{"id":"https://openalex.org/W648052672","doi":null,"title":"INFLAMMATORY AND HEMOSTATIC BIOMARKERS AND CORONARY ARTERY CALCIFICATION IN WOMEN UNDERGOING THE MENOPAUSAL TRANSITION","display_name":"INFLAMMATORY AND HEMOSTATIC BIOMARKERS AND CORONARY ARTERY CALCIFICATION IN WOMEN UNDERGOING THE MENOPAUSAL TRANSITION","publication_year":2014,"publication_date":"2014-01-29","ids":{"openalex":"https://openalex.org/W648052672","mag":"648052672"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:20013","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","pdf_url":"http://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033094535","display_name":"Norman C. Wang","orcid":"https://orcid.org/0000-0002-8388-2146","observed_orcids":["https://orcid.org/0000-0002-8388-2146"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Norman C. Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8388-2146","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033094535"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perimenopause","display_name":"perimenopause","score":0.828000009059906},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5299999713897705},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hemostatic-biomarkers","display_name":"hemostatic biomarkers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/subclinical-atherosclerosis","display_name":"subclinical atherosclerosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cac-progression","display_name":"CAC progression","score":0.7409999966621399},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.8130000233650208},{"id":"https://openalex.org/keywords/black-women","display_name":"Black women","score":0.7139999866485596},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7689999938011169},{"id":"https://openalex.org/keywords/swans","display_name":"swans","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8491866588592529},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6542644500732422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.642966628074646},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6093968152999878},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5398013591766357},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.46369919180870056},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4532164931297302},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44338458776474},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.340880423784256},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20131579041481018}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:20013","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","pdf_url":"http://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:648052672","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR%2D3.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:20013","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","pdf_url":"http://d-scholarship.pitt.edu/20013/1/NCWang_MS_ETD_12.06.13_LR-3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W648052672.pdf","grobid_xml":"https://content.openalex.org/works/W648052672.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W55954079","https://openalex.org/W138338620","https://openalex.org/W174870447","https://openalex.org/W1117735932","https://openalex.org/W1453335796","https://openalex.org/W1514929390","https://openalex.org/W1520569529","https://openalex.org/W1531387524","https://openalex.org/W1595013592","https://openalex.org/W1601708437","https://openalex.org/W1651383390","https://openalex.org/W1965842829","https://openalex.org/W1967962375","https://openalex.org/W1969678022","https://openalex.org/W1970975213","https://openalex.org/W1976829766","https://openalex.org/W1978203083","https://openalex.org/W1980648524","https://openalex.org/W1982392960","https://openalex.org/W1982964937","https://openalex.org/W1987056651","https://openalex.org/W1991873795","https://openalex.org/W1991977311","https://openalex.org/W1993286003","https://openalex.org/W1993447122","https://openalex.org/W1993521638","https://openalex.org/W1994064869","https://openalex.org/W1996794112","https://openalex.org/W1997083908","https://openalex.org/W1999264494","https://openalex.org/W2003634371","https://openalex.org/W2009602476","https://openalex.org/W2011823786","https://openalex.org/W2012380963","https://openalex.org/W2012535717","https://openalex.org/W2012655616","https://openalex.org/W2013718123","https://openalex.org/W2015906981","https://openalex.org/W2018316010","https://openalex.org/W2019071303","https://openalex.org/W2022547103","https://openalex.org/W2022705938","https://openalex.org/W2022868918","https://openalex.org/W2024444522","https://openalex.org/W2024886564","https://openalex.org/W2026018907","https://openalex.org/W2027748017","https://openalex.org/W2035864756","https://openalex.org/W2035962722","https://openalex.org/W2039535075","https://openalex.org/W2039910385","https://openalex.org/W2042984581","https://openalex.org/W2046117118","https://openalex.org/W2050683601","https://openalex.org/W2050856345","https://openalex.org/W2051174201","https://openalex.org/W2051512233","https://openalex.org/W2054544120","https://openalex.org/W2055093326","https://openalex.org/W2058217708","https://openalex.org/W2065604182","https://openalex.org/W2065815469","https://openalex.org/W2067895655","https://openalex.org/W2068030410","https://openalex.org/W2070627144","https://openalex.org/W2071466550","https://openalex.org/W2074405755","https://openalex.org/W2081072549","https://openalex.org/W2084846835","https://openalex.org/W2104276995","https://openalex.org/W2104335422","https://openalex.org/W2105766576","https://openalex.org/W2117682656","https://openalex.org/W2117931787","https://openalex.org/W2118292856","https://openalex.org/W2119984740","https://openalex.org/W2122938990","https://openalex.org/W2125566242","https://openalex.org/W2125921569","https://openalex.org/W2127101722","https://openalex.org/W2129783757","https://openalex.org/W2134232124","https://openalex.org/W2135448547","https://openalex.org/W2140853784","https://openalex.org/W2148413329","https://openalex.org/W2150278133","https://openalex.org/W2150762378","https://openalex.org/W2151172917","https://openalex.org/W2152512217","https://openalex.org/W2153785016","https://openalex.org/W2154023207","https://openalex.org/W2158977363","https://openalex.org/W2164632621","https://openalex.org/W2165884492","https://openalex.org/W2170127099","https://openalex.org/W2170491971","https://openalex.org/W2396037438","https://openalex.org/W2589909250","https://openalex.org/W3022401702","https://openalex.org/W4236673002"],"related_works":["https://openalex.org/W2382725117","https://openalex.org/W1574513759","https://openalex.org/W2322013810","https://openalex.org/W1983022133","https://openalex.org/W2130304988","https://openalex.org/W2072963159","https://openalex.org/W2028535919","https://openalex.org/W4391424490","https://openalex.org/W2042693064","https://openalex.org/W2744729830"],"abstract_inverted_index":{"Aims:":[0],"Coronary":[1],"heart":[2],"disease":[3],"(CHD)":[4],"is":[5,326],"a":[6,147,284],"significant":[7,187,203],"public":[8],"health":[9],"issue":[10],"in":[11,25,60,227,298,323,339],"the":[12,37,73,79,105,123,158,169,237,242],"United":[13],"States.":[14],"The":[15,29],"relationships":[16],"of":[17,31,39,42,75,109,127,143,150,162,205,252,261,272,293,330],"inflammatory":[18],"and":[19,52,55,92,112,115,117,130,135,182,209,224,246,255,291,308,321],"hemostatic":[20,309],"biomarkers":[21,45,62,174,299,310],"to":[22,35,56],"subclinical":[23],"CHD":[24,337],"women":[26,145,235],"are":[27,311],"uncertain.":[28],"aims":[30],"this":[32],"study":[33],"were":[34,63,70,98,120,138,155,166,175,186,233,248,300],"test":[36],"associations":[38],"baseline":[40,47,110,128,159,179,314],"levels":[41],"four":[43],"novel":[44,173],"with":[46,65,146,178,221,250,259,270,303,313,328],"coronary":[48],"artery":[49],"calcification":[50],"(CAC)":[51],"CAC":[53,66,111,113,129,131,160,180,210,222,225,238,253,262,273,294,304,315,322,331],"progression;":[54],"evaluate":[57],"if":[58],"changes":[59],"these":[61],"associated":[64,177,220,249,258,269,302,312,327],"progression.":[67,263,305,332],"Methods:":[68],"Subjects":[69],"obtained":[71],"from":[72],"Study":[74],"Women\u2019s":[76],"Health":[77],"Across":[78],"Nation":[80],"Heart":[81],"Study.":[82],"C-reactive":[83],"protein":[84],"(CRP),":[85],"fibrinogen,":[86],"plasminogen-activator":[87],"inhibitor":[88],"type":[89],"1":[90],"(PAI-1),":[91],"tissue":[93],"plasminogen":[94],"activator":[95],"antigen":[96],"(tPA-ag)":[97],"log-transformed.":[99],"Logistic":[100],"regression":[101,119],"was":[102,211,218,257,268,283],"used":[103,121],"for":[104,122,157,190,198,236,319],"categorical":[106],"outcomes":[107,125],"(presence":[108],"progression),":[114],"tobit":[116],"linear":[118],"continuous":[124],"(extent":[126],"progression,":[132],"respectively).":[133],"Univariable":[134],"multivariable":[136,215],"analyses":[137,161],"performed.":[139],"Results:":[140],"A":[141,202],"total":[142],"372":[144],"mean":[148],"age":[149],"51.3":[151],"years":[152],"(SD,":[153],"2.8)":[154],"included":[156],"which":[163],"131":[164],"(35.2%)":[165],"black.":[167],"In":[168,213,241],"univariable":[170,243],"analyses,":[171,216,244],"all":[172],"positively":[176],"presence":[181,223,251,271,329],"extent":[183,226,260,292],"(p<0.001).":[184],"These":[185,333],"after":[188,196],"adjusting":[189,197],"traditional":[191],"risk":[192],"factors,":[193],"but":[194,229],"not":[195,230,301],"body":[199],"mass":[200],"index.":[201],"interaction":[204],"race":[206],"on":[207],"log(CRP)":[208,217],"present.":[212],"race-stratified":[214],"significantly":[219],"blacks,":[228],"whites.":[231],"There":[232,282],"252":[234],"progression":[239,254,274,295],"analyses.":[240],"log(PAI-1)":[245,256,267,290],"log(tPA-ag)":[247],"After":[264],"adjustment,":[265],"only":[266],"(OR,":[275],"1.91;":[276],"95%":[277],"CI,":[278],"1.24-":[279],"2.93;":[280],"p=0.003).":[281],"trend":[285],"towards":[286],"an":[287],"association":[288],"between":[289],"(p=0.06).":[296],"Changes":[297],"Conclusions:":[306],"Inflammatory":[307],"through":[316],"obesity,":[317],"except":[318],"CRP":[320],"blacks.":[324],"Log(PAI-1)":[325],"findings":[334],"may":[335],"improve":[336],"prevention":[338],"midlife":[340],"women.":[341]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
