{"id":"https://openalex.org/W642637554","doi":null,"title":"Les metal\u00b7loprote\u00efnases de matriu extracel\u00b7lular en la isqu\u00e8mia cerebral","display_name":"Les metal\u00b7loprote\u00efnases de matriu extracel\u00b7lular en la isqu\u00e8mia cerebral","publication_year":2005,"publication_date":"2005-05-09","ids":{"openalex":"https://openalex.org/W642637554","mag":"642637554"},"language":"ca","primary_location":{"id":"pmh:oai:diposit.ub.edu:2445/36020","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/36020","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Biologia Cel\u00b7lular i Anatomia Patol\u00f2gica","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086657224","display_name":"S\u00f2nia Sol\u00e9 i Tost","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S\u00f2nia Sol\u00e9 i Tost","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086657224"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":1.0},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.777999997138977},{"id":"https://openalex.org/keywords/transient-middle-cerebral-artery-occlusion","display_name":"transient middle cerebral artery occlusion","score":0.890999972820282},{"id":"https://openalex.org/keywords/reactive-microglia","display_name":"reactive microglia","score":0.75},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8410000205039978},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.4569999873638153},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4970000088214874},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.3160000145435333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.3700000047683716},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cerebral-infarct-volume","display_name":"cerebral infarct volume","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.709103524684906},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3342839777469635},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.32270294427871704},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.03629794716835022}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:diposit.ub.edu:2445/36020","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/36020","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Biologia Cel\u00b7lular i Anatomia Patol\u00f2gica","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:642637554","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/36020/1/00.SST_PREVI.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W214225535","https://openalex.org/W1480344559","https://openalex.org/W1532538322","https://openalex.org/W1536311055","https://openalex.org/W1541178031","https://openalex.org/W1568217878","https://openalex.org/W1572873372","https://openalex.org/W1576066788","https://openalex.org/W1597610606","https://openalex.org/W1638194466","https://openalex.org/W1764824114","https://openalex.org/W1913303705","https://openalex.org/W1960998237","https://openalex.org/W1963649966","https://openalex.org/W1968905163","https://openalex.org/W1971153516","https://openalex.org/W1974815300","https://openalex.org/W1974897112","https://openalex.org/W1976155297","https://openalex.org/W1976180665","https://openalex.org/W1978657262","https://openalex.org/W1979240963","https://openalex.org/W1984081331","https://openalex.org/W1987197699","https://openalex.org/W1987897015","https://openalex.org/W1992256854","https://openalex.org/W1992981081","https://openalex.org/W1994409333","https://openalex.org/W1998880226","https://openalex.org/W2005668137","https://openalex.org/W2007627771","https://openalex.org/W2011998352","https://openalex.org/W2012257028","https://openalex.org/W2012358648","https://openalex.org/W2013524931","https://openalex.org/W2021588766","https://openalex.org/W2027701573","https://openalex.org/W2028085174","https://openalex.org/W2035750459","https://openalex.org/W2036629337","https://openalex.org/W2036743679","https://openalex.org/W2043949364","https://openalex.org/W2048170591","https://openalex.org/W2053491108","https://openalex.org/W2054337761","https://openalex.org/W2056824541","https://openalex.org/W2057200339","https://openalex.org/W2061672007","https://openalex.org/W2066315131","https://openalex.org/W2070543132","https://openalex.org/W2075333475","https://openalex.org/W2078613021","https://openalex.org/W2079241115","https://openalex.org/W2086414747","https://openalex.org/W2090459889","https://openalex.org/W2106361045","https://openalex.org/W2108448511","https://openalex.org/W2109658199","https://openalex.org/W2110688089","https://openalex.org/W2112505121","https://openalex.org/W2113892795","https://openalex.org/W2122866927","https://openalex.org/W2124217305","https://openalex.org/W2126394436","https://openalex.org/W2130149492","https://openalex.org/W2135378702","https://openalex.org/W2138835400","https://openalex.org/W2144778448","https://openalex.org/W2160768922","https://openalex.org/W2163815564","https://openalex.org/W2165183041","https://openalex.org/W2387537945","https://openalex.org/W2416894794","https://openalex.org/W2486660199","https://openalex.org/W2895451238"],"related_works":["https://openalex.org/W7020830323","https://openalex.org/W1657375757","https://openalex.org/W7001684451","https://openalex.org/W2069192677","https://openalex.org/W2495013811","https://openalex.org/W2357635340","https://openalex.org/W422073648","https://openalex.org/W7065632250","https://openalex.org/W2125220660","https://openalex.org/W7216919443"],"abstract_inverted_index":{"[cat]":[0],"Aquesta":[1,182],"tesi":[2,183],"estudia":[3],"les":[4,35,69,78,95,223,246,258,344,363,405,442,462,489],"MMPs:":[5],"MMP-9,":[6,149,379,387],"MMP-2":[7,89],"i":[8,19,38,73,80,98,143,249,273,304,315,361,373,419,436,473,484],"MMP-3":[9,241,283],"en":[10,16,27,40,54,107,160,189,215,226,242,255,261,264,274,293,362,393,407,415,441,481,492],"relaci\u00f3":[11],"amb":[12,167,508],"la":[13,17,25,28,44,63,88,108,118,126,129,145,148,153,168,173,180,185,192,198,203,209,233,240,262,265,299,312,326,336,368,378,386,394,446,466,520],"isqu\u00e8mia":[14,48,134,199,234,300],"cerebral":[15,49,59,221,235],"rata":[18,45],"tamb\u00e9":[20],"un":[21,66,91,99,136,287,390,420],"possible":[22,288],"paper":[23,391],"de":[24,34,43,57,83,117,128,141,144,147,152,155,170,172,179,191,205,208,211,219,239,295,298,311,320,325,329,365,367,399,401,417,422,426,445,461,469,477,488,498,511,517,519],"MMP-9":[26,64,119,193,521],"divisi\u00f3":[29,395,447],"cel\u00b7lular.":[30,396,448,522],"Es":[31,111],"mostra":[32,184],"l'activaci\u00f3":[33,518],"gelatinases":[36],"(MMP-2":[37],"MMP-9)":[39],"el":[41,55,161,217,227,243,308,452,475,487,509],"cervell":[42,124,195,244,342],"despr\u00e9s":[46,178],"d'una":[47,52],"focal":[50,200],"transit\u00f2ria":[51,201],"hora":[53],"territori":[56],"l'art\u00e8ria":[58],"mitja.":[60],"S'observa":[61],"que":[62,74,87,232,404,479,490,503],"presenta":[65],"pic":[67],"a":[68,77,94,120,138,222,245,333,385],"24":[70,224,247,259],"hores":[71,97,225,248],"postisqu\u00e8mia":[72],"est\u00e0":[75,165],"associada":[76],"neurones":[79,256],"als":[81,102,250,278,349,358,371,374],"tractes":[82],"fibres":[84],"mielinitzades,":[85],"mentre":[86],"t\u00e9":[90],"augment":[92,164],"d'activitat":[93],"4":[96,103,251,271,303,359,372],"increment":[100,421],"enorme":[101],"dies,":[104,351],"localitzant-se":[105,254],"principalment":[106],"micr\u00f2glia":[109],"reactiva.":[110],"demostra,":[112],"per":[113,197,335,458,496],"primera":[114],"vegada,":[115],"l'alliberament":[116],"l'espai":[121,139],"extracel\u00b7lular":[122,140],"del":[123,270,505],"mitjan\u00e7ant":[125],"t\u00e8cnica":[127],"microdi\u00e0lisi":[130],"in":[131,285,428],"vivo.":[132],"La":[133,282],"provoca":[135],"alliberament":[137],"d\u00edmers":[142],"proforma":[146,204],"per\u00f2":[150,213],"no":[151,207,214],"forma":[154,210,319,327],"88":[156],"KD":[157],"observada":[158],"pr\u00e8viament":[159],"teixit.":[162],"Aquest":[163],"relacionat":[166],"infiltraci\u00f3":[169],"neutr\u00f2fils":[171,188],"sang":[174],"al":[175,194,341,353],"teixit":[176],"lesionat":[177],"isqu\u00e8mia.":[181],"contribuci\u00f3":[186],"dels":[187,355,471],"l'augment":[190],"indu\u00efda":[196],"(de":[202],"95-kDa,":[206],"88-kDa)":[212],"l'increment":[216],"volum":[218],"l'infart":[220],"nostre":[228],"model.":[229],"Tamb\u00e9":[230],"veiem":[231,403],"produeix":[236],"una":[237,318,381,410,432],"activaci\u00f3":[238],"dies":[252,280,360],"postisqu\u00e8mia,":[253],"(a":[257,268],"hores),":[260],"microvasculatura,":[263],"microglia":[266,369],"reactiva/macr\u00f2fags":[267],"partir":[269],"dies)":[272,306],"els":[275,346],"oligodendr\u00f2cits":[276],"(augmentada":[277],"14":[279,375],"postisqu\u00e8mia).":[281],"degrada":[284],"vitro":[286],"substrat:":[289],"l'agrina":[290],"neuronal":[291,328],"present":[292],"homogenats":[294],"cervell.":[296],"Despr\u00e9s":[297],"(als":[301],"1,":[302],"7":[305,350],"disminueix":[307],"contingut":[309],"d'agrina":[310],"membrana":[313],"cel\u00b7lular":[314,454,507],"es":[316,339,455],"genera":[317],"pes":[321],"molecular":[322],"m\u00e9s":[323,412],"baix":[324],"l'agrina,":[330],"deguda":[331],"segurament":[332],"proteolisi":[334],"MMP-3.":[337],"L'agrina":[338],"localitza":[340],"en:":[343],"neurones,":[345],"astr\u00f2cits":[347],"reactius":[348],"ac\u00famuls":[352],"voltant":[354],"vasos":[356],"sanguinis":[357],"ves\u00edcules":[364],"fagocitosi":[366],"reactiva":[370],"dies.":[376],"Finalment,":[377],"o":[380],"prote\u00efna":[382,440],"molt":[383],"semblant":[384],"podria":[388],"tenir":[389],"intracel\u00b7lular":[392],"En":[397],"cultius":[398],"c\u00e8l\u00b7lules":[400,406,478],"neuroblastoma":[402],"mitosi":[408],"presenten":[409],"immunoreactivitat":[411],"alta":[413],"(estudis":[414,425,468,494],"citometria":[416,497],"flux)":[418],"l'activitat":[423],"gelatinasa":[424],"zimografia":[427],"situ),":[429],"aix\u00ed":[430],"com":[431],"expressi\u00f3":[433],"precisa,":[434],"din\u00e0mica":[435],"ben":[437],"orquestrada":[438],"d'aquesta":[439],"diferents":[443],"etapes":[444],"Per":[449,500],"altra":[450],"banda,":[451],"creixement":[453,470,506,512],"veu":[456],"afectat":[457],"l'\u00fas":[459],"d'inhibidors":[460],"MMPs,":[463],"sense":[464],"afectar-ne":[465],"viabilitat":[467],"cultius)":[472],"augmenta":[474],"percentatge":[476],"estan":[480,491],"fase":[482],"S":[483],"G2":[485],"redu\u00efnt-se":[486],"G1":[493],"realitzats":[495],"flux).":[499],"\u00faltim":[501],"observem":[502],"l'estimulaci\u00f3":[504],"factor":[510],"transformant":[513],"(TGF-a)":[514],"\u00e9s":[515],"depenent":[516]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}