{"id":"https://openalex.org/W647596761","doi":null,"title":"Molecular and Genetic Analysis of Synaptic Signaling in Drosophila","display_name":"Molecular and Genetic Analysis of Synaptic Signaling in Drosophila","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W647596761","mag":"647596761"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/193514","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/193514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055623706","display_name":"Taryn Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Taryn Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055623706"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.17550000548362732,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-signaling","display_name":"synaptic signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.9559999704360962},{"id":"https://openalex.org/keywords/synaptic-vesicle-recycling","display_name":"synaptic vesicle recycling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/shibire","display_name":"shibire","score":0.7369999885559082},{"id":"https://openalex.org/keywords/synaptic-growth","display_name":"synaptic growth","score":0.6970000267028809},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ras-erk-signaling","display_name":"Ras/ERK signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6769136190414429},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4430438280105591},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4278922975063324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4090038537979126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35832810401916504},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3332614302635193},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.32528460025787354},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15216174721717834}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/193514","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/193514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:647596761","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/193514","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W106738307","https://openalex.org/W1510879979","https://openalex.org/W1523448884","https://openalex.org/W1526674447","https://openalex.org/W1532762518","https://openalex.org/W1555945582","https://openalex.org/W1569548564","https://openalex.org/W1602952479","https://openalex.org/W1608785134","https://openalex.org/W1644847400","https://openalex.org/W1645161804","https://openalex.org/W1656523230","https://openalex.org/W1673406285","https://openalex.org/W1698641492","https://openalex.org/W1703928766","https://openalex.org/W1785664262","https://openalex.org/W1868935533","https://openalex.org/W1876061808","https://openalex.org/W1884868796","https://openalex.org/W1887401978","https://openalex.org/W1937937601","https://openalex.org/W1941436081","https://openalex.org/W1964634661","https://openalex.org/W1967318257","https://openalex.org/W1968946845","https://openalex.org/W1969166506","https://openalex.org/W1971125188","https://openalex.org/W1973586624","https://openalex.org/W1973707586","https://openalex.org/W1974753375","https://openalex.org/W1979799439","https://openalex.org/W1980089349","https://openalex.org/W1980588340","https://openalex.org/W1984214648","https://openalex.org/W1986426121","https://openalex.org/W1987030209","https://openalex.org/W1988010188","https://openalex.org/W1988466312","https://openalex.org/W1991108340","https://openalex.org/W1992020799","https://openalex.org/W1993898140","https://openalex.org/W1998465031","https://openalex.org/W2000253969","https://openalex.org/W2002446420","https://openalex.org/W2004287825","https://openalex.org/W2007863157","https://openalex.org/W2008037029","https://openalex.org/W2008669399","https://openalex.org/W2010778459","https://openalex.org/W2011420167","https://openalex.org/W2011882079","https://openalex.org/W2014872693","https://openalex.org/W2015472050","https://openalex.org/W2015592781","https://openalex.org/W2018662966","https://openalex.org/W2019335710","https://openalex.org/W2020808982","https://openalex.org/W2021669986","https://openalex.org/W2023483843","https://openalex.org/W2023796149","https://openalex.org/W2032666422","https://openalex.org/W2043867460","https://openalex.org/W2044126921","https://openalex.org/W2044273755","https://openalex.org/W2044837620","https://openalex.org/W2045441934","https://openalex.org/W2046645924","https://openalex.org/W2048834802","https://openalex.org/W2049134173","https://openalex.org/W2052600995","https://openalex.org/W2053964608","https://openalex.org/W2055473408","https://openalex.org/W2056422983","https://openalex.org/W2056994440","https://openalex.org/W2057969497","https://openalex.org/W2057983666","https://openalex.org/W2064215369","https://openalex.org/W2065613854","https://openalex.org/W2066592391","https://openalex.org/W2068412840","https://openalex.org/W2069705491","https://openalex.org/W2070660603","https://openalex.org/W2071597246","https://openalex.org/W2071724966","https://openalex.org/W2072387005","https://openalex.org/W2076718555","https://openalex.org/W2077139708","https://openalex.org/W2081787892","https://openalex.org/W2082106253","https://openalex.org/W2083689477","https://openalex.org/W2086783008","https://openalex.org/W2087791380","https://openalex.org/W2087973535","https://openalex.org/W2089465514","https://openalex.org/W2090985642","https://openalex.org/W2093906292","https://openalex.org/W2100297823","https://openalex.org/W2101626807","https://openalex.org/W2102889876","https://openalex.org/W2110643873","https://openalex.org/W2112038940","https://openalex.org/W2118977349","https://openalex.org/W2121220832","https://openalex.org/W2128378368","https://openalex.org/W2129645512","https://openalex.org/W2133083344","https://openalex.org/W2137581426","https://openalex.org/W2140254301","https://openalex.org/W2145621796","https://openalex.org/W2146702633","https://openalex.org/W2150443013","https://openalex.org/W2157497892","https://openalex.org/W2159424315","https://openalex.org/W2160855812","https://openalex.org/W2171220723","https://openalex.org/W2411053549"],"related_works":["https://openalex.org/W192289891","https://openalex.org/W1673406285","https://openalex.org/W1884868796","https://openalex.org/W7044783999","https://openalex.org/W1835487219","https://openalex.org/W2052080357","https://openalex.org/W7097253765","https://openalex.org/W2602446249","https://openalex.org/W7073638443","https://openalex.org/W1569548564"],"abstract_inverted_index":{"Molecular":[0],"and":[1,21,35,53,83,102,150,159,185,212,265,269,296,325,334],"genetic":[2,90],"analysis":[3],"of":[4,18,51,66,78,86,99,139,167,180,214,221,272,299,314,342],"synaptic":[5,19,33,56,100,109,140,156,161,194,305],"signaling":[6,29,274,295],"in":[7,25,55,58,73,88,95,193,196,228,232,235,248,260,275,301,312,331,339,347,350],"Drosophila":[8,128,237,282],"has":[9,189,307,336],"yielded":[10],"many":[11],"insights":[12],"into":[13,201,319],"nervous":[14,39,263,315],"system":[15,40,316],"development,":[16],"properties":[17],"transmission,":[20],"how":[22],"long-lasting":[23],"changes":[24],"neurons":[26],"occur.":[27],"Synaptic":[28],"components":[30],"required":[31,154],"for":[32,123,155,209],"transmission":[34,101,110],"pathways":[36,322],"leading":[37],"to":[38,47,70,116,241,284,310,345],"plasticity":[41,324],"are":[42,153,172],"typically":[43],"conserved":[44],"from":[45,63,281,329],"insects":[46],"humans.":[48,351],"The":[49],"role":[50,192],"proteins":[52,171,183],"genes":[54],"function":[57,306],"flies":[59,197],"can":[60,198],"be":[61,199,290],"analyzed":[62],"the":[64,74,84,131,164,168,181,207,215,236,242,261,285,291,297,320,340],"level":[65],"a":[67,79,121,137,190,229],"single":[68],"synapse":[69],"complex":[71],"behaviors":[72],"whole":[75],"organism.":[76],"Because":[77],"fully":[80,174],"sequenced":[81],"genome":[82],"ease":[85],"mutagenesis":[87],"flies,":[89,105,332],"screens":[91],"have":[92,246],"been":[93,337],"useful":[94],"identifying":[96],"novel":[97,191],"regulators":[98,220],"long-term":[103,222,249,302,326],"memory.In":[104],"conditional":[106],"mutations":[107,124],"affecting":[108],"at":[111],"nerve":[112],"terminals":[113],"often":[114],"lead":[115],"temperature":[117],"sensitive":[118],"paralysis.":[119],"In":[120],"screen":[122,231],"that":[125,187,255,287],"interact":[126],"with":[127],"shibirets":[129],"mutants,":[130],"stoned":[132,170,182,188],"gene":[133,238],"was":[134],"identified":[135],"as":[136],"regulator":[138,244],"vesicle":[141,157],"cycling.":[142],"Stoned":[143],"encodes":[144],"two":[145,169],"neuronally":[146],"expressed":[147,259],"proteins,":[148],"stonedA":[149],"B,":[151],"which":[152],"recycling":[158],"normal":[160],"transmission.":[162],"However,":[163],"exact":[165],"functions":[166,270],"not":[173],"understood.":[175],"We":[176,253],"investigate":[177],"distinct":[178,203],"roles":[179],"here":[184,280],"show":[186],"growth.Memory":[195],"divided":[200],"genetically":[202],"phases":[204],"based":[205],"on":[206],"requirement":[208],"protein":[210],"synthesis":[211],"activation":[213],"transcription":[216],"factor":[217],"CREB.":[218],"Novel":[219],"olfactory":[223,250],"avoidance":[224,251],"memory":[225,327,348],"were":[226],"isolated":[227],"mutant":[230],"flies.":[233],"Mutants":[234],"lk6,":[239],"homologous":[240],"translational":[243],"MNK,":[245],"defects":[247],"memory.":[252],"find":[254],"lk6":[256],"is":[257,266],"highly":[258],"fly":[262,276],"system,":[264],"activated":[267],"by":[268],"downstream":[271],"Ras/ERK":[273],"neurons.":[277],"Insights":[278],"provided":[279],"add":[283],"evidence":[286],"MNK":[288],"may":[289],"link":[292],"between":[293],"ERK":[294],"regulation":[298],"translation":[300],"plasticity.Ultimately,":[303],"understanding":[304],"therapeutic":[308],"potential":[309,343],"aid":[311,346],"alleviation":[313],"dysfunction.":[317],"Insight":[318],"molecular":[321],"underlying":[323],"gained":[328],"studies":[330],"mollusks,":[333],"rodents":[335],"pivotal":[338],"development":[341],"drugs":[344],"deficits":[349]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
