{"id":"https://openalex.org/W645665606","doi":null,"title":"Development of Novel Assays for Measuring Different Molecular Forms of Prostate Specific Antigen","display_name":"Development of Novel Assays for Measuring Different Molecular Forms of Prostate Specific Antigen","publication_year":2009,"publication_date":"2009-10-09","ids":{"openalex":"https://openalex.org/W645665606","mag":"645665606"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22671","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22671","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/22671","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Zhu","orcid":"https://orcid.org/0000-0002-5348-7532","observed_orcids":["https://orcid.org/0000-0002-5348-7532"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lei Zhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5348-7532","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6940000057220459},{"id":"https://openalex.org/keywords/psa-isoforms","display_name":"PSA isoforms","score":0.8960000276565552},{"id":"https://openalex.org/keywords/free-psa","display_name":"free PSA","score":0.9710000157356262},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immunoassay-development","display_name":"immunoassay development","score":0.8389999866485596},{"id":"https://openalex.org/keywords/proximity-ligation-assay","display_name":"proximity ligation assay","score":0.8059999942779541},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8349999785423279},{"id":"https://openalex.org/keywords/diagnostic-specificity","display_name":"diagnostic specificity","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6686038970947266},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49270299077033997},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44489729404449463},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.39048629999160767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3803437352180481},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36093810200691223},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32489773631095886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18063154816627502},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14900687336921692}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/22671","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22671","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:645665606","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/22671/1/developm.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22671","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22671","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":475,"referenced_works":["https://openalex.org/W3221563","https://openalex.org/W16556138","https://openalex.org/W24890352","https://openalex.org/W30525785","https://openalex.org/W96058809","https://openalex.org/W147570767","https://openalex.org/W155079562","https://openalex.org/W190857994","https://openalex.org/W205768165","https://openalex.org/W221956105","https://openalex.org/W333212257","https://openalex.org/W1455378812","https://openalex.org/W1485235179","https://openalex.org/W1490083197","https://openalex.org/W1512351123","https://openalex.org/W1530875344","https://openalex.org/W1536690700","https://openalex.org/W1537007105","https://openalex.org/W1558007424","https://openalex.org/W1558396187","https://openalex.org/W1571849492","https://openalex.org/W1577965060","https://openalex.org/W1602882031","https://openalex.org/W1605638342","https://openalex.org/W1729812787","https://openalex.org/W1760204652","https://openalex.org/W1819910556","https://openalex.org/W1828456061","https://openalex.org/W1844603699","https://openalex.org/W1845134010","https://openalex.org/W1847856759","https://openalex.org/W1875933026","https://openalex.org/W1901056825","https://openalex.org/W1901811353","https://openalex.org/W1905007996","https://openalex.org/W1907187946","https://openalex.org/W1908305777","https://openalex.org/W1921899373","https://openalex.org/W1925466126","https://openalex.org/W1925864021","https://openalex.org/W1929126424","https://openalex.org/W1931988958","https://openalex.org/W1932287526","https://openalex.org/W1932417500","https://openalex.org/W1963517783","https://openalex.org/W1963764466","https://openalex.org/W1964375808","https://openalex.org/W1964816209","https://openalex.org/W1965572978","https://openalex.org/W1965795307","https://openalex.org/W1966477986","https://openalex.org/W1966517939","https://openalex.org/W1967410029","https://openalex.org/W1968083949","https://openalex.org/W1969111628","https://openalex.org/W1969925115","https://openalex.org/W1970047547","https://openalex.org/W1970062660","https://openalex.org/W1970233009","https://openalex.org/W1970713928","https://openalex.org/W1971428641","https://openalex.org/W1972581901","https://openalex.org/W1973198827","https://openalex.org/W1973361095","https://openalex.org/W1973674330","https://openalex.org/W1974001790","https://openalex.org/W1974326568","https://openalex.org/W1975510607","https://openalex.org/W1977088147","https://openalex.org/W1977093496","https://openalex.org/W1977290785","https://openalex.org/W1977546001","https://openalex.org/W1978127439","https://openalex.org/W1978187824","https://openalex.org/W1978549783","https://openalex.org/W1979000874","https://openalex.org/W1979385878","https://openalex.org/W1979985285","https://openalex.org/W1980159172","https://openalex.org/W1980866775","https://openalex.org/W1981042128","https://openalex.org/W1982544588","https://openalex.org/W1984192295","https://openalex.org/W1985057538","https://openalex.org/W1985298987","https://openalex.org/W1985784441","https://openalex.org/W1985993090","https://openalex.org/W1988085249","https://openalex.org/W1988162012","https://openalex.org/W1988686682","https://openalex.org/W1989696936","https://openalex.org/W1991938253","https://openalex.org/W1992490522","https://openalex.org/W1993263175","https://openalex.org/W1993293940","https://openalex.org/W1993437485","https://openalex.org/W1994136324","https://openalex.org/W1994381348","https://openalex.org/W1996487270","https://openalex.org/W1996681001","https://openalex.org/W1997014409","https://openalex.org/W1997492763","https://openalex.org/W1997965099","https://openalex.org/W1998394367","https://openalex.org/W1998570817","https://openalex.org/W1998602483","https://openalex.org/W2000814246","https://openalex.org/W2001238965","https://openalex.org/W2001290558","https://openalex.org/W2001873673","https://openalex.org/W2002384741","https://openalex.org/W2002756791","https://openalex.org/W2004785214","https://openalex.org/W2004787483","https://openalex.org/W2004944700","https://openalex.org/W2005503115","https://openalex.org/W2006291887","https://openalex.org/W2006509971","https://openalex.org/W2006813546","https://openalex.org/W2007315427","https://openalex.org/W2007782096","https://openalex.org/W2008005160","https://openalex.org/W2008246371","https://openalex.org/W2008381748","https://openalex.org/W2009017218","https://openalex.org/W2009317581","https://openalex.org/W2011166834","https://openalex.org/W2012195608","https://openalex.org/W2012218337","https://openalex.org/W2012348490","https://openalex.org/W2012587702","https://openalex.org/W2012593915","https://openalex.org/W2013176389","https://openalex.org/W2014482505","https://openalex.org/W2016313181","https://openalex.org/W2016592043","https://openalex.org/W2017675011","https://openalex.org/W2017766056","https://openalex.org/W2019023633","https://openalex.org/W2020207377","https://openalex.org/W2020254733","https://openalex.org/W2020636054","https://openalex.org/W2021377019","https://openalex.org/W2022008236","https://openalex.org/W2022148417","https://openalex.org/W2022490062","https://openalex.org/W2023339513","https://openalex.org/W2025319771","https://openalex.org/W2025383700","https://openalex.org/W2027011635","https://openalex.org/W2027197115","https://openalex.org/W2027679534","https://openalex.org/W2027925208","https://openalex.org/W2029761753","https://openalex.org/W2031014556","https://openalex.org/W2031159779","https://openalex.org/W2031383072","https://openalex.org/W2031747412","https://openalex.org/W2032165027","https://openalex.org/W2032553244","https://openalex.org/W2032704701","https://openalex.org/W2032942426","https://openalex.org/W2033017909","https://openalex.org/W2033225740","https://openalex.org/W2033692444","https://openalex.org/W2035241397","https://openalex.org/W2035936829","https://openalex.org/W2036902495","https://openalex.org/W2037119446","https://openalex.org/W2037335836","https://openalex.org/W2037594142","https://openalex.org/W2038348043","https://openalex.org/W2038516756","https://openalex.org/W2038611248","https://openalex.org/W2039227298","https://openalex.org/W2039527690","https://openalex.org/W2040172043","https://openalex.org/W2040206747","https://openalex.org/W2040523572","https://openalex.org/W2040776282","https://openalex.org/W2042299076","https://openalex.org/W2042346472","https://openalex.org/W2042713079","https://openalex.org/W2044916117","https://openalex.org/W2045239450","https://openalex.org/W2045275962","https://openalex.org/W2045383222","https://openalex.org/W2045732505","https://openalex.org/W2046003313","https://openalex.org/W2046960948","https://openalex.org/W2047200356","https://openalex.org/W2047784025","https://openalex.org/W2049067471","https://openalex.org/W2051769513","https://openalex.org/W2052903206","https://openalex.org/W2052931740","https://openalex.org/W2053554578","https://openalex.org/W2053988331","https://openalex.org/W2054043185","https://openalex.org/W2055261567","https://openalex.org/W2056289272","https://openalex.org/W2056437403","https://openalex.org/W2056603363","https://openalex.org/W2057048324","https://openalex.org/W2057338355","https://openalex.org/W2057469006","https://openalex.org/W2057627532","https://openalex.org/W2058221258","https://openalex.org/W2058541035","https://openalex.org/W2059681763","https://openalex.org/W2059987233","https://openalex.org/W2060714317","https://openalex.org/W2060860221","https://openalex.org/W2061261260","https://openalex.org/W2061879006","https://openalex.org/W2062016441","https://openalex.org/W2062203958","https://openalex.org/W2063151956","https://openalex.org/W2063178296","https://openalex.org/W2063969905","https://openalex.org/W2064061478","https://openalex.org/W2064426126","https://openalex.org/W2064525413","https://openalex.org/W2065218625","https://openalex.org/W2065330150","https://openalex.org/W2065717717","https://openalex.org/W2066533458","https://openalex.org/W2067530870","https://openalex.org/W2067535120","https://openalex.org/W2068309446","https://openalex.org/W2068350540","https://openalex.org/W2069017065","https://openalex.org/W2069588009","https://openalex.org/W2069898471","https://openalex.org/W2070303233","https://openalex.org/W2070701999","https://openalex.org/W2073020517","https://openalex.org/W2075188294","https://openalex.org/W2077039324","https://openalex.org/W2077100052","https://openalex.org/W2077555064","https://openalex.org/W2078038998","https://openalex.org/W2078354819","https://openalex.org/W2078778941","https://openalex.org/W2079591143","https://openalex.org/W2079724727","https://openalex.org/W2081776872","https://openalex.org/W2081933256","https://openalex.org/W2082709973","https://openalex.org/W2083057751","https://openalex.org/W2083518663","https://openalex.org/W2083562360","https://openalex.org/W2083995483","https://openalex.org/W2084333907","https://openalex.org/W2084513170","https://openalex.org/W2085115464","https://openalex.org/W2087329847","https://openalex.org/W2087922043","https://openalex.org/W2088466582","https://openalex.org/W2088576316","https://openalex.org/W2088888900","https://openalex.org/W2088987414","https://openalex.org/W2089017800","https://openalex.org/W2089267023","https://openalex.org/W2089300560","https://openalex.org/W2089415609","https://openalex.org/W2090416078","https://openalex.org/W2090944650","https://openalex.org/W2091401206","https://openalex.org/W2092356210","https://openalex.org/W2092705799","https://openalex.org/W2092956762","https://openalex.org/W2093846526","https://openalex.org/W2094229819","https://openalex.org/W2094420168","https://openalex.org/W2094720609","https://openalex.org/W2094817063","https://openalex.org/W2095376517","https://openalex.org/W2095499552","https://openalex.org/W2095618848","https://openalex.org/W2095761465","https://openalex.org/W2096289472","https://openalex.org/W2096800294","https://openalex.org/W2097408655","https://openalex.org/W2098381829","https://openalex.org/W2099712752","https://openalex.org/W2100001148","https://openalex.org/W2100007627","https://openalex.org/W2100331658","https://openalex.org/W2100893713","https://openalex.org/W2101103881","https://openalex.org/W2101190248","https://openalex.org/W2101258418","https://openalex.org/W2101341907","https://openalex.org/W2101436523","https://openalex.org/W2101703760","https://openalex.org/W2101794839","https://openalex.org/W2102807020","https://openalex.org/W2102948567","https://openalex.org/W2102978178","https://openalex.org/W2103709409","https://openalex.org/W2104521658","https://openalex.org/W2104823537","https://openalex.org/W2105397433","https://openalex.org/W2106066638","https://openalex.org/W2106595936","https://openalex.org/W2106787323","https://openalex.org/W2107837604","https://openalex.org/W2107937173","https://openalex.org/W2108540197","https://openalex.org/W2108860692","https://openalex.org/W2109850844","https://openalex.org/W2110080952","https://openalex.org/W2110533059","https://openalex.org/W2110886382","https://openalex.org/W2110975050","https://openalex.org/W2111051549","https://openalex.org/W2111843196","https://openalex.org/W2112689533","https://openalex.org/W2113962581","https://openalex.org/W2113999232","https://openalex.org/W2114286587","https://openalex.org/W2114469722","https://openalex.org/W2114809915","https://openalex.org/W2115514778","https://openalex.org/W2116222616","https://openalex.org/W2116541931","https://openalex.org/W2116544030","https://openalex.org/W2116998926","https://openalex.org/W2117169320","https://openalex.org/W2117570501","https://openalex.org/W2118488518","https://openalex.org/W2118495034","https://openalex.org/W2118905557","https://openalex.org/W2120565180","https://openalex.org/W2121103668","https://openalex.org/W2121158863","https://openalex.org/W2121518362","https://openalex.org/W2121518947","https://openalex.org/W2121591078","https://openalex.org/W2121658802","https://openalex.org/W2121940650","https://openalex.org/W2122064720","https://openalex.org/W2122296279","https://openalex.org/W2123002328","https://openalex.org/W2123086846","https://openalex.org/W2124141491","https://openalex.org/W2124421551","https://openalex.org/W2124472115","https://openalex.org/W2125163419","https://openalex.org/W2125496315","https://openalex.org/W2125764173","https://openalex.org/W2125972393","https://openalex.org/W2128297285","https://openalex.org/W2128741716","https://openalex.org/W2128923122","https://openalex.org/W2129292528","https://openalex.org/W2129452239","https://openalex.org/W2129528814","https://openalex.org/W2129800178","https://openalex.org/W2130686586","https://openalex.org/W2132160374","https://openalex.org/W2132528779","https://openalex.org/W2132565257","https://openalex.org/W2132767715","https://openalex.org/W2133577475","https://openalex.org/W2133915213","https://openalex.org/W2134148147","https://openalex.org/W2134235648","https://openalex.org/W2134886965","https://openalex.org/W2135457855","https://openalex.org/W2136285992","https://openalex.org/W2136408887","https://openalex.org/W2136700586","https://openalex.org/W2136709806","https://openalex.org/W2137632843","https://openalex.org/W2138678394","https://openalex.org/W2139308634","https://openalex.org/W2139358465","https://openalex.org/W2139855905","https://openalex.org/W2140053640","https://openalex.org/W2140687262","https://openalex.org/W2141319806","https://openalex.org/W2142072350","https://openalex.org/W2142760163","https://openalex.org/W2142775721","https://openalex.org/W2143186178","https://openalex.org/W2144211817","https://openalex.org/W2144713347","https://openalex.org/W2145881219","https://openalex.org/W2145984530","https://openalex.org/W2146822966","https://openalex.org/W2147010946","https://openalex.org/W2147402201","https://openalex.org/W2147660153","https://openalex.org/W2147852842","https://openalex.org/W2148236046","https://openalex.org/W2148319526","https://openalex.org/W2149247750","https://openalex.org/W2149411563","https://openalex.org/W2150512871","https://openalex.org/W2152561234","https://openalex.org/W2152603020","https://openalex.org/W2153389408","https://openalex.org/W2153549502","https://openalex.org/W2154264549","https://openalex.org/W2154558741","https://openalex.org/W2154738237","https://openalex.org/W2155680682","https://openalex.org/W2155987515","https://openalex.org/W2156585356","https://openalex.org/W2156642861","https://openalex.org/W2156776019","https://openalex.org/W2157043398","https://openalex.org/W2157794801","https://openalex.org/W2158753334","https://openalex.org/W2161637485","https://openalex.org/W2162061149","https://openalex.org/W2162461452","https://openalex.org/W2163087517","https://openalex.org/W2163647723","https://openalex.org/W2163895012","https://openalex.org/W2164442681","https://openalex.org/W2164652278","https://openalex.org/W2165936524","https://openalex.org/W2166228924","https://openalex.org/W2166919355","https://openalex.org/W2167279742","https://openalex.org/W2168080050","https://openalex.org/W2168957586","https://openalex.org/W2169221254","https://openalex.org/W2169385858","https://openalex.org/W2169618540","https://openalex.org/W2170500510","https://openalex.org/W2170641343","https://openalex.org/W2171181912","https://openalex.org/W2171505738","https://openalex.org/W2171626530","https://openalex.org/W2171655721","https://openalex.org/W2171682260","https://openalex.org/W2178799638","https://openalex.org/W2183911534","https://openalex.org/W2184395022","https://openalex.org/W2185762619","https://openalex.org/W2200859417","https://openalex.org/W2238052680","https://openalex.org/W2248254261","https://openalex.org/W2268606640","https://openalex.org/W2295904834","https://openalex.org/W2314106020","https://openalex.org/W2319972791","https://openalex.org/W2330292521","https://openalex.org/W2335679869","https://openalex.org/W2395925941","https://openalex.org/W2397885144","https://openalex.org/W2398956536","https://openalex.org/W2405914516","https://openalex.org/W2408153052","https://openalex.org/W2410556928","https://openalex.org/W2410738105","https://openalex.org/W2413039658","https://openalex.org/W2417667084","https://openalex.org/W2418606207","https://openalex.org/W2419409260","https://openalex.org/W2439585636","https://openalex.org/W2463051663","https://openalex.org/W2471590298","https://openalex.org/W2481932446","https://openalex.org/W2589113752","https://openalex.org/W4231269742","https://openalex.org/W4242861118","https://openalex.org/W4252086282","https://openalex.org/W4252605154","https://openalex.org/W4300606042","https://openalex.org/W4301042653"],"related_works":["https://openalex.org/W2099758666","https://openalex.org/W2094767771","https://openalex.org/W2010007122","https://openalex.org/W7095416763","https://openalex.org/W2042296966","https://openalex.org/W4300606042","https://openalex.org/W7098875741","https://openalex.org/W1927311511","https://openalex.org/W2185224832","https://openalex.org/W1907187946"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,9,39],"(PCa)":[2],"is":[3,28,218,263],"the":[4,42,81,140,215,228,260,275,296],"most":[5],"commonly":[6],"diagnosed":[7],"non-skin":[8],"and":[10,35,61,97,101,116,130,135,183,227,232,310,343],"second":[11],"leading":[12],"cause":[13],"of":[14,17,23,37,47,51,68,80,150,164,174,194,230,234,292,329,346],"cancer-related":[15],"death":[16],"men":[18,222],"in":[19,75,152,221,258,295,301,325],"developed":[20,129,189,272,314],"countries.":[21],"Measurement":[22],"prostate":[24,38],"specific":[25,344,351],"antigen":[26],"(PSA)":[27],"a":[29,111,264,315,322],"very":[30],"sensitive":[31,342],"method":[32,245],"for":[33,148,179,192,290,341,349],"diagnosing":[34],"monitoring":[36],"(PCa),":[40],"but":[41,284],"specificity":[43],"needs":[44],"improvement.":[45],"Measurements":[46],"different":[48],"molecular":[49],"forms":[50],"PSA":[52,122,126,156,293],"have":[53],"been":[54,73],"shown":[55],"to":[56,85,102,119,132,166,176,236,255,273],"improve":[57],"differentiation":[58],"between":[59,181,308],"PCa":[60,182,309],"benign":[62,184],"prostatic":[63,185],"diseases.":[64],"However,":[65],"accurate":[66],"measurement":[67,149,291,345],"some":[69],"isoforms":[70],"has":[71],"not":[72,287,305],"achieved":[74],"previous":[76,212],"assays.":[77,208],"The":[78,158],"aim":[79],"present":[82],"study":[83,331],"was":[84,169,271,286],"develop":[86],"new":[87],"assays":[88,109,144],"that":[89,162,214,333],"reliably":[90],"measure":[91,133,274],"enzymatically":[92,276],"active":[93,277],"PSA,":[94],"PSA-\u03b11-chymotryposin":[95],"(PSA-ACT)":[96],"PSA-\u03b11-protease":[98],"inhibitor":[99],"(PSA-API),":[100],"evaluate":[103],"their":[104],"diagnostic":[105,240],"value.":[106],"Double-label":[107],"immunofluorometric":[108],"using":[110],"novel":[112],"monoclonal":[113],"antibody":[114,118],"(MAb)":[115],"another":[117],"either":[120,244],"free":[121],"(fPSA)":[123],"or":[124,137],"total":[125],"(tPSA)":[127],"were":[128],"used":[131],"PSA-ACT":[134,151,165],"fPSA":[136,175],"tPSA":[138,167,177,237,303],"at":[139],"same":[141],"time.":[142],"These":[143],"provide":[145],"enough":[146,289],"sensitivity":[147,203,285],"sera":[153],"with":[154,206,223,243,336],"low":[155],"levels.":[157],"results":[159,210],"obtained":[160],"confirmed":[161,211],"proportion":[163,173,233],"(%PSA-ACT)":[168],"as":[170,172],"useful":[171,340],"(%fPSA)":[178],"discrimination":[180],"hyperplasia":[186],"(BPH).":[187],"We":[188,312],"an":[190],"immunoassay":[191],"detection":[193],"PSA-API":[195,216,235],"based":[196,248],"on":[197,249],"proximity":[198,317],"ligation,":[199],"which":[200,259,302,320,350],"improved":[201],"assay":[202,269,280],"10-fold":[204,323],"compared":[205,242],"conventional":[207],"Our":[209],"findings":[213],"level":[217],"somewhat":[219],"lower":[220],"than":[224],"without":[225],"PCa,":[226],"combination":[229],"%fPSA":[231],"(%PSA-API)":[238],"provides":[239],"improvement":[241,324],"alone.":[246],"Assays":[247],"this":[250],"principle":[251],"should":[252],"be":[253,354],"applicable":[254],"other":[256],"immunoassays":[257],"nonspecific":[261],"background":[262],"problem.":[265],"An":[266],"immunopeptidometric":[267],"sandwich":[268],"(IPMA)":[270],"PSA.":[278],"This":[279,327],"showed":[281],"high":[282],"specificity,":[283],"good":[288],"concentrations":[294],"gray":[297],"zone,":[298],"2-10":[299],"\u00b5g/L,":[300],"does":[304],"efficiently":[306],"differentiate":[307],"BPH.":[311],"further":[313],"solid-phase":[316],"ligation":[318],"immunoassay,":[319],"provided":[321],"sensitivity.":[326],"proof":[328],"concept":[330],"shows":[332],"peptides":[334],"reacting":[335],"proteins":[337],"are":[338],"potentially":[339],"protein":[347],"variants":[348],"MAbs":[352],"cannot":[353],"obtained.":[355]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}