{"id":"https://openalex.org/W64242960","doi":null,"title":"LGMD-1C: Role of Caveolin-3 in Neuromuscular Junction Structure and Function","display_name":"LGMD-1C: Role of Caveolin-3 in Neuromuscular Junction Structure and Function","publication_year":2009,"publication_date":"2009-12-18","ids":{"openalex":"https://openalex.org/W64242960","mag":"64242960"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10253","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","pdf_url":"http://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026961434","display_name":"Michael P. Hezel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Hezel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026961434"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00493139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.15800000727176666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-3","display_name":"caveolin-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/agrin","display_name":"agrin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/musk","display_name":"musk","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/limb-girdle-muscular-dystrophy","display_name":"limb-girdle muscular dystrophy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.37299999594688416},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.3089999854564667},{"id":"https://openalex.org/keywords/tetanic-contraction","display_name":"tetanic contraction","score":0.5210000276565552},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.47999998927116394},{"id":"https://openalex.org/keywords/distal-myopathy","display_name":"distal myopathy","score":0.6259999871253967},{"id":"https://openalex.org/keywords/rippling-muscle-disease","display_name":"rippling muscle disease","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2779024559","wikidata":"https://www.wikidata.org/wiki/Q4694120","display_name":"Agrin","level":4,"score":0.9782354831695557},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.7999880909919739},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.6532690525054932},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.5563263893127441},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5360100269317627},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4824846088886261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4493168890476227},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44395801424980164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4025852382183075},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3309440612792969},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22013181447982788},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2049294412136078},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18016818165779114}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10253","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","pdf_url":"http://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:64242960","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10253/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10253","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","pdf_url":"http://d-scholarship.pitt.edu/10253/1/hezelmp_etd_2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W64242960.pdf","grobid_xml":"https://content.openalex.org/works/W64242960.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W32666075","https://openalex.org/W1598713761","https://openalex.org/W1965480857","https://openalex.org/W1969273111","https://openalex.org/W1974248631","https://openalex.org/W1978279440","https://openalex.org/W1983433502","https://openalex.org/W1985460395","https://openalex.org/W1999743098","https://openalex.org/W2005229398","https://openalex.org/W2008741046","https://openalex.org/W2009136540","https://openalex.org/W2009967392","https://openalex.org/W2012524765","https://openalex.org/W2014987634","https://openalex.org/W2017086844","https://openalex.org/W2023145731","https://openalex.org/W2034364631","https://openalex.org/W2036436443","https://openalex.org/W2037267286","https://openalex.org/W2040880898","https://openalex.org/W2046952556","https://openalex.org/W2048411431","https://openalex.org/W2051927904","https://openalex.org/W2055851713","https://openalex.org/W2056801995","https://openalex.org/W2057947066","https://openalex.org/W2062785298","https://openalex.org/W2070988327","https://openalex.org/W2076951578","https://openalex.org/W2080112003","https://openalex.org/W2081225557","https://openalex.org/W2081617200","https://openalex.org/W2088189541","https://openalex.org/W2089011655","https://openalex.org/W2091741029","https://openalex.org/W2093245069","https://openalex.org/W2095245008","https://openalex.org/W2115039021","https://openalex.org/W2115807387","https://openalex.org/W2116916090","https://openalex.org/W2121216806","https://openalex.org/W2122524549","https://openalex.org/W2124205852","https://openalex.org/W2126068134","https://openalex.org/W2127319218","https://openalex.org/W2128393072","https://openalex.org/W2133016817","https://openalex.org/W2134505400","https://openalex.org/W2135486285","https://openalex.org/W2136088126","https://openalex.org/W2142138943","https://openalex.org/W2144696840","https://openalex.org/W2144760773","https://openalex.org/W2152953898","https://openalex.org/W2157387476","https://openalex.org/W2159204058","https://openalex.org/W2170257106"],"related_works":["https://openalex.org/W2136088126","https://openalex.org/W2554958434","https://openalex.org/W7097638086","https://openalex.org/W2021131295","https://openalex.org/W4407223002","https://openalex.org/W2517864599","https://openalex.org/W4380986550","https://openalex.org/W2076960937","https://openalex.org/W2115036072","https://openalex.org/W1978434103"],"abstract_inverted_index":{"Caveolin-3":[0],"is":[1,61,99,193,370],"a":[2,144,263,359],"muscle":[3,30,38,41,56,64,164,280],"specific":[4,165],"scaffolding":[5],"protein":[6],"with":[7,25,129],"both":[8],"structural":[9],"and":[10,28,40,48,104,109,113,118,168,207,301,317,349,367],"signaling":[11,76],"roles.":[12],"Lack":[13],"of":[14,75,163,183,202,214,225,278,312,342,375],"caveolin-3":[15,98,138,189,206,251,266,285,308,318,330,343],"expression":[16,248],"has":[17],"been":[18],"implicated":[19],"in":[20,88,124,147,187,217,246,249,267,272,283,307,315,328,338,372],"limb-girdle":[21],"muscular":[22,376],"dystrophy,":[23],"along":[24],"distal":[26],"myopathy":[27],"rippling":[29],"disease.":[31],"These":[32,120,260],"diseases":[33],"are":[34,50],"characterized":[35],"by":[36,116],"progressive":[37],"weakness":[39,65],"wasting.":[42],"Nicotinic":[43],"acetylcholine":[44],"receptor":[45],"(nAChR)":[46],"clustering":[47,90,103,132],"localization":[49],"important":[51,100,371],"for":[52,101,265],"efficient":[53,268],"nerve":[54],"to":[55,80,92,152,222,256,290,324],"contractile":[57,313,340,354],"signal":[58],"transmission.":[59],"It":[60],"hypothesized":[62],"that":[63,205,362],"could":[66],"originate":[67],"through":[68,161,170],"disrupted":[69],"nAChR":[70,89,102,111,131,148,159,269],"clustering,":[71,160],"disrupting":[72],"the":[73,78,81,84,110,130,223,243,250,257,279,284,305,329,345,373],"efficiency":[74],"from":[77],"motorneuron":[79],"muscle.":[82],"While":[83],"molecular":[85],"mechanisms":[86],"involved":[87],"remain":[91],"be":[93,325],"fully":[94],"defined,":[95],"we":[96],"hypothesize":[97],"overall":[105,244,297,353],"neuromuscular":[106,346,364,368],"junction":[107,347,365],"function.Caveolin-3":[108],"co-localize":[112],"associate":[114],"evidenced":[115],"immunofluorescence":[117],"immunoprecipitation.":[119],"results":[121,261],"were":[122,294],"replicated":[123],"differentiated":[125,137,174,188],"wildtype":[126,155,175,218,258,291,316],"myotubes":[127,191],"treated":[128,154],"agent,":[133],"neural":[134],"agrin.":[135],"In":[136,173],"null":[139,190,252,286,309,319,331],"myotubes,":[140,176],"agrin":[141,153,184,199,215],"treatment":[142,216],"yields":[143],"60%":[145],"reduction":[146],"clusters":[149],"as":[150,254,288],"compared":[151,255,289],"myotubes.":[156],"Agrin":[157,234],"induces":[158],"activation":[162,178,197],"kinase":[166],"(MuSK)":[167],"downstream":[169],"Rac-1":[171,177,196],"activation.":[172],"peaks":[179,210],"at":[180,211,231],"1":[181,212,232],"hour":[182,213],"treatment,":[185],"while":[186],"there":[192,334],"dramatically":[194],"reduced":[195],"upon":[198],"treatment.":[200],"Immunoprecipitation":[201],"MuSK":[203,208,226,236,247],"shows":[204],"association":[209],"cells.":[219],"This":[220,356],"corresponds":[221],"peak":[224],"phosphorylation":[227,237],"which":[228],"also":[229,295],"occurs":[230],"hour.":[233],"induced":[235],"was":[238,335],"decreased":[239,296],"more":[240],"significantly":[241],"than":[242],"decrease":[245],"cells":[253],"results.":[259],"indicate":[262],"role":[264],"clustering.Electromyography":[270],"studies":[271],"anesthetized":[273],"mice":[274,287],"indicated":[275,321],"lengthened":[276],"latencies":[277],"action":[281],"potential":[282],"mice.":[292,310],"There":[293],"electromyography":[298],"(EMG)":[299],"amplitude":[300],"EMG":[302],"area":[303],"under":[304],"curve":[306],"Comparison":[311],"strength":[314],"animals":[320],"tetanic":[322],"contractions":[323],"less":[326],"stable":[327],"animals,":[332],"though":[333],"late":[336],"potentiation":[337],"actual":[339],"strength.Lack":[341],"affects":[344],"formation":[348,366],"transmission":[350,369],"without":[351],"affecting":[352],"strength.":[355],"research":[357],"opens":[358],"novel":[360],"view,":[361],"correct":[363],"development":[374],"dystrophies.":[377]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
