{"id":"https://openalex.org/W64018904","doi":null,"title":"Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.","display_name":"Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W64018904","mag":"64018904","pmid":"https://pubmed.ncbi.nlm.nih.gov/23515184","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3601467"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2600915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3601467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3601467","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000141364","display_name":"Pauline Pl So","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline Pl So","raw_affiliation_strings":["Department of Medicine Graduate Program in Molecular Medicine, Boston University School of Medicine 72 East Concord Street, K-304, Boston, MA, 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Graduate Program in Molecular Medicine, Boston University School of Medicine 72 East Concord Street, K-304, Boston, MA, 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064032108","display_name":"Christina E. Khodr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina E Khodr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012268693","display_name":"Ci-Di Chen","orcid":"https://orcid.org/0000-0001-7112-2230","observed_orcids":["https://orcid.org/0000-0001-7112-2230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ci-Di Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052419811","display_name":"Carmela R. Abraham","orcid":"https://orcid.org/0000-0002-6649-1960","observed_orcids":["https://orcid.org/0000-0002-6649-1960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmela R Abraham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3609,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.50560636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"1","first_page":"15","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-beta-production","display_name":"amyloid-beta production","score":0.9020000100135803},{"id":"https://openalex.org/keywords/app-mutations","display_name":"APP mutations","score":0.5139999985694885},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.6078068614006042},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.6051819324493408},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5824281573295593},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5680288076400757},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5398312211036682},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5375672578811646},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.47461429238319397},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4470064640045166},{"id":"https://openalex.org/C123243835","wikidata":"https://www.wikidata.org/wiki/Q863465","display_name":"Bimolecular fluorescence complementation","level":3,"score":0.4403552711009979},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43771788477897644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4266001284122467},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4227031469345093},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4176996350288391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3796883225440979},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3540489077568054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3323974013328552},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32648804783821106},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19385400414466858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1693585216999054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08577191829681396},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2600915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3601467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23515184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23515184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of neurodegenerative disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3601467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3601467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Neurodegener Dis","raw_type":"Text"},{"id":"mag:2740904544","doi":null,"is_oa":false,"landing_page_url":"http://www.bu.edu/alzresearch/files/2014/06/Comparable-dimerization-Cam..pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:64018904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23515184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2600915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3601467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W174859322","https://openalex.org/W1536258113","https://openalex.org/W1544102899","https://openalex.org/W1565153664","https://openalex.org/W1734288496","https://openalex.org/W1861730929","https://openalex.org/W1965633082","https://openalex.org/W1975627206","https://openalex.org/W1979505297","https://openalex.org/W1982067620","https://openalex.org/W1987403479","https://openalex.org/W1988927287","https://openalex.org/W1993554801","https://openalex.org/W1997098324","https://openalex.org/W2007624075","https://openalex.org/W2007810468","https://openalex.org/W2014272598","https://openalex.org/W2018753627","https://openalex.org/W2024363942","https://openalex.org/W2025084653","https://openalex.org/W2026053103","https://openalex.org/W2027241185","https://openalex.org/W2028191533","https://openalex.org/W2028213861","https://openalex.org/W2030182984","https://openalex.org/W2030249003","https://openalex.org/W2030641075","https://openalex.org/W2033077848","https://openalex.org/W2038086035","https://openalex.org/W2039210066","https://openalex.org/W2041087658","https://openalex.org/W2043409309","https://openalex.org/W2043502436","https://openalex.org/W2046478450","https://openalex.org/W2046610378","https://openalex.org/W2048621255","https://openalex.org/W2053328915","https://openalex.org/W2054438061","https://openalex.org/W2058723245","https://openalex.org/W2060802768","https://openalex.org/W2066116456","https://openalex.org/W2066223581","https://openalex.org/W2066958493","https://openalex.org/W2067445072","https://openalex.org/W2076201821","https://openalex.org/W2079400095","https://openalex.org/W2081881251","https://openalex.org/W2082022687","https://openalex.org/W2085661619","https://openalex.org/W2088616718","https://openalex.org/W2090737341","https://openalex.org/W2094727963","https://openalex.org/W2097248196","https://openalex.org/W2126690234","https://openalex.org/W2127061690","https://openalex.org/W2131773654","https://openalex.org/W2132695172","https://openalex.org/W2133019124","https://openalex.org/W2139818289","https://openalex.org/W2142616340","https://openalex.org/W2152926110","https://openalex.org/W2164990833","https://openalex.org/W2167099782","https://openalex.org/W2168879529"],"related_works":["https://openalex.org/W2740904544","https://openalex.org/W7099015650","https://openalex.org/W2060802768","https://openalex.org/W1885637186","https://openalex.org/W2417948845","https://openalex.org/W2090150925","https://openalex.org/W3119714211","https://openalex.org/W2471686248","https://openalex.org/W2046682365","https://openalex.org/W1745162040"],"abstract_inverted_index":{"Alzheimer's":[0,148],"disease":[1,149],"(AD)":[2],"is":[3,23,67,117],"a":[4,56,189],"progressive":[5],"and":[6,14,53,95,139,161,178],"fatal":[7],"neurodegenerative":[8],"disorder":[9],"marked":[10],"by":[11,51],"memory":[12],"impairment":[13],"cognitive":[15],"deficits.":[16],"A":[17],"major":[18],"component":[19],"of":[20,26,35,45,58,61,80,89,118,191],"AD":[21],"pathology":[22],"the":[24,30,42,46,64,86,90,93],"accumulation":[25],"amyloid":[27,36,47],"plaques":[28],"in":[29,63,113,158,168,179,183],"brain,":[31],"which":[32],"are":[33,100,171,186],"comprised":[34],"beta":[37],"(A\u03b2)":[38],"peptides":[39],"derived":[40],"from":[41],"amyloidogenic":[43],"processing":[44],"precursor":[48],"protein":[49,91],"(A\u03b2PP)":[50],"\u03b2-":[52],"\u03b3-secretases.":[54],"In":[55],"subset":[57],"patients,":[59],"inheritance":[60],"mutations":[62,83,125,151],"A\u03b2PP":[65,106,124,156,169],"gene":[66],"responsible":[68],"for":[69,102,174],"altering":[70],"A\u03b2":[71,114,176,184],"production,":[72,115,177],"leading":[73],"to":[74,111,120],"early":[75],"onset":[76],"disease.":[77],"Interestingly,":[78],"many":[79],"these":[81],"familial":[82,123,147],"lie":[84],"within":[85],"transmembrane":[87,103],"domain":[88],"near":[92],"GxxxG":[94],"GxxxA":[96],"dimerization":[97,107,157,170],"motifs":[98],"that":[99,146,166],"important":[101],"interactions.":[104],"As":[105],"has":[108],"been":[109],"linked":[110],"changes":[112,167,182],"it":[116],"interest":[119],"know":[121],"whether":[122],"affect":[126,154],"full-length":[127,155],"APP":[128],"dimerization.":[129],"Using":[130],"bimolecular":[131],"fluorescence":[132],"complementation":[133],"(BiFC),":[134],"blue":[135],"native":[136],"gel":[137],"electrophoresis,":[138],"live":[140],"cell":[141],"chemical":[142],"cross-linking,":[143],"we":[144],"found":[145],"(FAD)":[150],"do":[152],"not":[153,172],"transfected":[159],"HEK293":[160],"COS7":[162],"cells.":[163],"It":[164],"follows":[165],"necessary":[173],"altered":[175],"FAD":[180],"mutations,":[181],"levels":[185],"more":[187],"likely":[188],"result":[190],"alternative":[192],"proteolytic":[193],"processing.":[194]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}