{"id":"https://openalex.org/W640105665","doi":null,"title":"\u59dc\u9ec4\u7d20\u4e0a\u8c03NF-\u03baB\u8bf1\u5bfc\u6025\u6027\u65e9\u5e7c\u7c92\u767d\u8840\u75c5HL-60\u7ec6\u80de\u51cb\u4ea1","display_name":"\u59dc\u9ec4\u7d20\u4e0a\u8c03NF-\u03baB\u8bf1\u5bfc\u6025\u6027\u65e9\u5e7c\u7c92\u767d\u8840\u75c5HL-60\u7ec6\u80de\u51cb\u4ea1","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W640105665","mag":"640105665"},"language":"zh","primary_location":{"id":"mag:640105665","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92062X/201112/37293085.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306547874","display_name":"\u5c71\u4e1c\u533b\u836f","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5c71\u4e1c\u533b\u836f","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011995230","display_name":"\u80e1\u4eae\u6749","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u80e1\u4eae\u6749","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007277633","display_name":"\u718a\u6587\u8273","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u718a\u6587\u8273","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034874308","display_name":"\u4f59\u8389\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4f59\u8389\u534e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051651976","display_name":"\u674e\u7389\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u7389\u534e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020250899","display_name":"\u90ed\u5764\u5143","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u90ed\u5764\u5143","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"12","first_page":"23","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8610000014305115},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9319999814033508},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.828000009059906},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33175456523895264}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:640105665","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92062X/201112/37293085.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306547874","display_name":"\u5c71\u4e1c\u533b\u836f","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5c71\u4e1c\u533b\u836f","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W5339414","https://openalex.org/W625797590","https://openalex.org/W995644640","https://openalex.org/W3030927061","https://openalex.org/W7109463374","https://openalex.org/W940235004","https://openalex.org/W7109463412","https://openalex.org/W943603051","https://openalex.org/W998084005","https://openalex.org/W1592424876"],"abstract_inverted_index":{"\u76ee\u7684\u89c2\u5bdf\u59dc\u9ec4\u7d20\u8bf1\u5bfc\u4eba\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5HL-60\u7ec6\u80de\u51cb\u4ea1\u7684\u4f5c\u7528,\u5e76\u63a2\u8ba8\u4f5c\u7528\u673a\u5236\u3002\u65b9\u6cd5\u7528\u53f0\u76fc\u84dd\u8ba1\u6570\u89c2\u5bdf\u59dc\u9ec4\u7d20\u5bf9HL-60\u7ec6\u80de\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528,AnnexinV-FITC/PI\u67d3\u8272\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1,RT-PCR\u68c0\u6d4b\u51cb\u4ea1\u76f8\u5173\u57fa\u56e0mRNA\u7684\u8868\u8fbe,Western":[0],"blot\u68c0\u6d4b\u7ec6\u80de\u5185NF-\u03baB":[1],"p65\u86cb\u767d\u7684\u8868\u8fbe\u3002\u7ed3\u679c\u59dc\u9ec4\u7d20\u5bf9HL-60\u7ec6\u80de\u751f\u957f\u6709\u6291\u5236\u4f5c\u7528,\u5e76\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u59dc\u9ec4\u7d20\u4f5c\u7528\u524d\u540eHL-60\u7ec6\u80de\u4e2d\u6297\u51cb\u4ea1\u57fa\u56e0Bcl-2\u548cBcl-xl\u8868\u8fbe\u65e0\u660e\u663e\u53d8\u5316;\u4fc3\u51cb\u4ea1\u57fa\u56e0Bax\u548cBid\u8868\u8fbe\u589e\u9ad8;P53\u57fa\u56e0\u5747\u4e0d\u8868\u8fbe;NF-\u03baB":[2],"mRNA\u548c\u86cb\u767d\u8868\u8fbe\u5747\u589e\u9ad8,\u5e76\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u7ed3\u8bba\u59dc\u9ec4\u7d20\u80fd\u8bf1\u5bfcHL-60\u7ec6\u80de\u51cb\u4ea1\u548c\u4e0a\u8c03\u4fc3\u51cb\u4ea1\u57fa\u56e0Bax\u548cBid,\u8fd9\u53ef\u80fd\u4e0eNF-\u03baB\u8868\u8fbe\u4e0a\u8c03\u6709\u5173\u3002":[3]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}