openalex.org/W2162756556"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,9,67,89,114,154,206,216,228,245],"is":[2,58,106,159,283],"the":[3,13,18,33,70,96,109,117,136,144,167,178,190,194,219,239,253,267,280,299,304,323],"most":[4],"common":[5],"noncutaneous":[6],"form":[7],"of":[8,72,87,108,112,177,182,189,308,322,331],"among":[10,193],"women":[11],"in":[12,32,133,162,252],"US.":[14],"In":[15,165,272],"recent":[16],"years,":[17],"overall":[19],"mortality":[20,36],"rate":[21],"has":[22,81,170],"declined,":[23],"yet":[24],"there":[25],"still":[26],"exists":[27],"a":[28,55,59,85,319],"significant":[29,301],"racial":[30,327],"disparity":[31],"incidence":[34],"and":[35,40,65,69,78,101,204,218,230,266,329,341],"between":[37,63,98,263],"African":[38],"American":[39],"Caucasian":[41],"women.":[42,345],"While":[43],"numerous":[44],"hypotheses":[45],"have":[46,93,129,311],"been":[47,82,172],"proposed":[48],"to":[49,135,186,277,303,338],"explain":[50],"this":[51,123,157,183,231,309],"difference,":[52],"few":[53,128],"offer":[54],"biological":[56],"explanation.There":[57],"well":[60],"established":[61],"association":[62,225,262],"estrogens":[64,100],"breast":[66,88,113,153,205,215,227,244,332],"risk,":[68,115,155,246],"ratio":[71,140],"two":[73],"estrogen":[74,138,163],"metabolites,":[75],"2-hydroxyestrone":[76],"(2OHE1)":[77],"16\u00e1-hydroxyestrone":[79],"(16OHE1),":[80],"implicated":[83],"as":[84,156,295,316],"marker":[86],"risk.":[90,207],"Many":[91],"studies":[92],"also":[94,151],"assessed":[95],"relationship":[97],"endogenous":[99],"mammographic":[102,131,201,264],"density.":[103],"Mammographic":[104],"density":[105,132,265],"one":[107],"strongest":[110],"predictors":[111],"but":[116],"mechanism":[118],"by":[119,285],"which":[120,334],"it":[121,247,317],"influences":[122],"risk":[124,217,229,324],"remains":[125],"unknown.":[126],"Nonetheless,":[127],"examined":[130],"relation":[134],"2OHE1:16OHE1":[137,179,209,254,268,281,305],"metabolite":[139],"(EMR).Research":[141],"suggests":[142,236],"that":[143,237,279],"Cytochrome":[145],"P450":[146],"1B1":[147],"(CYP1B1)":[148],"gene":[149,158],"may":[150],"mediate":[152],"very":[160],"active":[161],"metabolism.":[164],"fact,":[166],"Leu432Val":[168,199,221,241],"polymorphism":[169,232,242],"reportedly":[171],"associated":[173,212],"with":[174,213,226],"urinary":[175],"levels":[176],"EMR.The":[180,306],"objective":[181],"study":[184,310],"was":[185,211,233,270,275,298],"investigate":[187],"some":[188],"relationships":[191],"found":[192,276],"2OHE1:":[195],"16OHE1":[196],"EMR,":[197],"CYP1B1":[198,220,240],"polymorphism,":[200,222],"density,":[202],"race,":[203],"The":[208],"EMR":[210,269,282],"both":[214],"yet,":[223],"no":[224,261],"observed.":[234,271],"This":[235],"if":[238],"alters":[243],"does":[248],"so":[249],"through":[250],"variations":[251],"EMR.":[255],"When":[256],"taking":[257],"race":[258],"into":[259],"account,":[260],"culture,":[273],"evidence":[274],"suggest":[278],"influenced":[284],"subcellular":[286],"effects":[287],"or":[288],"other":[289],"intrinsic":[290],"factors":[291],"(i.e.":[292],"genetic":[293],"variation),":[294],"passage":[296],"number":[297],"only":[300],"contributor":[302],"results":[307],"great":[312],"public":[313],"health":[314],"significance,":[315],"provides":[318],"better":[320,339],"understanding":[321],"factors,":[325],"including":[326],"differences,":[328],"etiology":[330],"cancer,":[333],"will":[335],"ultimately":[336],"lead":[337],"prevention":[340],"treatment":[342],"for":[343],"all":[344]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}