{"id":"https://openalex.org/W64617248","doi":null,"title":"Assessment of tumour growth and of response to chemotherapy of human melanomas in athymic, nude mice.","display_name":"Assessment of tumour growth and of response to chemotherapy of human melanomas in athymic, nude mice.","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W64617248","mag":"64617248","pmid":"https://pubmed.ncbi.nlm.nih.gov/6932918","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1520785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113522568","display_name":"\u00d8ystein Fodstad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Fodstad","raw_affiliation_strings":["Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031832649","display_name":"Nina Aass","orcid":"https://orcid.org/0009-0004-6880-6622","observed_orcids":["https://orcid.org/0009-0004-6880-6622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Aass","raw_affiliation_strings":["Equinor Asa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Equinor Asa","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081357167","display_name":"Alexander Pihl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pihl","raw_affiliation_strings":["Equinor Asa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Equinor Asa","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7915,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92321557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":"146","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-melanoma","display_name":"human melanoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-doubling-time","display_name":"tumor doubling time","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy-response-assessment","display_name":"chemotherapy response assessment","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytostatic-drugs","display_name":"cytostatic agents","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C48900799","wikidata":"https://www.wikidata.org/wiki/Q1424376","display_name":"Doubling time","level":3,"score":0.779664933681488},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6905160546302795},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.5115872025489807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49040746688842773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43646135926246643},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38962116837501526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3814682066440582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3631654977798462},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3624159097671509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32517391443252563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14004069566726685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:1520785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2149253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer Suppl","raw_type":"Text"},{"id":"pmid:6932918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6932918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of cancer. Supplement","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1980-4101","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1980/3102","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1980","raw_type":"text"},{"id":"mag:64617248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6932918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1520785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1964243472","https://openalex.org/W2010922894","https://openalex.org/W2038281784","https://openalex.org/W2143804074","https://openalex.org/W2397947982","https://openalex.org/W2407673723"],"related_works":["https://openalex.org/W1991546979","https://openalex.org/W1973925436","https://openalex.org/W2082838704","https://openalex.org/W7097734226","https://openalex.org/W2092417861","https://openalex.org/W2060524209","https://openalex.org/W1981035638","https://openalex.org/W4298918784","https://openalex.org/W2137349471","https://openalex.org/W7095492067"],"abstract_inverted_index":{"The":[0,20,53],"growth":[1,21,46,64],"of":[2,23,41,51,70],"6":[3],"different":[4],"human":[5],"melanomas":[6],"xenografted":[7],"into":[8],"athymic":[9],"mice":[10],"was":[11,26,73],"followed":[12],"by":[13,67],"measuring":[14],"2":[15],"vertical":[16],"diameters":[17],"twice":[18],"weekly.":[19],"rate":[22,47],"the":[24,29,35,42,81,86],"xenografts":[25,43],"expressed":[27],"as":[28],"tumour":[30,54],"doubling":[31],"time,":[32],"measured":[33],"in":[34,80,85],"volume":[36],"range":[37],"30-60":[38],"mm3.":[39],"None":[40],"increased":[44],"their":[45],"with":[48],"increasing":[49],"number":[50],"passages.":[52],"lines,":[55],"which":[56],"were":[57],"histologically":[58],"very":[59],"similar,":[60],"showed":[61],"individual,":[62],"characteristic":[63],"rates":[65],"differing":[66],"a":[68],"factor":[69],"3.":[71],"Evidence":[72],"obtained":[74],"that":[75],"resistance":[76],"to":[77,92],"cytostatic":[78],"drugs":[79],"patients":[82],"is":[83],"retained":[84],"xenograft.":[87],"Procedures":[88],"for":[89],"evaluating":[90],"response":[91],"chemotherapy":[93],"are":[94],"discussed.":[95]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}