{"id":"https://openalex.org/W643826193","doi":"https://doi.org/10.1007/978-3-642-84842-1","title":"Gene Transfer and Therapy in the Nervous System","display_name":"Gene Transfer and Therapy in the Nervous System","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W643826193","doi":"https://doi.org/10.1007/978-3-642-84842-1","mag":"643826193"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-84842-1","doi":"https://doi.org/10.1007/978-3-642-84842-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-84842-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210183285","display_name":"Research and perspectives in neurosciences","issn_l":"0945-6082","issn":["0945-6082","2196-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Neurosciences","raw_type":"book"},"volume":null,"type":"book","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["Department of Neurosciences, The University of California, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, The University of California, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072604776","display_name":"Yves Christen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Christen","raw_affiliation_strings":["Fondation IPSEN pour la Recherche Th\u00e9rapeutique, Paris Cedex 15, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondation IPSEN pour la Recherche Th\u00e9rapeutique, Paris Cedex 15, France","institution_ids":["https://openalex.org/I183367347"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0011,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90740741,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nervous-system","display_name":"nervous system","score":0.9470000267028809},{"id":"https://openalex.org/keywords/somatic-gene-therapy","display_name":"somatic gene therapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/genetically-modified-cells","display_name":"genetically modified cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/neural-transplantation","display_name":"neural transplantation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.8690000176429749},{"id":"https://openalex.org/keywords/optic-tectum","display_name":"optic tectum","score":0.9100000262260437},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuronal-stem-cells","display_name":"neuronal stem cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/clonal-cell-lines","display_name":"clonal cell lines","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/herpes-simplex-virus-vectors","display_name":"herpes simplex virus vectors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dystrophin","display_name":"dystrophin","score":0.925000011920929},{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neurotrophin-receptors","display_name":"neurotrophin receptors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.7122519016265869},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.557251513004303},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5102229118347168},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41673150658607483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3946157693862915},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3401445746421814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3278177082538605},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30217063426971436}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-84842-1","doi":"https://doi.org/10.1007/978-3-642-84842-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-84842-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210183285","display_name":"Research and perspectives in neurosciences","issn_l":"0945-6082","issn":["0945-6082","2196-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Perspectives in Neurosciences","raw_type":"book"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974871382","https://openalex.org/W1973269732","https://openalex.org/W572236432","https://openalex.org/W1974458701","https://openalex.org/W7207062506","https://openalex.org/W4212909128","https://openalex.org/W1003759371","https://openalex.org/W2233655172","https://openalex.org/W2419132606","https://openalex.org/W2762566123"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}