{"id":"https://openalex.org/W645107986","doi":null,"title":"Polimorfismos do gene da adiponectina e vari\u00e1veis cl\u00ednicas, metab\u00f3licas e hormonais em mulheres com ou sem a s\u00edndrome dos ov\u00e1rios polic\u00edsticos (PCOS) e investiga\u00e7\u00e3o de um modelo animal para o estudo da PCOS","display_name":"Polimorfismos do gene da adiponectina e vari\u00e1veis cl\u00ednicas, metab\u00f3licas e hormonais em mulheres com ou sem a s\u00edndrome dos ov\u00e1rios polic\u00edsticos (PCOS) e investiga\u00e7\u00e3o de um modelo animal para o estudo da PCOS","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W645107986","mag":"645107986"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3182316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/25530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/25530","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073367570","display_name":"Simone Radavelli\u2010Bagatini","orcid":"https://orcid.org/0000-0001-6821-5217","observed_orcids":["https://orcid.org/0000-0001-6821-5217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Simone Radavelli\u2010Bagatini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6821-5217","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073367570"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adiponectin-gene-polymorphism","display_name":"adiponectin gene polymorphism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8539999723434448},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.6209999918937683},{"id":"https://openalex.org/keywords/obesity-related-comorbidities","display_name":"obesity-related comorbidities","score":0.753000020980835},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.7319999933242798},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6470000147819519},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/insl3","display_name":"INSL3","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3719719350337982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36377978324890137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36355066299438477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3359692692756653},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32899749279022217}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3182316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/25530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/25530","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/25530","pdf_url":"http://hdl.handle.net/10183/25530","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/25530","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/25530","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tese"},{"id":"mag:645107986","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/handle/10183/25530","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3182316","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/25530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W645107986.pdf","grobid_xml":"https://content.openalex.org/works/W645107986.grobid-xml"},"referenced_works_count":130,"referenced_works":["https://openalex.org/W274870157","https://openalex.org/W1512219751","https://openalex.org/W1524321743","https://openalex.org/W1587875569","https://openalex.org/W1968441810","https://openalex.org/W1969062482","https://openalex.org/W1973015402","https://openalex.org/W1973767865","https://openalex.org/W1975139296","https://openalex.org/W1976792873","https://openalex.org/W1977014295","https://openalex.org/W1978110386","https://openalex.org/W1980386342","https://openalex.org/W1981212119","https://openalex.org/W1981261500","https://openalex.org/W1984067141","https://openalex.org/W1987097625","https://openalex.org/W1989426622","https://openalex.org/W1989790361","https://openalex.org/W1991217537","https://openalex.org/W1991756333","https://openalex.org/W1991802772","https://openalex.org/W1996460442","https://openalex.org/W1998136513","https://openalex.org/W2001727439","https://openalex.org/W2004297889","https://openalex.org/W2007536509","https://openalex.org/W2007816906","https://openalex.org/W2008745028","https://openalex.org/W2009687204","https://openalex.org/W2012441815","https://openalex.org/W2014887370","https://openalex.org/W2017528217","https://openalex.org/W2024077295","https://openalex.org/W2025161277","https://openalex.org/W2027323593","https://openalex.org/W2031636230","https://openalex.org/W2035268417","https://openalex.org/W2036638698","https://openalex.org/W2036767439","https://openalex.org/W2037195862","https://openalex.org/W2037342776","https://openalex.org/W2037933947","https://openalex.org/W2038553345","https://openalex.org/W2039840029","https://openalex.org/W2042706232","https://openalex.org/W2042795018","https://openalex.org/W2043602778","https://openalex.org/W2044330243","https://openalex.org/W2044970382","https://openalex.org/W2048189375","https://openalex.org/W2048434957","https://openalex.org/W2050183502","https://openalex.org/W2050593976","https://openalex.org/W2050860606","https://openalex.org/W2050905678","https://openalex.org/W2051051060","https://openalex.org/W2052777370","https://openalex.org/W2053135489","https://openalex.org/W2054098071","https://openalex.org/W2055441713","https://openalex.org/W2058836224","https://openalex.org/W2059582640","https://openalex.org/W2060860924","https://openalex.org/W2061628881","https://openalex.org/W2065697164","https://openalex.org/W2067880100","https://openalex.org/W2069497802","https://openalex.org/W2069811362","https://openalex.org/W2073492807","https://openalex.org/W2073680003","https://openalex.org/W2078009607","https://openalex.org/W2088868617","https://openalex.org/W2091759162","https://openalex.org/W2092224577","https://openalex.org/W2097060572","https://openalex.org/W2100211815","https://openalex.org/W2101455689","https://openalex.org/W2102610155","https://openalex.org/W2106550052","https://openalex.org/W2107308379","https://openalex.org/W2107398359","https://openalex.org/W2108365489","https://openalex.org/W2108931588","https://openalex.org/W2109676898","https://openalex.org/W2114250093","https://openalex.org/W2116404316","https://openalex.org/W2118094114","https://openalex.org/W2120067353","https://openalex.org/W2120462461","https://openalex.org/W2121081996","https://openalex.org/W2121421463","https://openalex.org/W2122321060","https://openalex.org/W2123609879","https://openalex.org/W2124620553","https://openalex.org/W2125538252","https://openalex.org/W2126380783","https://openalex.org/W2127934772","https://openalex.org/W2129639179","https://openalex.org/W2129769597","https://openalex.org/W2129984638","https://openalex.org/W2130670158","https://openalex.org/W2131644715","https://openalex.org/W2132082799","https://openalex.org/W2134524309","https://openalex.org/W2135073334","https://openalex.org/W2136011008","https://openalex.org/W2138104224","https://openalex.org/W2143480465","https://openalex.org/W2147921895","https://openalex.org/W2149183746","https://openalex.org/W2152058698","https://openalex.org/W2152070401","https://openalex.org/W2155119234","https://openalex.org/W2157268169","https://openalex.org/W2159451281","https://openalex.org/W2160078415","https://openalex.org/W2161739242","https://openalex.org/W2162459586","https://openalex.org/W2162896364","https://openalex.org/W2163137121","https://openalex.org/W2168696616","https://openalex.org/W2186218348","https://openalex.org/W2324024668","https://openalex.org/W2394635838","https://openalex.org/W2399543664","https://openalex.org/W2409422761","https://openalex.org/W2626017884","https://openalex.org/W3025167876","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2130046556","https://openalex.org/W274870157","https://openalex.org/W7095868068","https://openalex.org/W2152058698","https://openalex.org/W2120898684","https://openalex.org/W2125538252","https://openalex.org/W7099567623","https://openalex.org/W2024077295","https://openalex.org/W4405920695","https://openalex.org/W4236211012"],"abstract_inverted_index":{"A":[0,28,106,233,405],"S\u00edndrome":[1],"dos":[2,235,269,350,407,674],"Ov\u00e1rios":[3],"Polic\u00edsticos":[4],"(PCOS)":[5],"\u00e9":[6],"uma":[7,18,524],"endocrinopatia":[8],"freq\u00fcente":[9,311,339],"em":[10,12,93,133,206,216,282,312,340,357,386,391,420,432,479,514,556,612,617,630,728],"mulheres":[11,95,188,217,241,283,313,341,421,433],"idade":[13],"reprodutiva,":[14],"sendo":[15,302],"caracterizada":[16],"por":[17,111,713],"variedade":[19],"de":[20,63,82,175,204,223,245,256,276,287,322,375,394,443,456,466,472,481,526,539,609,614,626,635,643,650,676,700,707,722,726,735,755],"manifesta\u00e7\u00f5es":[21],"cl\u00ednicas,":[22,509],"incluindo":[23],"resist\u00eancia":[24,598],"\u00e0":[25,35,85,300,645,648],"insulina":[26,36,205,680],"(RI).":[27],"adiponectina":[29,70,491],"est\u00e1":[30],"associada":[31],"com":[32,47,96,147,189,218,242,284,314,342,388,422,495,558,597,719,762],"a":[33,78,221,267,326,371,435,441,464,470,496,561,660,687,759],"sensibilidade":[34],"e":[37,75,77,91,98,114,121,127,131,143,162,171,180,196,210,220,252,273,279,286,290,382,390,401,417,424,429,450,468,498,512,542,606,625,629,639,647,679,703,717,724,743],"as":[38,154,348,580,593,665,730,740],"variantes":[39],"do":[40,67,104,152,156,228,237,307,409,488],"gene":[41,68,489],"desta":[42],"adipocina":[43],"podem":[44],"estar":[45],"envolvidas":[46],"aspectos":[48,601],"fisiopatol\u00f3gicos":[49],"da":[50,69,101,139,364,485,490,574,585,603,621,745],"RI.":[51],"No":[52],"estudo":[53,520,573,590],"1,":[54],"o":[55,264,303,331,334,368,447,451,459,519,572],"objetivo":[56],"foi":[57,109,244,255,275,374,393,412,522],"verificar":[58],"poss\u00edveis":[59],"associa\u00e7\u00f5es":[60],"entre":[61,504],"polimorfismos":[62,363],"nucleot\u00eddeos":[64],"\u00fanicos":[65],"(SNPs)":[66],"(SNPs":[71],"G276T,":[72,122],"T45G,":[73],"C11377G":[74,142,370,449],"G11391A)":[76],"composi\u00e7\u00e3o":[79],"corporal,":[80],"presen\u00e7a":[81,442,465],"comorbidades":[83],"relacionadas":[84,596],"obesidade,":[86,540],"bem":[87,191,683],"como":[88,192,454,684],"perfil":[89],"hormonal":[90],"metab\u00f3lico,":[92],"80":[94],"PCOS":[97,148,219,243,315,343,746],"37":[99],"controles":[100,200,231,254,392],"regi\u00e3o":[102,140,365,486],"sul":[103],"Brasil.":[105],"an\u00e1lise":[107,661],"genot\u00edpica":[108,373],"avaliada":[110],"PCR":[112,132],"convencional":[113],"digest\u00e3o":[115],"enzim\u00e1tica":[116],"para":[117,136,177,240,253,330,367,377,380,384,396,399,403,446,571,652,659],"os":[118,137,296,476,505,516,600,607],"SNPs":[119,138,297,351,477,484],"T45G":[120,266,333],"localizados":[123],"no":[124,695],"\u00e9xon":[125],"2":[126],"\u00edntron":[128],"2,":[129,521],"respectivamente,":[130,281,292],"tempo":[134],"real":[135],"promotora,":[141,366],"G11391A.":[144],"As":[145,544,633],"pacientes":[146,387,557],"eram":[149],"mais":[150,185,338,705],"jovens":[151],"que":[153,229,329,563,576,733],"participantes":[155],"grupo":[157],"controle":[158],"(21,30":[159],"\u00b1":[160,164],"6,01":[161],"29,86":[163],"5,15":[165],"anos,":[166],"p=0,0001).":[167],"Press\u00e3o":[168],"arterial":[169],"sist\u00f3lica":[170],"diast\u00f3lica":[172],"(p<0,03),":[173],"escore":[174],"Ferriman":[176],"hirsutismo":[178],"(p=0,0001)":[179],"rela\u00e7\u00e3o":[181,361,729],"cintura/quadril":[182],"(p=0,002)":[183],"foram":[184,212,298,352,591,637,657],"elevados":[186,706],"nas":[187,230,293,507],"PCOS,":[190,285,301,389,497,559],"triglicer\u00eddeos,":[193],"colesterol":[194],"total":[195],"LDLc":[197],"comparado":[198,325,686],"\u00e0s":[199,354,554],"(p<0,02).":[201],"Os":[202,483,587,655],"n\u00edveis":[203,608,675,720],"jejum,":[207],"HOMA,":[208],"testosterona":[209],"IAL":[211],"tamb\u00e9m":[213,547,692],"significativamente":[214,226],"maiores":[215],"concentra\u00e7\u00e3o":[222],"SHBG":[224],"mostrou-se":[225,337],"menor":[227,698],"(p=0,0001).":[232],"freq\u00fc\u00eancia":[234,268,372,406],"gen\u00f3tipos":[236,270,408,444,506],"SNP":[238,265,308,332,369,410,448,460],"G276T":[239,309],"52,6%":[246],"G/G,":[247,258],"33,3%":[248],"G/T,":[249,260],"14,1%":[250],"T/T":[251],"27%":[257],"62,2%":[259],"10,8%":[261],"T/T.":[262],"Para":[263,458,518],"T/T,":[271],"T/G":[272],"G/G":[274,385,413,425,469],"79,5%,":[277],"17,9%":[278],"2,6%,":[280],"62,2%,":[288],"37,8%":[289],"0%,":[291],"controles.":[294,632,688],"Ambos":[295],"associados":[299,718],"gen\u00f3tipo":[304,335,452],"polim\u00f3rfico":[305],"G/T+T/T":[306],"menos":[310],"(p=0,010;":[316],"Odds":[317],"ratio:":[318],"2,992;":[319],"95%":[320],"Intervalo":[321],"Confian\u00e7a:":[323],"1,278-7,006)":[324],"controles,":[327],"enquanto":[328],"selvagem":[336],"(p=0,048).":[344],"Na":[345],"amostra":[346],"estudada":[347],"freq\u00fc\u00eancias":[349,355],"similares":[353,553],"observadas":[356,555],"outras":[358],"popula\u00e7\u00f5es.":[359],"Em":[360],"aos":[362],"52,2%":[376],"C/C,":[378,397],"36,2%":[379],"C/G":[381,400],"11,6%":[383],"64,9%":[395],"32,4":[398],"2,7%":[402],"G/G.":[404],"G11391A":[411,461],"89%,":[414],"G/A":[415,427],"9,6%":[416],"A/A":[418,430],"1,4%":[419],"PCOS;":[423],"75,7%,":[426],"24,3%":[428],"0%":[431],"sem":[434],"s\u00edndrome.":[436],"Foram":[437],"consideradas":[438],"altera\u00e7\u00f5es":[439,594,760],"polim\u00f3rficas":[440],"C/G+G/G":[445],"C/C":[453],"aus\u00eancia":[455,471],"polimorfismo.":[457],"considerou-se":[462],"G/A+A/A":[463],"polimorfismo":[467],"altera\u00e7\u00e3o":[473],"polim\u00f3rfica.":[474],"Todos":[475],"est\u00e3o":[478],"equil\u00edbrio":[480],"Hardy-Weinberg.":[482],"promotora":[487],"n\u00e3o":[492,499],"mostraram":[493],"associa\u00e7\u00e3o":[494],"houve":[500],"diferen\u00e7a":[501],"estatisticamente":[502],"significativa":[503],"vari\u00e1veis":[508],"antropom\u00e9tricas,":[510],"metab\u00f3licas":[511,584,595,761],"hormonais":[513],"ambos":[515],"grupos.":[517],"utilizada":[523],"linhagem":[525],"camundongos":[527,565,615,636,736],"obesos":[528,737],"Neo-Zelandeses":[529],"(New":[530],"Zealand":[531],"Obese":[532],"mouse":[533],"ou":[534],"NZO":[535,667,690],"mouse),":[536],"modelo":[537,569,751],"polig\u00eanico":[538],"RI":[541],"hiperinsulinemia.":[543],"f\u00eameas":[545,613,634,666,734],"apresentam":[546],"fertilidade":[548],"reduzida.":[549],"Por":[550],"apresentarem":[551],"caracter\u00edsticas":[552,581],"estabeleceu-se":[560],"hip\u00f3tese":[562],"estes":[564],"poderiam":[566],"ser":[567,749],"um":[568,693,750],"promissor":[570],"s\u00edndrome,":[575],"pudesse":[577],"expressar":[578],"tanto":[579],"reprodutivas":[582],"quanto":[583],"PCOS.":[586],"objetivos":[588],"deste":[589],"caracterizar":[592],"insul\u00ednica,":[599],"morfol\u00f3gicos":[602],"estrutura":[604],"ovariana":[605,742],"horm\u00f4nios":[610],"reprodutivos":[611],"obesos,":[616],"tr\u00eas":[618],"diferentes":[619],"etapas":[620],"vida:":[622],"jovens,":[623],"adultos":[624],"meia":[627],"idade,":[628],"animais":[631],"pesadas":[638],"submetidas":[640],"ao":[641],"teste":[642],"toler\u00e2ncia":[644],"insulina,":[646],"coleta":[649],"sangue":[651],"dosagens":[653],"hormonais.":[654],"ov\u00e1rios":[656],"removidos":[658],"histol\u00f3gica.":[662],"Como":[663],"esperado,":[664],"apresentaram":[668,738],"maior":[669],"peso":[670],"corporal":[671],"(p=0,001),":[672],"aumento":[673,694],"glicose":[677],"(p=0,007)":[678],"(p=0,001)":[681],"basais,":[682],"RI,":[685],"Nas":[689],"observou-se":[691],"volume":[696],"ovariano,":[697],"n\u00famero":[699,704],"corpus":[701],"l\u00fateos":[702],"fol\u00edculos":[708,714],"totais":[709],"(p=0,0001),":[710],"representados":[711],"principalmente":[712],"atr\u00e9sicos":[715],"(p=0,03),":[716],"diminu\u00eddos":[721],"LH":[723],"aumentados":[725],"Estradiol,":[727],"controle.":[731],"Conclu\u00edmos":[732],"ambas":[739],"caracter\u00edsticas,":[741],"metab\u00f3lica":[744],"humana,":[747],"sugerindo":[748],"adequado":[752],"na":[753],"investiga\u00e7\u00e3o":[754],"mecanismos":[756],"patofisiol\u00f3gicos":[757],"ligados":[758],"anormalidades":[763],"reprodutivas.":[764]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}