{"id":"https://openalex.org/W645879712","doi":null,"title":"The Erythrocyte Transcriptome: Global Characterization and Therapeutic Implication","display_name":"The Erythrocyte Transcriptome: Global Characterization and Therapeutic Implication","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W645879712","mag":"645879712"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9812","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9812","pdf_url":"http://hdl.handle.net/10161/9812","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/9812","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079882392","display_name":"Jennifer F. Doss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Doss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079882392"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.13269999623298645,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.716225802898407},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.499528169631958},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.37244993448257446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.361613929271698},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31514638662338257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1956188678741455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10920196771621704},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07849600911140442}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9812","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9812","pdf_url":"http://hdl.handle.net/10161/9812","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:645879712","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/9812/1/Doss_duke_0066D_12742.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9812","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9812","pdf_url":"http://hdl.handle.net/10161/9812","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W645879712.pdf","grobid_xml":"https://content.openalex.org/works/W645879712.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W62257282","https://openalex.org/W108119807","https://openalex.org/W144423133","https://openalex.org/W153121858","https://openalex.org/W1492262148","https://openalex.org/W1519300192","https://openalex.org/W1638199269","https://openalex.org/W1967633197","https://openalex.org/W1972998779","https://openalex.org/W1975014281","https://openalex.org/W1979112943","https://openalex.org/W1982163838","https://openalex.org/W1983460624","https://openalex.org/W1983932066","https://openalex.org/W1984352048","https://openalex.org/W1987847236","https://openalex.org/W1989015932","https://openalex.org/W1989827688","https://openalex.org/W1991323387","https://openalex.org/W1993467866","https://openalex.org/W2000977869","https://openalex.org/W2005645711","https://openalex.org/W2006247279","https://openalex.org/W2010285985","https://openalex.org/W2013741571","https://openalex.org/W2013921359","https://openalex.org/W2014064723","https://openalex.org/W2014968377","https://openalex.org/W2015311527","https://openalex.org/W2018983995","https://openalex.org/W2020268876","https://openalex.org/W2023634791","https://openalex.org/W2023824803","https://openalex.org/W2026105799","https://openalex.org/W2033874071","https://openalex.org/W2034134298","https://openalex.org/W2044354693","https://openalex.org/W2051564672","https://openalex.org/W2053115283","https://openalex.org/W2053733754","https://openalex.org/W2063978477","https://openalex.org/W2063992468","https://openalex.org/W2065129911","https://openalex.org/W2066871041","https://openalex.org/W2068205741","https://openalex.org/W2072155079","https://openalex.org/W2073754499","https://openalex.org/W2080791129","https://openalex.org/W2081276164","https://openalex.org/W2083381199","https://openalex.org/W2085788459","https://openalex.org/W2087206434","https://openalex.org/W2087620958","https://openalex.org/W2090943742","https://openalex.org/W2095357177","https://openalex.org/W2100594852","https://openalex.org/W2100681150","https://openalex.org/W2102111081","https://openalex.org/W2108521659","https://openalex.org/W2114104545","https://openalex.org/W2114381883","https://openalex.org/W2117391818","https://openalex.org/W2119962312","https://openalex.org/W2122810813","https://openalex.org/W2125939997","https://openalex.org/W2129209049","https://openalex.org/W2130305733","https://openalex.org/W2130410032","https://openalex.org/W2132260682","https://openalex.org/W2135837360","https://openalex.org/W2137586531","https://openalex.org/W2139387137","https://openalex.org/W2140272588","https://openalex.org/W2140775205","https://openalex.org/W2149126003","https://openalex.org/W2149291473","https://openalex.org/W2149644357","https://openalex.org/W2154857300","https://openalex.org/W2160697532","https://openalex.org/W2164615751","https://openalex.org/W2164745666","https://openalex.org/W2166707978","https://openalex.org/W2167672607","https://openalex.org/W2168984079","https://openalex.org/W2169456326"],"related_works":["https://openalex.org/W2584966044","https://openalex.org/W2173562365","https://openalex.org/W62257282","https://openalex.org/W2516952825","https://openalex.org/W3146070037","https://openalex.org/W2559285662","https://openalex.org/W2106401347","https://openalex.org/W6958494067","https://openalex.org/W7097350743","https://openalex.org/W2158825911"],"abstract_inverted_index":{"A":[0],"blood":[1,22,43,49],"draw":[2],"is":[3,275],"one":[4],"of":[5,21,33,39,45,59,134,176,193,231,260,294,316,322,334,359,369,380],"the":[6,28,57,62,95,118,131,158,174,247,292,314,347,360,378],"most":[7,74],"readily":[8],"accessible,":[9],"commonly":[10],"practiced":[11],"medical":[12],"procedures":[13],"with":[14,125,223,306],"biomarker":[15],"utility.":[16,309],"In":[17],"particular,":[18],"transcriptome":[19],"signatures":[20],"cells":[23,40,50],"provide":[24,105,228,319],"valuable":[25],"insights":[26],"into":[27,89,107,346],"developmental":[29],"history":[30],"and":[31,66,104,123,162,199,284,301,330],"adaptations":[32],"these":[34,111,126,177,226,370],"circulating":[35],"cells.":[36,382],"The":[37,367],"majority":[38],"within":[41,246,266],"whole":[42],"consist":[44],"erythrocytes,":[46],"or":[47,137],"red":[48],"(RBCs)":[51],"that":[52,86,272],"are":[53],"primarily":[54],"responsible":[55],"for":[56,234,326],"transport":[58],"gases":[60],"throughout":[61],"bloodstream.":[63],"Terminally":[64],"differentiated":[65],"anucleate,":[67],"RBCs":[68],"were":[69,244],"once":[70],"thought":[71],"to":[72,82,97,110,115,156,164,172,318],"lack":[73],"RNAs.":[75],"However,":[76,130],"erythrocytes":[77],"have":[78,213],"been":[79,143],"recently":[80],"shown":[81],"contain":[83],"select":[84],"microRNAs":[85],"lend":[87],"insight":[88,106],"erythrocyte":[90,139,160,180,211,323,335,348,362],"pathophysiology.":[91],"Erythrocyte":[92],"RNAs":[93,140,181,212,222,227,243],"possess":[94],"ability":[96],"both":[98,194,325],"distinguish":[99],"between":[100],"erythroid":[101,121,169,217,253,278,381],"disease":[102],"subphenotypes,":[103],"mechanisms":[108],"contributing":[109],"differences.":[112],"We":[113],"aim":[114],"further":[116,235],"dissect":[117],"events":[119],"controlling":[120],"differentiation":[122,170],"pathophysiology":[124],"readily-accessible":[127],"genetic":[128,232],"materials.":[129],"complete":[132],"repertoire":[133,192],"either":[135],"small":[136],"large":[138],"has":[141,152],"not":[142],"determined.":[144],"Based":[145],"on":[146],"this":[147,267,273,352],"knowledge":[148],"gap,":[149],"my":[150],"dissertation":[151],"two":[153,311,371],"goals:":[154],"1)":[155],"define":[157],"comprehensive":[159],"transcriptome,":[161],"2)":[163],"utilize":[165],"an":[166,189,327],"in":[167,206,216,252,328,331,338,353,365],"vitro":[168,329,339],"model":[171],"elucidate":[173],"functions":[175,215,341],"newly":[178,240],"identified":[179,245],"during":[182,277,287,298],"development.":[183,254],"Using":[184],"high-throughput":[185],"sequencing,":[186],"we":[187,219],"show":[188],"extensive,":[190],"diverse":[191],"small-sized":[195],"(short,":[196],"18-24":[197],"nt)":[198,203],"large-sized":[200],"(long,":[201],">200":[202],"RNA":[204],"species":[205],"mature":[207,361],"erythrocytes.":[208],"Though":[209],"many":[210],"known":[214],"cells,":[218],"describe":[220],"several":[221,239],"unknown":[224],"functions;":[225],"a":[229,257,261,303,320,343,357,374],"wealth":[230],"loci":[233],"inquiry.":[236],"\\t":[237],"Additionally,":[238],"described,":[241],"primate-specific":[242],"miR-144/-451":[248],"locus":[249],"formerly":[250],"involved":[251],"I":[255],"performed":[256],"functional":[258],"investigation":[259],"previously":[262],"uncharacterized":[263],"microRNA,":[264],"miR-4732-3p,":[265],"locus.":[268],"My":[269],"study":[270],"demonstrates":[271],"microRNA":[274],"upregulated":[276],"development,":[279],"represses":[280],"SMAD2/4-dependent":[281],"TGF-\u03b2":[282,296],"signaling,":[283],"promotes":[285],"proliferation":[286],"erythropoiesis.":[288],"Thus,":[289],"miR-4732-3p":[290],"emphasizes":[291],"importance":[293],"balanced":[295],"signaling":[297],"primate":[299],"erythropoiesis,":[300],"represents":[302],"key":[304],"modulator":[305],"potential":[307],"therapeutic":[308],"These":[310],"studies":[312],"highlight":[313],"advantage":[315],"venipuncture":[317],"catalog":[321],"RNAs,":[324],"vivo":[332,354],"understanding":[333],"biology.":[336],"This":[337],"approach":[340,355],"as":[342],"continuous":[344],"window":[345],"development":[349],"program,":[350],"whereas":[351],"provides":[356,373],"snapshot":[358],"population":[363],"state":[364],"real-time.":[366],"integration":[368],"approaches":[372],"broad":[375],"perspective":[376],"covering":[377],"lifetime":[379]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}