{"id":"https://openalex.org/W646972460","doi":null,"title":"Investigation of the effects of Mechanical Strain in Human Tenocytes","display_name":"Investigation of the effects of Mechanical Strain in Human Tenocytes","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W646972460","mag":"646972460"},"language":"en","primary_location":{"id":"pmh:oai:ueaeprints.uea.ac.uk:42329","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Eleanor Jones","orcid":"https://orcid.org/0000-0003-1625-5174","observed_orcids":["https://orcid.org/0000-0003-1625-5174"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eleanor Jones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1625-5174","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tendinopathy","display_name":"tendinopathy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cyclic-tensile-strain","display_name":"cyclic tensile strain","score":0.890999972820282},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.859000027179718},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.671999990940094},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.828000009059906},{"id":"https://openalex.org/keywords/thrombospondin","display_name":"thrombospondin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.6230000257492065},{"id":"https://openalex.org/keywords/mannose-6-phosphate","display_name":"mannose-6-phosphate","score":0.7400000095367432},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.735161542892456},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5983312129974365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5231667160987854},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5080535411834717},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4997978210449219},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4900463819503784},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4756612181663513},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4583849310874939},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4300040602684021},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4214674234390259},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3219769597053528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3200678825378418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2989492416381836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1956510841846466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1894046664237976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18722814321517944},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0910833477973938}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ueaeprints.uea.ac.uk:42329","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:646972460","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572068","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ueaeprints.uea.ac.uk:42329","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/42329/1/2012JonesERPhD.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W646972460.pdf","grobid_xml":"https://content.openalex.org/works/W646972460.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1540209636","https://openalex.org/W1977024178","https://openalex.org/W2013987164","https://openalex.org/W2049201395","https://openalex.org/W2054895108","https://openalex.org/W2060028170","https://openalex.org/W2076497809","https://openalex.org/W2082252073","https://openalex.org/W2106333878","https://openalex.org/W2142691980","https://openalex.org/W2148037731","https://openalex.org/W2157234417","https://openalex.org/W2172114097"],"related_works":["https://openalex.org/W2033938878","https://openalex.org/W2087054594","https://openalex.org/W2184070580","https://openalex.org/W2590829504","https://openalex.org/W1993844591","https://openalex.org/W1974364745","https://openalex.org/W2061111746","https://openalex.org/W2330566858","https://openalex.org/W2034261911","https://openalex.org/W44878251"],"abstract_inverted_index":{"Tendinopathies":[0],"are":[1,23],"a":[2,96,126,132,155,271],"range":[3],"of":[4,53,76,99,118,149,188,229,233,236,285,293],"diseases":[5],"characterised":[6],"by":[7,67],"pain":[8],"and":[9,58,63,70,93,125,131,142,165],"insidious":[10],"degeneration.":[11],"Although":[12],"poorly":[13],"understood,":[14],"onset":[15],"is":[16,288],"often":[17],"associated":[18],"with":[19,111,175,179,202,249,261],"physical":[20],"activity.":[21],"Metalloproteinases":[22],"regulated":[24],"differentially":[25],"in":[26,30,37,154,163,172,196,212,226,290],"tendinopathy":[27],"causing":[28],"disruptions":[29],"extracellular":[31],"matrix":[32,166],"(ECM)":[33],"homeostasis.":[34],"An":[35],"increase":[36,211],"the":[38,51,74,104,186,189,192,227,291],"anti-inflammatory":[39],"cytokine":[40],"TGF\u03b2":[41,59,143,180,198,220,237,251,256,266],"has":[42],"also":[43,183],"been":[44],"documented.":[45],"This":[46,217],"project":[47],"aims":[48],"to":[49,72,139,281],"investigate":[50],"effect":[52,254],"cyclic":[54,151],"tensile":[55],"strain":[56,153,193,206,264],"loading":[57,176],"stimulation":[60],"on":[61],"protease":[62,164,241],"ECM":[64],"protein":[65],"expression":[66,174],"human":[68],"tenocytes":[69,79],"begin":[71],"characterise":[73],"pathway":[75],"mechanotransduction.":[77],"\\nHuman":[78],"were":[80,109,137],"seeded":[81],"at":[82,101],"1.5x106":[83],"cells/ml":[84],"into":[85],"collagen":[86],"gels":[87],"(rat":[88],"tail":[89],"type":[90],"I,":[91],"1mg/ml)":[92],"stretched":[94],"using":[95,103],"sinusoidal":[97],"waveform":[98],"0-5%":[100],"1Hz":[102],"Flexcell":[105],"FX4000T\u2122":[106],"system.":[107],"Cultures":[108],"treated":[110],"or":[112,116,214,242,246,258],"without":[113],"1ng/ml":[114],"TGF\u03b21":[115],"inhibitors":[117],"TGF\u03b2RI,":[119],"metalloproteinases,":[120],"RGD,":[121],"Mannose-6-phosphate,":[122],"integrin":[123,245],"\u03b21":[124],"thrombospondin":[127,247],"as":[128],"appropriate.":[129],"qRT-PCR":[130],"cell":[133],"based":[134],"luciferase":[135],"assay":[136],"used":[138],"assess":[140],"RNA":[141],"activity":[144,199],"respectively.":[145],"\\nThe":[146],"prolonged":[147],"application":[148],"5%":[150],"mechanical":[152,205],"3D":[156],"culture":[157],"system":[158,287],"induced":[159,194],"an":[160,223],"anabolic":[161],"response":[162],"genes.":[167],"In":[168],"most":[169],"genes":[170],"changes":[171,195],"gene":[173,230,259],"was":[177,200,209],"mirrored":[178],"stimulation.":[181],"We":[182],"demonstrated":[184],"that":[185,219],"inhibition":[187],"TGF\u03b2RI":[190],"abrogated":[191],"mRNA.":[197],"increased":[201],"48":[203],"hours":[204],"although":[207],"there":[208],"no":[210,253],"mRNA":[213],"total":[215],"TGF\u03b2.":[216],"indicates":[218],"activation":[221,238,257,267],"plays":[222],"important":[224],"role":[225],"mechanoregulation":[228],"expression.":[231],"Inhibition":[232],"potential":[234],"mechanisms":[235],"including;":[239],"serine":[240],"metalloproteinase":[243],"activity,":[244],"interaction":[248],"latent":[250],"showed":[252],"upon":[255],"regulation":[260],"strain.":[262],"Therefore":[263],"mediated":[265],"may":[268,278],"occur":[269],"via":[270],"novel":[272],"mechanism.":[273],"By":[274],"understanding":[275],"mechanotransduction,":[276],"we":[277],"be":[279],"able":[280],"determine":[282],"whether":[283],"dysregulation":[284],"this":[286],"involved":[289],"development":[292],"tendinopathy.":[294]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
