{"id":"https://openalex.org/W645658629","doi":null,"title":"An\u00e0lisi \u201cex vivo\u201d de mecanismes d\u2019inducci\u00f3 d\u2019apoptosi i resist\u00e8ncia al tractament en gliomes malignes","display_name":"An\u00e0lisi \u201cex vivo\u201d de mecanismes d\u2019inducci\u00f3 d\u2019apoptosi i resist\u00e8ncia al tractament en gliomes malignes","publication_year":2011,"publication_date":"2011-09-14","ids":{"openalex":"https://openalex.org/W645658629","mag":"645658629"},"language":"ca","primary_location":{"id":"pmh:oai:dnet:tdr_________::b8f6fb89b1d92c5da7f0af089e82609f","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/79040","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/34722","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041837392","display_name":"Ruth Villalonga-Planells","orcid":"https://orcid.org/0000-0002-5930-8435","observed_orcids":["https://orcid.org/0000-0002-5930-8435"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ruth Villalonga Planells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041837392"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.2410999983549118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nutlin","display_name":"nutlin","score":0.7070000171661377},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6790000200271606},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7450000047683716},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8230000138282776},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7789999842643738},{"id":"https://openalex.org/keywords/survivin-inhibitor","display_name":"survivin inhibitor","score":0.6660000085830688},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.3580000102519989},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ex-vivo-drug-screening","display_name":"ex vivo drug testing","score":0.4390000104904175},{"id":"https://openalex.org/keywords/glioma-cell-lines","display_name":"glioma cell lines","score":0.41999998688697815},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.42399999499320984},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7160093784332275},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6590207815170288},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.46954116225242615},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.42519891262054443},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39904549717903137},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37112241983413696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17449665069580078},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.1614331603050232},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.09583112597465515},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::b8f6fb89b1d92c5da7f0af089e82609f","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/79040","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/79040","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/79040","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:diposit.ub.edu:2445/34722","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/34722","pdf_url":"http://hdl.handle.net/2445/34722","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:645658629","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/34722/15/02.RVP_2de8.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/34722","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/34722","pdf_url":"http://hdl.handle.net/2445/34722","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W645658629.pdf","grobid_xml":"https://content.openalex.org/works/W645658629.grobid-xml"},"referenced_works_count":223,"referenced_works":["https://openalex.org/W32457357","https://openalex.org/W161836838","https://openalex.org/W338754679","https://openalex.org/W1523325879","https://openalex.org/W1525900448","https://openalex.org/W1544100339","https://openalex.org/W1551156322","https://openalex.org/W1560814177","https://openalex.org/W1578258220","https://openalex.org/W1591281137","https://openalex.org/W1607777232","https://openalex.org/W1650797637","https://openalex.org/W1745634660","https://openalex.org/W1864544636","https://openalex.org/W1918156452","https://openalex.org/W1963786645","https://openalex.org/W1967912613","https://openalex.org/W1968006317","https://openalex.org/W1969070551","https://openalex.org/W1969299292","https://openalex.org/W1971344938","https://openalex.org/W1971576831","https://openalex.org/W1971842120","https://openalex.org/W1972546051","https://openalex.org/W1974058961","https://openalex.org/W1975417521","https://openalex.org/W1976881265","https://openalex.org/W1977044507","https://openalex.org/W1977982272","https://openalex.org/W1978580213","https://openalex.org/W1979177187","https://openalex.org/W1979262539","https://openalex.org/W1979382207","https://openalex.org/W1979618048","https://openalex.org/W1979703188","https://openalex.org/W1980048431","https://openalex.org/W1982695619","https://openalex.org/W1983312081","https://openalex.org/W1984851072","https://openalex.org/W1986718289","https://openalex.org/W1987045589","https://openalex.org/W1987322786","https://openalex.org/W1987396009","https://openalex.org/W1988353983","https://openalex.org/W1989047636","https://openalex.org/W1989648954","https://openalex.org/W1990815825","https://openalex.org/W1992708996","https://openalex.org/W1993059855","https://openalex.org/W1993170641","https://openalex.org/W1994852323","https://openalex.org/W1994901446","https://openalex.org/W1999653222","https://openalex.org/W2001493754","https://openalex.org/W2003463790","https://openalex.org/W2004314923","https://openalex.org/W2004646359","https://openalex.org/W2005142336","https://openalex.org/W2006241446","https://openalex.org/W2007109655","https://openalex.org/W2007369689","https://openalex.org/W2007964976","https://openalex.org/W2008887283","https://openalex.org/W2009183786","https://openalex.org/W2010452001","https://openalex.org/W2010711320","https://openalex.org/W2011590696","https://openalex.org/W2014983456","https://openalex.org/W2016363865","https://openalex.org/W2018671779","https://openalex.org/W2019405732","https://openalex.org/W2019450608","https://openalex.org/W2019750481","https://openalex.org/W2021275669","https://openalex.org/W2022327201","https://openalex.org/W2022431825","https://openalex.org/W2022434488","https://openalex.org/W2022705243","https://openalex.org/W2023486531","https://openalex.org/W2023563217","https://openalex.org/W2025722611","https://openalex.org/W2025747700","https://openalex.org/W2026988411","https://openalex.org/W2027630134","https://openalex.org/W2028282498","https://openalex.org/W2029635647","https://openalex.org/W2030335946","https://openalex.org/W2030828764","https://openalex.org/W2031247754","https://openalex.org/W2031274194","https://openalex.org/W2034042949","https://openalex.org/W2034138274","https://openalex.org/W2035021866","https://openalex.org/W2036044314","https://openalex.org/W2036092325","https://openalex.org/W2036270526","https://openalex.org/W2036368737","https://openalex.org/W2036411709","https://openalex.org/W2036981704","https://openalex.org/W2037249620","https://openalex.org/W2037383080","https://openalex.org/W2037827070","https://openalex.org/W2040827479","https://openalex.org/W2040830294","https://openalex.org/W2042289233","https://openalex.org/W2042740031","https://openalex.org/W2044197183","https://openalex.org/W2044843189","https://openalex.org/W2045389765","https://openalex.org/W2045594601","https://openalex.org/W2046283106","https://openalex.org/W2047242201","https://openalex.org/W2048525179","https://openalex.org/W2050130956","https://openalex.org/W2051193631","https://openalex.org/W2053448633","https://openalex.org/W2053992683","https://openalex.org/W2056155809","https://openalex.org/W2057694525","https://openalex.org/W2058402966","https://openalex.org/W2060469321","https://openalex.org/W2060551076","https://openalex.org/W2062069198","https://openalex.org/W2062219923","https://openalex.org/W2062769503","https://openalex.org/W2063723780","https://openalex.org/W2064214863","https://openalex.org/W2064876412","https://openalex.org/W2065319085","https://openalex.org/W2066571367","https://openalex.org/W2067240980","https://openalex.org/W2068987819","https://openalex.org/W2069060151","https://openalex.org/W2072155586","https://openalex.org/W2075230059","https://openalex.org/W2075581657","https://openalex.org/W2075757507","https://openalex.org/W2078374613","https://openalex.org/W2080838269","https://openalex.org/W2084170466","https://openalex.org/W2084859122","https://openalex.org/W2085539288","https://openalex.org/W2086120407","https://openalex.org/W2087681835","https://openalex.org/W2089412998","https://openalex.org/W2089482729","https://openalex.org/W2090273457","https://openalex.org/W2091436921","https://openalex.org/W2091550554","https://openalex.org/W2093814864","https://openalex.org/W2095014345","https://openalex.org/W2096287682","https://openalex.org/W2097347894","https://openalex.org/W2097447643","https://openalex.org/W2097933346","https://openalex.org/W2099776053","https://openalex.org/W2100067355","https://openalex.org/W2100494757","https://openalex.org/W2102752109","https://openalex.org/W2103744931","https://openalex.org/W2104070387","https://openalex.org/W2104191744","https://openalex.org/W2105035331","https://openalex.org/W2105100844","https://openalex.org/W2105155498","https://openalex.org/W2106675906","https://openalex.org/W2106816824","https://openalex.org/W2108483542","https://openalex.org/W2108973415","https://openalex.org/W2110224130","https://openalex.org/W2110831405","https://openalex.org/W2112725705","https://openalex.org/W2113200003","https://openalex.org/W2115427429","https://openalex.org/W2115862526","https://openalex.org/W2116009473","https://openalex.org/W2119366577","https://openalex.org/W2120132028","https://openalex.org/W2120295238","https://openalex.org/W2120875343","https://openalex.org/W2123151929","https://openalex.org/W2124078079","https://openalex.org/W2126708001","https://openalex.org/W2127423053","https://openalex.org/W2128680272","https://openalex.org/W2129160559","https://openalex.org/W2130926378","https://openalex.org/W2132308700","https://openalex.org/W2132697290","https://openalex.org/W2132834292","https://openalex.org/W2135924782","https://openalex.org/W2139533680","https://openalex.org/W2140204488","https://openalex.org/W2140886363","https://openalex.org/W2143278431","https://openalex.org/W2143546230","https://openalex.org/W2143811153","https://openalex.org/W2143981899","https://openalex.org/W2146226600","https://openalex.org/W2150638747","https://openalex.org/W2151335185","https://openalex.org/W2153558039","https://openalex.org/W2154745425","https://openalex.org/W2157213801","https://openalex.org/W2157824687","https://openalex.org/W2157897307","https://openalex.org/W2161227192","https://openalex.org/W2161959295","https://openalex.org/W2163264715","https://openalex.org/W2163296210","https://openalex.org/W2164385994","https://openalex.org/W2164601967","https://openalex.org/W2165553904","https://openalex.org/W2167270041","https://openalex.org/W2167494923","https://openalex.org/W2168331385","https://openalex.org/W2170785948","https://openalex.org/W2172124462","https://openalex.org/W2318266513","https://openalex.org/W2337401423","https://openalex.org/W2408889139","https://openalex.org/W2442446063","https://openalex.org/W2750896950"],"related_works":["https://openalex.org/W2018049759","https://openalex.org/W7048216211","https://openalex.org/W1647600428","https://openalex.org/W6983539030","https://openalex.org/W2077688007","https://openalex.org/W2381784874","https://openalex.org/W7026961612","https://openalex.org/W1646674788","https://openalex.org/W2407459131","https://openalex.org/W2608773984"],"abstract_inverted_index":{"El":[0,212,425],"glioblastoma":[1,58,70,87,149,254,352,475],"multiforme":[2,59,88,255],"\u00e9s":[3,154,267],"una":[4,99,235,257,268,321,364,460],"de":[5,10,42,45,49,54,66,69,86,94,105,116,123,126,132,136,142,148,156,159,169,203,210,229,231,241,251,265,272,289,291,328,335,342,351,366,381,388,393,406,420,430,439,441,445,448,455],"les":[6,185,385,394],"neopl\u00e0sies":[7],"m\u00e9s":[8,62,168,317],"agressives":[9],"l\u2019adult,":[11],"malgrat":[12],"els":[13,52,80],"esfor\u00e7os":[14],"realitzats":[15],"en":[16,39,56,79,175,248,303,314,344,383,403,412,416,436,472],"millorar":[17],"el":[18,57,119,183,249,359,404,437],"seu":[19,110,296],"tractament,":[20],"la":[21,40,103,106,124,129,133,152,208,217,222,227,273,304,329,336,367,421,431,449,453,456,467,470],"superviv\u00e8ncia":[22,323],"dels":[23,35,73,306,378],"pacients":[24,252,473],"continua":[25],"sent":[26],"dolenta.":[27],"L\u2019objectiu":[28],"global":[29],"d\u2019aquesta":[30],"tesi":[31,337],"ha":[32,63],"estat":[33],"l\u2019estudi":[34],"mecanismes":[36],"moleculars":[37],"implicats":[38],"inducci\u00f3":[41,372],"mort,":[43],"parada":[44,158],"cicle":[46,160,407],"pels":[47],"inhibidors":[48,53,230],"MDM2":[50,95,112,232],"i":[51,83,128,145,165,188,324,347,397],"survivina":[55,292,299,309,382],"hum\u00e0,":[60],"a":[61,113,167,201,316,469],"perm\u00e8s":[64],"l\u2019establiment":[65],"cultius":[67,81,143,189,399],"primaris":[68,82,144,190],"hum\u00e0.":[71,89,353],"L\u2019efecte":[72],"compostos":[74],"s\u2019ha":[75],"estudiat":[76],"ex":[77],"vivo":[78],"l\u00ednies":[84,146,186,345,386,395],"cel\u2022lulars":[85,147,187,346,387,396],"Les":[90],"Nutlines":[91],"s\u00f3n":[92,196],"antagonistes":[93],"que":[96,151,226,358,374,452,464],"actuen,":[97],"amb":[98,173,178,191,214,246,253,256,320,325,361,427,474],"gran":[100],"especificitat,":[101],"despla\u00e7ant":[102],"uni\u00f3":[104],"prote\u00efna":[107,258,274],"p53":[108,127,180,193,259],"del":[109,140,295,398],"inhibidor":[111],"un":[114,179,192,282,326,348,434],"rang":[115],"dosi":[117],"nanomolar,":[118],"qual":[120],"comporta":[121],"l\u2019estabilitzaci\u00f3":[122],"mol\u00e8cula":[125,270],"posterior":[130],"activaci\u00f3":[131],"seva":[134],"via":[135,209],"senyalitzaci\u00f3.":[137],"Els":[138,354,443],"resultats":[139,355,444],"tractament":[141,199,250,360],"demostren":[150],"Nultina-3a":[153],"capa\u00e7":[155],"induir":[157,170],"cel\u2022lular":[161,219,423],"(p21),":[162],"apoptosi":[163],"(Noxa":[164],"Puma),":[166],"senesc\u00e8ncia":[171],"(marcatge":[172],"SA-\u03b2Gal)":[174],"aquelles":[176],"c\u00e8l\u2022lules":[177,205],"funcional.":[181,260],"Per":[182],"contrari,":[184],"no":[194],"funcional,":[195],"resistents":[197],"al":[198],"degut":[200],"l\u2019incapacitat":[202],"aquestes":[204],"per":[206,293],"activar":[207],"p53.":[211],"pretractament":[213,426],"Nutlina-3a":[215],"sensibilitza":[216],"l\u00ednia":[218,422],"U87-MG":[220],"enfront":[221],"radioter\u00e0pia.":[223],"Aix\u00f2":[224],"suggereix":[225],"utilitzaci\u00f3":[228],"podria":[233,458],"ser":[234,279,459],"nova":[236,461],"estrat\u00e8gia":[237],"terap\u00e8utica,":[238],"ja":[239],"sigui":[240],"forma":[242],"individual":[243],"o":[244,415],"combinada":[245],"radioter\u00e0pia":[247,432,471],"YM155":[261,277,343,362,428],"(1-(2-metoxietil)-2-metil-4,9-dioxo-3-(piracina-2":[262],"ymetil)-4,9-dihidro-1H-nafto[2,3-d":[263],"]bromuro":[264],"imidazolium),":[266],"petita":[269],"inhibidora":[271],"antiapopt\u00f2tica":[275],"Survivina.":[276],"va":[278,339],"seleccionat":[280],"mitjan\u00e7ant":[281],"cribratge":[283],"d\u2019alt":[284],"rendiment":[285],"com":[286,371],"supressor":[287],"espec\u00edfic":[288],"l'expressi\u00f3":[290],"inhibici\u00f3":[294,454],"promotor.":[297],"La":[298,308,391],"es":[300,310,338],"troba":[301,311],"sobreexpressada":[302],"majoria":[305],"tumors.":[307],"altament":[312],"expressada":[313],"gliomes":[315],"est\u00e0":[318],"associada":[319],"menor":[322],"augment":[327,435],"recurr\u00e8ncia":[330],"tumoral.":[331],"En":[332],"aquest":[333,446],"apartat":[334,447],"estudiar":[340],"l\u2019efecte":[341],"cultiu":[349],"primari":[350,400],"obtinguts":[356],"mostren":[357],"provoca":[363],"disminuci\u00f3":[365,377],"viabilitat":[368],"cel\u2022lular,":[369,408],"aix\u00ed":[370],"d\u2019apoptosi,":[373],"s\u2019acompanya":[375],"d\u2019una":[376],"nivells":[379],"proteics":[380],"totes":[384],"glioma":[389],"avaluades.":[390],"incubaci\u00f3":[392],"mostra":[401],"canvis":[402],"patr\u00f3":[405],"provocant":[409],"aturada":[410],"tant":[411],"fase":[413,417],"G0/G1":[414],"S":[418],"depenent":[419],"avaluada.":[424],"abans":[429],"indueix":[433],"nombre":[438],"focus":[440],"\u03b3-H2AX.":[442],"tesis":[450],"suggereixen":[451],"Survivina":[457],"eina":[462],"terap\u00e8utica":[463],"permetria":[465],"augmentar":[466],"sensibilitat":[468],"multiforme.":[476]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}