{"id":"https://openalex.org/W6477951","doi":null,"title":"Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS with Traditional Liquorice Beverage","display_name":"Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS with Traditional Liquorice Beverage","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W6477951","mag":"6477951"},"language":"en","primary_location":{"id":"mag:6477951","doi":null,"is_oa":false,"landing_page_url":"http://www.manuscriptsystem.com/global/showpaperpdf.aspx?doi=10.5923/j.aac.20150501.03","pdf_url":null,"source":{"id":"https://openalex.org/S2764783502","display_name":"Advances in Analytical Chemistry of Scientific & Academic Publishing","issn_l":"2163-2839","issn":["2163-2839","2163-2847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Advances in Analytical Chemistry of Scientific & Academic Publishing","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085070736","display_name":"Teeba Al. Shaikhli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teeba Al. Shaikhli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001122382","display_name":"Wael Abu Dayyih","orcid":"https://orcid.org/0000-0002-5832-7247","observed_orcids":["https://orcid.org/0000-0002-5832-7247","https://orcid.org/0000-0003-2432-9356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wael Abu Dayyih","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5832-7247","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014698040","display_name":"Eyad Mallah","orcid":"https://orcid.org/0000-0003-4794-954X","observed_orcids":["https://orcid.org/0000-0003-4794-954X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eyad Mallah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029410487","display_name":"Mohammed F. Hamad","orcid":"https://orcid.org/0000-0001-7275-8206","observed_orcids":["https://orcid.org/0000-0001-7275-8206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Hamad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7275-8206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009839170","display_name":"Nidal Adel Qinna","orcid":"https://orcid.org/0000-0002-9628-6036","observed_orcids":["https://orcid.org/0000-0002-9628-6036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nidal A. Qinna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9628-6036","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033752774","display_name":"Tawfiq Arafat","orcid":"https://orcid.org/0000-0002-8483-6985","observed_orcids":["https://orcid.org/0000-0002-8483-6985","https://orcid.org/0000-0002-4814-4447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tawfiq Arafat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8483-6985","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3671,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53065548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"1","first_page":"17","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rat-serum","display_name":"rat serum","score":0.6779999732971191},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cmax","display_name":"Cmax","score":0.718999981880188},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.8573925495147705},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7492119073867798},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.69411700963974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6912301778793335},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.6796317100524902},{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.6716617345809937},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6626551151275635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4456402659416199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1397976279258728},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.09869083762168884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08656695485115051},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:6477951","doi":null,"is_oa":false,"landing_page_url":"http://www.manuscriptsystem.com/global/showpaperpdf.aspx?doi=10.5923/j.aac.20150501.03","pdf_url":null,"source":{"id":"https://openalex.org/S2764783502","display_name":"Advances in Analytical Chemistry of Scientific & Academic Publishing","issn_l":"2163-2839","issn":["2163-2839","2163-2847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Advances in Analytical Chemistry of Scientific & Academic Publishing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2866735","https://openalex.org/W170116841","https://openalex.org/W1515542254","https://openalex.org/W1521212112","https://openalex.org/W1929292775","https://openalex.org/W1969592143","https://openalex.org/W1986182628","https://openalex.org/W2027526799","https://openalex.org/W2029287356","https://openalex.org/W2031557845","https://openalex.org/W2031578387","https://openalex.org/W2041656680","https://openalex.org/W2047207059","https://openalex.org/W2061248294","https://openalex.org/W2072004151","https://openalex.org/W2072369902","https://openalex.org/W2081583413","https://openalex.org/W2086647019","https://openalex.org/W2097961663","https://openalex.org/W2106023455","https://openalex.org/W2118859240","https://openalex.org/W2120183698","https://openalex.org/W2134628981","https://openalex.org/W2141470686","https://openalex.org/W2151268696","https://openalex.org/W2152392393","https://openalex.org/W2169405948","https://openalex.org/W2325735102","https://openalex.org/W2575600667"],"related_works":["https://openalex.org/W2292214102","https://openalex.org/W2012367877","https://openalex.org/W7216973800","https://openalex.org/W2024644426","https://openalex.org/W3213348783","https://openalex.org/W4309637779","https://openalex.org/W2003263694","https://openalex.org/W2134623527","https://openalex.org/W2172730596","https://openalex.org/W2602555809"],"abstract_inverted_index":{"s":[0],"The":[2,58,95],"objective":[3],"of":[4,30,37,65,110,123,145],"this":[5,157],"randomized":[6],"controlled":[7],"study":[8],"was":[9,43,61,98,127],"firstly,":[10],"developing":[11],"and":[12,16,52,89,104,120,153,156,162],"validating":[13],"a":[14,135,160],"simple":[15],"simultaneous":[17],"LC/MS":[18],"method":[19,97],"to":[20],"quantify":[21],"Atorvastatin":[22,38,42,116,149,165],"in":[23,39,45,69],"rat":[24],"serum.":[25],"Secondly,":[26],"investigating":[27],"the":[28,35,125,143],"effects":[29,144],"Liquorice":[31,113,124,146],"fresh":[32],"beverage":[33,147],"on":[34,115,148],"pharmacokinetics":[36],"serum":[40],"rats.":[41],"determined":[44],"rat's":[46],"plasma":[47],"using":[48],"high":[49],"resolution,":[50],"sensitivity":[51],"validated":[53],"Liquid":[54],"Chromatography\u2013Mass":[55],"Spectrometry":[56],"(LC-MS);":[57],"mobile":[59],"phase":[60],"(75%":[62],"methanol,":[63],"25%":[64],"0.2%":[66],"Formic":[67],"acid":[68],"water),":[70],"ACE":[71],"5":[72,84],"C8":[73],"Column":[74],"(50":[75],"X":[76],"2.1":[77],"mm,":[78],"5\u00b5),":[79],"1.0":[80],"ml/min":[81],"flow":[82],"rate,":[83],"microliters":[85],"Autosampler":[86],"injection":[87],"volume,":[88],"Glimepiride":[90],"as":[91,134],"an":[92],"internal":[93],"standard.":[94],"analytical":[96],"linear":[99],"with":[100],"acceptable":[101],"recovery,":[102],"precision":[103],"accuracy.":[105],"A":[106],"significant":[107,137],"(P":[108],"0.05)":[109],"single":[111,152],"dose":[112],"juice":[114],"Cmax":[117,126],"(29.847":[118],"ng/ml),":[119],"repeated":[121,154],"doses":[122,155],"(40.113":[128],"ng/ml)":[129],"which":[130],"is":[131],"also":[132],"considered":[133],"non-":[136],"effect":[138],"(P>0.05)":[139],"We":[140],"conclude":[141],"that":[142],"varies":[150],"between":[151],"can":[158],"be":[159],"result":[161],"could":[163],"affect":[164],"pharmacokinetics.":[166]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}