{"id":"https://openalex.org/W643445994","doi":null,"title":"Regulation of skeletal myogenesis by the mTOR signaling network","display_name":"Regulation of skeletal myogenesis by the mTOR signaling network","publication_year":2012,"publication_date":"2012-06-27","ids":{"openalex":"https://openalex.org/W643445994","mag":"643445994"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/32047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32047","pdf_url":"https://www.ideals.illinois.edu/items/32312/bitstreams/105919/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/32312/bitstreams/105919/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072319588","display_name":"Yejing Ge","orcid":"https://orcid.org/0000-0002-2555-7900","observed_orcids":["https://orcid.org/0000-0002-2555-7900"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yejing Ge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2555-7900","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072319588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03206342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-myogenesis","display_name":"skeletal myogenesis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/muscle-stem-cells","display_name":"muscle stem cells","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.7932025194168091},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6202910542488098},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5436457991600037},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42355093359947205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3353024125099182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31475257873535156},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15858596563339233}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/32047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32047","pdf_url":"https://www.ideals.illinois.edu/items/32312/bitstreams/105919/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:643445994","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/32047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/32047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32047","pdf_url":"https://www.ideals.illinois.edu/items/32312/bitstreams/105919/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W643445994.pdf","grobid_xml":"https://content.openalex.org/works/W643445994.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087089750","https://openalex.org/W2046323838","https://openalex.org/W1997642684","https://openalex.org/W7096172649","https://openalex.org/W281681086","https://openalex.org/W2795522992","https://openalex.org/W2163681072","https://openalex.org/W2017724192","https://openalex.org/W2008665411","https://openalex.org/W4308866743"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,37,41,158,228,279,369,381,460,677,700],"is":[2,82,114,197,284,314,327,513,575,619,642,714,803,839],"composed":[3],"of":[4,35,60,98,105,111,123,130,141,156,177,199,234,244,257,262,300,306,310,349,359,363,392,406,412,415,433,445,476,485,529,539,548,571,597,615,625,630,683,708,725,728,736,754,773,788,843,847,869,879,897,914,940],"post-mitotic":[5],"multinucleated":[6,28],"myofibers.":[7,29,55],"During":[8],"embryonic":[9],"skeletal":[10,36,61,131,157,264,407,477,549,587,676,887],"myogenesis,":[11,408,449,478,771],"cells":[12],"in":[13,45,64,95,208,217,281,303,331,339,352,367,457,462,487,521,524,554,561,580,584,621,628,673,679,699,711,733,770,828,872,886,890],"somites":[14],"commit":[15],"to":[16,26,47,52,164,185,211,240,329,337,901,920],"myogenic":[17,80,142,215,417,436,712,748,845,858,905],"lineage":[18],"and":[19,33,50,68,74,88,102,125,160,239,250,271,342,385,396,419,431,450,459,482,490,523,583,617,632,658,661,675,694,703,731,814,849,875,916,927,955],"differentiate":[20,49],"into":[21],"myoblasts,":[22,174],"which":[23,44,326,534,622],"then":[24],"fuse":[25,51],"form":[27,53],"Post-natal":[30],"growth,":[31,398,702],"repair,":[32],"maintenance":[34],"are":[38,918],"dependent":[39,387],"on":[40,147,820],"satellite":[42],"cells,":[43],"response":[46],"stimuli":[48],"new":[54],"Developmental":[56],"or":[57,775,800,833,923],"post-natal":[58],"failure":[59],"myogenesis":[62],"results":[63,276,366,465,627],"diverse":[65],"muscular":[66],"dystrophies":[67],"atrophies,":[69],"largely":[70],"impairing":[71],"life":[72],"quality":[73],"sometimes":[75],"directly":[76],"causing":[77],"death.":[78],"The":[79,108,681],"process":[81],"guided":[83],"by":[84,90,152,167,286,316,516,533,577,605,798,805,831,860],"various":[85],"environmental":[86],"cues":[87],"regulated":[89,576],"distinct":[91,192,912],"signaling":[92,149,519,689,871,884],"pathways,":[93],"resulting":[94],"the":[96,139,148,168,175,232,242,260,290,297,304,311,390,413,416,429,443,467,495,537,546,562,643,684,706,723,726,734,752,781,794,826,844,853,867,877,895,949],"activation":[97],"specific":[99],"transcription":[100,596],"factors":[101],"subsequent":[103,633],"reprogramming":[104],"gene":[106],"expression.":[107,288,503],"mammalian":[109],"target":[110,176,362,484],"rapamycin":[112,178,225,330,338],"(mTOR)":[113],"a":[115,120,145,353,361,434,473,480,498,527,530,542,557,611,764,840],"Ser/Thr":[116],"kinase":[117,201],"that":[118,196,224,278,442,451,510,569,592,640,666,742,837,933,952],"controls":[119,594],"wide":[121],"spectrum":[122],"cellular":[124],"developmental":[126],"processes":[127,155,951],"including":[128,194,691],"regulation":[129,348],"myogenesis.":[132,550,888,937],"In":[133,172,219,289,424,504,551,648,718,851],"my":[134],"dissertation":[135],"work,":[136],"I":[137,222,247,427,440,506,567,721,740,893],"investigate":[138],"mechanisms":[140,216,388],"regulation,":[143],"with":[144,236,346,556,763],"focus":[146],"network":[150],"assembled":[151],"mTOR.":[153,274],"Various":[154],"differentiation":[159,187,456,672,713,735,749,796,829,859,926],"remodeling":[161],"were":[162],"known":[163],"be":[165],"inhibited":[166],"mTOR-specific":[169],"inhibitor,":[170],"rapamycin.":[171,317],"cultured":[173],"\u2013":[179,181,268,438,541],"mTOR":[180,200,214,235,245,258,347,364,379,518,535,578,593,616,657,686,744,870,881],"had":[182,205,696],"been":[183,206,697],"reported":[184],"regulate":[186,936],"at":[188,389],"different":[189],"stages":[190,391],"through":[191,383,599],"mechanisms,":[193],"one":[195],"independent":[198],"activity.":[202],"However,":[203,705],"there":[204],"no":[207],"vivo":[209],"evidence":[210,238,508,637],"validate":[212,231],"those":[213,709],"vitro.":[218],"Chapter":[220,425,552,719],"II,":[221],"show":[223,277],"impairs":[226,747],"injury-induced":[227],"regeneration.":[229,377],"To":[230],"role":[233,707,766],"genetic":[237],"probe":[241],"mechanism":[243,500,532,885],"function,":[246],"have":[248,401,590],"generated":[249],"characterized":[251],"transgenic":[252],"mice":[253,283],"expressing":[254],"two":[255],"mutants":[256],"under":[259],"control":[261],"human":[263],"actin":[265],"(HSA)":[266],"promoter":[267],"rapamycin-resistant":[269],"(RR)":[270],"RR/kinase-inactive":[272],"(RR/KI)":[273],"My":[275,464],"regeneration":[280,301,382,461,678],"rapamycin-administered":[282],"restored":[285],"RR-mTOR":[287],"RR/KI-mTOR":[291,343],"mice,":[292],"nascent":[293,373,393],"myofiber":[294,374,394,397],"formation":[295,375,395],"during":[296,323,376,448,670],"early":[298,324],"phase":[299],"proceeds":[302],"presence":[305],"rapamycin,":[307],"but":[308,334,371,409],"growth":[309,370,469],"regenerating":[312,491,586],"myofibers":[313],"blocked":[315],"Igf2":[318,350],"mRNA":[319],"levels":[320,444],"increase":[321],"drastically":[322],"regeneration,":[325],"sensitive":[328],"WT":[332],"muscles":[333],"partially":[335],"resistant":[336],"both":[340,488,520,579],"RR-":[341],"muscles,":[344,492],"consistent":[345],"expression":[351,570],"kinase-independent":[354,384,517],"manner.":[355],"Furthermore,":[356],"systemic":[357],"ablation":[358],"S6K1,":[360,693,730],"kinase,":[365],"impaired":[368],"normal":[372],"Therefore,":[378],"regulates":[380,536,667,857],"kinaseiii":[386],"respectively.":[399],"MicroRNAs":[400],"emerged":[402],"as":[403,479,526,750,756,758],"key":[404],"regulators":[405,906],"our":[410],"knowledge":[411],"identity":[414],"miRNAs":[418],"their":[420,957],"targets":[421],"remains":[422],"limited.":[423],"III,":[426],"describe":[428],"identification":[430],"characterization":[432,939],"novel":[435,880,904],"microRNA":[437,499,659],"miR-125b.":[439],"find":[441,568,741],"miR-125b":[446,452,486,511],"decline":[447],"negatively":[453,514,856],"modulates":[454],"myoblast":[455,671,925],"culture":[458],"mice.":[463],"identify":[466,662],"insulin-like":[468],"factor":[470],"2":[471],"(Igf2),":[472],"critical":[474,841],"regulator":[475],"direct":[481],"major":[483],"myocytes":[489],"revealing":[493],"for":[494,767,903],"first":[496],"time":[497],"controlling":[501],"IGF-II":[502,540],"addition,":[505],"provide":[507],"suggesting":[509,836,932],"biogenesis":[512],"controlled":[515],"vitro":[522,674],"vivo,":[525],"part":[528],"dual":[531],"production":[538,629],"master":[543],"switch":[544],"governing":[545],"initiation":[547],"IV,":[553],"collaboration":[555],"former":[558],"graduate":[559],"student":[560],"lab,":[563],"Dr.":[564],"Yuting":[565],"Sun,":[566],"another":[572,654],"microRNA,":[573],"miR-1,":[574],"differentiating":[581],"myoblasts":[582],"mouse":[585,738],"muscle.":[588],"We":[589],"found":[591,919],"MyoD-dependent":[595],"miR-1":[598,618,623],"its":[600],"upstream":[601],"enhancer,":[602],"most":[603],"likely":[604],"regulating":[606],"MyoD":[607],"protein":[608,812],"stability.":[609],"Moreover,":[610,793],"functional":[612],"pathway":[613,665,855],"downstream":[614],"delineated,":[620],"suppression":[624],"HDAC4":[626],"follistatin":[631,641],"myocyte":[634,668],"fusion.":[635],"Collective":[636],"strongly":[638],"suggests":[639],"longsought":[644],"mTOR-regulated":[645],"fusion":[646,669,928],"factor.":[647],"summary,":[649],"these":[650,768,941],"findings":[651,865],"unravel":[652],"yet":[653],"link":[655],"between":[656],"biogenesis,":[660],"an":[663,898],"mTOR-miR-1-HDAC4-follistatin":[664],"vivo.":[680],"importance":[682],"canonical":[685],"complex":[687],"1":[688],"components,":[690],"raptor,":[692,729,755],"Rheb,":[695,759],"suggested":[698],"maintenance,":[701],"metabolism.":[704],"components":[710],"not":[715],"entirely":[716],"clear.":[717],"V,":[720],"report":[722],"investigation":[724],"functions":[727,846],"Rheb":[732,776,801,834],"C2C12":[737,778],"myoblasts.":[739],"although":[743],"knockdown":[745,753,785,802,824,946],"severely":[746],"expected,":[751],"well":[757],"enhances":[760],"differentiation.":[761,779],"Consistent":[762],"negative":[765],"proteins":[769],"overexpression":[772,787],"raptor":[774,799,832,848],"inhibits":[777],"On":[780],"other":[782],"hand,":[783],"neither":[784],"nor":[786],"S6K1":[789],"has":[790],"any":[791],"effect.":[792],"enhanced":[795],"elicited":[797,830],"accompanied":[804],"increased":[806],"Akt":[807],"activation,":[808],"elevated":[809],"IRS1":[810,823,838],"iv":[811],"levels,":[813],"decreased":[815],"Ser307":[816],"(human":[817],"Ser312)":[818],"phosphorylation":[819],"IRS1.":[821],"Finally,":[822],"eliminated":[825],"enhancement":[827],"knockdown,":[835],"mediator":[842],"Rheb.":[850],"conclusion,":[852],"Rheb-mTOR/raptor":[854],"suppressing":[861],"IRS1-PI3K-Akt":[862],"signaling.":[863],"These":[864],"underscore":[866],"versatility":[868],"biological":[873],"regulations":[874],"implicate":[876],"existence":[878],"complexes":[882],"and/or":[883],"Lastly":[889],"Appendix":[891],"B,":[892],"document":[894],"effort":[896],"RNAi":[899],"screening":[900],"search":[902],"among":[907],"secreted":[908],"factors.":[909],"A":[910],"few":[911],"groups":[913],"cytokines":[915],"chemokines":[917],"either":[921],"enhance":[922],"suppress":[924],"when":[929],"knocked":[930],"down,":[931],"they":[934,953],"may":[935],"Future":[938],"candidates":[942],"will":[943],"include":[944],"assessing":[945],"efficiency,":[947],"identifying":[948],"exact":[950],"regulate,":[954],"dissecting":[956],"regulatory":[958],"pathways.":[959]},"counts_by_year":[],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2016-06-24T00:00:00"}
