{"id":"https://openalex.org/W64706531","doi":null,"title":"Non-invasive imaging of PI3K/Akt/mTOR signalling in cancer.","display_name":"Non-invasive imaging of PI3K/Akt/mTOR signalling in cancer.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W64706531","mag":"64706531","pmid":"https://pubmed.ncbi.nlm.nih.gov/23145359","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2491948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102711630","display_name":"Snehal M. Gaikwad","orcid":"https://orcid.org/0000-0002-3366-4116","observed_orcids":["https://orcid.org/0000-0002-3366-4116"]},"institutions":[{"id":"https://openalex.org/I2800098698","display_name":"Tata Memorial Hospital","ror":"https://ror.org/010842375","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698"]},{"id":"https://openalex.org/I4210157422","display_name":"Advanced Centre for Treatment, Research and Education in Cancer","ror":"https://ror.org/05b9pgt88","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698","https://openalex.org/I4210157422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Snehal M Gaikwad","raw_affiliation_strings":["Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre Navi Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I2800098698","https://openalex.org/I4210157422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087782348","display_name":"Pritha Ray","orcid":"https://orcid.org/0000-0002-9281-2326","observed_orcids":["https://orcid.org/0000-0002-9281-2326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pritha Ray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2599,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7658445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"418","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-mtor-signalling","display_name":"PI3K/AKT/mTOR signalling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/noninvasive-molecular-imaging","display_name":"noninvasive molecular imaging","score":0.9120000004768372},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/platinum-based-drugs","display_name":"platinum drugs","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cell-survival-pathways","display_name":"cell survival pathways","score":0.7160000205039978},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8917144536972046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7635383605957031},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.563774824142456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5327931046485901},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5266163945198059},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4986686706542969},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4342508912086487},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4252970516681671},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3673088550567627},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3365761339664459},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30180275440216064},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2522618770599365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16652125120162964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.144733726978302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14458578824996948}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2491948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3484421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},{"id":"pmid:23145359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23145359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"mag:2188652184","doi":null,"is_oa":false,"landing_page_url":"http://ajnmmi.us/files/ajnmmi1206003.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:64706531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23145359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2491948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W36184282","https://openalex.org/W75753579","https://openalex.org/W1536110039","https://openalex.org/W1594020010","https://openalex.org/W1853860122","https://openalex.org/W1959848155","https://openalex.org/W1964314484","https://openalex.org/W1970082212","https://openalex.org/W1970131592","https://openalex.org/W1978463531","https://openalex.org/W1985478993","https://openalex.org/W1987551921","https://openalex.org/W1987759199","https://openalex.org/W1988602328","https://openalex.org/W1992257057","https://openalex.org/W1993382872","https://openalex.org/W1999278327","https://openalex.org/W2000963482","https://openalex.org/W2001568034","https://openalex.org/W2004688803","https://openalex.org/W2006511297","https://openalex.org/W2009326542","https://openalex.org/W2009886463","https://openalex.org/W2013118610","https://openalex.org/W2013472804","https://openalex.org/W2014031706","https://openalex.org/W2017851659","https://openalex.org/W2018023891","https://openalex.org/W2025280920","https://openalex.org/W2027690069","https://openalex.org/W2030899725","https://openalex.org/W2033222884","https://openalex.org/W2035029345","https://openalex.org/W2046328101","https://openalex.org/W2046571983","https://openalex.org/W2047049001","https://openalex.org/W2055397209","https://openalex.org/W2060157525","https://openalex.org/W2062295650","https://openalex.org/W2068653730","https://openalex.org/W2070732456","https://openalex.org/W2075048068","https://openalex.org/W2077223675","https://openalex.org/W2077776418","https://openalex.org/W2085375398","https://openalex.org/W2087861588","https://openalex.org/W2088845519","https://openalex.org/W2099617191","https://openalex.org/W2103971651","https://openalex.org/W2104461354","https://openalex.org/W2108099438","https://openalex.org/W2108746644","https://openalex.org/W2109566248","https://openalex.org/W2111620265","https://openalex.org/W2115954319","https://openalex.org/W2117631891","https://openalex.org/W2119156172","https://openalex.org/W2119507443","https://openalex.org/W2119863908","https://openalex.org/W2121332401","https://openalex.org/W2122426644","https://openalex.org/W2130177169","https://openalex.org/W2140973187","https://openalex.org/W2143958554","https://openalex.org/W2144040817","https://openalex.org/W2146133266","https://openalex.org/W2146414563","https://openalex.org/W2147237616","https://openalex.org/W2154692501","https://openalex.org/W2158200577","https://openalex.org/W2160689007","https://openalex.org/W2164277862","https://openalex.org/W2169302611","https://openalex.org/W2170567505","https://openalex.org/W2216554257","https://openalex.org/W2324016108","https://openalex.org/W2341084019","https://openalex.org/W2388163742","https://openalex.org/W2790263924","https://openalex.org/W2952165521","https://openalex.org/W3148490103"],"related_works":["https://openalex.org/W2188652184","https://openalex.org/W4412765088","https://openalex.org/W2059888019","https://openalex.org/W2082382893","https://openalex.org/W2188965426","https://openalex.org/W3176165488","https://openalex.org/W4408977770","https://openalex.org/W2083729029","https://openalex.org/W4243125471","https://openalex.org/W4385986528"],"abstract_inverted_index":{"Platinum":[0],"based":[1,24,204],"drugs":[2,25],"are":[3,44,70,84,95,177],"widely":[4],"used":[5],"to":[6,67,179],"treat":[7],"various":[8,167,194],"types":[9],"of":[10,20,38,51,53,77,81,105,115,164,201],"cancers":[11],"by":[12],"inducing":[13],"DNA":[14],"damage":[15],"mediated":[16],"cytotoxicity.":[17],"However,":[18],"acquirement":[19,163],"chemoresistance":[21,43,165],"towards":[22],"platinum":[23],"is":[26,120],"a":[27,31,134],"common":[28],"phenomenon":[29],"and":[30,42,94,125,129,148,159,188],"major":[32,89],"hurdle":[33],"in":[34,138,162,166],"combating":[35],"the":[36,39,54,59,112,156,186,199],"relapse":[37],"disease.":[40],"Oncogenesis":[41],"multifactorial":[45],"maladies":[46],"which":[47],"often":[48,71],"involve":[49],"deregulation":[50],"one":[52],"prime":[55],"cell":[56],"survival":[57],"pathways,":[58],"PI3K/Akt/mTOR":[60,157],"signalling":[61,183,203],"cascade.":[62],"The":[63],"genetic":[64],"alterations":[65],"related":[66],"this":[68,82,151,181],"pathway":[69,83,158],"responsible":[72],"for":[73,91,103,144,185],"initiation":[74],"and/or":[75],"maintenance":[76],"carcinogenesis.":[78],"Molecular":[79],"components":[80],"long":[85],"being":[86],"recognized":[87],"as":[88,100],"targets":[90],"therapeutic":[92],"intervention":[93],"now":[96],"also":[97],"have":[98],"emerged":[99],"potential":[101],"tools":[102],"diagnosis":[104,147],"cancer.":[106],"To":[107],"develop":[108],"novel":[109],"therapeutics":[110,187],"against":[111],"key":[113],"molecules":[114],"PI3K":[116,182,202],"pathway,":[117],"stringent":[118],"validation":[119],"required":[121],"using":[122,193],"both":[123],"in-vitro":[124],"in-vivo":[126],"models.":[127],"Repetitive":[128],"non-invasive":[130,173],"molecular":[131,174],"imaging":[132,140,175,195],"techniques,":[133],"relatively":[135],"recent":[136],"field":[137],"biomedical":[139],"hold":[141],"great":[142],"promises":[143],"monitoring":[145],"such":[146],"therapy.":[149],"In":[150],"review,":[152],"we":[153,170],"first":[154],"introduced":[155],"its":[160],"role":[161],"cancers.":[168],"Further":[169],"described":[171],"how":[172],"approaches":[176],"sought":[178],"use":[180],"axis":[184],"diagnosis.":[189],"A":[190],"theranostic":[191],"approach":[192],"modalities":[196],"should":[197],"be":[198],"future":[200],"drug":[205],"development":[206],"venture.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
