{"id":"https://openalex.org/W642864146","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","title":"AKAP9, a Regulator of Microtubule Dynamics, is Essential for Remodeling of the Blood\u2010Testis Barrier","display_name":"AKAP9, a Regulator of Microtubule Dynamics, is Essential for Remodeling of the Blood\u2010Testis Barrier","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W642864146","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","mag":"642864146"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.282.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032232580","display_name":"Deepak Venkatesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Venkatesh","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041273456","display_name":"Dolores D. Mruk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores Mruk","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","2--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","institution_ids":["https://openalex.org/I4210132262"]},{"raw_affiliation_string":"2--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110914299","display_name":"Jan Michael Herter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Herter","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054547306","display_name":"Xavier Culler\u00e9","orcid":"https://orcid.org/0000-0001-6983-4714","observed_orcids":["https://orcid.org/0000-0001-6983-4714"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xavier Cullere","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Cheng","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","2--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","institution_ids":["https://openalex.org/I4210132262"]},{"raw_affiliation_string":"2--> The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research, Population Council NewYork United States","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031800389","display_name":"Tanya N. Mayadas","orcid":"https://orcid.org/0000-0003-4143-3278","observed_orcids":["https://orcid.org/0000-0003-4143-3278"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Mayadas","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1--> Pathology Brigham and Women's Hospital and Harvard Medical, Boston, USA Boston Massachusetts United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01551494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akap9","display_name":"AKAP9","score":1.0},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.9570000171661377},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/spermiogenesis","display_name":"spermiogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.9300000071525574},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8679999709129333},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.4740000069141388},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.6140000224113464},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.7260000109672546},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8460512757301331},{"id":"https://openalex.org/C2778619154","wikidata":"https://www.wikidata.org/wiki/Q3493046","display_name":"Spermiogenesis","level":3,"score":0.8430126905441284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8040784597396851},{"id":"https://openalex.org/C2636012","wikidata":"https://www.wikidata.org/wiki/Q489842","display_name":"Blood\u2013testis barrier","level":4,"score":0.7014882564544678},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.6729509830474854},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6491601467132568},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.5947374701499939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5590328574180603},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5503180623054504},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.536084771156311},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4191853702068329},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2069544494152069},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1821177899837494},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11845150589942932},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0920063853263855},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.282.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.282.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2194405550","https://openalex.org/W4234719082","https://openalex.org/W3204562400","https://openalex.org/W2253219637","https://openalex.org/W2794322445","https://openalex.org/W2152172360","https://openalex.org/W2318344965","https://openalex.org/W2015336839","https://openalex.org/W2162553879","https://openalex.org/W2242456014"],"abstract_inverted_index":{"The":[0,20,50,77],"blood\u2010testis":[1],"barrier":[2,146,168],"(BTB)":[3],"is":[4,64,207],"formed":[5],"by":[6,160],"tight,":[7],"adherens":[8],"and":[9,56,71,94,134,141,165,170,220],"gap":[10,133],"junctions":[11],"between":[12],"adjacent":[13],"Sertoli":[14,129],"cells":[15],"of":[16,30,36,69,97,105,113,126,132,145,151,163,193,213],"the":[17,26,34,40,44,67,102,106,124,139,154,191,197,214,217],"seminiferous":[18,27],"tubules.":[19],"BTB":[21,75,107,140,215],"undergoes":[22],"extensive":[23],"remodeling":[24],"during":[25,200,216],"epithelial":[28,218],"cycle":[29,219],"spermatogenesis":[31],"to":[32,43,86,109],"allow":[33],"transport":[35,192],"preleptotene":[37],"spermatocytes":[38],"from":[39],"basal":[41],"compartment":[42,46,199],"adluminal":[45,198],"for":[47,188,209],"further":[48],"development.":[49],"actin":[51],"cytoskeleton":[52],"serves":[53],"unique":[54],"structural":[55],"supporting":[57],"roles":[58],"in":[59,74,99,120,123,128,174,182,190],"this":[60],"process,":[61],"but":[62],"little":[63],"known":[65],"about":[66],"role":[68,187],"microtubules":[70,127],"their":[72],"regulators":[73],"remodeling.":[76],"cAMP":[78],"responsive":[79],"scaffold":[80],"protein":[81],"AKAP9":[82,98,117,176,189,206],"has":[83],"been":[84],"shown":[85],"regulate":[87],"microtubule":[88],"dynamics.":[89],"We":[90],"demonstrate":[91],"that":[92,205],"conditional":[93],"inducible":[95],"deletion":[96,118],"mice":[100],"after":[101],"initial":[103],"formation":[104],"leads":[108],"infertility":[110],"despite":[111,148],"evidence":[112],"germ":[114],"cell":[115],"meiosis.":[116],"results":[119,203],"marked":[121],"alterations":[122],"integrity":[125,147,169],"cells,":[130],"mislocalization":[131],"tight":[135],"junctional":[136],"molecules":[137],"at":[138,153],"a":[142,186],"progressive":[143],"loss":[144],"normal":[149],"localization":[150],"F\u2010actin":[152],"BTB.":[155],"These":[156,202],"changes":[157],"were":[158,172],"accompanied":[159],"an":[161],"arrest":[162],"meiosis":[164,171],"spermiogenesis.":[166,201,222],"Unexpectedly,":[167],"restored":[173],"older":[175],"deficient":[177],"animals.":[178],"Yet,":[179],"significant":[180],"defects":[181],"spermiogenesis":[183],"persisted":[184],"suggesting":[185],"developing":[194],"spermatids":[195],"across":[196],"suggest":[204],"critical":[208],"both":[210],"dynamic":[211],"restructuring":[212],"subsequent":[221]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
