{"id":"https://openalex.org/W642930808","doi":null,"title":"Regulation Of Fatty Acid Desaturase Expression And Alternative Splicing","display_name":"Regulation Of Fatty Acid Desaturase Expression And Alternative Splicing","publication_year":2012,"publication_date":"2012-01-31","ids":{"openalex":"https://openalex.org/W642930808","mag":"642930808"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/29324","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/29324","pdf_url":"https://hdl.handle.net/1813/29324","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1813/29324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060793496","display_name":"Holly T. Reardon","orcid":"https://orcid.org/0000-0002-3489-1046","observed_orcids":["https://orcid.org/0000-0002-3489-1046"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Holly T. Reardon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3489-1046","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060793496"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-desaturase","display_name":"fatty acid desaturase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fads1","display_name":"FADS1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fads2","display_name":"FADS2","score":1.0},{"id":"https://openalex.org/keywords/fads3","display_name":"FADS3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9769999980926514},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.6809999942779541},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8309999704360962},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/sterol-response-element","display_name":"sterol response element","score":0.7720000147819519},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polypyrimidine-tract-binding-protein","display_name":"polypyrimidine tract-binding protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8080000281333923},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.46799999475479126},{"id":"https://openalex.org/keywords/lxr-agonists","display_name":"LXR agonists","score":0.9470000267028809},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6389999985694885},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.8519999980926514},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8389999866485596},{"id":"https://openalex.org/keywords/eicosanoid-precursors","display_name":"eicosanoid precursors","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5452781319618225},{"id":"https://openalex.org/C2777129432","wikidata":"https://www.wikidata.org/wiki/Q83133906","display_name":"Fatty acid desaturase","level":4,"score":0.5390908122062683},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5003230571746826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47354406118392944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39040231704711914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3842647969722748},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.38273900747299194},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3700264096260071},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34069788455963135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32482683658599854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2372787892818451},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.22776156663894653},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.07217934727668762},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.05374664068222046}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.cornell.edu:1813/29324","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/29324","pdf_url":"https://hdl.handle.net/1813/29324","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},{"id":"mag:642930808","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.cornell.edu/bitstream/1813/29324/1/htr2thesisPDF.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/29324","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/29324","pdf_url":"https://hdl.handle.net/1813/29324","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W642930808.pdf","grobid_xml":"https://content.openalex.org/works/W642930808.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1995239307","https://openalex.org/W2070487116","https://openalex.org/W2125416562","https://openalex.org/W2129670085","https://openalex.org/W2134292324"],"related_works":["https://openalex.org/W1983552431","https://openalex.org/W3177269307","https://openalex.org/W3158465551","https://openalex.org/W2169356768","https://openalex.org/W2052431418","https://openalex.org/W631470947","https://openalex.org/W2018483037","https://openalex.org/W1024974794","https://openalex.org/W2093550977","https://openalex.org/W2811215566"],"abstract_inverted_index":{"The":[0,32,264],"FADS1":[1,75,101,158,189],"and":[2,14,29,40,43,55,60,84,102,159,177,190,210,213,258,271,286,328,335,337],"FADS2":[3,42,69,103,161,191,209,230],"genes":[4,65],"encode":[5],"fatty":[6,18,233,243,315],"acid":[7,256,316],"desaturases":[8],"required":[9],"for":[10,279,343],"synthesis":[11],"of":[12,49,63,100,116,125,148,198,208,228,273,304,340],"omega-3":[13],"omega-6":[15,242,314],"long-chain":[16],"polyunsaturated":[17],"acids":[19,234,244],"(LCPUFA)":[20],"important":[21],"in":[22,77,131,174,218,245,254,321],"the":[23,126,146,199,309],"central":[24],"nervous":[25],"system,":[26],"inflammatory":[27],"response,":[28],"cardiovascular":[30],"health.":[31],"adjacent":[33],"FADS3":[34,44,169,186,280],"gene":[35,156],"is":[36,300],"a":[37,87,107,225,250,276,301,305],"putative":[38,127],"desaturase,":[39],"both":[41,114,160,173],"have":[45],"alternative":[46,61,206,329],"transcripts":[47,162],"(AT)":[48],"unknown":[50],"function.":[51],"Here,":[52],"genetic,":[53],"dietary":[54,149,166],"molecular":[56],"factors":[57],"regulating":[58],"expression":[59,76],"splicing":[62,207,330],"FADS":[64,155,296],"were":[66,163,171,192,215],"identified.":[67],"A":[68,182],"haplotype":[70,94,133],"was":[71],"significantly":[72,97],"associated":[73],"with":[74,86,106,249,261],"lymphoblasts":[78],"from":[79],"Japanese":[80],"International":[81],"HapMap":[82],"participants,":[83],"overlapped":[85],"predicted":[88],"sterol":[89],"response":[90,139,332],"element":[91],"(SRE).":[92],"Minor":[93],"homozygotes":[95],"had":[96],"higher":[98],"induction":[99],"after":[104],"treatment":[105],"statin":[108],"drug":[109],"or":[110],"an":[111,268],"LXR":[112],"agonist,":[113],"activators":[115],"SREBP-1c.":[117],"Sequencing":[118],"identified":[119],"2":[120],"deletions":[121],"within":[122],"150":[123],"bp":[124],"SRE":[128],"only":[129],"present":[130],"minor":[132],"carriers,":[134],"suggesting":[135],"this":[136],"region":[137],"controls":[138],"to":[140,241,283,313,333],"SREBP":[141],"-1c.":[142],"We":[143],"next":[144],"examined":[145],"effect":[147],"LCPUFA":[150],"levels":[151],"on":[152],"baboon":[153,175,220,265],"liver":[154,176],"expression.":[157],"downregulated":[164],"by":[165,236,295],"LCPUFA,":[167],"but":[168],"AT":[170,281],"upregulated,":[172],"human":[178],"liver-derived":[179],"HepG2":[180,195],"cells.":[181],"PPAR[gamma]":[183],"antagonist":[184],"prevented":[185],"upregulation,":[187],"while":[188],"unaffected.":[193],"In":[194],"cells,":[196,248],"knockdown":[197,247,288],"polypyrimidine":[200],"tract":[201],"binding":[202],"protein":[203],"(PTB)":[204],"modulated":[205],"FADS3.":[211],"PTB":[212,223,246,287],"FADS2AT1":[214],"inversely":[216],"correlated":[217],"neonatal":[219],"tissues,":[221],"implicating":[222],"as":[224],"major":[226],"regulator":[227],"tissue-specific":[229],"splicing.":[231],"Omega-3":[232],"decreased":[235],"nearly":[237],"one":[238],"half":[239],"relative":[240],"particularly":[251],"strong":[252],"decrease":[253],"eicosapentaenoic":[255],"concentration":[257],"its":[259],"ratio":[260,317],"arachidonic":[262],"acid.":[263],"results":[266,289],"showing":[267],"opposing":[269],"pattern":[270],"mechanism":[272,306],"regulation":[274],"suggested":[275,290],"dissimilar":[277],"function":[278],"compared":[282],"classical":[284],"desaturases,":[285],"possible":[291],"dominant":[292],"negative":[293],"inhibition":[294],"splice":[297],"variants.":[298],"This":[299],"rare":[302],"demonstration":[303],"specifically":[307],"altering":[308],"cellular":[310],"omega":[311],"-3":[312],"without":[318],"any":[319],"change":[320],"diet/media.":[322],"These":[323],"findings":[324],"reveal":[325],"how":[326],"genotype":[327],"affect":[331],"diet":[334],"medication,":[336],"alter":[338],"availability":[339],"eicosanoid":[341],"precursors":[342],"cell":[344],"signaling.":[345]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}