{"id":"https://openalex.org/W646687187","doi":"https://doi.org/10.1096/fasebj.21.6.a1444-c","title":"Ventilatory consequences of acute and chronic exposure to nicotine","display_name":"Ventilatory consequences of acute and chronic exposure to nicotine","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W646687187","doi":"https://doi.org/10.1096/fasebj.21.6.a1444-c","mag":"646687187"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1444-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1444-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1444-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043079732","display_name":"Cord Brundage","orcid":"https://orcid.org/0000-0002-7367-9371","observed_orcids":["https://orcid.org/0000-0002-7367-9371"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cord M Brundage","raw_affiliation_strings":["Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064256339","display_name":"Justin C Buehner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin C Buehner","raw_affiliation_strings":["Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000","institution_ids":["https://openalex.org/I141472210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033555817","display_name":"Barbara E. Taylor","orcid":"https://orcid.org/0000-0003-1635-6194","observed_orcids":["https://orcid.org/0000-0003-1635-6194"]},"institutions":[{"id":"https://openalex.org/I141472210","display_name":"University of Alaska Fairbanks","ror":"https://ror.org/01j7nq853","country_code":"US","type":"education","lineage":["https://openalex.org/I141472210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara E Taylor","raw_affiliation_strings":["Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Arctic BiologyUniversity of Alaska Fairbanks902 N Koyukuk DriveFairbanksAK99775\u20107000","institution_ids":["https://openalex.org/I141472210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I141472210"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07039963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.7480000257492065},{"id":"https://openalex.org/keywords/chronic-nicotine-exposure","display_name":"chronic nicotine exposure","score":0.6899999976158142},{"id":"https://openalex.org/keywords/respiratory-drive","display_name":"respiratory drive","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hypoxic-ventilatory-response","display_name":"hypoxic ventilatory response","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hypercapnic-ventilatory-response","display_name":"hypercapnic ventilatory response","score":0.996999979019165},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.5809999704360962},{"id":"https://openalex.org/keywords/tadpoles","display_name":"tadpoles","score":0.675000011920929},{"id":"https://openalex.org/keywords/bullfrog","display_name":"bullfrog","score":0.9520000219345093},{"id":"https://openalex.org/keywords/facial-nerve","display_name":"facial nerve","score":0.550000011920929},{"id":"https://openalex.org/keywords/hypoglossal-nerve","display_name":"hypoglossal nerve","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sudden-infant-death-syndrome","display_name":"sudden infant death syndrome","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8199476003646851},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5778562426567078},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5529845952987671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5396426320075989},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.5196338891983032},{"id":"https://openalex.org/C123792249","wikidata":"https://www.wikidata.org/wiki/Q5165875","display_name":"Control of respiration","level":3,"score":0.5170360207557678},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.5087190270423889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30443108081817627}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1444-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1444-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1444-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005002423","https://openalex.org/W2015389262","https://openalex.org/W2011857520","https://openalex.org/W1970114832","https://openalex.org/W2053922487","https://openalex.org/W1979596783","https://openalex.org/W2063934168","https://openalex.org/W2920921073","https://openalex.org/W2000794746","https://openalex.org/W9148121"],"abstract_inverted_index":{"Developmental":[0],"nicotine":[1,23,90,104,165],"exposure":[2,24,166,170],"has":[3],"been":[4],"associated":[5],"with":[6,59,103],"depressed":[7],"respiratory":[8,37,172],"responses":[9,153],"to":[10,73,81,89,125,133,140],"hypoxic":[11,34,82,126,142],"and":[12,21,26,35,48,66,83,116,127,156],"hypercapnic":[13,36,84,128,144],"conditions.":[14,85,129,145],"We":[15,39],"investigated":[16],"the":[17,31,46,52],"effect":[18],"that":[19,162,169],"chronic":[20],"acute":[22],"(CNE":[25],"ANE,":[27],"respectively)":[28],"had":[29],"on":[30],"attenuation":[32],"of":[33,43,51,106,164],"drive.":[38,173],"measured":[40],"neural":[41],"correlates":[42],"ventilation":[44],"from":[45],"facial":[47],"hypoglossal":[49],"nerves":[50],"isolated":[53],"tadpole":[54],"(Rana":[55],"catesbeiana)":[56],"brainstem":[57,108],"superfused":[58],"artificial":[60],"cerebrospinal":[61],"fluid":[62],"(aCSF).":[63],"Fictive":[64],"lung":[65,138,152],"gill":[67,121],"breaths":[68],"were":[69,87],"monitored":[70],"in":[71,79,123,175],"response":[72,80,124,139],"normoxic/normocapnic":[74],"conditions":[75],"as":[76,78],"well":[77],"Tadpoles":[86],"exposed":[88],"either":[91,141],"chronically":[92],"throughout":[93],"development":[94],"(18ng/ml":[95,109],"pond":[96],"water":[97],"for":[98,111],"10":[99],"weeks)":[100],"or":[101,143],"acutely":[102],"superfusion":[105],"their":[107],"aCSF":[110],"30":[112],"minutes).":[113],"Both":[114],"CNE":[115,130],"ANE":[117,155],"animals":[118],"demonstrated":[119],"neuroventilatory":[120],"ataxia":[122],"tadpoles":[131],"failed":[132],"produce":[134],"a":[135],"significant":[136,149],"fictive":[137],"There":[146],"was":[147],"no":[148],"difference":[150],"between":[151],"among":[154],"control":[157],"animals.":[158],"This":[159],"would":[160],"suggest":[161],"duration":[163],"influences":[167],"how":[168],"impacts":[171],"Implications":[174],"Sudden":[176],"Infant":[177],"Death":[178],"Syndrome":[179],"are":[180],"discussed.":[181],"Funded":[182],"by":[183],"NIH-NINDS":[184],"2U54NS041069-06AI.":[185]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}