{"id":"https://openalex.org/W6460401","doi":null,"title":"Low mature TGF-beta 2 levels in aqueous humor during uveitis.","display_name":"Low mature TGF-beta 2 levels in aqueous humor during uveitis.","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W6460401","mag":"6460401","pmid":"https://pubmed.ncbi.nlm.nih.gov/7522227"},"language":"en","primary_location":{"id":"pmid:7522227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7522227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.knaw.nl/portal/en/publications/2eb85811-1e08-422e-8b26-737c13d49d6a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112632781","display_name":"Joke Helena de Boer","orcid":"https://orcid.org/0000-0003-1712-3050","observed_orcids":["https://orcid.org/0000-0003-1712-3050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H de Boer","raw_affiliation_strings":["Netherlands Ophthalmic Research Institute, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Ophthalmic Research Institute, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071748458","display_name":"Jacqueline Limpens","orcid":"https://orcid.org/0000-0002-7362-8574","observed_orcids":["https://orcid.org/0000-0002-7362-8574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Limpens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088207762","display_name":"S. Orengo-Nania","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Orengo-Nania","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109349651","display_name":"P T de Jong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P T de Jong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040033296","display_name":"Ellen C. La Heij","orcid":"https://orcid.org/0000-0002-0813-9889","observed_orcids":["https://orcid.org/0000-0002-0813-9889"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E La Heij","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005016013","display_name":"Aize Kijlstra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kijlstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2999,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.95752849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"10","first_page":"3702","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.828000009059906},{"id":"https://openalex.org/keywords/vitreous-fluid","display_name":"vitreous fluid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/uveitis","display_name":"uveitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fuchs-heterochromic-cyclitis","display_name":"Fuchs' heterochromic cyclitis","score":0.921999990940094},{"id":"https://openalex.org/keywords/ocular-inflammation","display_name":"ocular inflammation","score":0.734000027179718},{"id":"https://openalex.org/keywords/blood-aqueous-barrier","display_name":"blood-aqueous barrier","score":0.8849999904632568},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7630000114440918},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tgf-beta-activation","display_name":"TGF-beta activation","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.8335400223731995},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.6881657838821411},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5981013178825378},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.4915965497493744},{"id":"https://openalex.org/C49651878","wikidata":"https://www.wikidata.org/wiki/Q1128474","display_name":"Radial immunodiffusion","level":3,"score":0.4765232801437378},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4374275505542755},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.4271969497203827},{"id":"https://openalex.org/C2776713392","wikidata":"https://www.wikidata.org/wiki/Q278859","display_name":"Uvea","level":3,"score":0.42659056186676025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41788309812545776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38551223278045654},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.2414265275001526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23688635230064392},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1803886592388153},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11617684364318848},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:7522227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7522227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.2429","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.2429","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/35/10/3702.full.pdf","raw_type":"text"},{"id":"pmh:knaw:oai:pure.knaw.nl:publications/2eb85811-1e08-422e-8b26-737c13d49d6a","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/2eb85811-1e08-422e-8b26-737c13d49d6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science, 35, 3702 - 3710. Association for Research in Vision and Ophthalmology Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:6460401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7522227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:knaw:oai:pure.knaw.nl:publications/2eb85811-1e08-422e-8b26-737c13d49d6a","doi":null,"is_oa":true,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/2eb85811-1e08-422e-8b26-737c13d49d6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science, 35, 3702 - 3710. Association for Research in Vision and Ophthalmology Inc.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W69115750","https://openalex.org/W90704299","https://openalex.org/W95729161","https://openalex.org/W101829053","https://openalex.org/W132121957","https://openalex.org/W158465960","https://openalex.org/W174750716","https://openalex.org/W196561931","https://openalex.org/W1486085957","https://openalex.org/W1512861794","https://openalex.org/W1563182712","https://openalex.org/W1573756429","https://openalex.org/W1594069877","https://openalex.org/W1599245394","https://openalex.org/W1605014691","https://openalex.org/W1971111760","https://openalex.org/W1971871612","https://openalex.org/W1973644988","https://openalex.org/W1983031935","https://openalex.org/W1986885905","https://openalex.org/W1988343605","https://openalex.org/W1997208457","https://openalex.org/W2013993175","https://openalex.org/W2018972324","https://openalex.org/W2021107622","https://openalex.org/W2021310874","https://openalex.org/W2033077619","https://openalex.org/W2033598785","https://openalex.org/W2039299132","https://openalex.org/W2041665122","https://openalex.org/W2043499070","https://openalex.org/W2057729296","https://openalex.org/W2060958447","https://openalex.org/W2071787763","https://openalex.org/W2073308867","https://openalex.org/W2082186503","https://openalex.org/W2108104357","https://openalex.org/W2115433613","https://openalex.org/W2117901334","https://openalex.org/W2118857294","https://openalex.org/W2122855514","https://openalex.org/W2164279207","https://openalex.org/W2249820745"],"related_works":["https://openalex.org/W7100654533","https://openalex.org/W2115433613","https://openalex.org/W7048777104","https://openalex.org/W2099842384","https://openalex.org/W2107448383","https://openalex.org/W2073537216","https://openalex.org/W2403073922","https://openalex.org/W2080344459","https://openalex.org/W2032731418","https://openalex.org/W2010538186"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"investigate":[2],"whether":[3],"transforming":[4],"growth":[5],"factor-beta":[6],"2":[7,31,74,129,159,164,182,197,226,235],"(TGF-beta":[8],"2),":[9],"a":[10,67,114,175,266],"strong":[11],"immunosuppressive":[12],"factor":[13],"normally":[14],"present":[15],"in":[16,21,35,76,133,192,199,205,212,228,237,268],"aqueous":[17,36,46,122,134,171,229,246],"humor,":[18,172,247],"is":[19],"involved":[20],"the":[22,117,120,143,223,232,269],"inflammatory":[23],"process":[24,271],"of":[25,39,49,60,116,119,137,151,254,272],"clinical":[26],"uveitis.":[27],"METHODS:":[28],"Mature":[29],"TGF-beta":[30,73,128,158,163,181,188,196,225,234,256,274],"levels":[32,75,130,165,198,227,236],"were":[33,79,101,111,131,202],"determined":[34,107],"humor":[37,47,85,135,230],"samples":[38,48,59,86,96,136,206,213],"9":[40],"patients":[41,51,62,88,138,152,208],"with":[42,52,63,89,139,153,209],"Fuchs'":[43],"heterochromic":[44],"cyclitis,":[45],"21":[50],"other":[53],"uveitis":[54,64,154,210],"entities,":[55],"and":[56,91,93,183,231],"vitreous":[57,94,193,200,238],"fluid":[58,95,201,239],"19":[61],"by":[65,108,252,265],"using":[66],"commercially":[68],"available":[69],"sandwich":[70],"ELISA:":[71],"Total":[72,195],"ocular":[77,243],"fluids":[78],"measured":[80],"after":[81],"heat":[82],"activation.":[83],"Aqueous":[84],"from":[87,97,207,214],"cataract":[90],"glaucoma":[92],"eye":[98,215],"bank":[99,216],"eyes":[100],"tested":[102],"as":[103,113],"controls.":[104],"Albumin":[105],"levels,":[106],"radial":[109],"immunodiffusion,":[110],"used":[112],"measure":[115],"disruption":[118],"blood":[121],"barrier.":[123],"RESULTS:":[124],"Significantly":[125],"lower":[126,204],"mature":[127,157,180,187,224,255],"detected":[132,191],"uveitis,":[140],"compared":[141],"to":[142,167,257],"two":[144],"control":[145],"groups":[146],"without":[147,155],"intraocular":[148],"inflammation.":[149,244],"Samples":[150],"detectable":[156],"did":[160],"contain":[161],"latent":[162,273],"(504":[166],"6024":[168],"pg/ml).":[169],"In":[170,245],"there":[173],"was":[174],"significant":[176],"negative":[177],"correlation":[178],"between":[179],"albumin":[184],"levels.":[185],"No":[186],"could":[189],"be":[190,250],"fluid.":[194],"significantly":[203],"than":[211],"eyes.":[217],"CONCLUSION:":[218],"These":[219],"results":[220],"indicate":[221],"that":[222],"total":[233],"are":[240],"reduced":[241],"during":[242],"this":[248],"might":[249],"caused":[251],"binding":[253],"serum":[258],"proteins,":[259],"for":[260],"instance,":[261],"alpha":[262],"2-macroglobulin,":[263],"or":[264],"disturbance":[267],"activation":[270],"2.":[275]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}