{"id":"https://openalex.org/W64836134","doi":null,"title":"Cleavage and activation of corneal matrix metalloproteases by Pseudomonas aeruginosa proteases.","display_name":"Cleavage and activation of corneal matrix metalloproteases by Pseudomonas aeruginosa proteases.","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W64836134","mag":"64836134","pmid":"https://pubmed.ncbi.nlm.nih.gov/8491548"},"language":"en","primary_location":{"id":"pmid:8491548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8491548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103279641","display_name":"Kousuke Matsumoto","orcid":"https://orcid.org/0000-0002-0446-780X","observed_orcids":["https://orcid.org/0000-0002-0446-780X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Matsumoto","raw_affiliation_strings":["Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111620080","display_name":"Naveed B.K. Shams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N B Shams","raw_affiliation_strings":["Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070476420","display_name":"Laila A. Hanninen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Hanninen","raw_affiliation_strings":["Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111559128","display_name":"Kenneth R. Kenyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K R Kenyon","raw_affiliation_strings":["Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute, Department of Ophthalmology,Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.1177,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86120062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"6","first_page":"1945","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.4794999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.4794999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9610000252723694},{"id":"https://openalex.org/keywords/protease-activation","display_name":"protease activation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/limited-proteolysis","display_name":"limited proteolysis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/corneal-fibroblasts","display_name":"corneal fibroblasts","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cornea","display_name":"cornea","score":0.7730000019073486},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9089999794960022},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.6579999923706055},{"id":"https://openalex.org/keywords/alkaline-protease","display_name":"alkaline protease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corneal-injury","display_name":"corneal injury","score":0.5680000185966492},{"id":"https://openalex.org/keywords/corneal-stroma","display_name":"corneal stroma","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8394118547439575},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.8034579753875732},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7113296389579773},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.6489481925964355},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6468629240989685},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.5789989829063416},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5114668607711792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48186811804771423},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4807034134864807},{"id":"https://openalex.org/C2910007452","wikidata":"https://www.wikidata.org/wiki/Q21114943","display_name":"Matrix Metalloproteinase 3","level":3,"score":0.47724437713623047},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42658519744873047},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.41228288412094116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3719663619995117},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34124433994293213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3243234157562256},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15069475769996643},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14758792519569397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8491548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8491548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:64836134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8491548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W18669667","https://openalex.org/W43078542","https://openalex.org/W59111121","https://openalex.org/W64749251","https://openalex.org/W118250415","https://openalex.org/W1498144012","https://openalex.org/W1560360966","https://openalex.org/W1669342624","https://openalex.org/W1750339447","https://openalex.org/W1859272595","https://openalex.org/W1882182790","https://openalex.org/W1910087083","https://openalex.org/W1948956821","https://openalex.org/W1955004414","https://openalex.org/W1967395072","https://openalex.org/W1997845654","https://openalex.org/W2010331410","https://openalex.org/W2034619157","https://openalex.org/W2060864127","https://openalex.org/W2079831464","https://openalex.org/W2107924955","https://openalex.org/W2126393216","https://openalex.org/W2132320308","https://openalex.org/W2290272847","https://openalex.org/W2301715754","https://openalex.org/W2315656359","https://openalex.org/W2418911758"],"related_works":["https://openalex.org/W2027479578","https://openalex.org/W116426194","https://openalex.org/W1994120158","https://openalex.org/W1994888246","https://openalex.org/W751510650","https://openalex.org/W2107924955","https://openalex.org/W1509296170","https://openalex.org/W2022932509","https://openalex.org/W163554593","https://openalex.org/W2969523836"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"the":[3,9,16,55,205,225],"effect":[4,17],"of":[5,11,18,23,45,51,79,115,155,170,199],"Pseudomonas":[6],"aeruginosa":[7,47,81,157],"on":[8,21],"expression":[10],"corneal":[12,24,34,69,132,148,191,237],"matrix":[13,25,102,119,137,179,220,238],"metalloproteases":[14,26,138],"and":[15,32,48,54,65,82,121,212],"its":[19],"proteases":[20],"activation":[22],"in":[27,85,93,130,167,218],"vitro.":[28],"METHODS:":[29],"Rat":[30],"corneas":[31,92,108,145],"human":[33,131,147,190],"fibroblasts":[35,149],"were":[36,58],"co-cultivated":[37],"with":[38,74,112,152,194],"two":[39,153],"different":[40],"strains":[41,154],"(RPS":[42],"&":[43],"599A)":[44],"P.":[46,80,156,200],"one":[49],"strain":[50,78,198],"Staphylococcus":[52],"aureus,":[53],"conditioned":[56],"media":[57],"analyzed":[59,84],"for":[60,158],"proteolytic":[61],"activity":[62],"by":[63,188,245],"gelatin":[64],"casein":[66],"zymography.":[67],"Human":[68],"fibroblast-conditioned":[70,133,192],"medium":[71,193,203],"was":[72,83],"incubated":[73],"that":[75,195,223],"from":[76,196,204,224],"either":[77,197],"a":[86,97,161],"similar":[87],"manner.":[88],"RESULTS:":[89],"Normal":[90],"rat":[91,107,144],"organ":[94],"culture":[95],"produce":[96,110],"65":[98],"kDa":[99,117,163,183],"gelatinase":[100,164],"(inactive":[101,118],"metalloprotease-2),":[103],"whereas":[104],"thermally":[105],"injured":[106],"additionally":[109],"gelatinases":[111],"molecular":[113],"masses":[114],"92":[116],"metalloproteases-9)":[120],">":[122],"200":[123],"kDa.":[124],"Matrix":[125],"metalloprotease-2":[126,221,239],"is":[127,185,215,240],"also":[128,186],"detected":[129],"medium.":[134],"Although":[135],"these":[136],"are":[139,150],"no":[140],"longer":[141],"detectable":[142],"when":[143],"or":[146],"co-cultured":[151],"48":[159],"hr,":[160],"58":[162,182],"fragment":[165,184],"appears":[166],"earlier":[168],"stages":[169],"co-culture.":[171],"In":[172],"contrast,":[173],"S.":[174],"aureus":[175],"does":[176],"not":[177],"affect":[178],"metalloprotease-2.":[180],"The":[181,234],"evident":[187],"incubating":[189],"aeruginosa.":[201],"Conditioned":[202],"RPS":[206],"strain,":[207,227],"which":[208,228],"produces":[209],"both":[210],"elastase":[211],"alkaline":[213,231],"protease,":[214],"more":[216],"effective":[217],"cleaving":[219],"than":[222],"599A":[226],"expresses":[229],"mainly":[230],"protease.":[232],"CONCLUSION:":[233],"secreted":[235],"inactive":[236],"activated":[241],"through":[242],"limited":[243],"proteolysis":[244],"pseudomonal":[246],"proteases.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
