{"id":"https://openalex.org/W6379543","doi":null,"title":"Extracellular mass transport considerations for space flight research concerning suspended and adherent in vitro cell cultures.","display_name":"Extracellular mass transport considerations for space flight research concerning suspended and adherent in vitro cell cultures.","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W6379543","mag":"6379543","pmid":"https://pubmed.ncbi.nlm.nih.gov/16145796"},"language":"en","primary_location":{"id":"pmid:16145796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16145796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021827367","display_name":"David M. Klaus","orcid":"https://orcid.org/0000-0003-0789-0176","observed_orcids":["https://orcid.org/0000-0003-0789-0176"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M Klaus","raw_affiliation_strings":["BioServe Space Technologies, Department of Aerospace Engineering Sciences, University of Colorado at Boulder, USA. klaus@colorado.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioServe Space Technologies, Department of Aerospace Engineering Sciences, University of Colorado at Boulder, USA. klaus@colorado.edu","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041292662","display_name":"Michael R. Benoit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Benoit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101520071","display_name":"Emily S. Nelson","orcid":"https://orcid.org/0000-0002-3454-4378","observed_orcids":["https://orcid.org/0000-0002-3454-4378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily S Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035549539","display_name":"TIMMOTHY G. HAMMOND","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timmothy G Hammond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6465,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81755861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"17","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/in-vitro-cell-culture","display_name":"in vitro cell culture","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-suspension-culture","display_name":"cell suspension culture","score":0.6190000176429749},{"id":"https://openalex.org/keywords/adherent-cell-culture","display_name":"adherent cell culture","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sedimentation","display_name":"sedimentation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/shear-force","display_name":"shear force","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-deformation","display_name":"cell deformation","score":0.3959999978542328},{"id":"https://openalex.org/keywords/structural-loads","display_name":"structural loads","score":0.5920000076293945},{"id":"https://openalex.org/keywords/confounding-variables","display_name":"confounding variables","score":0.5540000200271606},{"id":"https://openalex.org/keywords/spaceflight-research","display_name":"spaceflight research","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.5904337763786316},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.5623804926872253},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.4629638195037842},{"id":"https://openalex.org/C538625479","wikidata":"https://www.wikidata.org/wiki/Q6497624","display_name":"Buoyancy","level":2,"score":0.45475709438323975},{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.4432932734489441},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43381279706954956},{"id":"https://openalex.org/C134853933","wikidata":"https://www.wikidata.org/wiki/Q208641","display_name":"Hydrostatic equilibrium","level":2,"score":0.4204269349575043},{"id":"https://openalex.org/C71976986","wikidata":"https://www.wikidata.org/wiki/Q30006","display_name":"Gravitational acceleration","level":3,"score":0.41865724325180054},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38095077872276306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3001907467842102},{"id":"https://openalex.org/C124017977","wikidata":"https://www.wikidata.org/wiki/Q11412","display_name":"Gravitation","level":2,"score":0.2829391658306122},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.2702881693840027},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002498","descriptor_name":"Centrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006112","descriptor_name":"Gravitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008828","descriptor_name":"Microbiological Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008828","descriptor_name":"Microbiological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018470","descriptor_name":"Gravity, Altered","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16145796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16145796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology","raw_type":"Journal Article"},{"id":"mag:6379543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16145796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","score":0.6000000238418579,"display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W159726054","https://openalex.org/W1487904063","https://openalex.org/W1967139715","https://openalex.org/W1968163150","https://openalex.org/W1975970649","https://openalex.org/W1979588751","https://openalex.org/W1985049433","https://openalex.org/W1989505214","https://openalex.org/W1989640830","https://openalex.org/W1994692446","https://openalex.org/W2006118296","https://openalex.org/W2024041744","https://openalex.org/W2039463724","https://openalex.org/W2060157859","https://openalex.org/W2063635863","https://openalex.org/W2074079987","https://openalex.org/W2078498089","https://openalex.org/W2083545047","https://openalex.org/W2084291187","https://openalex.org/W2085974593","https://openalex.org/W2094012980","https://openalex.org/W2100221733","https://openalex.org/W2126903506","https://openalex.org/W2131666821","https://openalex.org/W2140653478","https://openalex.org/W2324438765","https://openalex.org/W2330439314","https://openalex.org/W2344254436","https://openalex.org/W2397478001","https://openalex.org/W2398807014","https://openalex.org/W2411411352","https://openalex.org/W2411705309","https://openalex.org/W2411933854","https://openalex.org/W2414346715","https://openalex.org/W2415199209","https://openalex.org/W2417143788"],"related_works":["https://openalex.org/W1502231888","https://openalex.org/W4292003674","https://openalex.org/W2055235650","https://openalex.org/W2246033233","https://openalex.org/W2045888925","https://openalex.org/W7036063707","https://openalex.org/W135193024","https://openalex.org/W2022997875","https://openalex.org/W2481424686","https://openalex.org/W1485147594"],"abstract_inverted_index":{"Conducting":[0],"biological":[1,28],"research":[2],"in":[3,15,34,82,140],"space":[4],"requires":[5],"consideration":[6],"be":[7,36,57,125,168],"given":[8],"to":[9,31,39,60],"isolating":[10],"appropriate":[11],"control":[12],"parameters.":[13,195],"For":[14],"vitro":[16],"cell":[17,91,116],"cultures,":[18],"numerous":[19],"environmental":[20],"factors":[21,102],"can":[22,56,167],"adversely":[23],"affect":[24],"data":[25],"interpretation.":[26],"A":[27,177],"response":[29],"attributed":[30],"microgravity":[32],"can,":[33],"theory,":[35],"explicitly":[37],"correlated":[38],"a":[40,53,83,190],"specific":[41,183],"lack":[42],"of":[43,64,89,97,112,122,132,192],"weight":[44],"or":[45,51,70,78,99,106,164,173],"gravity-driven":[46],"motion":[47,76],"occurring":[48],"to,":[49],"within":[50,77],"around":[52],"cell.":[54],"Weight":[55],"broken":[58],"down":[59],"include":[61],"the":[62,90,119,128,133,138,193],"formation":[63],"hydrostatic":[65],"gradients,":[66],"structural":[67],"load":[68],"(stress)":[69],"physical":[71],"deformation":[72],"(strain).":[73],"Gravitationally":[74],"induced":[75],"near":[79],"individual":[80],"cells":[81],"fluid":[84],"includes":[85],"sedimentation":[86],"(or":[87],"buoyancy)":[88],"and":[92,101,111,137],"associated":[93,103],"shear":[94],"forces,":[95],"displacement":[96],"cytoskeleton":[98],"organelles,":[100],"with":[104],"intra-":[105],"extracellular":[107],"mass":[108],"transport.":[109],"Finally,":[110],"particular":[113],"importance":[114],"for":[115,127,181,186],"culture":[117],"experiments,":[118],"collective":[120],"effects":[121],"gravity":[123],"must":[124],"considered":[126],"overall":[129],"system":[130],"consisting":[131],"cells,":[134],"their":[135],"environment":[136],"device":[139],"which":[141,166],"they":[142],"are":[143],"contained.":[144],"This":[145],"does":[146],"not,":[147],"however,":[148],"rule":[149],"out":[150],"other":[151],"confounding":[152],"variables":[153],"such":[154],"as":[155,189],"launch":[156],"acceleration,":[157],"on":[158],"orbit":[159],"vibration,":[160],"transient":[161],"acceleration":[162],"impulses":[163],"radiation,":[165],"isolated":[169],"using":[170],"onboard":[171],"centrifuges":[172],"vibration":[174],"isolation":[175],"techniques.":[176],"framework":[178],"is":[179],"offered":[180],"characterizing":[182],"cause-and-effect":[184],"relationships":[185],"gravity-dependent":[187],"responses":[188],"function":[191],"above":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}