{"id":"https://openalex.org/W6479336","doi":null,"title":"[Conservative treatment of children constipation with Macrogol 4,000].","display_name":"[Conservative treatment of children constipation with Macrogol 4,000].","publication_year":2008,"publication_date":"2008-08-01","ids":{"openalex":"https://openalex.org/W6479336","mag":"6479336","pmid":"https://pubmed.ncbi.nlm.nih.gov/18511892"},"language":"it","primary_location":{"id":"pmid:18511892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18511892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva pediatrica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023920879","display_name":"E Maiullari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Maiullari","raw_affiliation_strings":["Ospedale Infantile Regina Margherita, Torino, Italia. emaiullari@yahoo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale Infantile Regina Margherita, Torino, Italia. emaiullari@yahoo.it","institution_ids":["https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032530821","display_name":"E Bianco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E R Bianco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114252989","display_name":"M G Cortese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M G Cortese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Magro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Magro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034668652","display_name":"Riccardo Guan\u00e0","orcid":"https://orcid.org/0000-0002-0849-3431","observed_orcids":["https://orcid.org/0000-0002-0849-3431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Guan\u00e0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046072505","display_name":"Simona Vinardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Vinardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055378827","display_name":"Federico Canavese","orcid":"https://orcid.org/0000-0002-6114-5372","observed_orcids":["https://orcid.org/0000-0002-6114-5372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Canavese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3075,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65625771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"60","issue":"4","first_page":"407","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-constipation","display_name":"pediatric constipation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/osmotic-laxatives","display_name":"osmotic laxatives","score":0.9890000224113464},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.6959999799728394},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6389999985694885},{"id":"https://openalex.org/keywords/defecation-pain","display_name":"defecation pain","score":0.6779999732971191},{"id":"https://openalex.org/keywords/fecal-consistency","display_name":"stool consistency","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9459444284439087},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7908362150192261},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6706758737564087},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.594955563545227},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4102010428905487},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3304612636566162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.223846435546875}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:18511892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18511892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva pediatrica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2807781859","https://openalex.org/W255592531","https://openalex.org/W3106563860","https://openalex.org/W75150686","https://openalex.org/W47926209","https://openalex.org/W4293353638","https://openalex.org/W4291790229","https://openalex.org/W2158219831","https://openalex.org/W4298012701","https://openalex.org/W2129472946"],"abstract_inverted_index":{"AIM:":[0],"Macrogol":[1,27,68,81,96,212,238],"4,000":[2,28,69,82,213,239],"is":[3,12],"one":[4],"of":[5,25,38,54,58,67,73,80,95,122,133,153,203,232],"the":[6,36,65,71,114,120,137,154,170,176,180,185,193,204,215,227],"new":[7],"generation's":[8],"osmotic":[9],"laxatives.":[10],"It":[11],"constituted":[13],"by":[14,89,126,190,253],"a":[15,139,201],"heavy":[16],"molecular":[17],"weight":[18],"polymer":[19],"without":[20],"additional":[21],"salts.":[22],"In":[23],"most":[24],"patients":[26,197,208,219,247],"shows":[29],"its":[30],"efficacy":[31,66],"in":[32,52,70,75,85,131],"48":[33],"hours":[34],"from":[35,102,226],"beginning":[37],"treatment.":[39,228],"Daily":[40],"evacuations":[41,160],"has":[42,142,187],"been":[43,143,188],"reported":[44],"after":[45],"first":[46],"week":[47],"therapy":[48],"with":[49,92,113,136,148,248],"an":[50],"improvement":[51,225],"quality":[53],"life.":[55],"The":[56,78,98,108,146,230],"aim":[57],"this":[59,233],"observational":[60,234],"study":[61,99,235],"was":[62,83,111],"to":[63,105,175,244],"demonstrate":[64],"treatment":[72],"constipation":[74,90],"children.":[76],"METHODS:":[77],"effect":[79],"assessed":[84],"120":[86,171],"children":[87],"affected":[88,252],"treated":[91],"therapeutic":[93],"doses":[94],"4,000.":[97],"period":[100],"ranged":[101],"September":[103],"2006":[104],"March":[106],"2007.":[107],"data":[109],"analysis":[110],"collected":[112],"evaluations":[115],"concerning":[116],"clinical":[117,177,205],"examination":[118],"and":[119,161],"consultation":[121],"daily":[123,158],"diaries":[124],"assembled":[125],"parents,":[127],"tracking":[128],"stooling":[129],"pattern;":[130],"case":[132],"loosing":[134],"contacts":[135],"patient,":[138],"telephonic":[140],"survey":[141],"carried":[144],"out.":[145],"child":[147],"symptoms":[149],"improvement,":[150],"i.e.":[151],"reduction":[152],"pain":[155],"during":[156],"defecation,":[157],"spontaneous":[159],"better":[162],"stool":[163],"consistence,":[164],"were":[165],"considered":[166],"''normal''.":[167],"RESULTS:":[168],"Of":[169],"patients,":[172],"89":[173],"returned":[174],"follow-up,":[178,186],"while":[179],"remaining":[181],"31,":[182],"who":[183],"missed":[184],"contacted":[189],"telephone.":[191],"To":[192],"final":[194],"analysis,":[195],"103":[196],"(85.8%)":[198],"have":[199,210,223],"had":[200],"normalization":[202],"symptoms,":[206],"9":[207],"(7.5%)":[209],"refused":[211],"for":[214],"unpleasant":[216],"flavour,":[217],"8":[218],"(6.7%)":[220],"did":[221],"not":[222],"any":[224],"CONCLUSION:":[229],"results":[231],"suggest":[236],"that":[237],"could":[240],"be":[241],"very":[242],"useful":[243],"treat":[245],"pediatric":[246],"constipation,":[249],"also":[250],"those":[251],"neuronal":[254],"intestinal":[255],"displasia":[256],"(NID)":[257],"type":[258],"B.":[259]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}