{"id":"https://openalex.org/W647019759","doi":null,"title":"Bases moleculares de las alteraciones del tejido adiposo y cambios metab\u00f3licos asociados al s\u00edndrome lipodistr\u00f3fico en pacientes infectados por HIV-1","display_name":"Bases moleculares de las alteraciones del tejido adiposo y cambios metab\u00f3licos asociados al s\u00edndrome lipodistr\u00f3fico en pacientes infectados por HIV-1","publication_year":2012,"publication_date":"2012-11-21","ids":{"openalex":"https://openalex.org/W647019759","mag":"647019759"},"language":"es","primary_location":{"id":"pmh:oai:dnet:tdr_________::dd19574a09932bd57e2679188151571b","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/97344","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/36226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037565099","display_name":"Gallego Escuredo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gallego Escuredo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101707381","display_name":"Jos\u00e9 Miguel","orcid":"https://orcid.org/0000-0001-8013-919X","observed_orcids":["https://orcid.org/0000-0001-8013-919X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Miguel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-lipodystrophy","display_name":"HIV-associated lipodystrophy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.7099999785423279},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":0.8119999766349792},{"id":"https://openalex.org/keywords/adipogenesis-inhibition","display_name":"adipogenesis inhibition","score":0.5220000147819519},{"id":"https://openalex.org/keywords/white-adipocytes","display_name":"white adipocytes","score":0.6309999823570251},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6859999895095825},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7409999966621399},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.8870000243186951},{"id":"https://openalex.org/keywords/buffalo-hump","display_name":"buffalo hump","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lipomatosis","display_name":"lipomatosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/metabolic-changes","display_name":"metabolic changes","score":0.4449999928474426},{"id":"https://openalex.org/keywords/antiretroviral-therapy-adverse-effects","display_name":"antiretroviral therapy adverse effects","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.6642175316810608},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5192325711250305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158552527427673},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.32256412506103516},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.24587461352348328},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1553744673728943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08612129092216492},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.05481711030006409}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::dd19574a09932bd57e2679188151571b","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/97344","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/36226","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/36226","pdf_url":"http://hdl.handle.net/2445/36226","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Bioqu\u00edmica i Biologia Molecular (Biologia)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/97344","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/97344","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:647019759","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/36226/2/JMGE_TESIS.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/36226","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/36226","pdf_url":"http://hdl.handle.net/2445/36226","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Bioqu\u00edmica i Biologia Molecular (Biologia)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2437151533","display_name":null,"funder_award_id":"RD06/0006","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2620658983","display_name":null,"funder_award_id":"PI11/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6126592257","display_name":null,"funder_award_id":"I3SNS","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G73748090","display_name":null,"funder_award_id":"PI11/00376","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7965031981","display_name":null,"funder_award_id":"RD06/006","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8106444798","display_name":null,"funder_award_id":"INT11/240","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320324604","display_name":"Fundaci\u00f3n Para La Innovaci\u00f3n Y La Prospectiva En Salud En Espa\u00f1a","ror":"https://ror.org/04v8d4779"},{"id":"https://openalex.org/F4320326655","display_name":"Xunta de Galicia","ror":"https://ror.org/0181xnw06"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337847","display_name":"European AIDS Treatment Network","ror":"https://ror.org/03ash3475"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":"https://ror.org/02fe4h741"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W647019759.pdf","grobid_xml":"https://content.openalex.org/works/W647019759.grobid-xml"},"referenced_works_count":194,"referenced_works":["https://openalex.org/W6767451","https://openalex.org/W53784274","https://openalex.org/W60576863","https://openalex.org/W94744895","https://openalex.org/W122522238","https://openalex.org/W179857658","https://openalex.org/W187320686","https://openalex.org/W203306934","https://openalex.org/W251742802","https://openalex.org/W831018456","https://openalex.org/W1531479789","https://openalex.org/W1672804368","https://openalex.org/W1865630485","https://openalex.org/W1895081448","https://openalex.org/W1964823824","https://openalex.org/W1967632729","https://openalex.org/W1968091833","https://openalex.org/W1968485058","https://openalex.org/W1972437863","https://openalex.org/W1975673963","https://openalex.org/W1976844022","https://openalex.org/W1977994465","https://openalex.org/W1978444406","https://openalex.org/W1980517636","https://openalex.org/W1982472484","https://openalex.org/W1983005094","https://openalex.org/W1984717040","https://openalex.org/W1986219573","https://openalex.org/W1986464292","https://openalex.org/W1986484921","https://openalex.org/W1986842451","https://openalex.org/W1987088213","https://openalex.org/W1987120082","https://openalex.org/W1988869711","https://openalex.org/W1989924554","https://openalex.org/W1992326632","https://openalex.org/W1997353132","https://openalex.org/W1998660799","https://openalex.org/W1998933278","https://openalex.org/W1999015463","https://openalex.org/W1999290243","https://openalex.org/W1999791725","https://openalex.org/W2000665430","https://openalex.org/W2000700807","https://openalex.org/W2000941742","https://openalex.org/W2001097504","https://openalex.org/W2002050129","https://openalex.org/W2003804175","https://openalex.org/W2003828583","https://openalex.org/W2004211910","https://openalex.org/W2005063766","https://openalex.org/W2005317793","https://openalex.org/W2006152240","https://openalex.org/W2007311885","https://openalex.org/W2008284948","https://openalex.org/W2008423758","https://openalex.org/W2008681391","https://openalex.org/W2010066949","https://openalex.org/W2011388183","https://openalex.org/W2017506602","https://openalex.org/W2017983975","https://openalex.org/W2018231624","https://openalex.org/W2019113684","https://openalex.org/W2019620071","https://openalex.org/W2020659644","https://openalex.org/W2021546679","https://openalex.org/W2023530279","https://openalex.org/W2025665987","https://openalex.org/W2027386164","https://openalex.org/W2028328042","https://openalex.org/W2028657303","https://openalex.org/W2031514101","https://openalex.org/W2031577449","https://openalex.org/W2033600464","https://openalex.org/W2036630548","https://openalex.org/W2036775607","https://openalex.org/W2038797533","https://openalex.org/W2040328785","https://openalex.org/W2041841997","https://openalex.org/W2042339399","https://openalex.org/W2047442979","https://openalex.org/W2048411348","https://openalex.org/W2049677309","https://openalex.org/W2050775909","https://openalex.org/W2052439286","https://openalex.org/W2052442466","https://openalex.org/W2053192924","https://openalex.org/W2055172234","https://openalex.org/W2057444658","https://openalex.org/W2058410894","https://openalex.org/W2059553063","https://openalex.org/W2059998578","https://openalex.org/W2060621425","https://openalex.org/W2061549298","https://openalex.org/W2062057951","https://openalex.org/W2063749998","https://openalex.org/W2063949146","https://openalex.org/W2067416157","https://openalex.org/W2067695450","https://openalex.org/W2071059013","https://openalex.org/W2073056291","https://openalex.org/W2074914771","https://openalex.org/W2076310317","https://openalex.org/W2077364814","https://openalex.org/W2077488136","https://openalex.org/W2078637424","https://openalex.org/W2079132151","https://openalex.org/W2080401134","https://openalex.org/W2081705352","https://openalex.org/W2082516444","https://openalex.org/W2083600593","https://openalex.org/W2085653450","https://openalex.org/W2088482927","https://openalex.org/W2089040602","https://openalex.org/W2089071370","https://openalex.org/W2089817491","https://openalex.org/W2090832589","https://openalex.org/W2092468599","https://openalex.org/W2092989515","https://openalex.org/W2093063339","https://openalex.org/W2093196166","https://openalex.org/W2094498915","https://openalex.org/W2097511872","https://openalex.org/W2098076446","https://openalex.org/W2099746221","https://openalex.org/W2100599316","https://openalex.org/W2103714496","https://openalex.org/W2105014495","https://openalex.org/W2106986971","https://openalex.org/W2108551042","https://openalex.org/W2109159474","https://openalex.org/W2109812415","https://openalex.org/W2111729699","https://openalex.org/W2114291961","https://openalex.org/W2114650931","https://openalex.org/W2115703300","https://openalex.org/W2115784485","https://openalex.org/W2116404316","https://openalex.org/W2117261241","https://openalex.org/W2117854357","https://openalex.org/W2118250304","https://openalex.org/W2119331212","https://openalex.org/W2119433625","https://openalex.org/W2122204312","https://openalex.org/W2123268536","https://openalex.org/W2123297055","https://openalex.org/W2124358366","https://openalex.org/W2126521413","https://openalex.org/W2127829249","https://openalex.org/W2127996937","https://openalex.org/W2128635872","https://openalex.org/W2130030843","https://openalex.org/W2131140036","https://openalex.org/W2132358997","https://openalex.org/W2132670832","https://openalex.org/W2133374684","https://openalex.org/W2134233920","https://openalex.org/W2134944069","https://openalex.org/W2140266961","https://openalex.org/W2141670429","https://openalex.org/W2142272229","https://openalex.org/W2145090906","https://openalex.org/W2147029239","https://openalex.org/W2147954704","https://openalex.org/W2148750104","https://openalex.org/W2149019212","https://openalex.org/W2152197563","https://openalex.org/W2153253704","https://openalex.org/W2153944883","https://openalex.org/W2154281490","https://openalex.org/W2156188065","https://openalex.org/W2156877200","https://openalex.org/W2157138119","https://openalex.org/W2160234571","https://openalex.org/W2164676747","https://openalex.org/W2166190419","https://openalex.org/W2167825438","https://openalex.org/W2183080182","https://openalex.org/W2258524519","https://openalex.org/W2314621492","https://openalex.org/W2321852728","https://openalex.org/W2328134361","https://openalex.org/W2330371438","https://openalex.org/W2402447974","https://openalex.org/W2411181766","https://openalex.org/W2413802193","https://openalex.org/W2423137336","https://openalex.org/W2435567028","https://openalex.org/W2460435783","https://openalex.org/W2466050633","https://openalex.org/W2495233357","https://openalex.org/W3140139051","https://openalex.org/W4238221516","https://openalex.org/W4320578154"],"related_works":["https://openalex.org/W2052442466","https://openalex.org/W2002528842","https://openalex.org/W1978125049","https://openalex.org/W2466050633","https://openalex.org/W42783345","https://openalex.org/W2008284948","https://openalex.org/W1991575411","https://openalex.org/W2037561994","https://openalex.org/W7125676730","https://openalex.org/W2413877209"],"abstract_inverted_index":{"El":[0,14,308],"uso":[1],"de":[2,17,35,52,60,73,76,86,104,116,130,140,148,172,179,183,206,209,217,222,258,260,267,279,284,286,288,303,319,328,339,360,370,453,456,468,481,485,512,527,535,541,548,563,571,585,598],"la":[3,30,40,57,106,138,144,152,164,226,251,346,422,427,430,451,523],"terapia":[4],"HAART":[5],"(Highly-Active-Antiretroviral-Therapy),":[6],"puede":[7,396],"dar":[8],"lugar":[9],"a":[10,169,421,491,501,516,537,573],"m\u00faltiples":[11],"efectos":[12,75,126,156],"secundarios.":[13],"m\u00e1s":[15,292,385,520],"frecuente":[16],"ellos":[18],"es":[19,102,368,416],"el":[20,161,190,196,202,229,235,244,256,264,273,282,295,300,311,315,323,332,336,365,433,508,595,603],"denominado":[21],"HALS":[22,68],"(\u201cHIV-infection,":[23],"HAARTtreatment-":[24],"associated-lipodystrophy-syndrome\u201d)":[25],"que":[26,92,111,124,240,312,335,355,394,398,409,428,475,503,551,582],"comprende":[27],"alteraciones":[28,47,53,248,343,442],"como":[29,135,189,545],"lipoatrofia":[31],"periferica;":[32],"un":[33,71,96,373,387,402,454],"aumento":[34],"tejido":[36,43,184,191,197,203,220,230,245,265,274,296,316,324,337,351,366,377,414,596],"adiposo":[37,185,192,198,204,221,231,246,317,325,338,378,597],"visceral":[38,199,236],"o":[39,201,539],"lipomatosis":[41],"del":[42,65,376,389],"adiposo.":[44],"Adem\u00e1s,":[45],"estas":[46],"fisiol\u00f3gicas":[48],"pueden":[49],"ir":[50],"acompa\u00f1adas":[51],"metab\u00f3licas.\\n\\n\\t\\t\\t\\t":[54],"Para":[55,174],"saber":[56],"aportaci\u00f3n":[58],"individual":[59],"algunos":[61],"f\u00e1rmacos":[62,118],"al":[63,99,350,521],"desarrollo":[64],"s\u00edndrome":[66,100,434,542],"lipodistr\u00f3fico":[67],"se":[69,212,237,270,313,395,410,437,472,499,531,565,576],"realiz\u00f3":[70],"estudio":[72,309],"los":[74,180,210,476,492,497,504,583,599],"Efavirenz,":[77,91],"Nevirapina":[78,165],"(NNRTIs)":[79],"y":[80,113,142,146,195,234,322,380,407,483,518,590],"Kaletra":[81,112],"(PI)":[82],"sobre":[83],"adipocitos":[84,400],"primarios":[85],"linaje":[87],"blanco":[88,406],"en":[89,128,241,250,263,272,281,294,306,310,345,353,426,440,445,459,463,529,561,579,594],"cultivo.":[90],"no":[93,167,269,514],"era":[94],"considerado":[95],"f\u00e1rmaco":[97],"asociado":[98],"lipodistr\u00f3fico,":[101],"capaz":[103,369],"inhibir":[105],"adipog\u00e9nesis":[107,261],"con":[108,151,160,186,219,386,496,533,546,555,568],"mayor":[109],"potencia":[110],"Nevirapina.":[114],"Ninguno":[115],"estos":[117,155,399,586],"provoca":[119],"toxicidad":[120,131],"mitocondrial":[121],"por":[122,331,392,507,602],"lo":[123,393],"sus":[125],"ocurren":[127],"ausencia":[129,452],"mitocondrial.":[132,253],"Tanto":[133],"efavirenz":[134],"kaletra":[136],"reducen":[137],"secreci\u00f3n":[139,147],"adipoquinas":[141],"aumentan":[143],"expresi\u00f3n":[145,285,347,358],"citoquinas":[149],"relacionadas":[150],"inflamaci\u00f3n,":[153],"pero":[154],"siempre":[157],"son":[158],"mayores":[159],"EFV":[162],"mientras":[163],"parece":[166,291],"afectar":[168],"este":[170,413,465],"tipo":[171,390],"secreci\u00f3nes.\\n\\n\\t\\t\\t\\t":[173],"estudiar":[175],"las":[176,207,320,340,354,441],"caracter\u00edsticas":[177,215],"moleculares":[178,216],"diferentes":[181],"dep\u00f3sitos":[182,305],"comportamiento":[187,301,466],"opuesto":[188,302],"subcut\u00e1neo":[193,232,266,326],"lipoatr\u00f3fico":[194,233,327,352],"lipohipertr\u00f3fico":[200],"lipomatoso":[205,367,415],"\u201cbuffalo-hump\u201d":[208,321,341],"pacientes":[211,268,329,477,505,600],"han":[213],"comparado":[214],"ellas":[218],"individuos":[223],"control.":[224],"En":[225,254],"comparaci\u00f3n":[227],"entre":[228,405],"ha":[238,473,577],"observado":[239,262,474],"ambos":[242,304,446,469],"casos":[243],"presenta":[247,342],"similares":[249],"funci\u00f3n":[252],"cambio":[255],"descenso":[257],"marcadores":[259,287,540,547],"reproduce":[271],"visceral.":[275],"Este":[276],"hecho,":[277],"acompa\u00f1ado":[278],"diferencias":[280,439,495],"perfil":[283],"inflamaci\u00f3n":[289,457],"(que":[290],"leve":[293],"visceral),":[297],"podr\u00eda":[298,461],"explicar":[299,462],"pacientes.\\n\\n\\t\\t\\t\\t":[307],"compararon":[314],"lipomatosos":[318],"infectados":[330,506,601],"HIV-":[333],"indica":[334],"especificas":[344],"g\u00e9nica":[348],"respecto":[349,490],"destaca":[356],"una":[357],"normal":[359],"genes":[361],"adipog\u00e9nicos.":[362],"As\u00ed":[363],"mismo,":[364],"expresar":[371],"UCP1,":[372],"gen":[374],"caracter\u00edstico":[375],"marr\u00f3n,":[379,391],"su":[381],"capacidad":[382],"proliferativa":[383],"concuerda":[384],"fenotipo":[388,403],"decir":[397],"tienen":[401],"intermedio":[404],"marr\u00f3n":[408],"mantiene":[411,429],"cuando":[412],"utilizado":[417],"para":[418],"trasplante":[419],"aut\u00f3logo":[420],"zona":[423],"facial":[424],"lipoatr\u00f3fica":[425],"proliferaci\u00f3n":[431],"desarroll\u00e1ndose":[432],"h\u00e1mster.":[435],"No":[436],"observan":[438],"mitocondriales":[443],"observadas":[444],"tejidos.":[447],"Por":[448],"otra":[449],"parte":[450,464],"estado":[455],"local":[458],"BH":[460],"diferente":[467],"tejidos.\\n\\n\\t\\t\\t\\t":[470],"Adem\u00e1s":[471,575],"muestran":[478],"niveles":[479,526,559],"elevados":[480],"FGF21":[482,528],"disminuidos":[484,560,593],"FGF19":[486,564],"(dos":[487],"agentes":[488,587],"homeostaticos)":[489],"controles.":[493],"Estas":[494],"controles":[498],"acent\u00faan":[500],"medida":[502],"virus":[509,604],"HIV-1":[510],"pasan":[511],"ser":[513],"tratados":[515,517],"aun":[519],"desarrollar":[522],"lipodistrofia.":[524],"Los":[525,558],"suero":[530,562],"correlacionaban":[532],"indicadores":[534],"sensibilidad":[536],"insulina":[538],"metab\u00f3lico":[543],"as\u00ed":[544],"da\u00f1o":[549],"hep\u00e1tico":[550],"podr\u00edan":[552],"estar":[553],"relacionados":[554],"esteatosis":[556],"hep\u00e1tica.":[557],"correlacionan":[566],"negativamente":[567],"par\u00e1metros":[569],"indicativos":[570],"resistencia":[572],"insulina.":[574],"descrito":[578],"esta":[580],"tesis":[581],"receptores":[584],"endocrinos":[588],"FGFR1":[589],"\u03b2-Klotho":[591],"aparecen":[592],"HIV-1.":[605]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
