{"id":"https://openalex.org/W63764740","doi":null,"title":"Is it stress? The role of the CRF system and HPA axis, and the identification of brain sites involved in chronic food restriction-induced augmentation of heroin seeking","display_name":"Is it stress? The role of the CRF system and HPA axis, and the identification of brain sites involved in chronic food restriction-induced augmentation of heroin seeking","publication_year":2012,"publication_date":"2012-08-22","ids":{"openalex":"https://openalex.org/W63764740","mag":"63764740"},"language":"en","primary_location":{"id":"pmh:oai:https://spectrum.library.concordia.ca:974823","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/974823/4/SEDKI_MA_F2012.pdf","pdf_url":"https://spectrum.library.concordia.ca/974823/4/SEDKI_MA_F2012.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023484708","display_name":"Firas Sedki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Firas Sedki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023484708"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.04969999939203262,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-food-restriction","display_name":"chronic food restriction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/heroin-seeking","display_name":"heroin seeking","score":0.9359999895095825},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.5600000023841858},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9150000214576721},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.5230000019073486},{"id":"https://openalex.org/keywords/crf1-receptor-antagonist","display_name":"CRF1 receptor antagonist","score":0.656000018119812},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-antagonist","display_name":"glucocorticoid receptor antagonist","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nucleus-accumbens-shell","display_name":"nucleus accumbens shell","score":0.8460000157356262},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8109999895095825},{"id":"https://openalex.org/keywords/fos-immunoreactivity","display_name":"Fos-like immunoreactivity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.5180000066757202},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7519999742507935},{"id":"https://openalex.org/keywords/extinction","display_name":"extinction","score":0.5049999952316284},{"id":"https://openalex.org/keywords/drug-self-administration","display_name":"self-administration","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.8866063952445984},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6133392453193665},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5831268429756165},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.561014711856842},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.5602169036865234},{"id":"https://openalex.org/C2780004078","wikidata":"https://www.wikidata.org/wiki/Q4774743","display_name":"Antiglucocorticoid","level":4,"score":0.5572282075881958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5300968289375305},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5292239189147949},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.513181746006012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.511496901512146},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.5061408877372742},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.49527350068092346},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.480704128742218},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.4391515851020813},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4160520136356354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3802749514579773},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3727450966835022},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3656480312347412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18966910243034363},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12300664186477661},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11314207315444946},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://spectrum.library.concordia.ca:974823","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/974823/4/SEDKI_MA_F2012.pdf","pdf_url":"https://spectrum.library.concordia.ca/974823/4/SEDKI_MA_F2012.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:63764740","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/id/eprint/974823/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W122691953","https://openalex.org/W1495277562","https://openalex.org/W1518117902","https://openalex.org/W1678524661","https://openalex.org/W1933795318","https://openalex.org/W1949947575","https://openalex.org/W1951492130","https://openalex.org/W1971394163","https://openalex.org/W1977266070","https://openalex.org/W1987509241","https://openalex.org/W1998645186","https://openalex.org/W2000825098","https://openalex.org/W2001351189","https://openalex.org/W2023931775","https://openalex.org/W2026145070","https://openalex.org/W2039038315","https://openalex.org/W2041139441","https://openalex.org/W2041232094","https://openalex.org/W2044823814","https://openalex.org/W2046013541","https://openalex.org/W2053657245","https://openalex.org/W2055926767","https://openalex.org/W2069969297","https://openalex.org/W2071278141","https://openalex.org/W2082876506","https://openalex.org/W2090618383","https://openalex.org/W2098304576","https://openalex.org/W2102030231","https://openalex.org/W2102987338","https://openalex.org/W2111769038","https://openalex.org/W2130646478","https://openalex.org/W2136108338","https://openalex.org/W2140159910","https://openalex.org/W2156623031","https://openalex.org/W2167246321","https://openalex.org/W2171769039","https://openalex.org/W2221391747","https://openalex.org/W4298083387"],"related_works":["https://openalex.org/W2100347608","https://openalex.org/W2094827133","https://openalex.org/W1671645500","https://openalex.org/W4404891012","https://openalex.org/W7097807106","https://openalex.org/W2914152835","https://openalex.org/W2130646478","https://openalex.org/W2904965468","https://openalex.org/W2145956345","https://openalex.org/W2554731220"],"abstract_inverted_index":{"Drug":[0],"addiction":[1],"is":[2,47,101],"a":[3,32,64,155,182,204,215,230,264,305,331],"chronic":[4,35],"disease":[5],"characterized":[6],"by":[7,103],"recurring":[8],"episodes":[9],"of":[10,34,55,85,97,109,113,121,150,170,289,297,351],"abstinence":[11],"and":[12,71,115,213,286],"relapse.":[13],"The":[14,111,349],"mechanisms":[15],"that":[16,28,49,259],"underlie":[17],"this":[18,280],"pattern":[19],"are":[20],"yet":[21],"to":[22,43,59,90,132,147,161,238,274,323,339],"be":[23,263,330],"elucidated.":[24],"Recently,":[25],"we":[26],"reported":[27],"abstinent":[29],"rats":[30,129,144,179,282],"with":[31,248],"history":[33],"food":[36,50,82,118,340],"restriction":[37,51,341],"show":[38],"increased":[39],"heroin":[40,134,235],"seeking":[41,57,100,123,219,236],"compared":[42,237,322],"sated":[44,172,240,324],"controls.":[45],"It":[46],"thought":[48],"may":[52,261,328],"cause":[53,343],"sensitization":[54,84],"drug":[56,99,122,218],"due":[58],"its":[60],"stress-like":[61],"properties,":[62],"suggesting":[63],"critical":[65,265,332],"role":[66,112],"for":[67,135,246,319],"corticotropin-releasing":[68],"factor":[69,266,333],"(CRF)":[70],"corticosterone,":[72],"hormones":[73],"involved":[74,278],"in":[75,88,117,138,225,234,267,279,309,312,334,345,356],"the":[76,171,226,239,287,290,313,320],"stress":[77,260,327],"response.":[78],"Blocking":[79],"corticosterone":[80,116],"reduces":[81],"restriction-induced":[83,119],"locomotor":[86],"activity":[87],"response":[89],"cocaine,":[91],"while":[92],"acute":[93],"food-deprivation":[94],"induced":[95],"reinstatement":[96],"extinguished":[98],"attenuated":[102],"CRF":[104,114,193,251],"antagonism":[105],"but":[106],"not":[107,262,329],"removal":[108],"corticosterone.":[110],"augmentation":[120],"remains":[124],"unknown.":[125],"Here,":[126],"male":[127],"Long-Evans":[128],"were":[130,145,180,254,283],"trained":[131],"self-administer":[133],"10":[136],"days":[137,149],"operant":[139],"conditioning":[140],"chambers.":[141],"Following":[142],"self-administration":[143],"subjected":[146],"14":[148],"unrestricted":[151],"(sated":[152],"group)":[153,159],"or":[154,203,252],"mildly":[156],"restricted":[157],"(FDR":[158],"access":[160],"food,":[162],"which":[163],"maintained":[164],"their":[165],"body":[166,174],"weight":[167],"at":[168],"~75%":[169],"rats\u2019":[173],"weight.":[175],"On":[176],"day":[177],"14,":[178],"administered":[181],"selective":[183],"CRF1":[184],"receptor":[185,194,206],"antagonist":[186,195,207],"(R121919;":[187],"0.0,":[188,198,209],"20.0":[189],"mg/kg;":[190,211],"IP),":[191,212],"non-selective":[192],"(\u03b1-helical":[196],"CRF;":[197],"10.0,":[199],"25.0":[200],"\u03bcg/\u03bcl;":[201],"ICV)":[202],"glucocorticoid":[205],"(RU486;":[208],"30.0":[210],"underwent":[214],"1":[216],"h":[217],"test":[220],"under":[221],"extinction":[222],"conditions.":[223],"Rats":[224],"FDR":[227,321],"group":[228],"showed":[229],"statistically":[231,243,306],"significant":[232,244,307],"increase":[233],"group.":[241],"No":[242],"effects":[245],"treatment":[247],"R121919,":[249],"\u03b1-helical":[250],"RU486":[253],"observed.":[255],"These":[256],"findings":[257],"suggest":[258],"our":[268,335],"paradigm.":[269],"In":[270],"an":[271,295],"exploratory":[272],"study":[273],"identify":[275],"brain":[276,347],"sites":[277],"effect":[281],"sacrificed":[284],"post-test":[285],"expression":[288],"immediate":[291],"early":[292],"gene,":[293],"c-fos,":[294],"indicator":[296],"neuronal":[298],"activity,":[299],"was":[300,317],"measured":[301],"using":[302],"immunohistochemistry.":[303],"Interestingly,":[304],"decrease":[308],"Fos":[310],"immunoreactivity":[311],"nucleus":[314],"accumbens":[315],"shell":[316],"observed":[318],"rats.":[325],"Although":[326],"effect,":[336],"prolonged":[337],"exposure":[338],"does":[342],"alterations":[344],"reward-related":[346],"sites.":[348],"identification":[350],"specific":[352],"neuron":[353],"types":[354],"affected":[355],"these":[357],"regions":[358],"should":[359],"drive":[360],"future":[361],"studies.":[362]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}