{"id":"https://openalex.org/W646662492","doi":null,"title":"[Bifidobacterium cell wall proteins induced beta-defensin 2 mRNA expression in human intestinal epithelial cells].","display_name":"[Bifidobacterium cell wall proteins induced beta-defensin 2 mRNA expression in human intestinal epithelial cells].","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W646662492","mag":"646662492","pmid":"https://pubmed.ncbi.nlm.nih.gov/14619563"},"language":"zh","primary_location":{"id":"pmid:14619563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14619563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.cqvip.com/QK/90551A/200304/8399339.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083088757","display_name":"\u738b\u56fd\u5174","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoxing Wang","raw_affiliation_strings":["Research Unit of Infection & Immunity, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Infection & Immunity, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030871078","display_name":"Yun Feng","orcid":"https://orcid.org/0000-0002-9453-3259","observed_orcids":["https://orcid.org/0000-0002-9453-3259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014234144","display_name":"\u6c6a\u5b87\u8f89","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuhui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085405615","display_name":"\u9ec4\u5b81","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013013113","display_name":"\u5434\u7426","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075438269","display_name":"\u738b\u4f2f\u7476","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boyao Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7902,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7354375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"4","first_page":"622","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":1.0},{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/heat-killed-bacteria","display_name":"heat-killed bacteria","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27693837881088257}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:14619563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14619563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"English Abstract"},{"id":"mag:2474826097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14619563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:646662492","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/90551A/200304/8399339.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545744","display_name":"\u56db\u5ddd\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","issn_l":"1672-173X","issn":["1672-173X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u56db\u5ddd\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","raw_type":null}],"best_oa_location":{"id":"mag:646662492","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/90551A/200304/8399339.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545744","display_name":"\u56db\u5ddd\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","issn_l":"1672-173X","issn":["1672-173X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u56db\u5ddd\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u7248","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1479892322","https://openalex.org/W258552303","https://openalex.org/W160332205","https://openalex.org/W1160328306","https://openalex.org/W1028342289","https://openalex.org/W2978550106","https://openalex.org/W595482143","https://openalex.org/W1548538503","https://openalex.org/W7007484851","https://openalex.org/W291003994"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"examine":[2],"Bifidobacterium":[3,25,106],"mediated":[4],"induction":[5],"of":[6,22,48,57,78,92,130],"human":[7,13,118],"defensin":[8],"2":[9],"mRNA":[10,59,80,101],"expression":[11,102,116],"in":[12,28,31,60,81,103,117,127,135],"intestinal":[14,119],"epithelial":[15,120],"cells":[16,62],"and":[17,34,42,68,94],"define":[18],"the":[19,82,87,128,136],"bioactive":[20],"components":[21],"Bifidobacterium.":[23],"METHODS:":[24],"was":[26,38,63,74],"cultured":[27],"MRS":[29],"medium":[30],"anaerobic":[32],"incubator":[33],"its":[35,108],"cell":[36,45,90,95,109],"wall":[37,46,91,96,110],"isolated":[39],"by":[40,65],"sonication":[41],"centrifugation.":[43],"The":[44,55],"proteins":[47,97,111],"Bifidobacteria":[49],"were":[50],"extracted":[51],"with":[52],"2%":[53],"SDS.":[54],"level":[56],"hBD-2":[58,79,100,114],"HT-29":[61,84],"detected":[64],"reverse-transcription":[66],"PCR":[67],"Northern":[69],"blot":[70],"analysis.":[71],"RESULTS:":[72],"There":[73],"no":[75],"detectable":[76],"signal":[77],"unstimulated":[83],"cells.":[85],"However,":[86],"heat-killed":[88],"Bifidobacteria,":[89,93],"remarkably":[98],"induced":[99],"HT-29.":[104],"CONCLUSION:":[105],"or":[107],"can":[112],"induce":[113],"gene":[115],"cells,":[121],"which":[122],"may":[123],"play":[124],"a":[125],"role":[126],"mechanisms":[129],"innate":[131],"defense":[132],"against":[133],"pathogens":[134],"intestine.":[137]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
