{"id":"https://openalex.org/W63995578","doi":null,"title":"A Comparative Approach to Assessing the Functional and Structural Characteristics of Human FKBP52 in the Regulation of Steroid Hormone Receptor Signaling Pathway","display_name":"A Comparative Approach to Assessing the Functional and Structural Characteristics of Human FKBP52 in the Regulation of Steroid Hormone Receptor Signaling Pathway","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W63995578","mag":"63995578"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.utep.edu:open_etd-2255","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.utep.edu/open_etd/1256","pdf_url":"https://digitalcommons.utep.edu/open_etd/1256","source":{"id":"https://openalex.org/S4306402377","display_name":"DigitalCommons@UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses &amp; Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.utep.edu/open_etd/1256","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078761339","display_name":"Diondra C. Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diondra C. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078761339"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00315284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.06710000336170197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fkbp52","display_name":"FKBP52","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fkbp","display_name":"FKBP","score":0.8849999904632568},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/receptor-potentiation","display_name":"receptor potentiation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gain-of-function-screen","display_name":"gain-of-function screen","score":0.48399999737739563},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6100000143051147},{"id":"https://openalex.org/keywords/co-chaperones","display_name":"co-chaperones","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.5311260223388672},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5181609392166138},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5169429183006287},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5059852004051208},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4522767663002014},{"id":"https://openalex.org/C2779544216","wikidata":"https://www.wikidata.org/wiki/Q411546","display_name":"Steroid hormone receptor","level":5,"score":0.44508689641952515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4099389612674713},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39138007164001465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33076798915863037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2954728603363037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28139209747314453},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.17546617984771729},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.12279155850410461},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11985400319099426}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:digitalcommons.utep.edu:open_etd-2255","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.utep.edu/open_etd/1256","pdf_url":"https://digitalcommons.utep.edu/open_etd/1256","source":{"id":"https://openalex.org/S4306402377","display_name":"DigitalCommons@UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses &amp; Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.utep.edu:dissertations-7879","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.utep.edu/dissertations/AAI3636256","pdf_url":null,"source":{"id":"https://openalex.org/S4377196403","display_name":"scholarworks - UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Collection for University of Texas, El Paso","raw_type":"text"},{"id":"pmh:oai:scholarworks.utep.edu:dissertations-7879","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.utep.edu/dissertations/AAI3636256","pdf_url":null,"source":{"id":"https://openalex.org/S4377196403","display_name":"scholarworks - UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETD Collection for University of Texas, El Paso","raw_type":"text"},{"id":"pmh:oai:scholarworks.utep.edu:open_etd-2255","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.utep.edu/open_etd/1256","pdf_url":null,"source":{"id":"https://openalex.org/S4377196403","display_name":"scholarworks - UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses & Dissertations","raw_type":"text"},{"id":"mag:63995578","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.utep.edu/open_etd/1256/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.utep.edu:open_etd-2255","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.utep.edu/open_etd/1256","pdf_url":"https://digitalcommons.utep.edu/open_etd/1256","source":{"id":"https://openalex.org/S4306402377","display_name":"DigitalCommons@UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses &amp; Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1340722568","display_name":"Border Biomedical Research Center","funder_award_id":"G12RR008124","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1751573725","display_name":"RISE Research Scholars Program","funder_award_id":"R25GM069621","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3529779747","display_name":null,"funder_award_id":"5G12RR008124","funder_id":"https://openalex.org/F4320333121","funder_display_name":"University of Texas at El Paso"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320333121","display_name":"University of Texas at El Paso","ror":"https://ror.org/04d5vba33"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W63995578.pdf","grobid_xml":"https://content.openalex.org/works/W63995578.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1979381130","https://openalex.org/W2000460499","https://openalex.org/W2022882907"],"related_works":["https://openalex.org/W2982131253","https://openalex.org/W2087548953","https://openalex.org/W6980537811","https://openalex.org/W1521812805","https://openalex.org/W2053756955","https://openalex.org/W7096075705","https://openalex.org/W2148864400","https://openalex.org/W6991323511","https://openalex.org/W2109243666","https://openalex.org/W7095319843"],"abstract_inverted_index":{"The":[0],"52":[1],"kDa":[2],"FK506":[3],"binding":[4],"protein":[5,38],"(h52)":[6],"is":[7,22,34,77,115,212,229,296,332],"a":[8,35,78,102,119,140,192,199,249],"key":[9,452],"positive":[10,79],"regulator":[11,80],"of":[12,29,53,62,81,107,148,170,232,245,251,278,301,365],"Androgen":[13],"Receptor":[14],"(AR)":[15],"in":[16,50,59,69,97,122,240,248,261,267,355,382,413,427],"cellular":[17],"and":[18,21,39,58,71,86,105,135,150,156,181,265,288,349,416,424,440],"animal":[19],"models":[20],"an":[23,47,297,362],"attractive":[24],"target":[25],"for":[26,243,276,372,376,421,446],"the":[27,51,54,60,63,108,133,146,151,189,206,209,213,218,224,262,268,273,285,291,302,310,343,350,366,383,392],"treatment":[28],"prostate":[30],"cancer.":[31],"Human":[32],"FKBP52":[33,76,155,161,201,315],"known":[36],"regulatory":[37,215],"co-chaperone":[40],"that":[41,75,111,130,208,329,410],"has":[42],"been":[43],"shown":[44],"to":[45,95,144,176,314,454],"play":[46],"important":[48,179],"role":[49,200],"regulation":[52],"AR":[55,134,377],"signaling":[56,400],"pathway,":[57],"development":[61],"male":[64],"sexual":[65],"phenotype.":[66],"Cellular":[67],"studies":[68],"mammalian":[70,289],"yeast":[72,286],"cells":[73],"reveal":[74],"AR,":[82],"glucocorticoid":[83],"receptor":[84,88,279,428,434],"(GR),":[85],"progesterone":[87],"(PR),":[89],"potentiating":[90],"receptor-mediated":[91],"gene":[92],"expression":[93],"up":[94],"60-fold":[96],"some":[98],"systems.\\nIn":[99],"targeting":[100,123],"FKBP52,":[101],"thorough":[103],"investigation":[104],"understanding":[106],"structural":[109],"elements":[110],"underlay":[112],"its":[113,227],"function":[114],"necessary.":[116],"This":[117,203],"permits":[118],"logical":[120],"approach":[121,143],"specific":[124,411],"interaction":[125],"motifs,":[126],"such":[127],"as":[128,197,271,401,403,448],"those":[129],"exist":[131],"between":[132,154],"FKBP52.":[136],"Here":[137],"we":[138,166,186],"use":[139],"cross-species":[141],"comparative":[142],"analyze":[145],"mechanisms":[147],"potentiation":[149,233,246,280,307],"functional":[152],"difference":[153],"Danio":[157],"rerio":[158],"(Zebra":[159],"fish)":[160],"(DrFKBP52).":[162],"In":[163,283],"this":[164,171,184,339,359],"study":[165,185],"have":[167,187,223],"taken":[168],"advantage":[169],"by":[172,281,326,334],"comparing":[173],"their":[174],"differences":[175],"identify":[177],"additional":[178],"domains":[180,439],"residues.":[182],"Through":[183],"identified":[188,256,438],"FK2":[190,269,384,417],"domain,":[191,196,216],"previously":[193],"uncharacterized,":[194],"non-functional":[195],"playing":[198],"activity.":[202,234,319,435],"observation":[204],"dispels":[205],"notion":[207],"FK1":[210,263,415],"domain":[211,264,270,418],"sole":[214],"specifically":[217,455],"proline-rich":[219,225,303],"loop.":[220],"Though":[221],"both":[222,284,342,414],"loop,":[226,304],"presence":[228],"not":[230],"indicative":[231],"A":[235,379],"genetic":[236],"selection":[237],"screen":[238],"generated":[239],"Saccharomyces":[241],"cerevisiae":[242],"gain":[244],"activity,":[247,308],"library":[250],"randomly":[252],"mutated":[253],"DrFKBP52":[254,292],"genes,":[255],"two":[257],"residues:":[258],"position":[259,337],"111":[260,338],"157":[266],"being":[272],"critical":[274,420],"residues":[275,299,412,441,453],"activation":[277],"DrFKBP52.":[282],"model":[287],"cells,":[290],"mutation":[293,312],"A111V,":[294],"which":[295,430],"adjacent":[298],"downstream":[300],"confer":[305],"significant":[306],"whereas":[309],"same":[311],"introduced":[313],"only":[316],"slightly":[317],"elevates":[318],"Three":[320],"dimensional":[321],"crystal":[322],"structure":[323],"homology":[324],"modeling":[325],"I-TASSER":[327],"indicate":[328],"when":[330],"alanine":[331],"replaced":[333],"valine":[335],"at":[336],"change":[340,360],"affect":[341],"surface":[344,374],"charge":[345],"(to":[346,352],"more":[347,353],"neutral)":[348],"hydrophobicity":[351],"hydrophobic)":[354],"vicinity.":[356],"We":[357],"believe":[358],"induces":[361],"open":[363],"conformation":[364],"proline":[367],"rich":[368],"loop":[369],"notch,":[370],"allowing":[371],"sufficient":[373],"area":[375],"interaction.":[378],"second":[380],"residue":[381],"region,":[385],"T157R,":[386],"also":[387],"greatly":[388],"influences":[389],"potentiation.":[390],"Moreover,":[391],"DFKBPr52:":[393],"A111V":[394],"_T157R":[395],"double":[396],"mutant":[397],"potentiated":[398],"hormone":[399,433],"well":[402],"wild-type":[404],"hFKBP52.":[405],"Collectively":[406],"these":[407],"results":[408],"suggest":[409],"are":[419,425],"full":[422],"activity":[423],"involved":[426],"interactions,":[429],"potentiates":[431],"steroid":[432],"These":[436],"newly":[437],"could":[442,450],"possibly":[443],"become":[444],"targets":[445],"inhibitors":[447],"they":[449],"be":[451],"disrupt":[456],"AR-FKBP52":[457],"association.":[458]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
